CCL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCL2_HUMAN
• UniProt AC: P13500
• Protein Name: C-C motif chemokine 2
• Gene Name: CCL2
• Organism: Homo sapiens (Human).
• Sequence Length: 99
• Subcellular Localization: Secreted .
• Protein Description: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis..
• Protein Sequence: MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Pyrrolidone_carboxylic_acid	FIPQGLAQPDAINAP HCCCCCCCCCCCCCC	41.26	-
24	Pyrrolidone_carboxylic_acid	FIPQGLAQPDAINAP HCCCCCCCCCCCCCC	41.26	1661560
24	Pyrrolidone_carboxylic_acid	FIPQGLAQPDAINAP HCCCCCCCCCCCCCC	41.26	1661560
37	N-linked_Glycosylation	APVTCCYNFTNRKIS CCEEEEEECCCCCEE	24.29	UniProtKB CARBOHYD
50	Phosphorylation	ISVQRLASYRRITSS EEHHHHHHHCCCCCC	24.62	27732954
51	Phosphorylation	SVQRLASYRRITSSK EHHHHHHHCCCCCCC	9.78	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACKR1_HUMAN	ACKR1	physical	13679391
CCL2_HUMAN	CCL2	physical	7651403
CDC6_HUMAN	CDC6	physical	21383955
ORC2_HUMAN	ORC2	physical	21383955
ORC4_HUMAN	ORC4	physical	21383955
MCM2_HUMAN	MCM2	physical	21383955
MCM3_HUMAN	MCM3	physical	21383955
MCM7_HUMAN	MCM7	physical	21383955
CDC45_HUMAN	CDC45	physical	21383955
PCNA_HUMAN	PCNA	physical	21383955
CCR2_MOUSE	Ccr2	physical	8631787

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Pyrrolidone carboxylic acid

"Human monocyte chemoattractant protein-1 (MCP-1).";
Yoshimura T., Leonard E.J.;
Adv. Exp. Med. Biol. 305:47-56(1991).
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
PubMed: 1661560