UniProt ID | FBX6_HUMAN | |
---|---|---|
UniProt AC | Q9NRD1 | |
Protein Name | F-box only protein 6 | |
Gene Name | FBXO6 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 293 | |
Subcellular Localization | Cytoplasm . | |
Protein Description | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.. | |
Protein Sequence | MDAPHSKAALDSINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLMTLWKRKCLREGFITKDWDQPVADWKIFYFLRSLHRNLLRNPCAEEDMFAWQIDFNGGDRWKVESLPGAHGTDFPDPKVKKYFVTSYEMCLKSQLVDLVAEGYWEELLDTFRPDIVVKDWFAARADCGCTYQLKVQLASADYFVLASFEPPPVTIQQWNNATWTEVSYTFSDYPRGVRYILFQHGGRDTQYWAGWYGPRVTNSSIVVSPKMTRNQASSEAQPGQKHGQEEAAQSPYRAVVQIF | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
42 | Phosphorylation | LNCRLVCSLWRDLID HHHHHHHHHHHHHHH | 24.40 | 24719451 | |
66 | Ubiquitination | LREGFITKDWDQPVA HHCCCCCCCCCCCCH | 52.59 | 22817900 | |
251 | Phosphorylation | GWYGPRVTNSSIVVS EEECCCCCCCEEEEC | 30.57 | 29759185 | |
258 | Phosphorylation | TNSSIVVSPKMTRNQ CCCEEEECCCCCCCC | 14.12 | 23403867 | |
260 | Ubiquitination | SSIVVSPKMTRNQAS CEEEECCCCCCCCCC | 45.45 | 21906983 | |
262 | Phosphorylation | IVVSPKMTRNQASSE EEECCCCCCCCCCCC | 32.37 | 29759185 | |
275 | Ubiquitination | SEAQPGQKHGQEEAA CCCCCCCCCCHHHHH | 56.47 | 27667366 | |
284 | Phosphorylation | GQEEAAQSPYRAVVQ CHHHHHHCCCCCHHC | 21.12 | 23401153 | |
286 | Phosphorylation | EEAAQSPYRAVVQIF HHHHHCCCCCHHCCC | 19.22 | 23403867 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBX6_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBX6_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBX6_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...