LTOR5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LTOR5_HUMAN
• UniProt AC: O43504
• Protein Name: Ragulator complex protein LAMTOR5
• Gene Name: LAMTOR5
• Organism: Homo sapiens (Human).
• Sequence Length: 91
• Subcellular Localization: Cytoplasm. Lysosome.
• Protein Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication..
• Protein Sequence: MEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVLAQQAAKLTSDPTDIPVVCLESDNGNIMIQKHDGITVAVHKMAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEATLEQH -------CCCHHHHH		25944712
17	Phosphorylation	EDTMKNPSIVGVLCT HHHHCCCCEEEEEEE		27080861
24	Phosphorylation	SIVGVLCTDSQGLNL CEEEEEEECCCCCCC		25850435
26	Phosphorylation	VGVLCTDSQGLNLGC EEEEEECCCCCCCCC		17525332
36	Phosphorylation	LNLGCRGTLSDEHAG CCCCCCCCCCHHHHH		21712546
38	Phosphorylation	LGCRGTLSDEHAGVI CCCCCCCCHHHHHHH		21712546
83	Phosphorylation	IQKHDGITVAVHKMA EEEECCEEEEEEECC		20068231
91	Phosphorylation	VAVHKMAS------- EEEEECCC-------		20068231
108	Phosphorylation	------------------------ ------------------------		17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
26	S	Phosphorylation	Kinase	ATM	Q13315	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LTOR5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LTOR5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA6_HUMAN	NCOA6	physical	14578865
MAF1_HUMAN	MAF1	physical	16169070
GASP1_HUMAN	GPRASP1	physical	16169070
UT14A_HUMAN	UTP14A	physical	16169070
ZBT16_HUMAN	ZBTB16	physical	16169070
EF1A1_HUMAN	EEF1A1	physical	16169070
G3P_HUMAN	GAPDH	physical	16169070
GIT1_HUMAN	GIT1	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
SIN3A_HUMAN	SIN3A	physical	21706058
YTDC1_HUMAN	YTHDC1	physical	21988832
E2F1_HUMAN	E2F1	physical	23352642
CEP70_HUMAN	CEP70	physical	25416956
LTOR4_HUMAN	LAMTOR4	physical	25416956
ASGR1_HUMAN	ASGR1	physical	23241634
BHMT1_HUMAN	BHMT	physical	23241634
ACBP_HUMAN	DBI	physical	23241634
TGFB1_HUMAN	TGFB1	physical	23241634
RET4_HUMAN	RBP4	physical	23241634
CFAB_HUMAN	CFB	physical	23241634
HG2A_HUMAN	CD74	physical	23241634
MT2_HUMAN	MT2A	physical	23241634
TOP2B_HUMAN	TOP2B	physical	23241634
ALBU_HUMAN	ALB	physical	23241634
PDK1_HUMAN	PDK1	physical	23241634
A1AT_HUMAN	SERPINA1	physical	23241634
CO9_HUMAN	C9	physical	23241634
VATC1_HUMAN	ATP6V1C1	physical	26344197
P53_HUMAN	TP53	physical	26229107
S38A9_HUMAN	SLC38A9	physical	25567906

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.