RRAGD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRAGD_HUMAN
• UniProt AC: Q9NQL2
• Protein Name: Ras-related GTP-binding protein D
• Gene Name: RRAGD {ECO:0000312|HGNC:HGNC:19903}
• Organism: Homo sapiens (Human).
• Sequence Length: 400
• Subcellular Localization: Cytoplasm . Nucleus . Lysosome . Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942).
• Protein Description: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids..
• Protein Sequence: MSQVLGKPQPQDEDDAEEEEEEDELVGLADYGDGPDSSDADPDSGTEEGVLDFSDPFSTEVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKICREDVSNSSFVNFQIWDFPGQIDFFDPTFDYEMIFRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDMIDVVIDISCIYGLKEDGAGTPYDKESTAIIKLNNTTVLYLKEVTKFLALVCFVREESFERKGLIDYNFHCFRKAIHEVFEVRMKVVKSRKVQNRLQKKKRATPNGTPRVLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Ubiquitination	SDPFSTEVKPRILLM CCCCCCCCCCCEEEE	11.94	23000965
66	Ubiquitination	TEVKPRILLMGLRRS CCCCCCEEEEECHHC	2.58	21890473
71	Ubiquitination	RILLMGLRRSGKSSI CEEEEECHHCCCCCC	25.62	23000965
73	Phosphorylation	LLMGLRRSGKSSIQK EEEECHHCCCCCCEE	44.10	22673903
75	Ubiquitination	MGLRRSGKSSIQKVV EECHHCCCCCCEEEE	42.13	23000965
76	Phosphorylation	GLRRSGKSSIQKVVF ECHHCCCCCCEEEEE	35.88	26699800
77	Phosphorylation	LRRSGKSSIQKVVFH CHHCCCCCCEEEEEE	32.31	26699800
80	Ubiquitination	SGKSSIQKVVFHKMS CCCCCCEEEEEECCC	38.40	23000965
80 (in isoform 1)	Ubiquitination	-	38.40	21890473
85	Ubiquitination	IQKVVFHKMSPNETL CEEEEEECCCCCCEE	29.61	23000965
87	Phosphorylation	KVVFHKMSPNETLFL EEEEECCCCCCEEEE	29.40	23927012
91	Phosphorylation	HKMSPNETLFLESTN ECCCCCCEEEEECCC	29.47	23927012
96	Phosphorylation	NETLFLESTNKICRE CCEEEEECCCCCHHH	39.15	29255136
97	Phosphorylation	ETLFLESTNKICRED CEEEEECCCCCHHHH	31.02	29255136
161	Phosphorylation	ALARLHLTVTRAYKV HHHHHHCEEEEEEEC	14.75	26074081
163	Phosphorylation	ARLHLTVTRAYKVNT HHHHCEEEEEEECCC	12.35	26074081
166	Phosphorylation	HLTVTRAYKVNTDIN HCEEEEEEECCCCCC	16.51	26074081
243	Phosphorylation	KLIPQLPTLENLLNI HHHCCCCCHHHHHHH	56.12	20068231
253	Phosphorylation	NLLNIFISNSGIEKA HHHHHHHCCCCHHHH	17.75	20068231
316	Ubiquitination	TPYDKESTAIIKLNN CCCCCCCCEEEEECC	23.98	23000965
320	Ubiquitination	KESTAIIKLNNTTVL CCCCEEEEECCCEEE	38.76	23000965
328	Phosphorylation	LNNTTVLYLKEVTKF ECCCEEEEHHHHHHH	16.05	-
330	Ubiquitination	NTTVLYLKEVTKFLA CCEEEEHHHHHHHHH	36.26	23000965
334	Ubiquitination	LYLKEVTKFLALVCF EEHHHHHHHHHHHHH	43.48	23000965
391	Phosphorylation	LQKKKRATPNGTPRV HHHHCCCCCCCCCCC	22.71	24173317

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RRAGD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRAGD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRAGD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPTOR_HUMAN	RPTOR	physical	18497260
MTOR_HUMAN	MTOR	physical	18497260
RRAGB_HUMAN	RRAGB	physical	18497260
SYLC_HUMAN	LARS	physical	22424946
RPTOR_HUMAN	RPTOR	physical	22424946
RRAGB_HUMAN	RRAGB	physical	22424946
LTOR1_HUMAN	LAMTOR1	physical	22424946
RPTOR_HUMAN	RPTOR	physical	24337580
RRAGB_HUMAN	RRAGB	physical	24337580
RRAGC_HUMAN	RRAGC	physical	24337580
LTOR3_HUMAN	LAMTOR3	physical	20381137
LTOR2_HUMAN	LAMTOR2	physical	20381137
LTOR1_HUMAN	LAMTOR1	physical	20381137
RRAGB_HUMAN	RRAGB	physical	20381137

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.