dbPTM

SMRCD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SMRCD_HUMAN
UniProt AC	Q9H4L7
Protein Name	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Gene Name	SMARCAD1
Organism	Homo sapiens (Human).
Sequence Length	1026
Subcellular Localization	Nucleus. Chromosome. Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage.
Protein Description	DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing..
Protein Sequence	MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQYIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEYDSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALFTKMSKTNGLSEDLIWHCKTLIQERDVVIRLMNKCEDISNKLTKQVTMLTGNGGGWNIEQPSILNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCYYGSQEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLYLGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQYYTAEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYRHINNFQLDMDLILDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLEQDMTTVDEGDEGSMPADIATLLKTSMGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNLFNLDR -------CCCCCHHH	42.81	22223895
16	Ubiquitination	FRFEKRNKIEEAPEA HHHHHHCCCCCCCCC	56.37	29967540
24	Phosphorylation	IEEAPEATPQPSQPG CCCCCCCCCCCCCCC	22.31	28787133
24 (in isoform 2)	Phosphorylation	-	22.31	21406692
28	Phosphorylation	PEATPQPSQPGPSSP CCCCCCCCCCCCCCC	43.70	30278072
31	Ubiquitination	TPQPSQPGPSSPISL CCCCCCCCCCCCCCC	27.38	29967540
33	Phosphorylation	QPSQPGPSSPISLSA CCCCCCCCCCCCCCC	55.45	30278072
33 (in isoform 2)	Phosphorylation	-	55.45	21406692
34	Phosphorylation	PSQPGPSSPISLSAE CCCCCCCCCCCCCCC	29.41	30278072
34 (in isoform 2)	Phosphorylation	-	29.41	21406692
37	Phosphorylation	PGPSSPISLSAEEEN CCCCCCCCCCCCHHC	21.47	30278072
37 (in isoform 2)	Phosphorylation	-	21.47	27251275
38	Ubiquitination	GPSSPISLSAEEENA CCCCCCCCCCCHHCC	6.11	29967540
39	Phosphorylation	PSSPISLSAEEENAE CCCCCCCCCCHHCCC	27.18	29255136
39 (in isoform 2)	Phosphorylation	-	27.18	21406692
50	Phosphorylation	ENAEGEVSRANTPDS HCCCCCHHCCCCCCC	22.75	29255136
50 (in isoform 2)	Phosphorylation	-	22.75	21406692
54	Phosphorylation	GEVSRANTPDSDITE CCHHCCCCCCCCCCC	27.73	29255136
54 (in isoform 2)	Phosphorylation	-	27.73	24719451
57	Phosphorylation	SRANTPDSDITEKTE HCCCCCCCCCCCCCC	31.92	29255136
57 (in isoform 2)	Phosphorylation	-	31.92	24719451
60	Phosphorylation	NTPDSDITEKTEDSS CCCCCCCCCCCCCCC	36.10	29255136
60 (in isoform 2)	Phosphorylation	-	36.10	21406692
63	Phosphorylation	DSDITEKTEDSSVPE CCCCCCCCCCCCCCC	38.50	25159151
63 (in isoform 2)	Phosphorylation	-	38.50	21406692
66	Phosphorylation	ITEKTEDSSVPETPD CCCCCCCCCCCCCCC	27.31	25159151
66 (in isoform 2)	Phosphorylation	-	27.31	27251275
67	Phosphorylation	TEKTEDSSVPETPDN CCCCCCCCCCCCCCC	54.75	25159151
67 (in isoform 2)	Phosphorylation	-	54.75	21406692
71	Phosphorylation	EDSSVPETPDNERKA CCCCCCCCCCCCCHH	29.85	25159151
71 (in isoform 2)	Phosphorylation	-	29.85	27251275
77	Sumoylation	ETPDNERKASISYFK CCCCCCCHHHHHHHH	40.06	-
77	Sumoylation	ETPDNERKASISYFK CCCCCCCHHHHHHHH	40.06	28112733
77	Ubiquitination	ETPDNERKASISYFK CCCCCCCHHHHHHHH	40.06	-
77 (in isoform 2)	Ubiquitination	-	40.06	-
78	Phosphorylation	TPDNERKASISYFKN CCCCCCHHHHHHHHC	20.51	32142685
79	Phosphorylation	PDNERKASISYFKNQ CCCCCHHHHHHHHCC	18.33	23401153
79 (in isoform 2)	Phosphorylation	-	18.33	24719451
81	Phosphorylation	NERKASISYFKNQRG CCCHHHHHHHHCCCC	23.25	23927012
81 (in isoform 2)	Phosphorylation	-	23.25	21406692
82	Phosphorylation	ERKASISYFKNQRGI CCHHHHHHHHCCCCE	19.53	23403867
82 (in isoform 2)	Phosphorylation	-	19.53	27642862
84	Sumoylation	KASISYFKNQRGIQY HHHHHHHHCCCCEEE	43.89	-
84	Sumoylation	KASISYFKNQRGIQY HHHHHHHHCCCCEEE	43.89	28112733
91	Phosphorylation	KNQRGIQYIDLSSDS HCCCCEEEEECCCCC	8.42	26503892
95	Phosphorylation	GIQYIDLSSDSEDVV CEEEEECCCCCCCCC	28.49	26503892
95 (in isoform 2)	Phosphorylation	-	28.49	24719451
96	Phosphorylation	IQYIDLSSDSEDVVS EEEEECCCCCCCCCC	53.07	30266825
96 (in isoform 2)	Phosphorylation	-	53.07	21406692
97	Phosphorylation	QYIDLSSDSEDVVSP EEEECCCCCCCCCCC	53.31	32142685
98	Phosphorylation	YIDLSSDSEDVVSPN EEECCCCCCCCCCCC	37.33	23927012
98 (in isoform 2)	Phosphorylation	-	37.33	24719451
103	Phosphorylation	SDSEDVVSPNCSNTV CCCCCCCCCCCCCCC	15.39	30266825
107	Phosphorylation	DVVSPNCSNTVQEKT CCCCCCCCCCCEEEC	42.02	23927012
109	Phosphorylation	VSPNCSNTVQEKTFN CCCCCCCCCEEECCC	13.79	23927012
114	Phosphorylation	SNTVQEKTFNKDTVI CCCCEEECCCCCEEE	31.52	23927012
119	Phosphorylation	EKTFNKDTVIIVSEP EECCCCCEEEEEECC	18.40	23927012
119 (in isoform 2)	Phosphorylation	-	18.40	21406692
124	Phosphorylation	KDTVIIVSEPSEDEE CCEEEEEECCCCCHH	33.12	29255136
124 (in isoform 2)	Phosphorylation	-	33.12	24719451
127	Phosphorylation	VIIVSEPSEDEESQG EEEEECCCCCHHHCC	54.34	29255136
127 (in isoform 2)	Phosphorylation	-	54.34	24719451
132	Phosphorylation	EPSEDEESQGLPTMA CCCCCHHHCCCCCCH	27.74	25159151
132 (in isoform 2)	Phosphorylation	-	27.74	21406692
137	Phosphorylation	EESQGLPTMARRNDD HHHCCCCCCHHHCCC	28.62	23927012
137 (in isoform 2)	Phosphorylation	-	28.62	21406692
145	Phosphorylation	MARRNDDISELEDLS CHHHCCCHHHCCCHH	3.72	32142685
146	Phosphorylation	ARRNDDISELEDLSE HHHCCCHHHCCCHHH	43.02	19664994
146 (in isoform 2)	Phosphorylation	-	43.02	24719451
151	Phosphorylation	DISELEDLSELEDLK CHHHCCCHHHHHHHH	2.90	32142685
152	Phosphorylation	ISELEDLSELEDLKD HHHCCCHHHHHHHHH	53.08	19664994
152 (in isoform 2)	Phosphorylation	-	53.08	24719451
158	Ubiquitination	LSELEDLKDAKLQTL HHHHHHHHHHHHHHH	68.88	29967540
161	Sumoylation	LEDLKDAKLQTLKEL HHHHHHHHHHHHHHH	51.79	-
161	Sumoylation	LEDLKDAKLQTLKEL HHHHHHHHHHHHHHH	51.79	-
161	Ubiquitination	LEDLKDAKLQTLKEL HHHHHHHHHHHHHHH	51.79	29967540
164	Phosphorylation	LKDAKLQTLKELFPQ HHHHHHHHHHHHCCC	50.67	26074081
172	Ubiquitination	LKELFPQRSDNDLLK HHHHCCCCCCCHHHH	46.33	24816145
173	Phosphorylation	KELFPQRSDNDLLKL HHHCCCCCCCHHHHH	35.20	25159151
173 (in isoform 2)	Phosphorylation	-	35.20	27251275
182	Ubiquitination	NDLLKLIESTSTMDG CHHHHHHHCCCCHHH	59.40	22817900
209	Ubiquitination	GGGPRKRKLSSSSEP CCCCCCCCCCCCCCC	56.61	29967540
211	Phosphorylation	GPRKRKLSSSSEPYE CCCCCCCCCCCCCCC	31.07	23927012
211	Ubiquitination	GPRKRKLSSSSEPYE CCCCCCCCCCCCCCC	31.07	24816145
211 (in isoform 2)	Phosphorylation	-	31.07	24719451
212	Phosphorylation	PRKRKLSSSSEPYEE CCCCCCCCCCCCCCC	48.60	23927012
212 (in isoform 2)	Phosphorylation	-	48.60	24719451
213	Phosphorylation	RKRKLSSSSEPYEED CCCCCCCCCCCCCCC	35.03	25159151
213 (in isoform 2)	Phosphorylation	-	35.03	24719451
214	Phosphorylation	KRKLSSSSEPYEEDE CCCCCCCCCCCCCCC	44.53	23927012
214 (in isoform 2)	Phosphorylation	-	44.53	24719451
217	Phosphorylation	LSSSSEPYEEDEFND CCCCCCCCCCCCCCC	28.09	23927012
227	Phosphorylation	DEFNDDQSIKKTRLD CCCCCCCCHHHHCCC	43.29	23927012
231	Phosphorylation	DDQSIKKTRLDHGEE CCCCHHHHCCCCCCC	31.31	23403867
231 (in isoform 2)	Phosphorylation	-	31.31	21406692
239	Phosphorylation	RLDHGEESNESAESS CCCCCCCCCCCCCCC	41.41	23401153
239 (in isoform 2)	Phosphorylation	-	41.41	24719451
241	Phosphorylation	DHGEESNESAESSSN CCCCCCCCCCCCCCC	61.68	32645325
242	Phosphorylation	HGEESNESAESSSNW CCCCCCCCCCCCCCH	41.40	22167270
242 (in isoform 2)	Phosphorylation	-	41.40	24719451
245	Phosphorylation	ESNESAESSSNWEKQ CCCCCCCCCCCHHHH	38.49	22167270
246	Phosphorylation	SNESAESSSNWEKQE CCCCCCCCCCHHHHH	21.13	22167270
246 (in isoform 2)	Phosphorylation	-	21.13	21406692
247	Phosphorylation	NESAESSSNWEKQES CCCCCCCCCHHHHHH	56.06	22167270
254	Phosphorylation	SNWEKQESIVLKLQK CCHHHHHHHHHHHHH	18.59	28111955
258	Sumoylation	KQESIVLKLQKEFPN HHHHHHHHHHHHCCC	37.67	-
258	Sumoylation	KQESIVLKLQKEFPN HHHHHHHHHHHHCCC	37.67	-
258	Ubiquitination	KQESIVLKLQKEFPN HHHHHHHHHHHHCCC	37.67	23000965
260	Ubiquitination	ESIVLKLQKEFPNFD HHHHHHHHHHCCCCC	41.46	33845483
261	Ubiquitination	SIVLKLQKEFPNFDK HHHHHHHHHCCCCCH	72.29	21890473
261	Ubiquitination	SIVLKLQKEFPNFDK HHHHHHHHHCCCCCH	72.29	21890473
261	Ubiquitination	SIVLKLQKEFPNFDK HHHHHHHHHCCCCCH	72.29	23000965
261 (in isoform 1)	Ubiquitination	-	72.29	21890473
261 (in isoform 2)	Ubiquitination	-	72.29	21890473
265	Ubiquitination	KLQKEFPNFDKQELR HHHHHCCCCCHHHHH	64.17	24816145
268	Trimethylation	KEFPNFDKQELREVL HHCCCCCHHHHHHHH	41.35	-
268	Methylation	KEFPNFDKQELREVL HHCCCCCHHHHHHHH	41.35	23644510
268	Ubiquitination	KEFPNFDKQELREVL HHCCCCCHHHHHHHH	41.35	29967540
275	Ubiquitination	KQELREVLKEHEWMY HHHHHHHHHHCCHHH	4.64	32015554
276	Ubiquitination	QELREVLKEHEWMYT HHHHHHHHHCCHHHH	63.30	32015554
282	Ubiquitination	LKEHEWMYTEALESL HHHCCHHHHHHHHHC	11.51	29967540
294	Ubiquitination	ESLKVFAEDQDMQYV HHCCCHHCCCCCCEE	44.75	29967540
302	Phosphorylation	DQDMQYVSQSEVPNG CCCCCEECHHCCCCC	24.05	17525332
304	Phosphorylation	DMQYVSQSEVPNGKE CCCEECHHCCCCCCC	32.81	29523821
304	Ubiquitination	DMQYVSQSEVPNGKE CCCEECHHCCCCCCC	32.81	24816145
310	Acetylation	QSEVPNGKEVSSRSQ HHCCCCCCCCCCCCC	62.68	26051181
310	Ubiquitination	QSEVPNGKEVSSRSQ HHCCCCCCCCCCCCC	62.68	22817900
310 (in isoform 1)	Ubiquitination	-	62.68	21890473
310 (in isoform 2)	Ubiquitination	-	62.68	21890473
313	Phosphorylation	VPNGKEVSSRSQNYP CCCCCCCCCCCCCCC	22.56	-
314	Phosphorylation	PNGKEVSSRSQNYPK CCCCCCCCCCCCCCC	40.92	-
316	Phosphorylation	GKEVSSRSQNYPKNA CCCCCCCCCCCCCCC	25.40	-
319	Phosphorylation	VSSRSQNYPKNATKT CCCCCCCCCCCCCHH	14.14	-
330	Ubiquitination	ATKTKLKQKFSMKAQ CCHHHHHHHHHHHHC	63.56	29967540
333	Phosphorylation	TKLKQKFSMKAQNGF HHHHHHHHHHHCCCC	26.80	24719451
333 (in isoform 2)	Phosphorylation	-	26.80	24719451
335	Sumoylation	LKQKFSMKAQNGFNK HHHHHHHHHCCCCCC	45.69	-
335	Acetylation	LKQKFSMKAQNGFNK HHHHHHHHHCCCCCC	45.69	25953088
335	Sumoylation	LKQKFSMKAQNGFNK HHHHHHHHHCCCCCC	45.69	28112733
337	Ubiquitination	QKFSMKAQNGFNKKR HHHHHHHCCCCCCHH	45.09	29967540
346	Sumoylation	GFNKKRKKNVFNPKR CCCCHHHCCCCCHHH	63.48	-
346	Sumoylation	GFNKKRKKNVFNPKR CCCCHHHCCCCCHHH	63.48	-
346	Ubiquitination	GFNKKRKKNVFNPKR CCCCHHHCCCCCHHH	63.48	24816145
350	Ubiquitination	KRKKNVFNPKRVVED HHHCCCCCHHHCCCC	36.58	29967540
351	Ubiquitination	RKKNVFNPKRVVEDS HHCCCCCHHHCCCCC	17.86	32142685
352	Acetylation	KKNVFNPKRVVEDSE HCCCCCHHHCCCCCC	59.95	7495705
352	Ubiquitination	KKNVFNPKRVVEDSE HCCCCCHHHCCCCCC	59.95	32142685
362	Phosphorylation	VEDSEYDSGSDVGSS CCCCCCCCCCCCCCC	39.02	25137130
364	Phosphorylation	DSEYDSGSDVGSSLD CCCCCCCCCCCCCCC	32.83	25137130
366	Ubiquitination	EYDSGSDVGSSLDED CCCCCCCCCCCCCCC	9.55	29967540
368	Phosphorylation	DSGSDVGSSLDEDYS CCCCCCCCCCCCCCC	27.81	25137130
368	Ubiquitination	DSGSDVGSSLDEDYS CCCCCCCCCCCCCCC	27.81	29967540
369	Phosphorylation	SGSDVGSSLDEDYSS CCCCCCCCCCCCCCC	33.63	25137130
374	Phosphorylation	GSSLDEDYSSGEEVM CCCCCCCCCCCCCHH	11.59	27251275
374 (in isoform 2)	Phosphorylation	-	11.59	27251275
375	Phosphorylation	SSLDEDYSSGEEVME CCCCCCCCCCCCHHC	44.16	25137130
376	Phosphorylation	SLDEDYSSGEEVMED CCCCCCCCCCCHHCC	43.95	25137130
376 (in isoform 2)	Phosphorylation	-	43.95	27251275
382	Ubiquitination	SSGEEVMEDGYKGKI CCCCCHHCCCCCCCH	54.16	22817900
388	Ubiquitination	MEDGYKGKILHFLQD HCCCCCCCHHHHHHC	37.63	29967540
397	Phosphorylation	LHFLQDASIGELTLI HHHHHCCCCCCEEEC	39.14	-
410	Ubiquitination	LIPQCSQKKAQKITE ECHHCCHHCCHHHHH	33.51	22505724
410 (in isoform 2)	Ubiquitination	-	33.51	-
411 (in isoform 2)	Ubiquitination	-	48.70	-
423	Phosphorylation	TELRPFNSWEALFTK HHCCCCCCHHHHHHH	27.03	21406692
429	Phosphorylation	NSWEALFTKMSKTNG CCHHHHHHHHHCCCC	27.04	21406692
430	Acetylation	SWEALFTKMSKTNGL CHHHHHHHHHCCCCC	33.57	26051181
430	Ubiquitination	SWEALFTKMSKTNGL CHHHHHHHHHCCCCC	33.57	29967540
430 (in isoform 2)	Ubiquitination	-	33.57	-
432	Phosphorylation	EALFTKMSKTNGLSE HHHHHHHHCCCCCCH	37.57	21406692
434	Phosphorylation	LFTKMSKTNGLSEDL HHHHHHCCCCCCHHH	27.49	21406692
438	Phosphorylation	MSKTNGLSEDLIWHC HHCCCCCCHHHHHHH	30.39	21406692
438 (in isoform 2)	Phosphorylation	-	30.39	21406692
446	Ubiquitination	EDLIWHCKTLIQERD HHHHHHHHHHHHHHH	33.22	29967540
446 (in isoform 2)	Ubiquitination	-	33.22	-
461	Ubiquitination	VVIRLMNKCEDISNK HHHHHHHHCHHHHHH	25.65	29967540
468	Acetylation	KCEDISNKLTKQVTM HCHHHHHHHHHEEEE	51.23	25953088
468	Ubiquitination	KCEDISNKLTKQVTM HCHHHHHHHHHEEEE	51.23	29967540
468 (in isoform 2)	Ubiquitination	-	51.23	-
471	Sumoylation	DISNKLTKQVTMLTG HHHHHHHHEEEECCC	53.89	28112733
473	Ubiquitination	SNKLTKQVTMLTGNG HHHHHHEEEECCCCC	3.46	33845483
475	Ubiquitination	KLTKQVTMLTGNGGG HHHHEEEECCCCCCC	3.11	33845483
494	Phosphorylation	QPSILNQSLSLKPYQ CCCHHCCCCCCCCCC	20.89	24719451
496	Phosphorylation	SILNQSLSLKPYQKV CHHCCCCCCCCCCCC	39.32	24719451
540	Ubiquitination	IAFLAYLYQEGNNGP HHHHHHHHHCCCCCC	7.58	29967540
559	Ubiquitination	VPASTIDNWLREVNL EEHHHHHHHHHHHHH	35.51	32015554
561	Ubiquitination	ASTIDNWLREVNLWC HHHHHHHHHHHHHHC	4.14	32015554
695	Sumoylation	RMFSSKTKSADEQSI HHHCCCCCCCCCCHH	47.59	-
695	Sumoylation	RMFSSKTKSADEQSI HHHCCCCCCCCCCHH	47.59	-
695	Ubiquitination	RMFSSKTKSADEQSI HHHCCCCCCCCCCHH	47.59	24816145
695 (in isoform 2)	Ubiquitination	-	47.59	-
698	Ubiquitination	SSKTKSADEQSIYEK CCCCCCCCCCHHHHH	62.65	33845483
704	Ubiquitination	ADEQSIYEKERIAHA CCCCHHHHHHHHHHH	46.93	33845483
705	Ubiquitination	DEQSIYEKERIAHAK CCCHHHHHHHHHHHH	35.01	21906983
705 (in isoform 1)	Ubiquitination	-	35.01	21890473
705 (in isoform 2)	Ubiquitination	-	35.01	21890473
712	Ubiquitination	KERIAHAKQIIKPFI HHHHHHHHHHHHHHH	31.96	29967540
716	Sumoylation	AHAKQIIKPFILRRV HHHHHHHHHHHHHHH	35.19	-
716	Sumoylation	AHAKQIIKPFILRRV HHHHHHHHHHHHHHH	35.19	-
724	Sumoylation	PFILRRVKEEVLKQL HHHHHHHHHHHHHHC	46.47	-
724	Sumoylation	PFILRRVKEEVLKQL HHHHHHHHHHHHHHC	46.47	28112733
724	Ubiquitination	PFILRRVKEEVLKQL HHHHHHHHHHHHHHC	46.47	29967540
729	Acetylation	RVKEEVLKQLPPKKD HHHHHHHHHCCCCCC	55.77	133747
734	Ubiquitination	VLKQLPPKKDRIELC HHHHCCCCCCCEEEE	66.42	24816145
760	Ubiquitination	GLFNRLKKSINNLEK HHHHHHHHHHHHHHH	62.25	29967540
767	Ubiquitination	KSINNLEKNTEMCNV HHHHHHHHHHHHHHH	72.79	29967540
767 (in isoform 2)	Phosphorylation	-	72.79	30622161
769	Ubiquitination	INNLEKNTEMCNVMM HHHHHHHHHHHHHHH	35.84	29967540
780	Ubiquitination	NVMMQLRKMANHPLL HHHHHHHHHHCCCHH	51.46	29967540
782 (in isoform 2)	Ubiquitination	-	17.76	-
792	Phosphorylation	PLLHRQYYTAEKLKE CHHHHHHHCHHHHHH	7.37	24719451
793	Phosphorylation	LLHRQYYTAEKLKEM HHHHHHHCHHHHHHH	24.33	24719451
796	Ubiquitination	RQYYTAEKLKEMSQL HHHHCHHHHHHHHHH	63.50	29967540
798	Ubiquitination	YYTAEKLKEMSQLML HHCHHHHHHHHHHHH	63.54	29967540
800	Ubiquitination	TAEKLKEMSQLMLKE CHHHHHHHHHHHHCC	2.71	29967540
801	Phosphorylation	AEKLKEMSQLMLKEP HHHHHHHHHHHHCCC	22.66	-
837	Phosphorylation	LHVLCKQYRHINNFQ HHHHHHHCCCCCCCC	6.94	17322306
847	Oxidation	INNFQLDMDLILDSG CCCCCCCEEEEECCC	6.50	17322306
853	Phosphorylation	DMDLILDSGKFRVLG CEEEEECCCCHHHHH	40.20	-
880	Phosphorylation	VVLFSQFTMMLDILE EEEECHHHHHHHHHH	8.27	-
896	Ubiquitination	LLKHHQHRYLRLDGK HHHHCCCCEEECCCC	26.13	33845483
897	Phosphorylation	LKHHQHRYLRLDGKT HHHCCCCEEECCCCC	8.27	-
902	Ubiquitination	HRYLRLDGKTQISER CCEEECCCCCCHHHH	39.23	33845483
903	Ubiquitination	RYLRLDGKTQISERI CEEECCCCCCHHHHH	36.60	22817900
903 (in isoform 1)	Ubiquitination	-	36.60	21890473
904	Phosphorylation	YLRLDGKTQISERIH EEECCCCCCHHHHHH	36.34	29083192
905	Ubiquitination	LRLDGKTQISERIHL EECCCCCCHHHHHHH	40.47	33845483
905 (in isoform 2)	Ubiquitination	-	40.47	21890473
907	Phosphorylation	LDGKTQISERIHLID CCCCCCHHHHHHHHH	15.82	29083192
918	Phosphorylation	HLIDEFNTDMDIFVF HHHHHCCCCCHHHHH	37.71	29083192
928	Phosphorylation	DIFVFLLSTKAGGLG HHHHHHHHCCCCCCC	29.97	24719451
929	Phosphorylation	IFVFLLSTKAGGLGI HHHHHHHCCCCCCCC	25.53	29083192
970	Ubiquitination	CHRVGQTKEVLVIKL HHHCCCCCEEEEEEE	37.63	29967540
972	Ubiquitination	RVGQTKEVLVIKLIS HCCCCCEEEEEEEHH	5.72	29967540
982	Ubiquitination	IKLISQGTIEESMLK EEEHHCCCHHHHHHH	19.99	32015554
987	Sulfoxidation	QGTIEESMLKINQQK CCCHHHHHHHHHHHH	5.10	21406390
988	Ubiquitination	GTIEESMLKINQQKL CCHHHHHHHHHHHHH	7.58	32015554
989	Ubiquitination	TIEESMLKINQQKLK CHHHHHHHHHHHHHC	30.85	32015554
991	Ubiquitination	EESMLKINQQKLKLE HHHHHHHHHHHHCCC	36.32	32015554
994	Acetylation	MLKINQQKLKLEQDM HHHHHHHHHCCCCCC	37.51	23749302
996	Sumoylation	KINQQKLKLEQDMTT HHHHHHHCCCCCCCC	57.95	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SMRCD_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SMRCD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SMRCD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIF1B_HUMAN	TRIM28	physical	21549307
CBX3_HUMAN	CBX3	physical	21549307
HDAC1_HUMAN	HDAC1	physical	21549307
HDAC2_HUMAN	HDAC2	physical	21549307
MTA3_HUMAN	MTA3	physical	21549307
RING1_HUMAN	RING1	physical	21549307
MTA2_HUMAN	MTA2	physical	21549307
E2F6_HUMAN	E2F6	physical	21549307
EHMT2_HUMAN	EHMT2	physical	21549307
TYY1_HUMAN	YY1	physical	21549307
LMBL2_HUMAN	L3MBTL2	physical	21549307
DMAP1_HUMAN	DMAP1	physical	21549307
EHMT1_HUMAN	EHMT1	physical	21549307
PELP1_HUMAN	PELP1	physical	21549307
WIZ_HUMAN	WIZ	physical	21549307
KDM1A_HUMAN	KDM1A	physical	21549307
CHD4_HUMAN	CHD4	physical	21549307
SIN3A_HUMAN	SIN3A	physical	21549307
XRCC6_HUMAN	XRCC6	physical	21549307
PARP1_HUMAN	PARP1	physical	21549307
MSH2_HUMAN	MSH2	physical	21549307
XRCC5_HUMAN	XRCC5	physical	21549307
RFC4_HUMAN	RFC4	physical	21549307
SMC1A_HUMAN	SMC1A	physical	21549307
RFC5_HUMAN	RFC5	physical	21549307
RFC3_HUMAN	RFC3	physical	21549307
RFC2_HUMAN	RFC2	physical	21549307
TOP2A_HUMAN	TOP2A	physical	21549307
SMC3_HUMAN	SMC3	physical	21549307
MSH3_HUMAN	MSH3	physical	21549307
PRKDC_HUMAN	PRKDC	physical	21549307
MSH6_HUMAN	MSH6	physical	21549307
RAD50_HUMAN	RAD50	physical	21549307
RUVB2_HUMAN	RUVBL2	physical	21549307
RUVB1_HUMAN	RUVBL1	physical	21549307
ACL6A_HUMAN	ACTL6A	physical	21549307
SMRC2_HUMAN	SMARCC2	physical	21549307
SMCA5_HUMAN	SMARCA5	physical	21549307
SNF5_HUMAN	SMARCB1	physical	21549307
SMCE1_HUMAN	SMARCE1	physical	21549307
HELLS_HUMAN	HELLS	physical	21549307
SMRC1_HUMAN	SMARCC1	physical	21549307
SMCA4_HUMAN	SMARCA4	physical	21549307
PB1_HUMAN	PBRM1	physical	21549307
SMRD2_HUMAN	SMARCD2	physical	21549307
SSRP1_HUMAN	SSRP1	physical	21549307
BAZ1A_HUMAN	BAZ1A	physical	21549307
SP16H_HUMAN	SUPT16H	physical	21549307
ARID2_HUMAN	ARID2	physical	21549307
TF3C4_HUMAN	GTF3C4	physical	21549307
TF3C5_HUMAN	GTF3C5	physical	21549307
TF3C3_HUMAN	GTF3C3	physical	21549307
TF3C2_HUMAN	GTF3C2	physical	21549307
TF3C1_HUMAN	GTF3C1	physical	21549307
DDX17_HUMAN	DDX17	physical	21549307
DDX5_HUMAN	DDX5	physical	21549307
ZNF8_HUMAN	ZNF8	physical	21549307
ZN649_HUMAN	ZNF649	physical	21549307
ZN566_HUMAN	ZNF566	physical	21549307
ZN460_HUMAN	ZNF460	physical	21549307
RBAK_HUMAN	RBAK	physical	21549307
ZN829_HUMAN	ZNF829	physical	21549307
ZN689_HUMAN	ZNF689	physical	21549307
Z324A_HUMAN	ZNF324	physical	21549307
ZN302_HUMAN	ZNF302	physical	21549307
ZCH18_HUMAN	ZC3H18	physical	21549307
ZNF24_HUMAN	ZNF24	physical	21549307
ZN235_HUMAN	ZNF235	physical	21549307
APC7_HUMAN	ANAPC7	physical	21549307
CDC23_HUMAN	CDC23	physical	21549307
CDC16_HUMAN	CDC16	physical	21549307
APC5_HUMAN	ANAPC5	physical	21549307
APC1_HUMAN	ANAPC1	physical	21549307
ANC2_HUMAN	ANAPC2	physical	21549307
CDC27_HUMAN	CDC27	physical	21549307
DDX3X_HUMAN	DDX3X	physical	21549307
DD19A_HUMAN	DDX19A	physical	21549307
DHX9_HUMAN	DHX9	physical	21549307
HNRPK_HUMAN	HNRNPK	physical	21549307
HNRH1_HUMAN	HNRNPH1	physical	21549307
HNRPM_HUMAN	HNRNPM	physical	21549307
MATR3_HUMAN	MATR3	physical	21549307
NUMA1_HUMAN	NUMA1	physical	21549307
PTBP1_HUMAN	PTBP1	physical	21549307
FUBP3_HUMAN	FUBP3	physical	21549307
CPSF3_HUMAN	CPSF3	physical	21549307
KHDR1_HUMAN	KHDRBS1	physical	21549307
HNRPR_HUMAN	HNRNPR	physical	21549307
DNJA2_HUMAN	DNAJA2	physical	21549307
COT2_HUMAN	NR2F2	physical	21549307
LAS1L_HUMAN	LAS1L	physical	21549307
LAP2A_HUMAN	TMPO	physical	21549307
LAP2B_HUMAN	TMPO	physical	21549307
PCBP1_HUMAN	PCBP1	physical	21549307
HNRPD_HUMAN	HNRNPD	physical	21549307
NONO_HUMAN	NONO	physical	21549307
CPSF1_HUMAN	CPSF1	physical	21549307
SRSF1_HUMAN	SRSF1	physical	21549307
HNRPU_HUMAN	HNRNPU	physical	21549307
WDR18_HUMAN	WDR18	physical	21549307
HNRPL_HUMAN	HNRNPL	physical	21549307
RPA49_HUMAN	POLR1E	physical	21549307
PRP19_HUMAN	PRPF19	physical	21549307
ILF3_HUMAN	ILF3	physical	21549307
SF3B3_HUMAN	SF3B3	physical	21549307
LMNB1_HUMAN	LMNB1	physical	21549307
CSK21_HUMAN	CSNK2A1	physical	21549307
U2AF2_HUMAN	U2AF2	physical	21549307
CPSF2_HUMAN	CPSF2	physical	21549307
UBP7_HUMAN	USP7	physical	21549307
SF3B2_HUMAN	SF3B2	physical	21549307
WDR33_HUMAN	WDR33	physical	21549307
BEND3_HUMAN	BEND3	physical	21549307
SYMPK_HUMAN	SYMPK	physical	21549307
MDN1_HUMAN	MDN1	physical	21549307
PCNA_HUMAN	PCNA	physical	21549307
RBGPR_HUMAN	RAB3GAP2	physical	22863883
AN32A_HUMAN	ANP32A	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
136000	Adermatoglyphia (ADERM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SMRCD_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-54; SER-124; SER-127;SER-132; SER-146 AND SER-152, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-37; SER-98;SER-124; SER-127; SER-211; SER-212; SER-213; SER-214; TYR-217 ANDSER-302, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79; SER-124; SER-127;SER-132; SER-146; SER-152; SER-211; SER-212 AND SER-214, AND MASSSPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-127; SER-132AND SER-302, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-37; SER-39;SER-95; SER-96; SER-98; SER-103; SER-124; SER-127; SER-211; SER-213;SER-214; SER-239 AND SER-242, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-37; SER-39;THR-54; SER-57 AND SER-67, AND MASS SPECTROMETRY.	15302935 [Abstract]