dbPTM

CDN1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDN1A_HUMAN
UniProt AC	P38936
Protein Name	Cyclin-dependent kinase inhibitor 1
Gene Name	CDKN1A
Organism	Homo sapiens (Human).
Sequence Length	164
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. [PubMed: 11595739]
Protein Sequence	MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEPAGDVR ------CCCCCCCCC	52.89	15574338
16	Ubiquitination	RQNPCGSKACRRLFG CCCCCCCHHHHHHHC	36.47	13678583
27	Phosphorylation	RLFGPVDSEQLSRDC HHHCCCCHHHHHHHH	27.72	27732954
31	Phosphorylation	PVDSEQLSRDCDALM CCCHHHHHHHHHHHH	26.26	25849741
50	Ubiquitination	QEARERWNFDFVTET HHHHHHCCCCEEECC	32.60	-
57	Phosphorylation	NFDFVTETPLEGDFA CCCEEECCCCCCCCH	24.65	22817900
65	Phosphorylation	PLEGDFAWERVRGLG CCCCCCHHHHHCCCC	8.23	-
75	Ubiquitination	VRGLGLPKLYLPTGP HCCCCCCCEECCCCC	55.60	21890473
75	Ubiquitination	VRGLGLPKLYLPTGP HCCCCCCCEECCCCC	55.60	21906983
77	Phosphorylation	GLGLPKLYLPTGPRR CCCCCCEECCCCCCC	19.43	28674419
80	Phosphorylation	LPKLYLPTGPRRGRD CCCEECCCCCCCCCC	58.17	25329316
91	Phosphorylation	RGRDELGGGRRPGTS CCCCCCCCCCCCCCC	38.77	12058028
97	Phosphorylation	GGGRRPGTSPALLQG CCCCCCCCCHHHHCC	33.93	28348404
98	Phosphorylation	GGRRPGTSPALLQGT CCCCCCCCHHHHCCC	17.68	22817900
109	Ubiquitination	LQGTAEEDHVDLSLS HCCCCCCCCEEEEEE	38.32	-
114	Phosphorylation	EEDHVDLSLSCTLVP CCCCEEEEEEEEEEC	17.48	18794347
123	Phosphorylation	SCTLVPRSGEQAEGS EEEEECCCCCCCCCC	40.38	23403867
130	Phosphorylation	SGEQAEGSPGGPGDS CCCCCCCCCCCCCCC	16.33	19664994
132	Phosphorylation	EQAEGSPGGPGDSQG CCCCCCCCCCCCCHH	57.53	17325029
137	Phosphorylation	SPGGPGDSQGRKRRQ CCCCCCCCHHHHHCC	40.21	23403867
141	Acetylation	PGDSQGRKRRQTSMT CCCCHHHHHCCCCHH	59.77	25231691
141	Ubiquitination	PGDSQGRKRRQTSMT CCCCHHHHHCCCCHH	59.77	13678583
145	Phosphorylation	QGRKRRQTSMTDFYH HHHHHCCCCHHHHHH	20.75	19822666
146	Phosphorylation	GRKRRQTSMTDFYHS HHHHCCCCHHHHHHH	16.02	11756412
148	Phosphorylation	KRRQTSMTDFYHSKR HHCCCCHHHHHHHHH	23.79	17283049
151	Phosphorylation	QTSMTDFYHSKRRLI CCCHHHHHHHHHHHH	14.16	24719451
153	Phosphorylation	SMTDFYHSKRRLIFS CHHHHHHHHHHHHHC	19.24	15851482
154	Ubiquitination	MTDFYHSKRRLIFSK HHHHHHHHHHHHHCC	28.38	13678583
154	Acetylation	MTDFYHSKRRLIFSK HHHHHHHHHHHHHCC	28.38	25231683
156	Dimethylation	DFYHSKRRLIFSKRK HHHHHHHHHHHCCCC	35.55	-
156	Methylation	DFYHSKRRLIFSKRK HHHHHHHHHHHCCCC	35.55	101521401
157	Phosphorylation	FYHSKRRLIFSKRKP HHHHHHHHHHCCCCC	5.57	-
160	Phosphorylation	SKRRLIFSKRKP--- HHHHHHHCCCCC---	25.26	18794347
161	Acetylation	KRRLIFSKRKP---- HHHHHHCCCCC----	54.41	25231695
161	Ubiquitination	KRRLIFSKRKP---- HHHHHHCCCCC----	54.41	-
163	Acetylation	RLIFSKRKP------ HHHHCCCCC------	59.83	25231687
163	Ubiquitination	RLIFSKRKP------ HHHHCCCCC------	59.83	-
164	Phosphorylation	LIFSKRKP------- HHHCCCCC-------	54.18	19664994
175	Ubiquitination	------------------ ------------------		-
175	Acetylation	------------------ ------------------		-
179	Phosphorylation	---------------------- ----------------------		15001356
180	Phosphorylation	----------------------- -----------------------		17855660
185	Phosphorylation	---------------------------- ----------------------------		-
187	Phosphorylation	------------------------------ ------------------------------		15851482
188	Ubiquitination	------------------------------- -------------------------------		-
188	Acetylation	------------------------------- -------------------------------		-
190	Methylation	--------------------------------- ---------------------------------		-
194	Phosphorylation	------------------------------------- -------------------------------------		10753973
195	Acetylation	-------------------------------------- --------------------------------------		-
195	Ubiquitination	-------------------------------------- --------------------------------------		-
197	Acetylation	---------------------------------------- ----------------------------------------		-
197	Ubiquitination	---------------------------------------- ----------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
55	T	Phosphorylation	Kinase	MELK	Q61846	PSP
57	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
57	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
57	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
57	T	Phosphorylation	Kinase	MAPK9	P45984	GPS
57	T	Phosphorylation	Kinase	MAPK_GROUP	-	PhosphoELM
57	T	Phosphorylation	Kinase	GSK3A	P49840	PSP
57	T	Phosphorylation	Kinase	GSK3B	P49841	PSP
57	T	Phosphorylation	Kinase	GSK3B	P49841	GPS
57	T	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
80	T	Phosphorylation	Kinase	LKB1	Q15831	Uniprot
98	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
98	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
98	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
98	S	Phosphorylation	Kinase	MAP3K5	Q99683	GPS
98	S	Phosphorylation	Kinase	MAPK9	P45984	GPS
98	S	Phosphorylation	Kinase	MAPK10	P53779	GPS
98	S	Phosphorylation	Kinase	CDK4	P11802	PSP
98	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
114	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
130	S	Phosphorylation	Kinase	MAPK9	P45984	GPS
130	S	Phosphorylation	Kinase	MAPK10	P53779	GPS
130	S	Phosphorylation	Kinase	P38A	Q16539	PSP
130	S	Phosphorylation	Kinase	MAPK14	P47811	GPS
130	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
130	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
130	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
130	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
130	S	Phosphorylation	Kinase	MAPK_GROUP	-	PhosphoELM
130	S	Phosphorylation	Kinase	CDK6	Q00534	PSP
130	S	Phosphorylation	Kinase	CDK4	P11802	PSP
130	S	Phosphorylation	Kinase	CDK2	P24941	PSP
130	S	Phosphorylation	Kinase	CDK1	P06493	PSP
145	T	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
145	T	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
145	T	Phosphorylation	Kinase	PIM2	Q9P1W9	Uniprot
145	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
145	T	Phosphorylation	Kinase	PKA	-	Uniprot
145	T	Phosphorylation	Kinase	AKT1	P31749	Uniprot
145	T	Phosphorylation	Kinase	PIM1	P11309	Uniprot
145	T	Phosphorylation	Kinase	DAPK3	O43293	PSP
145	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
146	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
146	S	Phosphorylation	Kinase	AKT1	P31749	PSP
146	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
146	S	Phosphorylation	Kinase	PKC	-	Uniprot
146	S	Phosphorylation	Kinase	PIM1	P11309	PSP
146	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
146	S	Phosphorylation	Kinase	LATS2	Q9NRM7	PSP
146	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
146	S	Phosphorylation	Kinase	NUAK1	O60285	Uniprot
146	S	Phosphorylation	Kinase	PIM2	Q9P1W9	PSP
153	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
153	S	Phosphorylation	Kinase	DYR1B	Q9Y463	PhosphoELM
160	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
160	S	Phosphorylation	Kinase	PKC	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	RNF126	Q9BV68	PMID:23026136
-	K	Ubiquitination	E3 ubiquitin ligase	DTL	Q9NZJ0	PMID:18703516
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:12393444
-	K	Ubiquitination	E3 ubiquitin ligase	CDC20	Q12834	PMID:17679094
-	K	Ubiquitination	E3 ubiquitin ligase	CDCA3	Q99618	PMID:14761977
-	K	Ubiquitination	E3 ubiquitin ligase	MDM4	O15151	PMID:18086887
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:10698510
-	K	Ubiquitination	E3 ubiquitin ligase	MKRN1	Q9UHC7	PMID:19536131
-	K	Ubiquitination	E3 ubiquitin ligase	RNF144B	Q7Z419	PMID:12853982
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:31831018

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
2	S	ubiquitylation	15574338
Ubiquitination at Ser-2 leads to degradation by the proteasome pathway.
80	T	Phosphorylation	25329316
UV radiation-induced phosphorylation at Thr-80 by LKB1 and at Ser-146 by NUAK1 leads to its degradation.
114	S	Phosphorylation	18794347
Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex.
114	S	ubiquitylation	18794347
Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex.
141	K	Acetylation	-
Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163.
145	T	Phosphorylation	10753973
Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.
145	T	Phosphorylation	10753973
Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability.
145	T	Phosphorylation	10753973
Phosphorylation of Thr-145 by PIM2 enhances CDKN1A stability and inhibits cell proliferation.
146	S	Phosphorylation	10753973
Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.
146	S	Phosphorylation	10753973
UV radiation-induced phosphorylation at Thr-80 by LKB1 and at Ser-146 by NUAK1 leads to its degradation.
154	K	Acetylation	23213251
Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163.
161	K	Acetylation	-
Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163.
163	K	Acetylation	-
Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDN1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TEX11_HUMAN	TEX11	physical	16189514
CC85B_HUMAN	CCDC85B	physical	16189514
PCNA_HUMAN	PCNA	physical	16189514
CDK2_HUMAN	CDK2	physical	10878006
GA45A_HUMAN	GADD45A	physical	10973963
BCCIP_HUMAN	BCCIP	physical	10878006
PARP1_HUMAN	PARP1	physical	12930846
PCNA_HUMAN	PCNA	physical	12930846
CDK2_HUMAN	CDK2	physical	12839982
CCNE1_HUMAN	CCNE1	physical	12839982
RACK1_HUMAN	GNB2L1	physical	16169070
HDA11_HUMAN	HDAC11	physical	16169070
PCNA_HUMAN	PCNA	physical	9465025
M3K5_HUMAN	MAP3K5	physical	12820963
TS101_HUMAN	TSG101	physical	11943869
PCNA_HUMAN	PCNA	physical	8861913
CIZ1_HUMAN	CIZ1	physical	10529385
SET_HUMAN	SET	physical	12407107
CUL4A_HUMAN	CUL4A	physical	18794347
DDB1_HUMAN	DDB1	physical	18794347
DTL_HUMAN	DTL	physical	18794347
PCNA_HUMAN	PCNA	physical	11313979
PSME3_HUMAN	PSME3	physical	17588519
PCNA_HUMAN	PCNA	physical	17588519
SKP2_HUMAN	SKP2	physical	17477906
HDAC1_HUMAN	HDAC1	physical	20154723
CDK2_HUMAN	CDK2	physical	20102411
CDK4_HUMAN	CDK4	physical	20102411
CDK6_HUMAN	CDK6	physical	20102411
MK08_HUMAN	MAPK8	physical	20102411
JUN_HUMAN	JUN	physical	20102411
DTL_HUMAN	DTL	physical	18703516
DDB1_HUMAN	DDB1	physical	18703516
G3P_HUMAN	GAPDH	physical	16474839
SET_HUMAN	SET	physical	16474839
PCNA_HUMAN	PCNA	physical	16474839
MDM2_HUMAN	MDM2	physical	14761977
PCNA_HUMAN	PCNA	physical	16082198
CCNB1_HUMAN	CCNB1	physical	16082198
HDAC1_HUMAN	HDAC1	physical	16082198
HDAC4_HUMAN	HDAC4	physical	16082198
HDAC6_HUMAN	HDAC6	physical	16082198
CCND1_HUMAN	CCND1	physical	16082198
HDAC2_HUMAN	HDAC2	physical	16082198
R144B_HUMAN	RNF144B	physical	12853982
EP300_HUMAN	EP300	physical	18263614
MDM4_HUMAN	MDM4	physical	18086887
PRS8_HUMAN	PSMC5	physical	18086887
PCNA_HUMAN	PCNA	physical	18086887
DTL_HUMAN	DTL	physical	20606006
CDK4_HUMAN	CDK4	physical	17556661
CCND1_HUMAN	CCND1	physical	17556661
NEMO_HUMAN	IKBKG	physical	19609363
OPTN_HUMAN	OPTN	physical	19609363
NPM_HUMAN	NPM1	physical	19221506
MDM4_HUMAN	MDM4	physical	21148311
SPRE1_HUMAN	SPRED1	physical	21900206
ATX3_HUMAN	ATXN3	physical	21900206
VATA_HUMAN	ATP6V1A	physical	21900206
HMGX3_HUMAN	HMGXB3	physical	21900206
P53_HUMAN	TP53	physical	21900206
CSAD_HUMAN	CSAD	physical	21900206
S10A8_HUMAN	S100A8	physical	21900206
CPNE6_HUMAN	CPNE6	physical	21900206
GBB2_HUMAN	GNB2	physical	21900206
EXT2_HUMAN	EXT2	physical	21900206
CAB45_HUMAN	SDF4	physical	21900206
FAD1_HUMAN	FLAD1	physical	21900206
CPNE2_HUMAN	CPNE2	physical	21900206
OTUB1_HUMAN	OTUB1	physical	21900206
ECHB_HUMAN	HADHB	physical	21900206
WIZ_HUMAN	WIZ	physical	21900206
TAF5L_HUMAN	TAF5L	physical	21900206
TCPH_HUMAN	CCT7	physical	21900206
BAG6_HUMAN	BAG6	physical	21900206
UB2D1_HUMAN	UBE2D1	physical	21900206
RBM48_HUMAN	RBM48	physical	21900206
GDF9_HUMAN	GDF9	physical	21900206
DEAF1_HUMAN	DEAF1	physical	21900206
TZAP_HUMAN	ZBTB48	physical	21900206
ZBT16_HUMAN	ZBTB16	physical	21900206
TBA1A_HUMAN	TUBA1A	physical	21900206
KLH23_HUMAN	KLHL23	physical	21900206
F13A_HUMAN	F13A1	physical	21900206
SUMO3_HUMAN	SUMO3	physical	21900206
VIME_HUMAN	VIM	physical	21900206
ODPB_HUMAN	PDHB	physical	21900206
TYB4_HUMAN	TMSB4X	physical	21900206
DDAH2_HUMAN	DDAH2	physical	21900206
ATS10_HUMAN	ADAMTS10	physical	21900206
WDR73_HUMAN	WDR73	physical	21900206
HEM1_HUMAN	ALAS1	physical	21900206
TLE1_HUMAN	TLE1	physical	21900206
TRM2A_HUMAN	TRMT2A	physical	21900206
ACTB_HUMAN	ACTB	physical	21900206
CSN6_HUMAN	COPS6	physical	21900206
UBP4_HUMAN	USP4	physical	21900206
RS2_HUMAN	RPS2	physical	21900206
CATB_HUMAN	CTSB	physical	21900206
A2MG_HUMAN	A2M	physical	21900206
MED31_HUMAN	MED31	physical	21900206
CENPB_HUMAN	CENPB	physical	21900206
SP110_HUMAN	SP110	physical	21900206
A1BG_HUMAN	A1BG	physical	21900206
CO4A5_HUMAN	COL4A5	physical	21900206
RAI1_HUMAN	RAI1	physical	21900206
ATPB_HUMAN	ATP5B	physical	21900206
DC1I1_HUMAN	DYNC1I1	physical	21900206
EF1A1_HUMAN	EEF1A1	physical	21900206
FBN3_HUMAN	FBN3	physical	21900206
NPRL2_HUMAN	NPRL2	physical	21900206
APLP1_HUMAN	APLP1	physical	21900206
INP5K_HUMAN	INPP5K	physical	21900206
U119A_HUMAN	UNC119	physical	21900206
CELF3_HUMAN	CELF3	physical	21900206
GNB5_HUMAN	GNB5	physical	21900206
MSH2_HUMAN	MSH2	physical	21900206
LRIF1_HUMAN	LRIF1	physical	21900206
ANGP2_HUMAN	ANGPT2	physical	21900206
TBB3_HUMAN	TUBB3	physical	21900206
SCG1_HUMAN	CHGB	physical	21900206
ZN431_HUMAN	ZNF431	physical	21900206
MYOME_HUMAN	PDE4DIP	physical	21900206
ACL6B_HUMAN	ACTL6B	physical	21900206
KPYM_HUMAN	PKM	physical	21900206
TNR16_HUMAN	NGFR	physical	21900206
DOCK7_HUMAN	DOCK7	physical	21900206
SYQ_HUMAN	QARS	physical	21900206
ING5_HUMAN	ING5	physical	21900206
ZN135_HUMAN	ZNF135	physical	21900206
KMT2B_HUMAN	KMT2B	physical	21900206
TBB2B_HUMAN	TUBB2B	physical	21900206
FIBB_HUMAN	FGB	physical	21900206
RBBP4_HUMAN	RBBP4	physical	21900206
HXD8_HUMAN	HOXD8	physical	21900206
TETN_HUMAN	CLEC3B	physical	21900206
NRBP_HUMAN	NRBP1	physical	21900206
FAF1_HUMAN	FAF1	physical	21900206
SETB1_HUMAN	SETDB1	physical	21900206
ESR1_HUMAN	ESR1	physical	17911387
PCNA_HUMAN	PCNA	physical	11559705
CDK1_HUMAN	CDK1	physical	11559705
CCNB1_HUMAN	CCNB1	physical	11559705
NF2L2_HUMAN	NFE2L2	physical	19560419
PCNA_HUMAN	PCNA	physical	20605778
FKBPL_HUMAN	FKBPL	physical	15664193
MDM2_HUMAN	MDM2	physical	14633995
CDN1B_HUMAN	CDKN1B	genetic	18850315
CCND2_HUMAN	CCND2	physical	15169570
CDK4_HUMAN	CDK4	physical	15169570
CDK2_HUMAN	CDK2	physical	12800980
CDK2_HUMAN	CDK2	physical	11477082
CCNE1_HUMAN	CCNE1	physical	11477082
PCNA_HUMAN	PCNA	physical	22383522
CCNE1_HUMAN	CCNE1	physical	8891332
BRAP_HUMAN	BRAP	physical	15340083
1433T_HUMAN	YWHAQ	physical	20086099
MDM2_HUMAN	MDM2	physical	20086099
PSA3_HUMAN	PSMA3	physical	20086099
MDM2_HUMAN	MDM2	physical	20308078
P63_HUMAN	TP63	genetic	21511729
CCNA1_HUMAN	CCNA1	physical	12383116
CDK2_HUMAN	CDK2	physical	12383116
CCND1_HUMAN	CCND1	physical	12383116
CDK4_HUMAN	CDK4	physical	12383116
RN126_HUMAN	RNF126	physical	23026136
A4_HUMAN	APP	physical	21832049
CCNE1_HUMAN	CCNE1	physical	16765349
CDK2_HUMAN	CDK2	physical	16765349
CCND2_HUMAN	CCND2	physical	16765349
PCNA_HUMAN	PCNA	physical	11302688
BCCIP_HUMAN	BCCIP	physical	14726710
CDK14_HUMAN	CDK14	physical	17517622
PCNA_HUMAN	PCNA	physical	7911228
CCNE1_HUMAN	CCNE1	physical	8756624
NOV_HUMAN	NOV	physical	8756624
CCND1_HUMAN	CCND1	physical	8756624
CDK2_HUMAN	CDK2	physical	8756624
CDK4_HUMAN	CDK4	physical	8756624
CEBPA_HUMAN	CEBPA	physical	9372966
CDK2_HUMAN	CDK2	physical	9660939
CCNA2_HUMAN	CCNA2	physical	8662825
CCNB1_HUMAN	CCNB1	physical	8662825
CCND1_HUMAN	CCND1	physical	8662825
PCNA_HUMAN	PCNA	physical	8662825
CCNE1_HUMAN	CCNE1	physical	8662825
H15_HUMAN	HIST1H1B	physical	8662825
CCNE2_HUMAN	CCNE2	physical	9840943
TRI39_HUMAN	TRIM39	physical	23213251
MKRN1_HUMAN	MKRN1	physical	19536131
CDK5_HUMAN	CDK5	physical	15890360
CDK2_HUMAN	CDK2	physical	15890360
CCNE1_HUMAN	CCNE1	physical	9472014
CDK2_HUMAN	CDK2	physical	9472014
PCNA_HUMAN	PCNA	physical	10022118
CDK2_HUMAN	CDK2	physical	10022118
PCNA_HUMAN	PCNA	physical	9546435
RN114_HUMAN	RNF114	genetic	23645206
TNIP2_HUMAN	TNIP2	physical	21988832
HNRPK_HUMAN	HNRNPK	physical	21988832
THIO_HUMAN	TXN	physical	21988832
RL35_HUMAN	RPL35	physical	21988832
FAD1_HUMAN	FLAD1	physical	21988832
GCKR_HUMAN	GCKR	physical	21988832
HPPD_HUMAN	HPD	physical	21988832
PCNA_HUMAN	PCNA	physical	21988832
RL18_HUMAN	RPL18	physical	21988832
SIPA1_HUMAN	SIPA1	physical	21988832
NR1H2_HUMAN	NR1H2	physical	21988832
TNIP1_HUMAN	TNIP1	physical	21988832
TXD11_HUMAN	TXNDC11	physical	21988832
NKD2_HUMAN	NKD2	physical	21988832
CXL13_HUMAN	CXCL13	physical	24027428
CDK2_HUMAN	CDK2	physical	8622677
CDK4_HUMAN	CDK4	physical	8622677
GRP78_HUMAN	HSPA5	physical	23443559
CDK4_HUMAN	CDK4	physical	23443559
RBL2_HUMAN	RBL2	physical	23443559
RAVR1_HUMAN	RAVER1	physical	23443559
GRP75_HUMAN	HSPA9	physical	23443559
CDK5_HUMAN	CDK5	physical	23443559
CCND2_HUMAN	CCND2	physical	23443559
CCND3_HUMAN	CCND3	physical	23443559
MOGS_HUMAN	MOGS	physical	23443559
UBP11_HUMAN	USP11	physical	23443559
TBB5_HUMAN	TUBB	physical	23443559
CCNE2_HUMAN	CCNE2	physical	23443559
CCND1_HUMAN	CCND1	physical	23443559
CCNA2_HUMAN	CCNA2	physical	23443559
UBR4_HUMAN	UBR4	physical	23443559
GGYF2_HUMAN	GIGYF2	physical	23443559
IRS4_HUMAN	IRS4	physical	23443559
TBCD4_HUMAN	TBC1D4	physical	23443559
HSP7C_HUMAN	HSPA8	physical	23443559
LPPRC_HUMAN	LRPPRC	physical	23443559
CKS2_HUMAN	CKS2	physical	23443559
CCNE1_HUMAN	CCNE1	physical	23443559
PUM1_HUMAN	PUM1	physical	23443559
UBR5_HUMAN	UBR5	physical	23443559
TBA1A_HUMAN	TUBA1A	physical	23443559
CRTC2_HUMAN	CRTC2	physical	23443559
AMOT_HUMAN	AMOT	physical	23443559
ANR17_HUMAN	ANKRD17	physical	23443559
YTHD1_HUMAN	YTHDF1	physical	23443559
EPN4_HUMAN	CLINT1	physical	23443559
DDB1_HUMAN	DDB1	physical	23443559
CPVL_HUMAN	CPVL	physical	23443559
FBX21_HUMAN	FBXO21	physical	23443559
NUCL_HUMAN	NCL	physical	23443559
CDK2_HUMAN	CDK2	physical	23443559
4EBP3_HUMAN	EIF4EBP3	physical	23443559
HSP72_HUMAN	HSPA2	physical	23443559
ROA2_HUMAN	HNRNPA2B1	physical	23443559
DOCK7_HUMAN	DOCK7	physical	23443559
MARK2_HUMAN	MARK2	physical	23443559
CCNB1_HUMAN	CCNB1	physical	23443559
LIPB1_HUMAN	PPFIBP1	physical	23443559
CCNO_HUMAN	CCNO	physical	23443559
MTMR5_HUMAN	SBF1	physical	23443559
PCNA_HUMAN	PCNA	physical	23443559
ABR_HUMAN	ABR	physical	23443559
RS16_HUMAN	RPS16	physical	23443559
U520_HUMAN	SNRNP200	physical	23443559
CDC20_HUMAN	CDC20	physical	23443559
PRP8_HUMAN	PRPF8	physical	23443559
CKS1_HUMAN	CKS1B	physical	23443559
SPT6H_HUMAN	SUPT6H	physical	23443559
IF2B1_HUMAN	IGF2BP1	physical	23443559
KPB1_HUMAN	PHKA1	physical	23443559
LIPA1_HUMAN	PPFIA1	physical	23443559
KCC2D_HUMAN	CAMK2D	physical	23443559
PHKG2_HUMAN	PHKG2	physical	23443559
CE290_HUMAN	CEP290	physical	23443559
CDK3_HUMAN	CDK3	physical	23443559
RS4X_HUMAN	RPS4X	physical	23443559
EPIPL_HUMAN	EPPK1	physical	23443559
ODPX_HUMAN	PDHX	physical	23443559
PUF60_HUMAN	PUF60	physical	23443559
RS25_HUMAN	RPS25	physical	23443559
U5S1_HUMAN	EFTUD2	physical	23443559
UBB_HUMAN	UBB	physical	23443559
NET4_HUMAN	NTN4	physical	23443559
SNTB2_HUMAN	SNTB2	physical	23443559
RS9_HUMAN	RPS9	physical	23443559
K1H1_HUMAN	KRT31	physical	25416956
PCNA_HUMAN	PCNA	physical	25416956
ITF2_HUMAN	TCF4	physical	25416956
TRAF1_HUMAN	TRAF1	physical	25416956
IKZF3_HUMAN	IKZF3	physical	25416956
TEX11_HUMAN	TEX11	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
PCNA_HUMAN	PCNA	physical	25411249
PCNA_HUMAN	PCNA	physical	23223023
PCNA_HUMAN	PCNA	physical	20606006
AKT2_HUMAN	AKT2	physical	16982699
CCNA1_HUMAN	CCNA1	physical	16982699
CDK2_HUMAN	CDK2	physical	25483090
CCND1_HUMAN	CCND1	physical	21516116
CCNA2_HUMAN	CCNA2	physical	26496610
CCND3_HUMAN	CCND3	physical	26496610
CDK1_HUMAN	CDK1	physical	26496610
CDK2_HUMAN	CDK2	physical	26496610
PCNA_HUMAN	PCNA	physical	26496610
SSXT_HUMAN	SS18	physical	26496610
CCNE2_HUMAN	CCNE2	physical	26496610
RUSC2_HUMAN	RUSC2	physical	26496610
CCNA1_HUMAN	CCNA1	physical	25241761
STAT3_HUMAN	STAT3	physical	25241761
CDN1B_HUMAN	CDKN1B	physical	25241761
SMAD4_HUMAN	SMAD4	physical	25241761
MDM2_HUMAN	MDM2	physical	25241761
FOXO1_HUMAN	FOXO1	physical	25241761
SKP2_HUMAN	SKP2	physical	25241761
HDAC1_HUMAN	HDAC1	physical	25241761
CBP_HUMAN	CREBBP	physical	25241761
PCNA_HUMAN	PCNA	physical	26272819
SMAD3_HUMAN	SMAD3	physical	22995475
KAT2B_HUMAN	KAT2B	physical	22995475
CCND1_HUMAN	CCND1	physical	23007395
CDK4_HUMAN	CDK4	physical	23007395
CDK2_HUMAN	CDK2	physical	23007395
CHIP_HUMAN	STUB1	physical	28232384
PCNA_HUMAN	PCNA	physical	11463845
CDK2_HUMAN	CDK2	physical	11463845
CDK4_HUMAN	CDK4	physical	11463845

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDN1A_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"N-acetylation and ubiquitin-independent proteasomal degradation ofp21(Cip1)."; Chen X., Chi Y., Bloecher A., Aebersold R., Clurman B.E.,Roberts J.M.; Mol. Cell 16:839-847(2004). Cited for: PROTEIN SEQUENCE OF 2-16, ACETYLATION AT SER-2, AND MASS SPECTROMETRY.	15574338 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASSSPECTROMETRY.	18669648 [Abstract]
"PCNA-dependent regulation of p21 ubiquitylation and degradation viathe CRL4Cdt2 ubiquitin ligase complex."; Abbas T., Sivaprasad U., Terai K., Amador V., Pagano M., Dutta A.; Genes Dev. 22:2496-2506(2008). Cited for: UBIQUITINATION, DOMAIN PIP-BOX K+4 MOTIF, INTERACTION WITH PCNA,MUTAGENESIS OF SER-114 AND 144-GLN--PHE-150, AND PHOSPHORYLATION ATSER-114.	18794347 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Reversible phosphorylation at the C-terminal regulatory domain ofp21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding."; Scott M.T., Morrice N., Ball K.L.; J. Biol. Chem. 275:11529-11537(2000). Cited for: PROTEIN SEQUENCE OF 136-148, PHOSPHORYLATION AT THR-145; SER-146 ANDSER-160, AND MASS SPECTROMETRY.	10753973 [Abstract]
"Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability andinhibits cell proliferation in HCT116 cells."; Wang Z., Zhang Y., Gu J.J., Davitt C., Reeves R., Magnuson N.S.; Int. J. Biochem. Cell Biol. 42:1030-1038(2010). Cited for: PHOSPHORYLATION AT THR-145 BY PIM2.	20307683 [Abstract]
"Only Akt1 is required for proliferation, while Akt2 promotes cellcycle exit through p21 binding."; Heron-Milhavet L., Franckhauser C., Rana V., Berthenet C., Fisher D.,Hemmings B.A., Fernandez A., Lamb N.J.; Mol. Cell. Biol. 26:8267-8280(2006). Cited for: PHOSPHORYLATION AT THR-145.	16982699 [Abstract]
"Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1kinase."; Wang Z., Bhattacharya N., Mixter P.F., Wei W., Sedivy J.,Magnuson N.S.; Biochim. Biophys. Acta 1593:45-55(2002). Cited for: PHOSPHORYLATION AT THR-145 BY PIM1, SUBCELLULAR LOCATION, ANDINTERACTION WITH PIM1.	12431783 [Abstract]
"Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding andproliferation of endothelial cells."; Roessig L., Jadidi A.S., Urbich C., Badorff C., Zeiher A.M.,Dimmeler S.; Mol. Cell. Biol. 21:5644-5657(2001). Cited for: PHOSPHORYLATION AT THR-145, MUTAGENESIS OF THR-145 AND SER-146, ANDSUBCELLULAR LOCATION.	11463845 [Abstract]

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