MARK2_HUMAN - dbPTM
MARK2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MARK2_HUMAN
UniProt AC Q7KZI7
Protein Name Serine/threonine-protein kinase MARK2
Gene Name MARK2 {ECO:0000312|EMBL:AAH08771.2}
Organism Homo sapiens (Human).
Sequence Length 788
Subcellular Localization Cell membrane
Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Cell projection, dendrite . Cytoplasm . Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relo
Protein Description Serine/threonine-protein kinase. [PubMed: 23666762 Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU]
Protein Sequence MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSSARTPLP
------CCCCCCCCC		32.4819413330
2Phosphorylation------MSSARTPLP
------CCCCCCCCC		32.4825159151
3Phosphorylation-----MSSARTPLPT
-----CCCCCCCCCC		22.0720068231
6Phosphorylation--MSSARTPLPTLNE
--CCCCCCCCCCCCC		28.9718691976
7 (in isoform 10)Phosphorylation-30.6818691976
7 (in isoform 12)Phosphorylation-30.6818691976
7 (in isoform 13)Phosphorylation-30.6818691976
7 (in isoform 14)Phosphorylation-30.6818691976
7 (in isoform 2)Phosphorylation-30.6818691976
7 (in isoform 3)Phosphorylation-30.6818691976
7 (in isoform 6)Phosphorylation-30.6818691976
7 (in isoform 7)Phosphorylation-30.6818691976
9 (in isoform 10)Phosphorylation-35.7218691976
9 (in isoform 12)Phosphorylation-35.7218691976
9 (in isoform 13)Phosphorylation-35.7218691976
9 (in isoform 14)Phosphorylation-35.7218691976
9 (in isoform 2)Phosphorylation-35.7218691976
9 (in isoform 3)Phosphorylation-35.7218691976
9 (in isoform 6)Phosphorylation-35.7218691976
9 (in isoform 7)Phosphorylation-35.7218691976
10PhosphorylationSARTPLPTLNERDTE
CCCCCCCCCCCCCCC		50.3118691976
10 (in isoform 10)Phosphorylation-50.3129743597
10 (in isoform 12)Phosphorylation-50.3129743597
10 (in isoform 13)Phosphorylation-50.3129743597
10 (in isoform 14)Phosphorylation-50.3129743597
10 (in isoform 2)Phosphorylation-50.3129743597
10 (in isoform 3)Phosphorylation-50.3129743597
10 (in isoform 6)Phosphorylation-50.3129743597
10 (in isoform 7)Phosphorylation-50.3129743597
20PhosphorylationERDTEQPTLGHLDSK
CCCCCCCCCCCCCCC		45.1023828894
26PhosphorylationPTLGHLDSKPSSKSN
CCCCCCCCCCCHHHC		53.4823401153
27UbiquitinationTLGHLDSKPSSKSNM
CCCCCCCCCCHHHCC		48.89-
29PhosphorylationGHLDSKPSSKSNMIR
CCCCCCCCHHHCCCC		54.8825849741
30PhosphorylationHLDSKPSSKSNMIRG
CCCCCCCHHHCCCCC		48.9425850435
40PhosphorylationNMIRGRNSATSADEQ
CCCCCCCCCCCCCCC		31.4025159151
40 (in isoform 4)Phosphorylation-31.4018220336
42PhosphorylationIRGRNSATSADEQPH
CCCCCCCCCCCCCCC		25.0330266825
42 (in isoform 4)Phosphorylation-25.0318220336
43PhosphorylationRGRNSATSADEQPHI
CCCCCCCCCCCCCCC		33.1823927012
43 (in isoform 4)Phosphorylation-33.1818220336
53PhosphorylationEQPHIGNYRLLKTIG
CCCCCCCCCHHHHHC		9.4523403867
58PhosphorylationGNYRLLKTIGKGNFA
CCCCHHHHHCCCCCH		34.6322617229
61UbiquitinationRLLKTIGKGNFAKVK
CHHHHHCCCCCHHHH		46.99-
77UbiquitinationARHILTGKEVAVKII
HHHHHCCCCHHEEEC		43.72-
82UbiquitinationTGKEVAVKIIDKTQL
CCCCHHEEECCHHHC		24.98-
86UbiquitinationVAVKIIDKTQLNSSS
HHEEECCHHHCCHHH		27.97-
87PhosphorylationAVKIIDKTQLNSSSL
HEEECCHHHCCHHHH		34.24-
91PhosphorylationIDKTQLNSSSLQKLF
CCHHHCCHHHHHHHH		29.8725159151
92PhosphorylationDKTQLNSSSLQKLFR
CHHHCCHHHHHHHHH		33.7125159151
93PhosphorylationKTQLNSSSLQKLFRE
HHHCCHHHHHHHHHH		34.3425159151
124PhosphorylationEVIETEKTLYLVMEY
EEECCCCEEEEEEHH		17.8825921289
133PhosphorylationYLVMEYASGGEVFDY
EEEEHHHCCHHHHHH		46.5625921289
177UbiquitinationFIVHRDLKAENLLLD
HCCCCCCCHHHCEEC		58.92-
197PhosphorylationKIADFGFSNEFTFGN
EECCCCCCCCEECCC		35.5128464451
201PhosphorylationFGFSNEFTFGNKLDT
CCCCCCEECCCCHHH		25.1826074081
208PhosphorylationTFGNKLDTFCGSPPY
ECCCCHHHCCCCCCC		31.1214976552
212PhosphorylationKLDTFCGSPPYAAPE
CHHHCCCCCCCCCHH		24.7119664994
215PhosphorylationTFCGSPPYAAPELFQ
HCCCCCCCCCHHHHC		20.8423898821
224UbiquitinationAPELFQGKKYDGPEV
CHHHHCCCCCCCCCC		37.06-
272PhosphorylationGKYRIPFYMSTDCEN
CCCCCCEEECCCHHH		5.7029496907
274PhosphorylationYRIPFYMSTDCENLL
CCCCEEECCCHHHHH		15.0921082442
275PhosphorylationRIPFYMSTDCENLLK
CCCEEECCCHHHHHH		28.3021082442
290PhosphorylationKFLILNPSKRGTLEQ
HHHCCCHHHCCCHHH		33.6321406692
2912-HydroxyisobutyrylationFLILNPSKRGTLEQI
HHCCCHHHCCCHHHH		56.98-
291AcetylationFLILNPSKRGTLEQI
HHCCCHHHCCCHHHH		56.9825953088
294PhosphorylationLNPSKRGTLEQIMKD
CCHHHCCCHHHHHHH		31.0221082442
300UbiquitinationGTLEQIMKDRWMNVG
CCHHHHHHHCCCCCC		45.85-
323PhosphorylationYVEPLPDYKDPRRTE
CCCCCCCCCCCCHHH		18.49-
329PhosphorylationDYKDPRRTELMVSMG
CCCCCCHHHEEEECC		34.4522461510
334PhosphorylationRRTELMVSMGYTREE
CHHHEEEECCCCHHH		7.7923403867
337PhosphorylationELMVSMGYTREEIQD
HEEEECCCCHHHHHH		8.2523403867
338PhosphorylationLMVSMGYTREEIQDS
EEEECCCCHHHHHHH		26.3523403867
351PhosphorylationDSLVGQRYNEVMATY
HHHHHHHHHHHHHHH		14.0518691976
357PhosphorylationRYNEVMATYLLLGYK
HHHHHHHHHHHHCCC		9.1518691976
358PhosphorylationYNEVMATYLLLGYKS
HHHHHHHHHHHCCCC		5.94-
363PhosphorylationATYLLLGYKSSELEG
HHHHHHCCCCHHCCC		13.99-
365PhosphorylationYLLLGYKSSELEGDT
HHHHCCCCHHCCCCE		22.1430266825
366PhosphorylationLLLGYKSSELEGDTI
HHHCCCCHHCCCCEE		41.8930266825
367 (in isoform 13)Phosphorylation-58.9125849741
367 (in isoform 14)Phosphorylation-58.9125849741
372PhosphorylationSSELEGDTITLKPRP
CHHCCCCEEEEEECC		27.0723403867
374PhosphorylationELEGDTITLKPRPSA
HCCCCEEEEEECCCC		30.7123403867
376UbiquitinationEGDTITLKPRPSADL
CCCEEEEEECCCCCC		30.26-
376 (in isoform 13)Phosphorylation-30.2630266825
376 (in isoform 14)Phosphorylation-30.2630266825
380PhosphorylationITLKPRPSADLTNSS
EEEEECCCCCCCCCC		35.3823927012
384PhosphorylationPRPSADLTNSSAPSP
ECCCCCCCCCCCCCC		33.3325849741
385 (in isoform 13)Phosphorylation-41.0623927012
385 (in isoform 14)Phosphorylation-41.0623927012
386PhosphorylationPSADLTNSSAPSPSH
CCCCCCCCCCCCCCC		23.7325159151
386 (in isoform 13)Phosphorylation-23.7323927012
386 (in isoform 14)Phosphorylation-23.7323927012
387PhosphorylationSADLTNSSAPSPSHK
CCCCCCCCCCCCCCC		46.3929255136
388 (in isoform 13)Phosphorylation-14.3823927012
388 (in isoform 14)Phosphorylation-14.3823927012
389 (in isoform 13)Phosphorylation-49.0428450419
389 (in isoform 14)Phosphorylation-49.0428450419
390PhosphorylationLTNSSAPSPSHKVQR
CCCCCCCCCCCCCHH		38.4629255136
390 (in isoform 13)Phosphorylation-38.4625849741
390 (in isoform 14)Phosphorylation-38.4625849741
392PhosphorylationNSSAPSPSHKVQRSV
CCCCCCCCCCCHHCC		40.0329255136
394UbiquitinationSAPSPSHKVQRSVSA
CCCCCCCCCHHCCCC		44.38-
398PhosphorylationPSHKVQRSVSANPKQ
CCCCCHHCCCCCHHH		11.8829396449
400PhosphorylationHKVQRSVSANPKQRR
CCCHHCCCCCHHHCC		24.4728176443
400 (in isoform 15)Phosphorylation-24.4725849741
400 (in isoform 16)Phosphorylation-24.4725849741
409PhosphorylationNPKQRRFSDQAAGPA
CHHHCCCCCCCCCCC		27.3123927012
409 (in isoform 15)Phosphorylation-27.3130266825
409 (in isoform 16)Phosphorylation-27.3130266825
418 (in isoform 15)Phosphorylation-31.7023927012
418 (in isoform 16)Phosphorylation-31.7023927012
419PhosphorylationAAGPAIPTSNSYSKK
CCCCCCCCCCCCCHH		34.1318691976
419 (in isoform 15)Phosphorylation-34.1323927012
419 (in isoform 16)Phosphorylation-34.1323927012
420PhosphorylationAGPAIPTSNSYSKKT
CCCCCCCCCCCCHHH		20.5823927012
421 (in isoform 15)Phosphorylation-47.6623927012
421 (in isoform 16)Phosphorylation-47.6623927012
422PhosphorylationPAIPTSNSYSKKTQS
CCCCCCCCCCHHHCC		30.4719664994
422 (in isoform 15)Phosphorylation-30.4728450419
422 (in isoform 16)Phosphorylation-30.4728450419
423PhosphorylationAIPTSNSYSKKTQSN
CCCCCCCCCHHHCCC		28.8520363803
423 (in isoform 15)Phosphorylation-28.8525849741
423 (in isoform 16)Phosphorylation-28.8525849741
424PhosphorylationIPTSNSYSKKTQSNN
CCCCCCCCHHHCCCC		27.7425627689
443PhosphorylationRPEEDRESGRKASST
CCHHHHHHCCCCCCC		44.8026074081
448PhosphorylationRESGRKASSTAKVPA
HHHCCCCCCCCCCCC		31.1228450419
449PhosphorylationESGRKASSTAKVPAS
HHCCCCCCCCCCCCC		36.9322617229
450PhosphorylationSGRKASSTAKVPASP
HCCCCCCCCCCCCCC		28.1823401153
456PhosphorylationSTAKVPASPLPGLER
CCCCCCCCCCCCCCC		22.3919664994
456 (in isoform 4)Phosphorylation-22.3918220336
459 (in isoform 13)Phosphorylation-49.0225849741
460 (in isoform 10)Phosphorylation-48.1025849741
460 (in isoform 2)Phosphorylation-48.1025849741
460 (in isoform 7)Phosphorylation-48.1025849741
464 (in isoform 13)Phosphorylation-45.1324719451
465 (in isoform 10)Phosphorylation-64.9424719451
465 (in isoform 2)Phosphorylation-64.9424719451
465 (in isoform 7)Phosphorylation-64.9424719451
466PhosphorylationPGLERKKTTPTPSTN
CCCCCCCCCCCCCCC		40.8323401153
467PhosphorylationGLERKKTTPTPSTNS
CCCCCCCCCCCCCCC		33.7623927012
469PhosphorylationERKKTTPTPSTNSVL
CCCCCCCCCCCCCCC		27.9825159151
471PhosphorylationKKTTPTPSTNSVLST
CCCCCCCCCCCCCCC		42.5723927012
471 (in isoform 13)Phosphorylation-42.5728450419
472PhosphorylationKTTPTPSTNSVLSTS
CCCCCCCCCCCCCCC		32.4923927012
472 (in isoform 10)Phosphorylation-32.4928450419
472 (in isoform 13)Phosphorylation-32.4928450419
472 (in isoform 2)Phosphorylation-32.4928450419
472 (in isoform 7)Phosphorylation-32.4928450419
473 (in isoform 10)Phosphorylation-34.1628450419
473 (in isoform 2)Phosphorylation-34.1628450419
473 (in isoform 7)Phosphorylation-34.1628450419
474PhosphorylationTPTPSTNSVLSTSTN
CCCCCCCCCCCCCCC		25.2323403867
477PhosphorylationPSTNSVLSTSTNRSR
CCCCCCCCCCCCCCC		20.3923927012
478PhosphorylationSTNSVLSTSTNRSRN
CCCCCCCCCCCCCCC		35.1023403867
479PhosphorylationTNSVLSTSTNRSRNS
CCCCCCCCCCCCCCC		21.9525159151
480PhosphorylationNSVLSTSTNRSRNSP
CCCCCCCCCCCCCCC		34.4423403867
481 (in isoform 13)Phosphorylation-39.4325849741
482 (in isoform 10)Phosphorylation-36.7625849741
482 (in isoform 2)Phosphorylation-36.7625849741
482 (in isoform 7)Phosphorylation-36.7625849741
483PhosphorylationLSTSTNRSRNSPLLE
CCCCCCCCCCCCCHH		37.5730266825
483 (in isoform 13)Phosphorylation-37.5725849741
484 (in isoform 10)Phosphorylation-44.3925849741
484 (in isoform 2)Phosphorylation-44.3925849741
484 (in isoform 7)Phosphorylation-44.3925849741
486PhosphorylationSTNRSRNSPLLERAS
CCCCCCCCCCHHHHH		18.8029255136
486 (in isoform 4)Phosphorylation-18.8018220336
488 (in isoform 13)Phosphorylation-8.5528450419
489 (in isoform 10)Phosphorylation-4.8028450419
489 (in isoform 2)Phosphorylation-4.8028450419
489 (in isoform 7)Phosphorylation-4.8028450419
492 (in isoform 15)Phosphorylation-10.3425849741
492 (in isoform 16)Phosphorylation-10.3425849741
493PhosphorylationSPLLERASLGQASIQ
CCCHHHHHHCCHHHH		38.9725159151
493 (in isoform 4)Phosphorylation-38.9725849741
493 (in isoform 5)Phosphorylation-38.9725849741
493 (in isoform 9)Phosphorylation-38.9725849741
497 (in isoform 15)Phosphorylation-13.5524719451
497 (in isoform 16)Phosphorylation-13.5524719451
498PhosphorylationRASLGQASIQNGKDS
HHHHCCHHHHCCCCC		19.4728355574
498 (in isoform 4)Phosphorylation-19.4724719451
498 (in isoform 5)Phosphorylation-19.4724719451
498 (in isoform 9)Phosphorylation-19.4724719451
504 (in isoform 15)Phosphorylation-50.7228450419
504 (in isoform 16)Phosphorylation-50.7228450419
505PhosphorylationSIQNGKDSLTMPGSR
HHHCCCCCCCCCCCH		29.2628348404
505 (in isoform 15)Phosphorylation-29.2628450419
505 (in isoform 16)Phosphorylation-29.2628450419
505 (in isoform 4)Phosphorylation-29.2628450419
505 (in isoform 5)Phosphorylation-29.2628450419
505 (in isoform 9)Phosphorylation-29.2628450419
506 (in isoform 4)Phosphorylation-7.3428450419
506 (in isoform 5)Phosphorylation-7.3428450419
506 (in isoform 9)Phosphorylation-7.3428450419
511PhosphorylationDSLTMPGSRASTASA
CCCCCCCCHHHHHHH		20.8528555341
514PhosphorylationTMPGSRASTASASAA
CCCCCHHHHHHHHHH		24.3229255136
514 (in isoform 15)Phosphorylation-24.3225849741
514 (in isoform 16)Phosphorylation-24.3225849741
515PhosphorylationMPGSRASTASASAAV
CCCCHHHHHHHHHHH		24.5229255136
515 (in isoform 4)Phosphorylation-24.5225849741
515 (in isoform 5)Phosphorylation-24.5225849741
515 (in isoform 9)Phosphorylation-24.5225849741
516 (in isoform 15)Phosphorylation-10.7025849741
516 (in isoform 16)Phosphorylation-10.7025849741
517PhosphorylationGSRASTASASAAVSA
CCHHHHHHHHHHHHH		23.8930576142
517 (in isoform 4)Phosphorylation-23.8925849741
517 (in isoform 5)Phosphorylation-23.8925849741
517 (in isoform 9)Phosphorylation-23.8925849741
519PhosphorylationRASTASASAAVSAAR
HHHHHHHHHHHHHHC		17.7926330541
521 (in isoform 15)Phosphorylation-8.0328450419
521 (in isoform 16)Phosphorylation-8.0328450419
522 (in isoform 4)Phosphorylation-3.9128450419
522 (in isoform 5)Phosphorylation-3.9128450419
522 (in isoform 9)Phosphorylation-3.9128450419
523PhosphorylationASASAAVSAARPRQH
HHHHHHHHHHCHHHH		16.1026330541
533PhosphorylationRPRQHQKSMSASVHP
CHHHHHHHCCCCCCC		16.0528857561
535PhosphorylationRQHQKSMSASVHPNK
HHHHHHCCCCCCCCC		25.2023401153
537PhosphorylationHQKSMSASVHPNKAS
HHHHCCCCCCCCCCC		17.4122617229
544PhosphorylationSVHPNKASGLPPTES
CCCCCCCCCCCCCCC		42.3323312004
549PhosphorylationKASGLPPTESNCEVP
CCCCCCCCCCCCCCC		50.5428348404
550 (in isoform 10)Ubiquitination-45.8121890473
550 (in isoform 2)Ubiquitination-45.8121890473
550 (in isoform 7)Ubiquitination-45.8121890473
551PhosphorylationSGLPPTESNCEVPRP
CCCCCCCCCCCCCCC		49.6226657352
559PhosphorylationNCEVPRPSTAPQRVP
CCCCCCCCCCCCCCC		38.1825849741
560PhosphorylationCEVPRPSTAPQRVPV
CCCCCCCCCCCCCCC		45.0725849741
569PhosphorylationPQRVPVASPSAHNIS
CCCCCCCCCCCCCCC		21.4429255136
571PhosphorylationRVPVASPSAHNISSS
CCCCCCCCCCCCCCC		39.4029255136
576PhosphorylationSPSAHNISSSGGAPD
CCCCCCCCCCCCCCC		24.6225159151
577PhosphorylationPSAHNISSSGGAPDR
CCCCCCCCCCCCCCC		29.2525159151
578PhosphorylationSAHNISSSGGAPDRT
CCCCCCCCCCCCCCC		34.1626055452
583 (in isoform 4)Ubiquitination-70.2921890473
583 (in isoform 5)Ubiquitination-70.2921890473
583 (in isoform 9)Ubiquitination-70.2921890473
585PhosphorylationSGGAPDRTNFPRGVS
CCCCCCCCCCCCCCC		48.9023312004
589MethylationPDRTNFPRGVSSRST
CCCCCCCCCCCCCCC		54.75115482587
592PhosphorylationTNFPRGVSSRSTFHA
CCCCCCCCCCCCEEC		23.9022322096
593PhosphorylationNFPRGVSSRSTFHAG
CCCCCCCCCCCEECC		28.0422322096
595PhosphorylationPRGVSSRSTFHAGQL
CCCCCCCCCEECCCC		37.0630266825
596PhosphorylationRGVSSRSTFHAGQLR
CCCCCCCCEECCCCC		20.5222322096
604 (in isoform 12)Ubiquitination-43.0921890473
604 (in isoform 3)Ubiquitination-43.0921890473
604 (in isoform 6)Ubiquitination-43.0921890473
613PhosphorylationRDQQNLPYGVTPASP
CCCCCCCCCCCCCCC		27.6521945579
616PhosphorylationQNLPYGVTPASPSGH
CCCCCCCCCCCCCCC		14.5821945579
619PhosphorylationPYGVTPASPSGHSQG
CCCCCCCCCCCCCCC		22.3229255136
621PhosphorylationGVTPASPSGHSQGRR
CCCCCCCCCCCCCCC		46.7929255136
624PhosphorylationPASPSGHSQGRRGAS
CCCCCCCCCCCCCCC		37.5429255136
628MethylationSGHSQGRRGASGSIF
CCCCCCCCCCCCCHH		52.4380699891
631PhosphorylationSQGRRGASGSIFSKF
CCCCCCCCCCHHHHH		35.5823401153
633PhosphorylationGRRGASGSIFSKFTS
CCCCCCCCHHHHHHH		20.2630266825
636PhosphorylationGASGSIFSKFTSKFV
CCCCCHHHHHHHHHH		25.7823403867
637UbiquitinationASGSIFSKFTSKFVR
CCCCHHHHHHHHHHH		41.7421890473
637 (in isoform 1)Ubiquitination-41.7421890473
637 (in isoform 11)Ubiquitination-41.7421890473
637 (in isoform 8)Ubiquitination-41.7421890473
639PhosphorylationGSIFSKFTSKFVRRN
CCHHHHHHHHHHHHH		34.4423312004
640PhosphorylationSIFSKFTSKFVRRNL
CHHHHHHHHHHHHHC		27.5128857561
641UbiquitinationIFSKFTSKFVRRNLS
HHHHHHHHHHHHHCH		44.83-
648PhosphorylationKFVRRNLSFRFARRN
HHHHHHCHHHHHHHC		20.2324719451
667PhosphorylationESKDRVETLRPHVVG
CHHHHHHHHCHHHCC		25.8017192257
675PhosphorylationLRPHVVGSGGNDKEK
HCHHHCCCCCCHHHH		31.7320873877
692PhosphorylationFREAKPRSLRFTWSM
HHHCCCCCEEEEEEC		32.2120860994
698PhosphorylationRSLRFTWSMKTTSSM
CCEEEEEECCCCCCC		13.82-
701PhosphorylationRFTWSMKTTSSMEPN
EEEEECCCCCCCCHH		24.2224961811
702PhosphorylationFTWSMKTTSSMEPNE
EEEECCCCCCCCHHH		17.1824961811
716UbiquitinationEMMREIRKVLDANSC
HHHHHHHHHHCCCCC		53.46-
722PhosphorylationRKVLDANSCQSELHE
HHHHCCCCCCHHHHH		18.4314976552
759PhosphorylationVCKLPRLSLNGVRFK
HHCCCCEEECCEEEE		22.5227067055
769PhosphorylationGVRFKRISGTSMAFK
CEEEEECCCCHHHHH		39.8018691976
771PhosphorylationRFKRISGTSMAFKNI
EEEECCCCHHHHHHH		14.4523312004
772PhosphorylationFKRISGTSMAFKNIA
EEECCCCHHHHHHHH		16.1923312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
91SPhosphorylationKinaseCAMK1Q14012
Uniprot
92SPhosphorylationKinaseCAMK1Q14012
Uniprot
93SPhosphorylationKinaseCAMK1Q14012
Uniprot
208TPhosphorylationKinaseSTK11Q15831
PhosphoELM
208TPhosphorylationKinaseTAOK1Q7L7X3
Uniprot
212SPhosphorylationKinaseGSK3BP49841
PSP
294TPhosphorylationKinaseCAMK1Q14012
Uniprot
400SPhosphorylationKinasePRKD1Q15139
PSP
400SPhosphorylationKinasePRKD2Q9BZL6
PSP
400SPhosphorylationKinaseMARK2Q7KZI7
PSP
409SPhosphorylationKinasePKACAP17612
PSP
596TPhosphorylationKinasePRKCAP17252
GPS
596TPhosphorylationKinasePRKCDQ05655
GPS
596TPhosphorylationKinasePRKCIP41743
GPS
596TPhosphorylationKinasePKCZQ05513
PSP
-KUbiquitinationE3 ubiquitin ligaseSMURF1Q9HCE7
PMID:20804422
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
208TPhosphorylation

14976552
208TPhosphorylation

14976552
212SPhosphorylation

14976552
596TPhosphorylation

15084291
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MARK2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AKT1_HUMANAKT1physical
18292230
DTNA_HUMANDTNAphysical
19615732
FUCO_HUMANFUCA1physical
19615732
KINH_HUMANKIF5Bphysical
19615732
MARK1_HUMANMARK1physical
19615732
MARK3_HUMANMARK3physical
19615732
KPCI_HUMANPRKCIphysical
19615732
SNTB2_HUMANSNTB2physical
19615732
UTRO_HUMANUTRNphysical
19615732
1433F_HUMANYWHAHphysical
19615732
ARHG2_HUMANARHGEF2physical
19615732
GASP1_HUMANGPRASP1physical
19615732
C43BP_HUMANCOL4A3BPphysical
19615732
SMAP_HUMANC11orf58physical
19615732
CLAP2_HUMANCLASP2physical
19615732
MPPA_HUMANPMPCAphysical
19615732
PHLP1_HUMANPHLPP1physical
19615732
MTCL1_HUMANMTCL1physical
19615732
KI13B_HUMANKIF13Bphysical
19615732
UTP18_HUMANUTP18physical
19615732
MARK4_HUMANMARK4physical
19615732
CE85L_HUMANCEP85Lphysical
19615732
HDAC7_HUMANHDAC7physical
16980613
1433F_HUMANYWHAHphysical
14676191
MTCL1_HUMANMTCL1physical
20360068
MARK2_HUMANMARK2physical
20360068
MARK2_HUMANMARK2physical
16472737
1433E_HUMANYWHAEphysical
16968750
RFIP2_HUMANRAB11FIP2physical
16775013
1433T_HUMANYWHAQphysical
19553522
PTPA_HUMANPPP2R4physical
15324659
KPCI_HUMANPRKCIphysical
15324659
1433B_HUMANYWHABphysical
15324659
1433G_HUMANYWHAGphysical
15324659
ARHG2_HUMANARHGEF2physical
21513698
UTRO_HUMANUTRNphysical
19945424
DMD_HUMANDMDphysical
19945424
PINK1_HUMANPINK1physical
22238344
KI13B_HUMANKIF13Bphysical
20194617
1433T_HUMANYWHAQphysical
19011111
GAB1_HUMANGAB1physical
22883624
GAB2_HUMANGAB2physical
22883624
RNF41_HUMANRNF41physical
24259665
KCC1A_HUMANCAMK1physical
17442826
TAU_HUMANMAPTphysical
24251416
BAIP2_HUMANBAIAP2physical
24165937
CRTC2_MOUSECrtc2physical
18626018
MTCL1_HUMANMTCL1physical
23902687
CAZA1_HUMANCAPZA1physical
26496610
CAZA2_HUMANCAPZA2physical
26496610
CAPZB_HUMANCAPZBphysical
26496610
AP2M1_HUMANAP2M1physical
26496610
2AAA_HUMANPPP2R1Aphysical
26496610
2A5E_HUMANPPP2R5Ephysical
26496610
HERC2_HUMANHERC2physical
26496610
DLG5_HUMANDLG5physical
26496610
WDR46_HUMANWDR46physical
26496610
PDCD7_HUMANPDCD7physical
26496610
PRDX3_HUMANPRDX3physical
26496610
NUPL2_HUMANNUPL2physical
26496610
CLAP2_HUMANCLASP2physical
26496610
MTCL1_HUMANMTCL1physical
26496610
CAMP2_HUMANCAMSAP2physical
26496610
CLAP1_HUMANCLASP1physical
26496610
RSF1_HUMANRSF1physical
26496610
CCD82_HUMANCCDC82physical
26496610
SOGA1_HUMANSOGA1physical
26496610
FXL16_HUMANFBXL16physical
26496610
FRYL_HUMANFRYLphysical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MARK2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456 AND SER-571, ANDMASS SPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-40; THR-42;SER-43; SER-197; THR-208; SER-365; SER-390; SER-409; THR-419; SER-420;SER-422; TYR-423; SER-456; SER-471; SER-479; SER-486; SER-533;SER-569; SER-571; SER-619; SER-621; SER-631 AND SER-722, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-456 ANDSER-569, AND MASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-43; SER-390;SER-409; SER-456; SER-483; SER-486; SER-493; SER-569; SER-619; SER-631AND THR-667, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; THR-42; SER-456;SER-486; SER-569; SER-571; SER-576; SER-619 AND SER-621, AND MASSSPECTROMETRY.
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, AND MASSSPECTROMETRY.
"Proteomics analysis of protein kinases by target class-selectiveprefractionation and tandem mass spectrometry.";
Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R.,Keri G., Wehland J., Daub H.;
Mol. Cell. Proteomics 6:537-547(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; THR-208; SER-456;THR-469; SER-479; SER-486; SER-569; SER-571; SER-619 AND SER-631, ANDMASS SPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-486, AND MASSSPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, AND MASSSPECTROMETRY.
"aPKC acts upstream of PAR-1b in both the establishment andmaintenance of mammalian epithelial polarity.";
Suzuki A., Hirata M., Kamimura K., Maniwa R., Yamanaka T., Mizuno K.,Kishikawa M., Hirose H., Amano Y., Izumi N., Miwa Y., Ohno S.;
Curr. Biol. 14:1425-1435(2004).
Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-596,MUTAGENESIS OF THR-596, AND INTERACTION WITH YWHAZ.
"Atypical PKC phosphorylates PAR-1 kinases to regulate localizationand activity.";
Hurov J.B., Watkins J.L., Piwnica-Worms H.;
Curr. Biol. 14:736-741(2004).
Cited for: PHOSPHORYLATION AT THR-596, MUTAGENESIS OF THR-596, AND SUBCELLULARLOCATION.
"LKB1 is a master kinase that activates 13 kinases of the AMPKsubfamily, including MARK/PAR-1.";
Lizcano J.M., Goeransson O., Toth R., Deak M., Morrice N.A.,Boudeau J., Hawley S.A., Udd L., Maekelae T.P., Hardie D.G.,Alessi D.R.;
EMBO J. 23:833-843(2004).
Cited for: FUNCTION, ENZYME REGULATION, PHOSPHORYLATION AT THR-208, ANDMUTAGENESIS OF THR-208.

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