RRAGB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRAGB_HUMAN
• UniProt AC: Q5VZM2
• Protein Name: Ras-related GTP-binding protein B {ECO:0000305}
• Gene Name: RRAGB {ECO:0000312|HGNC:HGNC:19901}
• Organism: Homo sapiens (Human).
• Sequence Length: 374
• Subcellular Localization: Cytoplasm . Lysosome .
• Protein Description: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway..
• Protein Sequence: MEESDSEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEESDSEK -------CCCCCCCC	13.39	22814378
4	Phosphorylation	----MEESDSEKTTE ----CCCCCCCCCCC	32.88	23401153
6	Phosphorylation	--MEESDSEKTTEKE --CCCCCCCCCCCCC	50.72	29255136
9	Phosphorylation	EESDSEKTTEKENLG CCCCCCCCCCCCCCC	35.81	29083192
10	Phosphorylation	ESDSEKTTEKENLGP CCCCCCCCCCCCCCC	57.01	29083192
10	Ubiquitination	ESDSEKTTEKENLGP CCCCCCCCCCCCCCC	57.01	27667366
29	Phosphorylation	PLGEPEGSLGWVLPN CCCCCCCCCCCCCCC	23.27	27251275
48	Ubiquitination	KKVLLMGKSGSGKTS CEEEEECCCCCCCHH	37.36	27667366
49	Phosphorylation	KVLLMGKSGSGKTSM EEEEECCCCCCCHHH	32.25	20068231
51	Phosphorylation	LLMGKSGSGKTSMRS EEECCCCCCCHHHHH	44.18	20068231
54	Phosphorylation	GKSGSGKTSMRSIIF CCCCCCCHHHHHHHH	31.14	20068231
55	Phosphorylation	KSGSGKTSMRSIIFA CCCCCCHHHHHHHHH	18.71	20068231
58	Phosphorylation	SGKTSMRSIIFANYI CCCHHHHHHHHHHHH	16.05	20068231
64	Phosphorylation	RSIIFANYIARDTRR HHHHHHHHHHHHHHH	7.79	20068231
69	Phosphorylation	ANYIARDTRRLGATI HHHHHHHHHHHCCHH	16.49	24719451
137	Ubiquitination	FMENYFTSQRDNIFR HHHHHCHHCCCCHHC	17.20	27667366
157	Phosphorylation	IYVFDVESRELEKDM EEEEECCCCHHHHHH	30.79	-
161	Ubiquitination	DVESRELEKDMHYYQ ECCCCHHHHHHHHHH	42.11	29967540
165	Ubiquitination	RELEKDMHYYQSCLE CHHHHHHHHHHHHHH	28.43	27667366
175	Ubiquitination	QSCLEAILQNSPDAK HHHHHHHHHCCCCCE	5.20	33845483
189	Ubiquitination	KIFCLVHKMDLVQED EEEEEEECHHHHCHH	26.99	29967540
203	Ubiquitination	DQRDLIFKEREEDLR HHHHHHHHHHHHHHH	49.20	33845483
225	Ubiquitination	CSCFRTSIWDETLYK CCHHCCCCCCHHHHH	5.48	21890473
234	Ubiquitination	DETLYKAWSSIVYQL CHHHHHHHHHHHHHH	6.61	23000965
239	Ubiquitination	KAWSSIVYQLIPNVQ HHHHHHHHHHCCCHH	8.91	23000965
253	Ubiquitination	QQLEMNLRNFAEIIE HHHHHHHHHHHHHHH	31.08	21890473
262	Ubiquitination	FAEIIEADEVLLFER HHHHHHHHHEEHHHH	33.47	23000965
263 (in isoform 2)	Ubiquitination	-	41.96	21890473
263	Ubiquitination	AEIIEADEVLLFERA HHHHHHHHEEHHHHC	41.96	21890473
267	Ubiquitination	EADEVLLFERATFLV HHHHEEHHHHCCEEE	5.37	23000965
272	Ubiquitination	LLFERATFLVISHYQ EHHHHCCEEEEECCC	5.11	23000965
276	Phosphorylation	RATFLVISHYQCKEQ HCCEEEEECCCCHHH	14.52	29083192
277	Ubiquitination	ATFLVISHYQCKEQR CCEEEEECCCCHHHH	12.93	23000965
278	Phosphorylation	TFLVISHYQCKEQRD CEEEEECCCCHHHHH	14.60	29083192
291 (in isoform 1)	Ubiquitination	-	49.04	21890473
291	Ubiquitination	RDAHRFEKISNIIKQ HHHHHHHHHHHHHHH	49.04	21890473
293	Phosphorylation	AHRFEKISNIIKQFK HHHHHHHHHHHHHHH	32.80	28060719
297	Ubiquitination	EKISNIIKQFKLSCS HHHHHHHHHHHHHHH	45.98	-
297	Acetylation	EKISNIIKQFKLSCS HHHHHHHHHHHHHHH	45.98	19824289
300	Acetylation	SNIIKQFKLSCSKLA HHHHHHHHHHHHHHH	36.68	19824297
300	Ubiquitination	SNIIKQFKLSCSKLA HHHHHHHHHHHHHHH	36.68	23000965
305	Ubiquitination	QFKLSCSKLAASFQS HHHHHHHHHHHHHHC	46.61	23000965
305	Acetylation	QFKLSCSKLAASFQS HHHHHHHHHHHHHHC	46.61	19824305
309	Phosphorylation	SCSKLAASFQSMEVR HHHHHHHHHHCCCCC	20.43	21406692
312	Phosphorylation	KLAASFQSMEVRNSN HHHHHHHCCCCCCCC	18.20	21406692
360	Ubiquitination	NARKHFEKLERVDGP HHHHHHHHHHCCCCC	55.49	-
360	Acetylation	NARKHFEKLERVDGP HHHHHHHHHHCCCCC	55.49	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RRAGB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRAGB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRAGB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RRAGD_HUMAN	RRAGD	physical	11073942
RRAGC_HUMAN	RRAGC	physical	11073942
RPTOR_HUMAN	RPTOR	physical	18497260
A4_HUMAN	APP	physical	21832049
KCRB_HUMAN	CKB	physical	22863883
XPO2_HUMAN	CSE1L	physical	22863883
GSHB_HUMAN	GSS	physical	22863883
RASL1_HUMAN	RASAL1	physical	22863883
1433B_HUMAN	YWHAB	physical	22863883
LTOR5_HUMAN	LAMTOR5	physical	22980980
LTOR4_HUMAN	LAMTOR4	physical	22980980
RRAGC_HUMAN	RRAGC	physical	24337580
RPTOR_HUMAN	RPTOR	physical	24337580
MTOR_HUMAN	MTOR	physical	24337580
RRAGD_HUMAN	RRAGD	physical	24337580
LTOR3_HUMAN	LAMTOR3	physical	20381137
LTOR2_HUMAN	LAMTOR2	physical	20381137
LTOR1_HUMAN	LAMTOR1	physical	20381137
S38A9_HUMAN	SLC38A9	physical	25567906
LTOR1_HUMAN	LAMTOR1	physical	25567906
LTOR2_HUMAN	LAMTOR2	physical	25567906
RRAGC_HUMAN	RRAGC	physical	25567906

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.