dbPTM

RSF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RSF1_HUMAN
UniProt AC	Q96T23
Protein Name	Remodeling and spacing factor 1
Gene Name	RSF1
Organism	Homo sapiens (Human).
Sequence Length	1441
Subcellular Localization	Nucleus .
Protein Description	Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. [PubMed: 12972596 Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain]
Protein Sequence	MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 3)	Ubiquitination	-	19.76	21890473
36 (in isoform 3)	Ubiquitination	-	5.16	21890473
45 (in isoform 3)	Ubiquitination	-	43.24	21890473
77	Acetylation	LHLKLMRKIGKSVTA HHHHHHHHHCCCCCH	41.67	7306949
80	Ubiquitination	KLMRKIGKSVTADRW HHHHHHCCCCCHHHH	45.27	-
89	Ubiquitination	VTADRWEKYLIKICQ CCHHHHHHHHHHHHH	38.10	21890473
89 (in isoform 1)	Ubiquitination	-	38.10	21890473
136	Acetylation	CQFDDNLKFKNIINE CCCCCCCCCCCCCCH	61.62	20167786
136	Sumoylation	CQFDDNLKFKNIINE CCCCCCCCCCCCCCH	61.62	28112733
136	Ubiquitination	CQFDDNLKFKNIINE CCCCCCCCCCCCCCH	61.62	-
138	Ubiquitination	FDDNLKFKNIINEED CCCCCCCCCCCCHHH	45.72	-
158	Ubiquitination	LQPIGRDKDGLMYWY EEECCCCCCCCEEEE	52.95	-
174 (in isoform 2)	Ubiquitination	-	19.94	21890473
174 (in isoform 3)	Ubiquitination	-	19.94	21890473
184 (in isoform 2)	Ubiquitination	-	66.97	-
186	Phosphorylation	EQDDQDGSSWKCIVR EECCCCCCEEEEEEE	41.12	-
189	Ubiquitination	DQDGSSWKCIVRNRN CCCCCEEEEEEECHH	18.94	-
213 (in isoform 2)	Ubiquitination	-	7.39	21890473
215	Sumoylation	QIDPVLLKNSSQQDN HCCHHHCCCCCCCCC	51.10	28112733
215	Ubiquitination	QIDPVLLKNSSQQDN HCCHHHCCCCCCCCC	51.10	21890473
215 (in isoform 1)	Ubiquitination	-	51.10	21890473
217	Phosphorylation	DPVLLKNSSQQDNSS CHHHCCCCCCCCCCC	28.12	19664995
218	Phosphorylation	PVLLKNSSQQDNSSR HHHCCCCCCCCCCCC	41.05	19664995
223	Phosphorylation	NSSQQDNSSRESPSL CCCCCCCCCCCCCCC	38.78	25159151
224	Phosphorylation	SSQQDNSSRESPSLE CCCCCCCCCCCCCCC	46.45	25159151
227	Phosphorylation	QDNSSRESPSLEDEE CCCCCCCCCCCCCHH	20.76	26503892
229	Phosphorylation	NSSRESPSLEDEETK CCCCCCCCCCCHHHH	54.38	29255136
235	Phosphorylation	PSLEDEETKKEEETP CCCCCHHHHHHHCCH	45.42	20068231
236	Sumoylation	SLEDEETKKEEETPK CCCCHHHHHHHCCHH	62.56	28112733
241	Phosphorylation	ETKKEEETPKQEEQK HHHHHHCCHHHHHHH	38.78	26074081
243	Sumoylation	KKEEETPKQEEQKES HHHHCCHHHHHHHHH	77.19	28112733
246 (in isoform 3)	Ubiquitination	-	65.54	21890473
247 (in isoform 2)	Ubiquitination	-	54.81	21890473
248	Sumoylation	TPKQEEQKESEKMKS CHHHHHHHHHHHHHC	67.50	28112733
252	Acetylation	EEQKESEKMKSEEQP HHHHHHHHHHCCCCC	61.99	18528591
252	Sumoylation	EEQKESEKMKSEEQP HHHHHHHHHHCCCCC	61.99	28112733
254	Sumoylation	QKESEKMKSEEQPMD HHHHHHHHCCCCCCC	66.82	-
254	Sumoylation	QKESEKMKSEEQPMD HHHHHHHHCCCCCCC	66.82	28112733
254	Ubiquitination	QKESEKMKSEEQPMD HHHHHHHHCCCCCCC	66.82	21906983
254 (in isoform 1)	Ubiquitination	-	66.82	21890473
255	Phosphorylation	KESEKMKSEEQPMDL HHHHHHHCCCCCCCC	42.75	-
256 (in isoform 2)	Ubiquitination	-	55.95	21890473
266	Phosphorylation	PMDLENRSTANVLEE CCCCCCHHHHHHHHH	43.37	27732954
267	Phosphorylation	MDLENRSTANVLEET CCCCCHHHHHHHHHH	21.00	27732954
274	Phosphorylation	TANVLEETTVKKEKE HHHHHHHHHCCCCCC	27.75	28555341
277	Sumoylation	VLEETTVKKEKEDEK HHHHHHCCCCCCCHH	53.79	-
277	Sumoylation	VLEETTVKKEKEDEK HHHHHHCCCCCCCHH	53.79	25114211
278	Acetylation	LEETTVKKEKEDEKE HHHHHCCCCCCCHHH	70.45	18528597
278	Sumoylation	LEETTVKKEKEDEKE HHHHHCCCCCCCHHH	70.45	-
284	Sumoylation	KKEKEDEKELVKLPV CCCCCCHHHHHCCCE	69.53	-
284	Sumoylation	KKEKEDEKELVKLPV CCCCCCHHHHHCCCE	69.53	28112733
288	Sumoylation	EDEKELVKLPVIVKL CCHHHHHCCCEEEEE	60.75	28112733
288	Ubiquitination	EDEKELVKLPVIVKL CCHHHHHCCCEEEEE	60.75	21890473
288 (in isoform 1)	Ubiquitination	-	60.75	21890473
294	Sumoylation	VKLPVIVKLEKPLPE HCCCEEEEECCCCCC	39.54	-
294	Acetylation	VKLPVIVKLEKPLPE HCCCEEEEECCCCCC	39.54	25953088
294	Sumoylation	VKLPVIVKLEKPLPE HCCCEEEEECCCCCC	39.54	28112733
297	Acetylation	PVIVKLEKPLPENEE CEEEEECCCCCCCHH	63.39	25953088
297	Ubiquitination	PVIVKLEKPLPENEE CEEEEECCCCCCCHH	63.39	21906983
297 (in isoform 1)	Ubiquitination	-	63.39	21890473
305	Acetylation	PLPENEEKKIIKEES CCCCCHHHHHHHHCC	42.99	26051181
305	Sumoylation	PLPENEEKKIIKEES CCCCCHHHHHHHHCC	42.99	28112733
306	Sumoylation	LPENEEKKIIKEESD CCCCHHHHHHHHCCH	53.60	28112733
309	Sumoylation	NEEKKIIKEESDSFK CHHHHHHHHCCHHHH	59.92	-
309	Sumoylation	NEEKKIIKEESDSFK CHHHHHHHHCCHHHH	59.92	28112733
314	Phosphorylation	IIKEESDSFKENVKP HHHHCCHHHHHHCCC	47.71	27251275
316	Ubiquitination	KEESDSFKENVKPIK HHCCHHHHHHCCCEE	52.94	-
320	Acetylation	DSFKENVKPIKVEVK HHHHHHCCCEEEEEE	53.24	26051181
320	Ubiquitination	DSFKENVKPIKVEVK HHHHHHCCCEEEEEE	53.24	-
323	Sumoylation	KENVKPIKVEVKECR HHHCCCEEEEEEECC	40.65	-
323	Sumoylation	KENVKPIKVEVKECR HHHCCCEEEEEEECC	40.65	28112733
327	Sumoylation	KPIKVEVKECRADPK CCEEEEEEECCCCCC	37.28	28112733
327 (in isoform 2)	Ubiquitination	-	37.28	-
335 (in isoform 2)	Ubiquitination	-	65.83	-
337	Sumoylation	RADPKDTKSSMEKPV CCCCCCCHHHCCCCC	51.14	-
337	Sumoylation	RADPKDTKSSMEKPV CCCCCCCHHHCCCCC	51.14	28112733
342	Acetylation	DTKSSMEKPVAQEPE CCHHHCCCCCCCCCC	35.83	26051181
342	Sumoylation	DTKSSMEKPVAQEPE CCHHHCCCCCCCCCC	35.83	28112733
358	Sumoylation	IEFGGNIKSSHEITE EECCCCCCCCCCCCC	50.32	28112733
358	Ubiquitination	IEFGGNIKSSHEITE EECCCCCCCCCCCCC	50.32	-
366	Ubiquitination	SSHEITEKSTEETEK CCCCCCCCCHHHHHH	54.77	-
367	Phosphorylation	SHEITEKSTEETEKL CCCCCCCCHHHHHHH	34.52	20860994
373	Sumoylation	KSTEETEKLKNDQQA CCHHHHHHHCCCHHC	72.66	28112733
381	Sumoylation	LKNDQQAKIPLKKRE HCCCHHCCCCCCCCC	40.28	28112733
381	Ubiquitination	LKNDQQAKIPLKKRE HCCCHHCCCCCCCCC	40.28	-
387	Phosphorylation	AKIPLKKREIKLSDD CCCCCCCCCEECCCC	49.65	17081983
390	Sumoylation	PLKKREIKLSDDFDS CCCCCCEECCCCCCC	36.87	-
390	Sumoylation	PLKKREIKLSDDFDS CCCCCCEECCCCCCC	36.87	28112733
390	Ubiquitination	PLKKREIKLSDDFDS CCCCCCEECCCCCCC	36.87	-
392	Phosphorylation	KKREIKLSDDFDSPV CCCCEECCCCCCCCC	30.08	30266825
397	Phosphorylation	KLSDDFDSPVKGPLC ECCCCCCCCCCCCCC	31.42	29255136
400	Acetylation	DDFDSPVKGPLCKSV CCCCCCCCCCCCCCC	59.19	26051181
400	Sumoylation	DDFDSPVKGPLCKSV CCCCCCCCCCCCCCC	59.19	28112733
405	Sumoylation	PVKGPLCKSVTPTKE CCCCCCCCCCCCCHH	56.49	28112733
406	Phosphorylation	VKGPLCKSVTPTKEF CCCCCCCCCCCCHHH	30.17	30266825
408	Phosphorylation	GPLCKSVTPTKEFLK CCCCCCCCCCHHHHH	32.12	23401153
410	Phosphorylation	LCKSVTPTKEFLKDE CCCCCCCCHHHHHHH	33.56	30266825
411	Ubiquitination	CKSVTPTKEFLKDEI CCCCCCCHHHHHHHH	47.90	21890473
411 (in isoform 1)	Ubiquitination	-	47.90	21890473
415	Sumoylation	TPTKEFLKDEIKQEE CCCHHHHHHHHHHHH	59.65	-
415	Sumoylation	TPTKEFLKDEIKQEE CCCHHHHHHHHHHHH	59.65	28112733
419	Sumoylation	EFLKDEIKQEEETCK HHHHHHHHHHHHHHH	50.00	-
419	Sumoylation	EFLKDEIKQEEETCK HHHHHHHHHHHHHHH	50.00	28112733
424	Phosphorylation	EIKQEEETCKRISTI HHHHHHHHHHHHHHH	26.97	24732914
426	Acetylation	KQEEETCKRISTITA HHHHHHHHHHHHHHH	61.25	26051181
429	Phosphorylation	EETCKRISTITALGH HHHHHHHHHHHHCCC	20.14	25159151
430	Phosphorylation	ETCKRISTITALGHE HHHHHHHHHHHCCCC	21.70	20068231
432	Phosphorylation	CKRISTITALGHEGK HHHHHHHHHCCCCCC	18.87	20068231
439	Acetylation	TALGHEGKQLVNGEV HHCCCCCCCCCCCCC	37.16	25953088
439	Sumoylation	TALGHEGKQLVNGEV HHCCCCCCCCCCCCC	37.16	28112733
446 (in isoform 3)	Ubiquitination	-	10.41	21890473
447	Phosphorylation	QLVNGEVSDERVAPN CCCCCCCCCCCCCCC	29.47	20068231
456	Sumoylation	ERVAPNFKTEPIETK CCCCCCCCCCCCCCC	59.63	-
456	Acetylation	ERVAPNFKTEPIETK CCCCCCCCCCCCCCC	59.63	26051181
456	Sumoylation	ERVAPNFKTEPIETK CCCCCCCCCCCCCCC	59.63	25114211
456	Ubiquitination	ERVAPNFKTEPIETK CCCCCCCCCCCCCCC	59.63	-
457	Phosphorylation	RVAPNFKTEPIETKF CCCCCCCCCCCCCCE	42.74	26074081
457 (in isoform 2)	Ubiquitination	-	42.74	21890473
457 (in isoform 3)	Ubiquitination	-	42.74	21890473
462	Phosphorylation	FKTEPIETKFYETKE CCCCCCCCCEEECCC	27.46	26074081
463	Sumoylation	KTEPIETKFYETKEE CCCCCCCCEEECCCC	32.91	28112733
463	Ubiquitination	KTEPIETKFYETKEE CCCCCCCCEEECCCC	32.91	21890473
463 (in isoform 1)	Ubiquitination	-	32.91	21890473
465	Phosphorylation	EPIETKFYETKEESY CCCCCCEEECCCCCC	25.01	23403867
467	Phosphorylation	IETKFYETKEESYSP CCCCEEECCCCCCCC	32.17	23927012
467 (in isoform 2)	Ubiquitination	-	32.17	-
468	Sumoylation	ETKFYETKEESYSPS CCCEEECCCCCCCCC	47.77	-
468	Sumoylation	ETKFYETKEESYSPS CCCEEECCCCCCCCC	47.77	28112733
468	Ubiquitination	ETKFYETKEESYSPS CCCEEECCCCCCCCC	47.77	-
471	Phosphorylation	FYETKEESYSPSKDR EEECCCCCCCCCCCC	31.81	22167270
472	Phosphorylation	YETKEESYSPSKDRN EECCCCCCCCCCCCC	28.07	23927012
473	Phosphorylation	ETKEESYSPSKDRNI ECCCCCCCCCCCCCE	31.79	29255136
475	Phosphorylation	KEESYSPSKDRNIIT CCCCCCCCCCCCEEE	41.05	30266825
476	Acetylation	EESYSPSKDRNIITE CCCCCCCCCCCEEEC	65.18	26051181
482	Phosphorylation	SKDRNIITEGNGTES CCCCCEEECCCCHHH	33.76	26074081
487	Phosphorylation	IITEGNGTESLNSVI EEECCCCHHHHHHHH	26.80	21406692
489	Phosphorylation	TEGNGTESLNSVITS ECCCCHHHHHHHHHH	32.46	21406692
492	Phosphorylation	NGTESLNSVITSMKT CCHHHHHHHHHHCCC	21.86	21406692
495	Phosphorylation	ESLNSVITSMKTGEL HHHHHHHHHCCCCCC	22.17	21406692
496	Phosphorylation	SLNSVITSMKTGELE HHHHHHHHCCCCCCC	13.73	21406692
498	Sumoylation	NSVITSMKTGELEKE HHHHHHCCCCCCCEE	53.82	28112733
498	Ubiquitination	NSVITSMKTGELEKE HHHHHHCCCCCCCEE	53.82	21906983
498 (in isoform 1)	Ubiquitination	-	53.82	21890473
506	Phosphorylation	TGELEKETAPLRKDA CCCCCEECCCCCCCC	44.64	20860994
506 (in isoform 3)	Ubiquitination	-	44.64	21890473
514	Phosphorylation	APLRKDADSSISVLE CCCCCCCCCCCEEEE	53.72	17525332
515	Phosphorylation	PLRKDADSSISVLEI CCCCCCCCCCEEEEH	31.15	29214152
516	Phosphorylation	LRKDADSSISVLEIH CCCCCCCCCEEEEHH	21.30	26462736
518	Phosphorylation	KDADSSISVLEIHSQ CCCCCCCEEEEHHHC	23.69	29978859
524	Phosphorylation	ISVLEIHSQKAQIEE CEEEEHHHCCCCCCC	38.75	17525332
539	Phosphorylation	PDPPEMETSLDSSEM CCCCCCCCCCCHHHH	33.02	25159151
540	Phosphorylation	DPPEMETSLDSSEMA CCCCCCCCCCHHHHH	19.51	25159151
543	Phosphorylation	EMETSLDSSEMAKDL CCCCCCCHHHHHHHH	33.23	23403867
544	Phosphorylation	METSLDSSEMAKDLS CCCCCCHHHHHHHHC	30.93	23403867
554	Phosphorylation	AKDLSSKTALSSTES HHHHCCCCHHHCCCC	34.48	23403867
557	Phosphorylation	LSSKTALSSTESCTM HCCCCHHHCCCCCCC	32.52	23403867
558	Phosphorylation	SSKTALSSTESCTMK CCCCHHHCCCCCCCC	36.72	23403867
559	Phosphorylation	SKTALSSTESCTMKG CCCHHHCCCCCCCCC	28.65	23403867
561	Phosphorylation	TALSSTESCTMKGEE CHHHCCCCCCCCCCC	18.25	25159151
563	Phosphorylation	LSSTESCTMKGEEKS HHCCCCCCCCCCCCC	31.06	25159151
565	Acetylation	STESCTMKGEEKSPK CCCCCCCCCCCCCCC	45.04	26051181
565	Sumoylation	STESCTMKGEEKSPK CCCCCCCCCCCCCCC	45.04	28112733
570	Phosphorylation	TMKGEEKSPKTKKDK CCCCCCCCCCCCCCC	34.60	23401153
587	Acetylation	PILECLEKLEKSKKT CHHHHHHHHHHHHCC	49.34	26051181
591	Phosphorylation	CLEKLEKSKKTFLDK HHHHHHHHHCCHHCC	29.97	26074081
594	Phosphorylation	KLEKSKKTFLDKDAQ HHHHHHCCHHCCCHH	32.92	30183078
604	Phosphorylation	DKDAQRLSPIPEEVP CCCHHHCCCCCCCCC	23.99	29255136
612	Phosphorylation	PIPEEVPKSTLESEK CCCCCCCHHHHCCCC	62.34	18669648
613	Phosphorylation	IPEEVPKSTLESEKP CCCCCCHHHHCCCCC	31.96	30266825
614	Phosphorylation	PEEVPKSTLESEKPG CCCCCHHHHCCCCCC	40.44	30266825
617	Phosphorylation	VPKSTLESEKPGSPE CCHHHHCCCCCCCCC	54.77	29255136
622	Phosphorylation	LESEKPGSPEAAETS HCCCCCCCCCHHHCC	28.26	29255136
628	Phosphorylation	GSPEAAETSPPSNII CCCCHHHCCCCCCHH	41.63	29255136
629	Phosphorylation	SPEAAETSPPSNIID CCCHHHCCCCCCHHH	26.73	29255136
632	Phosphorylation	AAETSPPSNIIDHCE HHHCCCCCCHHHHHH	44.00	30266825
643	Phosphorylation	DHCEKLASEKEVVEC HHHHHHHCCCCEEEE	60.69	26074081
645	Acetylation	CEKLASEKEVVECQS HHHHHCCCCEEEEEE	54.00	26051181
657 (in isoform 2)	Ubiquitination	-	28.63	21890473
660	Phosphorylation	TSTVGGQSVKKVDLE CCCCCCEEEEEEEHH	38.90	28985074
662	Acetylation	TVGGQSVKKVDLETL CCCCEEEEEEEHHHH	52.94	25953088
662	Sumoylation	TVGGQSVKKVDLETL CCCCEEEEEEEHHHH	52.94	28112733
663	Sumoylation	VGGQSVKKVDLETLK CCCEEEEEEEHHHHH	38.53	-
663	Sumoylation	VGGQSVKKVDLETLK CCCEEEEEEEHHHHH	38.53	28112733
668	Phosphorylation	VKKVDLETLKEDSEF EEEEEHHHHHCCCCC	50.88	23312004
668 (in isoform 2)	Ubiquitination	-	50.88	21890473
670	Sumoylation	KVDLETLKEDSEFTK EEEHHHHHCCCCCEE	67.88	-
670	Sumoylation	KVDLETLKEDSEFTK EEEHHHHHCCCCCEE	67.88	28112733
677	Sumoylation	KEDSEFTKVEMDNLD HCCCCCEEEEECCCC	41.33	-
677	Sumoylation	KEDSEFTKVEMDNLD HCCCCCEEEEECCCC	41.33	28112733
688	Phosphorylation	DNLDNAQTSGIEEPS CCCCCCCCCCCCCCC	26.89	20873877
689	Phosphorylation	NLDNAQTSGIEEPSE CCCCCCCCCCCCCCC	26.20	21815630
695	Phosphorylation	TSGIEEPSETKGSMQ CCCCCCCCCCCCCCC	62.27	25332170
698	Sumoylation	IEEPSETKGSMQKSK CCCCCCCCCCCCCCC	44.96	-
698	Sumoylation	IEEPSETKGSMQKSK CCCCCCCCCCCCCCC	44.96	28112733
698	Ubiquitination	IEEPSETKGSMQKSK CCCCCCCCCCCCCCC	44.96	6983
698 (in isoform 1)	Ubiquitination	-	44.96	21890473
700	Phosphorylation	EPSETKGSMQKSKFK CCCCCCCCCCCCCCE	21.42	28555341
709	Sumoylation	QKSKFKYKLVPEEET CCCCCEEEECCCCCC	43.53	28112733
709	Ubiquitination	QKSKFKYKLVPEEET CCCCCEEEECCCCCC	43.53	21906983
709 (in isoform 1)	Ubiquitination	-	43.53	21890473
717 (in isoform 2)	Ubiquitination	-	31.31	21890473
736	Phosphorylation	QKEGIKLTIRISSRK HHHCCEEEEEECCCC	11.83	20068231
738	Phosphorylation	EGIKLTIRISSRKKK HCCEEEEEECCCCCC	19.94	17081983
740	Phosphorylation	IKLTIRISSRKKKPD CEEEEEECCCCCCCC	17.78	27282143
741	Phosphorylation	KLTIRISSRKKKPDS EEEEEECCCCCCCCC	45.83	20068231
748	Phosphorylation	SRKKKPDSPPKVLEP CCCCCCCCCCCCCCC	52.18	23927012
758	Sumoylation	KVLEPENKQEKTEKE CCCCCCCHHHHCHHH	59.16	-
758	Acetylation	KVLEPENKQEKTEKE CCCCCCCHHHHCHHH	59.16	22424773
758	Sumoylation	KVLEPENKQEKTEKE CCCCCCCHHHHCHHH	59.16	28112733
758	Ubiquitination	KVLEPENKQEKTEKE CCCCCCCHHHHCHHH	59.16	21906983
758 (in isoform 1)	Ubiquitination	-	59.16	21890473
768	Sumoylation	KTEKEEEKTNVGRTL HCHHHHHHCHHHHHH	48.99	-
768	Phosphorylation	KTEKEEEKTNVGRTL HCHHHHHHCHHHHHH	48.99	17081983
768	Sumoylation	KTEKEEEKTNVGRTL HCHHHHHHCHHHHHH	48.99	28112733
772	Phosphorylation	EEEKTNVGRTLRRSP HHHHCHHHHHHCCCC	20.94	17081983
774	Phosphorylation	EKTNVGRTLRRSPRI HHCHHHHHHCCCCCC	20.77	28555341
778	Phosphorylation	VGRTLRRSPRISRPT HHHHHCCCCCCCCCC	16.46	23312004
782	Phosphorylation	LRRSPRISRPTAKVA HCCCCCCCCCCCHHH	33.22	22817900
785 (in isoform 2)	Ubiquitination	-	37.69	-
787	Acetylation	RISRPTAKVAEIRDQ CCCCCCCHHHHHHHH	44.44	26051181
787 (in isoform 3)	Ubiquitination	-	44.44	21890473
795	Sumoylation	VAEIRDQKADKKRGE HHHHHHHHHHHCCCC	63.94	28112733
799	Sumoylation	RDQKADKKRGEGEDE HHHHHHHCCCCCCCH	67.21	28112733
811	Phosphorylation	EDEVEEESTALQKTD CCHHHHHHHHCHHCC	23.43	29978859
812	Phosphorylation	DEVEEESTALQKTDK CHHHHHHHHCHHCCH	34.37	29978859
816	Acetylation	EESTALQKTDKKEIL HHHHHCHHCCHHHHH	60.59	26051181
817	Phosphorylation	ESTALQKTDKKEILK HHHHCHHCCHHHHHH	39.84	29978859
824	Ubiquitination	TDKKEILKKSEKDTN CCHHHHHHHHHCCCC	60.97	-
825	Ubiquitination	DKKEILKKSEKDTNS CHHHHHHHHHCCCCC	61.47	-
832	Phosphorylation	KSEKDTNSKVSKVKP HHHCCCCCCCCCCCC	36.20	29496963
856	Phosphorylation	RTRGRWKYSSNDESE CCCCCEEECCCCCCC	15.46	22210691
857	Phosphorylation	TRGRWKYSSNDESEG CCCCEEECCCCCCCC	20.95	20873877
858	Phosphorylation	RGRWKYSSNDESEGS CCCEEECCCCCCCCC	45.25	20873877
862	Phosphorylation	KYSSNDESEGSGSEK EECCCCCCCCCCCCC	50.55	22210691
865	Phosphorylation	SNDESEGSGSEKSSA CCCCCCCCCCCCCCC	34.78	22210691
867	Phosphorylation	DESEGSGSEKSSAAS CCCCCCCCCCCCCCC	43.48	29449344
870	Phosphorylation	EGSGSEKSSAASEEE CCCCCCCCCCCCHHH	22.58	30108239
871	Phosphorylation	GSGSEKSSAASEEEE CCCCCCCCCCCHHHH	38.63	30108239
874	Phosphorylation	SEKSSAASEEEEEKE CCCCCCCCHHHHHHH	45.30	25849741
882	Phosphorylation	EEEEEKESEEAILAD HHHHHHHHHHHHHCC	52.37	30108239
946	Ubiquitination	QHKLLCEKLEEQLQD HHHHHHHHHHHHHHH	61.27	-
959	Ubiquitination	QDLDVALKKKERAER HHHHHHHHHHHHHHH	52.65	-
973	Phosphorylation	RRKERLVYVGISIEN HHHHCEEEEEEEHHH	9.50	-
977	Phosphorylation	RLVYVGISIENIIPP CEEEEEEEHHHCCCC	20.23	-
990	Phosphorylation	PPQEPDFSEDQEEKK CCCCCCCCCCHHHHH	47.87	-
998 (in isoform 2)	Ubiquitination	-	77.60	21890473
1003	Phosphorylation	KKKDSKKSKANLLER HHHHHHHHHHHHHHH	40.51	20873877
1004	Ubiquitination	KKDSKKSKANLLERR HHHHHHHHHHHHHHH	50.61	-
1039	Sumoylation	EAIEDDIKEADGGGV HHHHHHHHHCCCCCC	54.57	28112733
1039	Ubiquitination	EAIEDDIKEADGGGV HHHHHHHHHCCCCCC	54.57	2190698
1039 (in isoform 1)	Ubiquitination	-	54.57	21890473
1050	Acetylation	GGGVGRGKDISTITG CCCCCCCCCHHHHCC	50.99	19608861
1050	Ubiquitination	GGGVGRGKDISTITG CCCCCCCCCHHHHCC	50.99	19608861
1053	Phosphorylation	VGRGKDISTITGHRG CCCCCCHHHHCCCCC	24.72	20068231
1054	Phosphorylation	GRGKDISTITGHRGK CCCCCHHHHCCCCCC	23.92	20068231
1056	Phosphorylation	GKDISTITGHRGKDI CCCHHHHCCCCCCCH	27.33	21406692
1061	Acetylation	TITGHRGKDISTILD HHCCCCCCCHHHHCH	52.42	21466224
1064	Phosphorylation	GHRGKDISTILDEER CCCCCCHHHHCHHHH	21.38	28555341
1086	Phosphorylation	RAAAARRKKRRRLND HHHHHHHHHHHHHHC	45.11	17081983
1088	Phosphorylation	AAARRKKRRRLNDLD HHHHHHHHHHHHCCC	31.80	17081983
1095	Phosphorylation	RRRLNDLDSDSNLDE HHHHHCCCCCCCCCH	53.94	17081983
1096	Phosphorylation	RRLNDLDSDSNLDEE HHHHCCCCCCCCCHH	50.68	21082442
1098	Phosphorylation	LNDLDSDSNLDEEES HHCCCCCCCCCHHHC	43.15	21082442
1105	Phosphorylation	SNLDEEESEDEFKIS CCCCHHHCCCCCCCC	54.34	21082442
1115	Phosphorylation	EFKISDGSQDEFVVS CCCCCCCCCCCEEEC	39.17	22468782
1135	Phosphorylation	ESEEDPPSNDDSDTD CCCCCCCCCCCCCCH	59.27	20363803
1139	Phosphorylation	DPPSNDDSDTDFCSR CCCCCCCCCCHHHHH	45.32	20363803
1141	Phosphorylation	PSNDDSDTDFCSRRL CCCCCCCCHHHHHHH	34.62	18452278
1171	Phosphorylation	RKTPKKKYSDDDEEE HCCCCCCCCCCCHHH	26.64	25137130
1172	Phosphorylation	KTPKKKYSDDDEEEE CCCCCCCCCCCHHHH	43.36	20873877
1180	Phosphorylation	DDDEEEESEENSRDS CCCHHHHHHHHHCCC	54.19	25137130
1184	Phosphorylation	EEESEENSRDSESDF HHHHHHHHCCCCCCC	40.52	25137130
1187	Phosphorylation	SEENSRDSESDFSDD HHHHHCCCCCCCCCC	37.58	25137130
1189	Phosphorylation	ENSRDSESDFSDDFS HHHCCCCCCCCCCCC	48.16	25137130
1192	Phosphorylation	RDSESDFSDDFSDDF CCCCCCCCCCCCHHH	41.06	25137130
1196	Phosphorylation	SDFSDDFSDDFVETR CCCCCCCCHHHHHHH	43.17	25137130
1202	Phosphorylation	FSDDFVETRRRRSRR CCHHHHHHHHHHHHH	24.95	21406692
1211	Phosphorylation	RRRSRRNQKRQINYK HHHHHHHHHHCCCCC	40.26	17525332
1213	Phosphorylation	RSRRNQKRQINYKED HHHHHHHHCCCCCCC	32.61	17525332
1216	Phosphorylation	RNQKRQINYKEDSES HHHHHCCCCCCCCCC	33.22	17525332
1217	Phosphorylation	NQKRQINYKEDSESD HHHHCCCCCCCCCCC	19.86	20164059
1221	Phosphorylation	QINYKEDSESDGSQK CCCCCCCCCCCCCHH	39.84	17525332
1223	Phosphorylation	NYKEDSESDGSQKSL CCCCCCCCCCCHHHH	51.75	17525332
1226	Phosphorylation	EDSESDGSQKSLRRG CCCCCCCCHHHHHHH	39.15	17525332
1229	Phosphorylation	ESDGSQKSLRRGKEI CCCCCHHHHHHHHHH	21.33	30631047
1234	Acetylation	QKSLRRGKEIRRVHK HHHHHHHHHHHHHHH	48.43	30583831
1245	Phosphorylation	RVHKRRLSSSESEES HHHHHCCCCCCCHHH	29.97	23898821
1246	Phosphorylation	VHKRRLSSSESEESY HHHHCCCCCCCHHHH	42.59	28348404
1247	Phosphorylation	HKRRLSSSESEESYL HHHCCCCCCCHHHHH	41.59	25159151
1249	Phosphorylation	RRLSSSESEESYLSK HCCCCCCCHHHHHHC	48.92	25159151
1252	Phosphorylation	SSSESEESYLSKNSE CCCCCHHHHHHCCCC	27.59	25159151
1253	Phosphorylation	SSESEESYLSKNSED CCCCHHHHHHCCCCC	20.48	23403867
1255	Phosphorylation	ESEESYLSKNSEDDE CCHHHHHHCCCCCHH	22.89	25884760
1257	Phosphorylation	EESYLSKNSEDDELA HHHHHHCCCCCHHHH	47.45	18669648
1258	Phosphorylation	ESYLSKNSEDDELAK HHHHHCCCCCHHHHH	46.25	28355574
1267	Phosphorylation	DDELAKESKRSVRKR CHHHHHHHHHHHHHH	32.44	18669648
1277	Phosphorylation	SVRKRGRSTDEYSEA HHHHHCCCCCCCCCH	42.93	23927012
1278	Phosphorylation	VRKRGRSTDEYSEAD HHHHCCCCCCCCCHH	31.33	23927012
1281	Phosphorylation	RGRSTDEYSEADEEE HCCCCCCCCCHHHHH	18.02	30278072
1282	Phosphorylation	GRSTDEYSEADEEEE CCCCCCCCCHHHHHH	25.02	23927012
1294	Acetylation	EEEEEEGKPSRKRLH HHHHHCCCCCHHHHH	43.00	23236377
1296	Phosphorylation	EEEEGKPSRKRLHRI HHHCCCCCHHHHHCC	54.65	23403867
1305	Phosphorylation	KRLHRIETDEEESCD HHHHCCCCCCHHHCC	46.47	29255136
1310	Phosphorylation	IETDEEESCDNAHGD CCCCCHHHCCCCCCC	30.01	22167270
1315	Phosphorylation	EESCDNAHGDANQPA HHHCCCCCCCCCCCC	40.70	17525332
1325	Phosphorylation	ANQPARDSQPRVLPS CCCCCCCCCCCCCCC	36.21	17525332
1332	Phosphorylation	SQPRVLPSEQESTKK CCCCCCCCCCCCCCC	47.99	24732914
1335	Phosphorylation	RVLPSEQESTKKPYR CCCCCCCCCCCCCCC	57.22	16964243
1336	Phosphorylation	VLPSEQESTKKPYRI CCCCCCCCCCCCCCC	45.26	21815630
1337	Phosphorylation	LPSEQESTKKPYRIE CCCCCCCCCCCCCCC	42.19	21815630
1338	Acetylation	PSEQESTKKPYRIES CCCCCCCCCCCCCCC	62.12	23749302
1339	Acetylation	SEQESTKKPYRIESD CCCCCCCCCCCCCCC	47.58	19608861
1341	Phosphorylation	QESTKKPYRIESDEE CCCCCCCCCCCCCCH	32.86	23927012
1345	Phosphorylation	KKPYRIESDEEEDFE CCCCCCCCCCHHHHC	48.20	29255136
1349	Phosphorylation	RIESDEEEDFENVGK CCCCCCHHHHCCCCC	66.99	17081983
1359	Phosphorylation	ENVGKVGSPLDYSLV CCCCCCCCCCCEEEE	25.85	29255136
1363	Phosphorylation	KVGSPLDYSLVDLPS CCCCCCCEEEEECCC	16.16	25463755
1364	Phosphorylation	VGSPLDYSLVDLPST CCCCCCEEEEECCCC	22.91	25463755
1365	Phosphorylation	GSPLDYSLVDLPSTN CCCCCEEEEECCCCC	2.57	17081983
1370	Phosphorylation	YSLVDLPSTNGQSPG EEEEECCCCCCCCCC	41.63	30266825
1371	Phosphorylation	SLVDLPSTNGQSPGK EEEECCCCCCCCCCH	41.24	29255136
1375	Phosphorylation	LPSTNGQSPGKAIEN CCCCCCCCCCHHHHH	36.70	29255136
1378	Acetylation	TNGQSPGKAIENLIG CCCCCCCHHHHHHCC	49.96	23954790
1386	Acetylation	AIENLIGKPTEKSQT HHHHHCCCCCCCCCC	41.60	23749302
1388	Phosphorylation	ENLIGKPTEKSQTPK HHHCCCCCCCCCCCC	60.58	18669648
1390	Acetylation	LIGKPTEKSQTPKDN HCCCCCCCCCCCCCC	50.79	23749302
1391	Phosphorylation	IGKPTEKSQTPKDNS CCCCCCCCCCCCCCC	32.81	21712546
1393	Phosphorylation	KPTEKSQTPKDNSTA CCCCCCCCCCCCCCC	39.12	21712546
1406	Phosphorylation	TASASLASNGTSGGQ CCCHHHHCCCCCCCC	40.88	25159151
1409	Phosphorylation	ASLASNGTSGGQEAG HHHHCCCCCCCCCCC	28.57	25627689
1410	Phosphorylation	SLASNGTSGGQEAGA HHHCCCCCCCCCCCC	42.18	25627689
1434	Phosphorylation	RVTDLVDYVCNSEQL HHHHHHHHHHCCCCC	10.22	30108239
1438	Phosphorylation	LVDYVCNSEQL---- HHHHHHCCCCC----	22.92	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1359	S	Phosphorylation	Kinase	PLK1	P53350	PSP
1375	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RSF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RSF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SMCA5_HUMAN	SMARCA5	physical	18519663
SMCA5_HUMAN	SMARCA5	physical	12972596

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RSF1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1050; LYS-1061 AND LYS-1339,AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-397; THR-1305; SER-1345;SER-1359 AND SER-1375, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473; SER-540; SER-622;THR-1305; SER-1345; SER-1359; TYR-1363 AND SER-1375, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392; SER-397; SER-604;SER-622; SER-629; SER-1221; SER-1223; SER-1226; SER-1277; THR-1278;TYR-1281; THR-1305; SER-1345; SER-1359; SER-1364 AND SER-1375, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524; SER-1221; SER-1223;SER-1226 AND SER-1325, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604, AND MASSSPECTROMETRY.	17287340 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1345, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-397; SER-604; SER-622;SER-748; SER-778; SER-782; SER-1096; SER-1098; SER-1105; SER-1221;SER-1223; SER-1226; SER-1345; SER-1359 AND SER-1375, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-506, AND MASSSPECTROMETRY.	17924679 [Abstract]