LTOR5_HUMAN - dbPTM
LTOR5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LTOR5_HUMAN
UniProt AC O43504
Protein Name Ragulator complex protein LAMTOR5
Gene Name LAMTOR5
Organism Homo sapiens (Human).
Sequence Length 91
Subcellular Localization Cytoplasm. Lysosome.
Protein Description As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication..
Protein Sequence MEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVLAQQAAKLTSDPTDIPVVCLESDNGNIMIQKHDGITVAVHKMAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEATLEQH
-------CCCHHHHH
25944712
17PhosphorylationEDTMKNPSIVGVLCT
HHHHCCCCEEEEEEE
27080861
24PhosphorylationSIVGVLCTDSQGLNL
CEEEEEEECCCCCCC
25850435
26PhosphorylationVGVLCTDSQGLNLGC
EEEEEECCCCCCCCC
17525332
36PhosphorylationLNLGCRGTLSDEHAG
CCCCCCCCCCHHHHH
21712546
38PhosphorylationLGCRGTLSDEHAGVI
CCCCCCCCHHHHHHH
21712546
83PhosphorylationIQKHDGITVAVHKMA
EEEECCEEEEEEECC
20068231
91PhosphorylationVAVHKMAS-------
EEEEECCC-------
20068231
108Phosphorylation------------------------
------------------------
17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
26SPhosphorylationKinaseATMQ13315
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LTOR5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LTOR5_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NCOA6_HUMANNCOA6physical
14578865
MAF1_HUMANMAF1physical
16169070
GASP1_HUMANGPRASP1physical
16169070
UT14A_HUMANUTP14Aphysical
16169070
ZBT16_HUMANZBTB16physical
16169070
EF1A1_HUMANEEF1A1physical
16169070
G3P_HUMANGAPDHphysical
16169070
GIT1_HUMANGIT1physical
16169070
CE126_HUMANKIAA1377physical
16169070
LRIF1_HUMANLRIF1physical
16169070
SIN3A_HUMANSIN3Aphysical
21706058
YTDC1_HUMANYTHDC1physical
21988832
E2F1_HUMANE2F1physical
23352642
CEP70_HUMANCEP70physical
25416956
LTOR4_HUMANLAMTOR4physical
25416956
ASGR1_HUMANASGR1physical
23241634
BHMT1_HUMANBHMTphysical
23241634
ACBP_HUMANDBIphysical
23241634
TGFB1_HUMANTGFB1physical
23241634
RET4_HUMANRBP4physical
23241634
CFAB_HUMANCFBphysical
23241634
HG2A_HUMANCD74physical
23241634
MT2_HUMANMT2Aphysical
23241634
TOP2B_HUMANTOP2Bphysical
23241634
ALBU_HUMANALBphysical
23241634
PDK1_HUMANPDK1physical
23241634
A1AT_HUMANSERPINA1physical
23241634
CO9_HUMANC9physical
23241634
VATC1_HUMANATP6V1C1physical
26344197
P53_HUMANTP53physical
26229107
S38A9_HUMANSLC38A9physical
25567906

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LTOR5_HUMAN

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Related Literatures of Post-Translational Modification

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