OPRD_HUMAN - dbPTM
OPRD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPRD_HUMAN
UniProt AC P41143
Protein Name Delta-type opioid receptor
Gene Name OPRD1
Organism Homo sapiens (Human).
Sequence Length 372
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine..
Protein Sequence MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18N-linked_GlycosylationLQPPLFANASDAYPS
CCCCCCCCHHHCCCC		32.42UniProtKB CARBOHYD
33N-linked_GlycosylationACPSAGANASGPPGA
CCCCCCCCCCCCCCC		33.45UniProtKB CARBOHYD
126PhosphorylationLLCKAVLSIDYYNMF
HHHHHHHCCCHHHHH		13.5525072903
129PhosphorylationKAVLSIDYYNMFTSI
HHHHCCCHHHHHHHH		8.6225072903
130PhosphorylationAVLSIDYYNMFTSIF
HHHCCCHHHHHHHHH		9.0825072903
134PhosphorylationIDYYNMFTSIFTLTM
CCHHHHHHHHHHHHH		15.3325072903
135PhosphorylationDYYNMFTSIFTLTMM
CHHHHHHHHHHHHHH		12.3925072903
138PhosphorylationNMFTSIFTLTMMSVD
HHHHHHHHHHHHCCC		21.4625072903
140PhosphorylationFTSIFTLTMMSVDRY
HHHHHHHHHHCCCHH		14.0525072903
143PhosphorylationIFTLTMMSVDRYIAV
HHHHHHHCCCHHHHH		15.2825072903
211PhosphorylationSPSWYWDTVTKICVF
CCHHHHHHHHHHHHH		18.87-
213PhosphorylationSWYWDTVTKICVFLF
HHHHHHHHHHHHHHH		19.45-
249PhosphorylationSVRLLSGSKEKDRSL
HHHHHCCCCHHHHHH		33.9824260401
333S-palmitoylationKRCFRQLCRKPCGRP
HHHHHHHCCCCCCCC		3.88-
343PhosphorylationPCGRPDPSSFSRARE
CCCCCCHHHHHHHHH		51.9325002506
344PhosphorylationCGRPDPSSFSRAREA
CCCCCHHHHHHHHHH		32.4011085981
346PhosphorylationRPDPSSFSRAREATA
CCCHHHHHHHHHHHH		27.2925002506
358PhosphorylationATARERVTACTPSDG
HHHHHHHCCCCCCCC		23.4111040053
361PhosphorylationRERVTACTPSDGPGG
HHHHCCCCCCCCCCC		24.3011040053
363PhosphorylationRVTACTPSDGPGGGA
HHCCCCCCCCCCCCC		36.7311040053
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
344SPhosphorylationKinasePKC-FAMILY-GPS
344SPhosphorylationKinasePKC_GROUP-PhosphoELM
358TPhosphorylationKinaseADRBK1P25098
GPS
361TPhosphorylationKinaseADRBK1P25098
GPS
361TPhosphorylationKinaseGRK3P35626
PSP
363SPhosphorylationKinaseARBK1P25098
PhosphoELM
363SPhosphorylationKinaseGRK3P35626
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OPRD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPRD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GASP1_HUMANGPRASP1physical
12142540
OPRD_HUMANOPRD1physical
11278447
ARRB1_HUMANARRB1physical
11259507
ARRB2_HUMANARRB2physical
11259507
CALX_HUMANCANXphysical
11054417
HSP74_HUMANHSPA4physical
11054417
S61A1_HUMANSEC61A1physical
11054417
GASP1_HUMANGPRASP1physical
15086532
AUP1_HUMANAUP1physical
23840749
CXA4_HUMANGJA4physical
23840749
DOK4_HUMANDOK4physical
23840749
SIAH1_HUMANSIAH1physical
23840749
SIAH2_HUMANSIAH2physical
23840749
VAPA_HUMANVAPAphysical
23840749
WLS_HUMANWLSphysical
23840749
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00838 Dezocine (USAN); Dalgan (TN)
D01340 Naloxone hydrochloride (JP16/USP); Narcan (TN)
D02095 Naltrexone hydrochloride (USP); ReVia (TN)
D04924 Meptazinol hydrochloride (USAN)
D05007 Metkephamid acetate (USAN)
D05113 Naltrexone (USAN/INN); Vivitrol (TN)
D06618 Methylnaltrexone bromide (USAN); Relistor (TN)
D07937 Etorphine (INN)
D08182 Meptazinol (INN)
D08249 Naloxone (INN); DBL Naloxone (TN)
D10403 Eluxadoline (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPRD_HUMAN

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Related Literatures of Post-Translational Modification

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