CDC45_HUMAN - dbPTM
CDC45_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDC45_HUMAN
UniProt AC O75419
Protein Name Cell division control protein 45 homolog
Gene Name CDC45
Organism Homo sapiens (Human).
Sequence Length 566
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Required for initiation of chromosomal DNA replication..
Protein Sequence MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAFLEHKEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEARRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKENLREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSLSRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLLSKHLLKSFVCSTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8UbiquitinationMFVSDFRKEFYEVVQ
CCHHHHHHHHHHHHH		52.7721890473
8UbiquitinationMFVSDFRKEFYEVVQ
CCHHHHHHHHHHHHH		52.7721890473
8UbiquitinationMFVSDFRKEFYEVVQ
CCHHHHHHHHHHHHH		52.7721890473
8UbiquitinationMFVSDFRKEFYEVVQ
CCHHHHHHHHHHHHH		52.7721890473
16PhosphorylationEFYEVVQSQRVLLFV
HHHHHHHHCCEEEEE		14.3527251275
25PhosphorylationRVLLFVASDVDALCA
CEEEEECCCHHHHHH		32.6323285258
62UbiquitinationWQELETAFLEHKEQF
HHHHHHHHHHCHHHE		12.2722817900
67UbiquitinationTAFLEHKEQFHYFIL
HHHHHCHHHEEEEEE		61.4621890473
88UbiquitinationVDLLDILQPDEDTIF
CCHHHHCCCCCCEEE		43.6723000965
91UbiquitinationLDILQPDEDTIFFVC
HHHCCCCCCEEEEEE		64.8323000965
93UbiquitinationILQPDEDTIFFVCDT
HCCCCCCEEEEEECC		20.0323000965
102UbiquitinationFFVCDTHRPVNVVNV
EEEECCCCCEEEEEE		38.6721890473
115UbiquitinationNVYNDTQIKLLIKQD
EEECCCEEEEEEECC		3.5421890473
120SumoylationTQIKLLIKQDDDLEV
CEEEEEEECCCCCCC		47.87-
130PhosphorylationDDLEVPAYEDIFRDE
CCCCCCCHHHHCCCH		14.2018669648
144PhosphorylationEEEDEEHSGNDSDGS
HHHCCCCCCCCCCCC		42.4421712546
148PhosphorylationEEHSGNDSDGSEPSE
CCCCCCCCCCCCCCH		48.1221082442
151PhosphorylationSGNDSDGSEPSEKRT
CCCCCCCCCCCHHHH		51.8525850435
153UbiquitinationNDSDGSEPSEKRTRL
CCCCCCCCCHHHHHH		49.8623000965
154PhosphorylationDSDGSEPSEKRTRLE
CCCCCCCCHHHHHHH		52.2623186163
156UbiquitinationDGSEPSEKRTRLEEE
CCCCCCHHHHHHHHH		64.5023000965
158UbiquitinationSEPSEKRTRLEEEIV
CCCCHHHHHHHHHHH		51.1523000965
167UbiquitinationLEEEIVEQTMRRRQR
HHHHHHHHHHHHHHH		29.6921890473
168PhosphorylationEEEIVEQTMRRRQRR
HHHHHHHHHHHHHHH		10.11-
169SulfoxidationEEIVEQTMRRRQRRE
HHHHHHHHHHHHHHH		2.9121406390
176UbiquitinationMRRRQRREWEARRRD
HHHHHHHHHHHHHHH		52.4323000965
180UbiquitinationQRREWEARRRDILFD
HHHHHHHHHHHHCEE		23.7421890473
186UbiquitinationARRRDILFDYEQYEY
HHHHHHCEEHHHHHC		10.8422817900
191UbiquitinationILFDYEQYEYHGTSS
HCEEHHHHHCCCCHH		13.4021890473
191UbiquitinationILFDYEQYEYHGTSS
HCEEHHHHHCCCCHH		13.4021890473
220UbiquitinationLNDMLWWAIVGLTDQ
HHHHHHHHHHCCCHH		3.8022817900
225UbiquitinationWWAIVGLTDQWVQDK
HHHHHCCCHHHHHHH		21.8821890473
232UbiquitinationTDQWVQDKITQMKYV
CHHHHHHHHHHCCEE		30.4822817900
236UbiquitinationVQDKITQMKYVTDVG
HHHHHHHCCEECHHH		2.2422817900
237UbiquitinationQDKITQMKYVTDVGV
HHHHHHCCEECHHHH		27.1021963094
237UbiquitinationQDKITQMKYVTDVGV
HHHHHHCCEECHHHH		27.1021890473
240UbiquitinationITQMKYVTDVGVLQR
HHHCCEECHHHHHHH		23.1321963094
241UbiquitinationTQMKYVTDVGVLQRH
HHCCEECHHHHHHHH		25.7321890473
247UbiquitinationTDVGVLQRHVSRHNH
CHHHHHHHHHHCCCC		28.1927667366
262PhosphorylationRNEDEENTLSVDCTR
CCCCCCCCEEEECEE		24.5625849741
263UbiquitinationNEDEENTLSVDCTRI
CCCCCCCEEEECEEE		7.6729967540
264UbiquitinationEDEENTLSVDCTRIS
CCCCCCEEEECEEEE		17.5522817900
264PhosphorylationEDEENTLSVDCTRIS
CCCCCCEEEECEEEE		17.5528122231
268PhosphorylationNTLSVDCTRISFEYD
CCEEEECEEEEEEEH		26.9523312004
269UbiquitinationTLSVDCTRISFEYDL
CEEEECEEEEEEEHH		28.9621890473
269UbiquitinationTLSVDCTRISFEYDL
CEEEECEEEEEEEHH		28.9621890473
277UbiquitinationISFEYDLRLVLYQHW
EEEEEHHHHHHHCCH		21.6123000965
277UbiquitinationISFEYDLRLVLYQHW
EEEEEHHHHHHHCCH		21.6121890473
280UbiquitinationEYDLRLVLYQHWSLH
EEHHHHHHHCCHHHH		3.9423000965
282UbiquitinationDLRLVLYQHWSLHDS
HHHHHHHCCHHHHHH		27.6723000965
291UbiquitinationWSLHDSLCNTSYTAA
HHHHHHHCCCCCHHH		6.3821963094
291UbiquitinationWSLHDSLCNTSYTAA
HHHHHHHCCCCCHHH		6.3821890473
294UbiquitinationHDSLCNTSYTAARFK
HHHHCCCCCHHHHHH		13.3927667366
301UbiquitinationSYTAARFKLWSVHGQ
CCHHHHHHHHHHHHH		43.4222817900
304UbiquitinationAARFKLWSVHGQKRL
HHHHHHHHHHHHHHH		18.0521890473
304UbiquitinationAARFKLWSVHGQKRL
HHHHHHHHHHHHHHH		18.0521890473
305UbiquitinationARFKLWSVHGQKRLQ
HHHHHHHHHHHHHHH		3.8821963094
309UbiquitinationLWSVHGQKRLQEFLA
HHHHHHHHHHHHHHH		60.7229967540
311UbiquitinationSVHGQKRLQEFLADM
HHHHHHHHHHHHHHC		8.0323000965
312UbiquitinationVHGQKRLQEFLADMG
HHHHHHHHHHHHHCC		43.3527667366
314UbiquitinationGQKRLQEFLADMGLP
HHHHHHHHHHHCCCC		4.3723000965
316UbiquitinationKRLQEFLADMGLPLK
HHHHHHHHHCCCCHH		15.2923000965
323UbiquitinationADMGLPLKQVKQKFQ
HHCCCCHHHHHHHHH		51.6223000965
323UbiquitinationADMGLPLKQVKQKFQ
HHCCCCHHHHHHHHH		51.6221890473
325UbiquitinationMGLPLKQVKQKFQAM
CCCCHHHHHHHHHHC		7.2921890473
326UbiquitinationGLPLKQVKQKFQAMD
CCCHHHHHHHHHHCC		45.3223000965
328UbiquitinationPLKQVKQKFQAMDIS
CHHHHHHHHHHCCCC		33.4523000965
337UbiquitinationQAMDISLKENLREMI
HHCCCCHHHHHHHHH		37.4521906983
337UbiquitinationQAMDISLKENLREMI
HHCCCCHHHHHHHHH		37.4521890473
338UbiquitinationAMDISLKENLREMIE
HCCCCHHHHHHHHHH		67.7821890473
341UbiquitinationISLKENLREMIEESA
CCHHHHHHHHHHHHH		42.9129967540
350UbiquitinationMIEESANKFGMKDMR
HHHHHHHHHCCCCCE		42.9121906983
350UbiquitinationMIEESANKFGMKDMR
HHHHHHHHHCCCCCE		42.9121890473
354UbiquitinationSANKFGMKDMRVQTF
HHHHHCCCCCEEEEE		49.07-
355UbiquitinationANKFGMKDMRVQTFS
HHHHCCCCCEEEEEE		22.6423000965
355UbiquitinationANKFGMKDMRVQTFS
HHHHCCCCCEEEEEE		22.6421890473
358UbiquitinationFGMKDMRVQTFSIHF
HCCCCCEEEEEEEEE		5.1623000965
359UbiquitinationGMKDMRVQTFSIHFG
CCCCCEEEEEEEEEC		26.8527667366
360PhosphorylationMKDMRVQTFSIHFGF
CCCCEEEEEEEEECC		19.25-
360UbiquitinationMKDMRVQTFSIHFGF
CCCCEEEEEEEEECC		19.2523000965
365UbiquitinationVQTFSIHFGFKHKFL
EEEEEEEECCCCCHH		13.5123000965
365UbiquitinationVQTFSIHFGFKHKFL
EEEEEEEECCCCCHH		13.5121890473
369UbiquitinationSIHFGFKHKFLASDV
EEEECCCCCHHHHHH		24.6821963094
369UbiquitinationSIHFGFKHKFLASDV
EEEECCCCCHHHHHH		24.6821890473
374UbiquitinationFKHKFLASDVVFATM
CCCCHHHHHHEEEEH		32.8429967540
382UbiquitinationDVVFATMSLMESPEK
HHEEEEHHHHCCCCC		21.8821890473
382UbiquitinationDVVFATMSLMESPEK
HHEEEEHHHHCCCCC		21.8821890473
399UbiquitinationSGTDHFIQALDSLSR
CCHHHHHHHHHHHCC		34.6221890473
403PhosphorylationHFIQALDSLSRSNLD
HHHHHHHHHCCCCHH		29.1526437602
405PhosphorylationIQALDSLSRSNLDKL
HHHHHHHCCCCHHHH		37.3022673903
411UbiquitinationLSRSNLDKLYHGLEL
HCCCCHHHHHHHHHH		54.8623000965
411AcetylationLSRSNLDKLYHGLEL
HCCCCHHHHHHHHHH		54.8625953088
411UbiquitinationLSRSNLDKLYHGLEL
HCCCCHHHHHHHHHH		54.8621890473
413PhosphorylationRSNLDKLYHGLELAK
CCCHHHHHHHHHHHH		10.2830576142
420UbiquitinationYHGLELAKKQLRATQ
HHHHHHHHHHHHHHH		54.3929967540
421UbiquitinationHGLELAKKQLRATQQ
HHHHHHHHHHHHHHH		49.29-
425UbiquitinationLAKKQLRATQQTIAS
HHHHHHHHHHHHHHH		20.5322817900
429UbiquitinationQLRATQQTIASCLCT
HHHHHHHHHHHHHHH		14.5321963094
436UbiquitinationTIASCLCTNLVISQG
HHHHHHHHHHEEECC		20.7427667366
443UbiquitinationTNLVISQGPFLYCSL
HHHEEECCCEEEEEC		14.2423000965
443UbiquitinationTNLVISQGPFLYCSL
HHHEEECCCEEEEEC		14.2421890473
452UbiquitinationFLYCSLMEGTPDVML
EEEEECCCCCCCEEE		66.2729967540
459UbiquitinationEGTPDVMLFSRPASL
CCCCCEEEECCCHHH		3.3722817900
463UbiquitinationDVMLFSRPASLSLLS
CEEEECCCHHHHHHH		25.6321963094
467PhosphorylationFSRPASLSLLSKHLL
ECCCHHHHHHHHHHH		25.4324719451
470UbiquitinationPASLSLLSKHLLKSF
CHHHHHHHHHHHHHH		24.2727667366
471UbiquitinationASLSLLSKHLLKSFV
HHHHHHHHHHHHHHH		37.9422817900
473UbiquitinationLSLLSKHLLKSFVCS
HHHHHHHHHHHHHHC		8.0727667366
475UbiquitinationLLSKHLLKSFVCSTK
HHHHHHHHHHHHCCC		48.4821963094
482UbiquitinationKSFVCSTKNRRCKLL
HHHHHCCCCCCCCCH		31.9627667366
483UbiquitinationSFVCSTKNRRCKLLP
HHHHCCCCCCCCCHH		36.4027667366
503UbiquitinationPLSMEHGTVTVVGIP
CCEECCCEEEEEECC		18.2122817900
504UbiquitinationLSMEHGTVTVVGIPP
CEECCCEEEEEECCC		4.5329967540
507UbiquitinationEHGTVTVVGIPPETD
CCCEEEEEECCCCCC		4.1421963094
513PhosphorylationVVGIPPETDSSDRKN
EEECCCCCCCCCCCC		47.13-
514UbiquitinationVGIPPETDSSDRKNF
EECCCCCCCCCCCCC		44.4727667366
516UbiquitinationIPPETDSSDRKNFFG
CCCCCCCCCCCCCHH		44.2233845483
517UbiquitinationPPETDSSDRKNFFGR
CCCCCCCCCCCCHHH		70.3127667366
519UbiquitinationETDSSDRKNFFGRAF
CCCCCCCCCCHHHHH		64.2027667366
524MethylationDRKNFFGRAFEKAAE
CCCCCHHHHHHHHHH		30.83-
528SumoylationFFGRAFEKAAESTSS
CHHHHHHHHHHCCHH		46.58-
528UbiquitinationFFGRAFEKAAESTSS
CHHHHHHHHHHCCHH		46.5827667366
528SumoylationFFGRAFEKAAESTSS
CHHHHHHHHHHCCHH		46.58-
529UbiquitinationFGRAFEKAAESTSSR
HHHHHHHHHHCCHHH		14.8427667366
550UbiquitinationDLSVIELKAEDRSKF
CEEEEEEEHHHHHHH		36.6229967540
551UbiquitinationLSVIELKAEDRSKFL
EEEEEEEHHHHHHHH		36.2227667366
560UbiquitinationDRSKFLDALISLLS-
HHHHHHHHHHHHHC-		14.6727667366
582Ubiquitination-----------------------
-----------------------		29967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDC45_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDC45_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDC45_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ORC2_HUMANORC2physical
12614612
ORC1_HUMANORC1physical
12614612
ORC6_HUMANORC6physical
12614612
MCM3_HUMANMCM3physical
12614612
MCM6_HUMANMCM6physical
12614612
MCM7_HUMANMCM7physical
12614612
CCL2_HUMANCCL2physical
21383955
H31_HUMANHIST1H3Aphysical
20818375
CDK2_HUMANCDK2physical
15753125
MCM10_HUMANMCM10physical
15232106
ORC5_HUMANORC5physical
15232106
ORC3_HUMANORC3physical
15232106
CDN1A_HUMANCDKN1Aphysical
15232106
CDN2A_HUMANCDKN2Aphysical
15232106
ARF_HUMANCDKN2Aphysical
15232106
DTD1_HUMANDTD1physical
20065034
TOPB1_HUMANTOPBP1physical
20065034
TPPC3_HUMANTRAPPC3physical
21988832
CEP55_HUMANCEP55physical
25416956
ACTZ_HUMANACTR1Aphysical
26344197
RFC1_HUMANRFC1physical
26344197
CDN1A_HUMANCDKN1Aphysical
25241761
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDC45_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-130; SER-144; SER-148AND SER-151, AND MASS SPECTROMETRY.

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