DOK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOK4_HUMAN
• UniProt AC: Q8TEW6
• Protein Name: Docking protein 4
• Gene Name: DOK4
• Organism: Homo sapiens (Human).
• Sequence Length: 326
• Protein Description: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells..
• Protein Sequence: MATNFSDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEKYPDEKSVCLRGCPKVTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEEWYKTLSVECLGSRLNDISLGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQITHENIYLWDIHNPRVKLVSWPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQIYQRVHSATLAIAEQHKRVLLEMEKNVRLLNKGTEHYSYPCTPTTMLPRSAYWHHITGSQNIAEASSYAGEGYGAAQASSETDLLNRFILLKPKPSQGDSSEAKTPSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	SDIVKQGYVKMKSRK HHHHHHCCCEECCCC	8.39	-
34	Phosphorylation	CWLVFRKSSSKGPQR EEEEEECCCCCCCCH	35.27	26270265
35	Phosphorylation	WLVFRKSSSKGPQRL EEEEECCCCCCCCHH	38.82	27422710
36	Phosphorylation	LVFRKSSSKGPQRLE EEEECCCCCCCCHHH	49.04	26270265
52	S-palmitoylation	YPDEKSVCLRGCPKV CCCCCCEECCCCCCE	2.50	29575903
66	Ubiquitination	VTEISNVKCVTRLPK EEEEECCEEEECCCH	27.51	-
104	Phosphorylation	ELEAEEWYKTLSVEC CHHHHHHHHHHCHHH	9.44	-
106	Phosphorylation	EAEEWYKTLSVECLG HHHHHHHHHCHHHHC	14.47	-
165	Phosphorylation	QITHENIYLWDIHNP EECCCCEEEEECCCC	17.20	18180459
220	Phosphorylation	TQEGEQIYQRVHSAT CCCCHHHHHHHHHHH	7.03	22817900
225	Phosphorylation	QIYQRVHSATLAIAE HHHHHHHHHHHHHHH	21.79	19664994
252	Phosphorylation	VRLLNKGTEHYSYPC EEECCCCCCCCCCCC	22.62	29978859
255	Phosphorylation	LNKGTEHYSYPCTPT CCCCCCCCCCCCCCC	12.03	27259358
256	Phosphorylation	NKGTEHYSYPCTPTT CCCCCCCCCCCCCCC	25.22	29978859
257	Phosphorylation	KGTEHYSYPCTPTTM CCCCCCCCCCCCCCC	8.65	29978859
260	Phosphorylation	EHYSYPCTPTTMLPR CCCCCCCCCCCCCCC	21.11	29978859
262	Phosphorylation	YSYPCTPTTMLPRSA CCCCCCCCCCCCCHH	13.49	29978859
263	Phosphorylation	SYPCTPTTMLPRSAY CCCCCCCCCCCCHHC	20.22	29978859
314	Phosphorylation	ILLKPKPSQGDSSEA EEECCCCCCCCCCCC	53.58	-
318	Phosphorylation	PKPSQGDSSEAKTPS CCCCCCCCCCCCCCC	36.58	17929957
319	Phosphorylation	KPSQGDSSEAKTPSQ CCCCCCCCCCCCCCC	46.44	17929957
323	Phosphorylation	GDSSEAKTPSQ---- CCCCCCCCCCC----	34.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOK4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RET_HUMAN	RET	physical	11470823
OPRM_HUMAN	OPRM1	physical	23840749
KDM1A_HUMAN	KDM1A	physical	26186194
GSE1_HUMAN	GSE1	physical	26186194
KPB2_HUMAN	PHKA2	physical	26186194
SMRCD_HUMAN	SMARCAD1	physical	26186194
TOPK_HUMAN	PBK	physical	26186194
RCOR1_HUMAN	RCOR1	physical	26186194
RCOR3_HUMAN	RCOR3	physical	26186194
KPBB_HUMAN	PHKB	physical	26186194
SAHH3_HUMAN	AHCYL2	physical	26186194
SAHH2_HUMAN	AHCYL1	physical	26186194
SPT5H_HUMAN	SUPT5H	physical	26186194
KBTB7_HUMAN	KBTBD7	physical	26186194
KBTB6_HUMAN	KBTBD6	physical	26186194
CWC22_HUMAN	CWC22	physical	26186194
ANK3_HUMAN	ANK3	physical	26186194
HM20A_HUMAN	HMG20A	physical	26186194
PHKG2_HUMAN	PHKG2	physical	26186194
MIER1_HUMAN	MIER1	physical	26186194
CCM2_HUMAN	CCM2	physical	25814554
DOK3_HUMAN	DOK3	physical	25814554
FAK1_HUMAN	PTK2	physical	25814554
STAT2_HUMAN	STAT2	physical	25814554
LIX1_HUMAN	LIX1	physical	25814554
OLIG1_HUMAN	OLIG1	physical	25814554
RET7_HUMAN	RBP7	physical	25814554
MARE3_HUMAN	MAPRE3	physical	25814554
GSE1_HUMAN	GSE1	physical	28514442
HM20A_HUMAN	HMG20A	physical	28514442
KPB2_HUMAN	PHKA2	physical	28514442
PHKG2_HUMAN	PHKG2	physical	28514442
KPBB_HUMAN	PHKB	physical	28514442
TOPK_HUMAN	PBK	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
SAHH3_HUMAN	AHCYL2	physical	28514442
CWC22_HUMAN	CWC22	physical	28514442
KBTB6_HUMAN	KBTBD6	physical	28514442
SAHH2_HUMAN	AHCYL1	physical	28514442
SMRCD_HUMAN	SMARCAD1	physical	28514442
ANK3_HUMAN	ANK3	physical	28514442
RCOR3_HUMAN	RCOR3	physical	28514442
SPT5H_HUMAN	SUPT5H	physical	28514442
MIER1_HUMAN	MIER1	physical	28514442
RCOR1_HUMAN	RCOR1	physical	28514442
SPT4H_HUMAN	SUPT4H1	physical	28514442
FHL2_HUMAN	FHL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.