GASP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GASP1_HUMAN
• UniProt AC: Q5JY77
• Protein Name: G-protein coupled receptor-associated sorting protein 1
• Gene Name: GPRASP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1395
• Subcellular Localization: Cytoplasm .
• Protein Description: Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2..
• Protein Sequence: MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMPGASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASPLVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRPTSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQTNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSEHEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPEENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADEASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTGAEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCESRTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSCDTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGVRCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAIIGSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIGSWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEEVIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESETEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESKPENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSPVFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCEMFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESSSCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRMIRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVSEFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQGKTDNQNDPEGDQEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTGAEIESG ------CCCCEECCC	57.30	28122231
8	Phosphorylation	MTGAEIESGAQVKPE CCCCEECCCCCCCCC	45.12	28122231
39	Ubiquitination	VPLVVRPKVRTQAQI CCEEECCCCCCCCCC	33.51	21890473
68	Phosphorylation	GASTKVETSAVGGAR CCCCCEEECCCCCCC	25.60	-
144	Phosphorylation	EDRELVNTDTESFPR CCHHHCCCCCCCCHH	36.50	29083192
146	Phosphorylation	RELVNTDTESFPRRK HHHCCCCCCCCHHHH	31.33	29083192
148	Phosphorylation	LVNTDTESFPRRKAH HCCCCCCCCHHHHHH	42.52	29083192
163	Phosphorylation	YQAGFQPSFRSKEET HHCCCCCCCCCCCCC	23.62	28857561
181	Phosphorylation	SWCCPRPTSKQEASP CCCCCCCCCCCCCCC	50.24	30576142
182	Phosphorylation	WCCPRPTSKQEASPN CCCCCCCCCCCCCCC	34.72	30576142
190	Phosphorylation	KQEASPNSDFKWVDK CCCCCCCCCCCCCCC	48.05	23532336
205	Phosphorylation	SVSSLFWSGDEVTAK CHHHHCCCCCEEEEE	29.09	27732954
297	Phosphorylation	EVYVESSSGSEHEDH EEEEECCCCCCCHHH	56.47	-
631	Phosphorylation	CVEGDVNSKSSLEDK HHCCCCCCCCCCCCH	33.49	-
653	Phosphorylation	FGAKEEVSMKHGTGV CCCCCCCCCCCCCCC	25.95	23403867
658	Phosphorylation	EVSMKHGTGVRCRFM CCCCCCCCCCCCEEE	32.02	23403867
761	Phosphorylation	WKEDEAISEATDREE CCHHHHHHHHCCCHH	28.38	29514088
764	Phosphorylation	DEAISEATDREESRP HHHHHHHCCCHHHCC	31.38	29514088
899	Phosphorylation	QAVEEMESETEEETI HHHHHHHHCCCCEEE	48.81	-
1175	Phosphorylation	DPFIHEISKIAMGMR CHHHHHHHHHHHHCC	18.28	-
1199	Phosphorylation	IRDSGVVSLIETLLN HHHHCHHHHHHHHHC	22.63	22210691
1203	Phosphorylation	GVVSLIETLLNYPSS CHHHHHHHHHCCCCH	29.56	24719451
1207	Phosphorylation	LIETLLNYPSSRVRT HHHHHHCCCCHHHHH	12.40	22817900
1210	Phosphorylation	TLLNYPSSRVRTSFL HHHCCCCHHHHHHHH	30.23	22210691
1256	Phosphorylation	VDSPEQLSGIRMIRH CCCHHHHCCHHHEEC	31.69	24719451
1265	Phosphorylation	IRMIRHLTTTTDYHT HHHEECCCCCCCHHH	18.90	29116813
1266	Phosphorylation	RMIRHLTTTTDYHTL HHEECCCCCCCHHHH	33.77	25072903
1267	Phosphorylation	MIRHLTTTTDYHTLV HEECCCCCCCHHHHH	16.66	25072903
1268	Phosphorylation	IRHLTTTTDYHTLVA EECCCCCCCHHHHHH	32.25	25072903
1270	Phosphorylation	HLTTTTDYHTLVANY CCCCCCCHHHHHHHH	8.46	25072903
1272	Phosphorylation	TTTTDYHTLVANYMS CCCCCHHHHHHHHHH	19.39	25072903
1277	Phosphorylation	YHTLVANYMSGFLSL HHHHHHHHHHHHHHH	5.28	25072903
1279	Phosphorylation	TLVANYMSGFLSLLA HHHHHHHHHHHHHHH	18.94	25072903
1283	Phosphorylation	NYMSGFLSLLATGNA HHHHHHHHHHHHCCH	21.05	25072903
1287	Phosphorylation	GFLSLLATGNAKTRF HHHHHHHHCCHHHHH	30.82	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GASP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GASP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GASP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OPRD_HUMAN	OPRD1	physical	12142540

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.