HEPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEPH_HUMAN
• UniProt AC: Q9BQS7
• Protein Name: Hephaestin
• Gene Name: HEPH
• Organism: Homo sapiens (Human).
• Sequence Length: 1158
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1..
• Protein Sequence: MESGHLLWALLFMQSLWPQLTDGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESGHLLWAL -----CCHHHHHHHH	43.29	29978859
15	Phosphorylation	WALLFMQSLWPQLTD HHHHHHHHHHHHCCC	22.18	29978859
21	Phosphorylation	QSLWPQLTDGATRVY HHHHHHCCCCCEEEE	27.43	29978859
25	Phosphorylation	PQLTDGATRVYYLGI HHCCCCCEEEEEEEE	26.63	29978859
29	Phosphorylation	DGATRVYYLGIRDVQ CCCEEEEEEEEEECC	8.80	-
39	Phosphorylation	IRDVQWNYAPKGRNV EEECCCCCCCCCCCC	22.71	-
60	Phosphorylation	DSDIVASSFLKSDKN CCHHHHHHHHCCCCC	25.51	24719451
164	N-linked_Glycosylation	PGGSHIYNWTIPEGH CCCCEEEEEECCCCC	28.89	UniProtKB CARBOHYD
205	Phosphorylation	GLIGPLITCKRGALD CCHHHHHEECCCCCC	21.47	-
236	N-linked_Glycosylation	LFSVVDENLSWHLNE EEEEECCCCCEECCC	34.61	UniProtKB CARBOHYD
420	Phosphorylation	SDKFFQKSSSRIGGT CHHHHHHHHCCCCCE	23.82	20068231
421	Phosphorylation	DKFFQKSSSRIGGTY HHHHHHHHCCCCCEE	30.58	20068231
422	Phosphorylation	KFFQKSSSRIGGTYW HHHHHHHCCCCCEEE	34.70	20068231
427	Phosphorylation	SSSRIGGTYWKVRYE HHCCCCCEEEEEEEE	22.46	20068231
428	Phosphorylation	SSRIGGTYWKVRYEA HCCCCCEEEEEEEEH	13.40	20068231
476	Phosphorylation	QVVFYNRASQPFSMQ EEEEEECCCCCCEEC	14.64	20068231
481	Phosphorylation	NRASQPFSMQPHGVF ECCCCCCEECCCEEE	24.16	20068231
496	Phosphorylation	YEKDYEGTVYNDGSS EECCCCCCEECCCCC	14.10	26699800
498	Phosphorylation	KDYEGTVYNDGSSYP CCCCCCEECCCCCCC	13.84	26699800
502	Phosphorylation	GTVYNDGSSYPGLVA CCEECCCCCCCCEEE	29.57	26699800
503	Phosphorylation	TVYNDGSSYPGLVAK CEECCCCCCCCEEEC	40.66	26699800
504	Phosphorylation	VYNDGSSYPGLVAKP EECCCCCCCCEEECC	11.74	26699800
516	Phosphorylation	AKPFEKVTYRWTVPP ECCCCEEEEEEECCC	20.59	20068231
517	Phosphorylation	KPFEKVTYRWTVPPH CCCCEEEEEEECCCC	13.72	20068231
520	Phosphorylation	EKVTYRWTVPPHAGP CEEEEEEECCCCCCC	17.71	20068231
528	Phosphorylation	VPPHAGPTAQDPACL CCCCCCCCCCCHHHH	35.71	20068231
536	Phosphorylation	AQDPACLTWMYFSAA CCCHHHHCEEECCCC	14.20	20068231
539	Phosphorylation	PACLTWMYFSAADPI HHHHCEEECCCCCCC	5.97	20068231
541	Phosphorylation	CLTWMYFSAADPIRD HHCEEECCCCCCCCC	12.69	20068231
588	N-linked_Glycosylation	LFTVLDENKSWYSNA EEEEECCCCCHHCCH	43.24	UniProtKB CARBOHYD
590	Phosphorylation	TVLDENKSWYSNANQ EEECCCCCHHCCHHH	42.71	20068231
608	Phosphorylation	MLDFRLLSEDIEGFQ HHHHHHHHCCCCCCC	37.50	24719451
617	Phosphorylation	DIEGFQDSNRMHAIN CCCCCCCCCCHHHHC	18.62	24719451
629	Phosphorylation	AINGFLFSNLPRLDM HHCCCHHCCCCCCCC	39.34	24719451
662	Phosphorylation	VHGVMFQGNTVQLQG CCEEEECCCEEEECC	22.10	-
671	Phosphorylation	TVQLQGMRKGAAMLF EEEECCCCCCCHHCC	40.87	-
683	Phosphorylation	MLFPHTFVMAIMQPD HCCCCEEEEEECCCC	2.38	-
714	N-linked_Glycosylation	AGMRAIYNVSQCPGH HHCEEEEEHHHCCCC	22.35	UniProtKB CARBOHYD
758	N-linked_Glycosylation	SWEREWHNQSEKDSY CCCCCCCCCCCCCCC	48.42	UniProtKB CARBOHYD
801	Phosphorylation	FRIPRPRTGPEEHLG EECCCCCCCCHHHHC	60.82	20068231
829	N-linked_Glycosylation	LTVVFKNNASRPYSV EEEEECCCCCCCEEE	39.62	UniProtKB CARBOHYD
855	Phosphorylation	WPLAAEPGEVVTYQW EEEECCCCCEEEEEE	31.66	20068231
873	N-linked_Glycosylation	ERSGPGPNDSACVSW CCCCCCCCCHHHHHH	62.88	UniProtKB CARBOHYD
931	N-linked_Glycosylation	LFLIFDENKSWYLEE EEEEECCCCCEEEEE	45.57	UniProtKB CARBOHYD
935	Phosphorylation	FDENKSWYLEENVAT ECCCCCEEEEECCCC	16.01	-
1066	Phosphorylation	LFTVFSRTEHLSPLT HHHHHHCCCCCCCCE	26.93	17929957
1070	Phosphorylation	FSRTEHLSPLTVITK HHCCCCCCCCEEEEC	21.55	17929957
1070	O-linked_Glycosylation	FSRTEHLSPLTVITK HHCCCCCCCCEEEEC	21.55	OGP
1073	O-linked_Glycosylation	TEHLSPLTVITKETE CCCCCCCEEEECCCC	17.16	OGP
1076	O-linked_Glycosylation	LSPLTVITKETEKAV CCCCEEEECCCCCCC	20.63	OGP
1079	O-linked_Glycosylation	LTVITKETEKAVPPR CEEEECCCCCCCCCC	44.32	OGP
1124	O-linked_Glycosylation	VTLLLVVLALGGVVW HHHHHHHHHHCHHHH	2.25	-
1127	O-linked_Glycosylation	LLVVLALGGVVWYQH HHHHHHHCHHHHHHH	22.65	-
1130	O-linked_Glycosylation	VLALGGVVWYQHRQR HHHHCHHHHHHHHHH	4.45	-
1133	O-linked_Glycosylation	LGGVVWYQHRQRKLR HCHHHHHHHHHHHHH	15.02	-
1145	Phosphorylation	KLRRNRRSILDDSFK HHHHCHHHHHHCHHH	25.02	24670416
1150	Phosphorylation	RRSILDDSFKLLSFK HHHHHHCHHHHHHCC	24.77	26657352
1152	Ubiquitination	SILDDSFKLLSFKQ- HHHHCHHHHHHCCC-	53.09	-
1155	Phosphorylation	DDSFKLLSFKQ---- HCHHHHHHCCC----	40.61	23403867
1199	Phosphorylation	------------------------------------------------ ------------------------------------------------		24719451
1204	Phosphorylation	----------------------------------------------------- -----------------------------------------------------		24719451
1209	Phosphorylation	---------------------------------------------------------- ----------------------------------------------------------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEPH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEPH_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HEPH_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.