ASGR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASGR1_HUMAN
• UniProt AC: P07306
• Protein Name: Asialoglycoprotein receptor 1
• Gene Name: ASGR1
• Organism: Homo sapiens (Human).
• Sequence Length: 291
• Subcellular Localization: Isoform H1a: Membrane; Single-pass type II membrane protein.; Isoform H1b: Secreted .
• Protein Description: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface..
• Protein Sequence: MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTKEYQDLQ ------CCHHHHHHH	32.36	-
5	Phosphorylation	---MTKEYQDLQHLD ---CCHHHHHHHCCC	14.64	29116813
16	Phosphorylation	QHLDNEESDHHQLRK HCCCCCCCCHHHHHC	35.74	29116813
36	S-palmitoylation	QPLLQRLCSGPRLLL HHHHHHHCCCHHHHH	4.88	8943311
79	N-linked_Glycosylation	GLRETFSNFTASTEA HHHHHHHHCCCCCHH	33.81	19159218
81	O-linked_Glycosylation	RETFSNFTASTEAQV HHHHHHCCCCCHHHH	24.77	-
93	O-linked_Glycosylation	AQVKGLSTQGGNVGR HHHCCCCCCCCHHHH	35.95	OGP
147	N-linked_Glycosylation	QMAALQGNGSERTCC HHHHHCCCCCCCEEE	37.55	19159218
149	O-linked_Glycosylation	AALQGNGSERTCCPV HHHCCCCCCCEEEEC	28.09	-
285	Phosphorylation	ETELDKASQEPPLL- CHHHHHHHCCCCCC-	40.60	8943311
285	O-linked_Glycosylation	ETELDKASQEPPLL- CHHHHHHHCCCCCC-	40.60	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASGR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASGR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASGR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CERS2_HUMAN	CERS2	physical	11543633
A4_HUMAN	APP	physical	21832049
EDEM1_HUMAN	EDEM1	physical	23233672
SYVN1_HUMAN	SYVN1	physical	23233672
FBX6_HUMAN	FBXO6	physical	23233672
GRP78_HUMAN	HSPA5	physical	23233672
ZEP1_HUMAN	HIVEP1	physical	21988832
CERS2_HUMAN	CERS2	physical	21988832
PLVAP_HUMAN	PLVAP	physical	28514442
PTN2_HUMAN	PTPN2	physical	28514442
GABT_HUMAN	ABAT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79 AND ASN-147, AND MASSSPECTROMETRY.
PubMed: 19159218

Palmitoylation

"Fatty acylation of the rat and human asialoglycoprotein receptors. Aconserved cytoplasmic cysteine residue is acylated in all receptorsubunits.";
Zeng F.Y., Weigel P.H.;
J. Biol. Chem. 271:32454-32460(1996).
Cited for: PALMITOYLATION AT CYS-36.
PubMed: 8943311