E2F6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E2F6_HUMAN
• UniProt AC: O75461
• Protein Name: Transcription factor E2F6
• Gene Name: E2F6
• Organism: Homo sapiens (Human).
• Sequence Length: 281
• Subcellular Localization: Nucleus.
• Protein Description: Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase..
• Protein Sequence: MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINLEDNVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIDLVEKKSKNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERLAYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEELLEVSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Sumoylation	SQQRPARKLPSLLLD CCCCCCCCCCHHHCC	67.85	28112733
9	Ubiquitination	SQQRPARKLPSLLLD CCCCCCCCCCHHHCC	67.85	-
12	Phosphorylation	RPARKLPSLLLDPTE CCCCCCCHHHCCCCH	41.93	-
21	Phosphorylation	LLDPTEETVRRRCRD HCCCCHHHHHHHCCC	17.06	24719451
38	Phosphorylation	NVEGLLPSKIRINLE CCCCCCCCCEEEECC	40.46	24719451
43 (in isoform 2)	Ubiquitination	-	27.77	-
50	Phosphorylation	NLEDNVQYVSMRKAL ECCCCEEEEEHHHHH	7.10	28796482
52	Phosphorylation	EDNVQYVSMRKALKV CCCEEEEEHHHHHCC	14.13	28796482
66 (in isoform 2)	Ubiquitination	-	4.36	-
74	Acetylation	SLVYLTRKFMDLVRS EEHHHHHHHHHHHHH	39.54	7303075
86 (in isoform 2)	Ubiquitination	-	3.16	21906983
91	Acetylation	GGILDLNKVATKLGV CCCCCHHHHHHHHCC	40.31	7298809
95	Ubiquitination	DLNKVATKLGVRKRR CHHHHHHHHCCCCCC	33.24	-
95	Acetylation	DLNKVATKLGVRKRR CHHHHHHHHCCCCCC	33.24	7298819
100	Acetylation	ATKLGVRKRRVYDIT HHHHCCCCCCEEEHH	41.99	7298829
109	Ubiquitination	RVYDITNVLDGIDLV CEEEHHHHCCCCCCH	3.74	-
109 (in isoform 2)	Ubiquitination	-	3.74	21906983
110	Ubiquitination	VYDITNVLDGIDLVE EEEHHHHCCCCCCHH	5.61	-
118	Ubiquitination	DGIDLVEKKSKNHIR CCCCCHHHHCCCCEE	55.67	21906983
118 (in isoform 1)	Ubiquitination	-	55.67	21906983
119	Ubiquitination	GIDLVEKKSKNHIRW CCCCHHHHCCCCEEE	53.83	-
141	Ubiquitination	FGAVPQQKKLQEELS CCCCCCHHHHHHHHH	50.64	2190698
141 (in isoform 1)	Ubiquitination	-	50.64	21906983
142	Ubiquitination	GAVPQQKKLQEELSD CCCCCHHHHHHHHHH	51.57	-
175	Ubiquitination	LFELTDDKENERLAY HHHHCCCCCCCEEEE	66.31	-
221	Phosphorylation	APREDSITVHIRSTN CCCCCEEEEEEEECC	15.24	22985185
226	Phosphorylation	SITVHIRSTNGPIDV EEEEEEEECCCCEEE	26.14	-
243	Phosphorylation	CEVEQGQTSNKRSEG EEECCCCCCCCCCCC	40.88	-
280	Phosphorylation	SEELLEVSN------ HHHHHHHCC------	27.70	28509920

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
52	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E2F6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E2F6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RYBP_HUMAN	RYBP	physical	11171983
TFDP1_HUMAN	TFDP1	physical	16189514
TFDP2_HUMAN	TFDP2	physical	16189514
RING1_HUMAN	RING1	physical	11171983
RYBP_HUMAN	RYBP	physical	12411495
EZH1_HUMAN	EZH1	physical	16565076
EZH2_HUMAN	EZH2	physical	16565076
KMT2A_HUMAN	KMT2A	physical	16951254
KMT2D_HUMAN	KMT2D	physical	16951254
EPC1_MOUSE	Epc1	physical	15536069
TFDP1_MOUSE	Tfdp1	physical	15536069
EPC1_HUMAN	EPC1	physical	15536069
EED_HUMAN	EED	physical	15536069
EZH2_HUMAN	EZH2	physical	15536069
LMBL2_HUMAN	L3MBTL2	physical	21596310
A4_HUMAN	APP	physical	21832049
TFDP1_HUMAN	TFDP1	physical	25416956
TFDP2_HUMAN	TFDP2	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
MGAP_HUMAN	MGA	physical	26186194
TFDP1_HUMAN	TFDP1	physical	26186194
RYBP_HUMAN	RYBP	physical	26186194
COMD6_HUMAN	COMMD6	physical	26186194
COMD4_HUMAN	COMMD4	physical	26186194
TFDP2_HUMAN	TFDP2	physical	26186194
WDR5_HUMAN	WDR5	physical	26186194
RING2_HUMAN	RNF2	physical	26186194
LMBL2_HUMAN	L3MBTL2	physical	26186194
PCGF6_HUMAN	PCGF6	physical	26186194
TFDP1_HUMAN	TFDP1	physical	9501179
TFDP2_HUMAN	TFDP2	physical	9501179
TFDP2_HUMAN	TFDP2	physical	21516116
PCGF6_HUMAN	PCGF6	physical	28514442
LMBL2_HUMAN	L3MBTL2	physical	28514442
TFDP2_HUMAN	TFDP2	physical	28514442
RYBP_HUMAN	RYBP	physical	28514442
HDAC1_HUMAN	HDAC1	physical	28514442
COMD4_HUMAN	COMMD4	physical	28514442
WDR5_HUMAN	WDR5	physical	28514442
TFDP1_HUMAN	TFDP1	physical	28514442
MGAP_HUMAN	MGA	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.