| UniProt ID | EZH1_HUMAN | |
|---|---|---|
| UniProt AC | Q92800 | |
| Protein Name | Histone-lysine N-methyltransferase EZH1 | |
| Gene Name | EZH1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 747 | |
| Subcellular Localization | Nucleus . Colocalizes with trimethylated 'Lys-27' of histone H3. | |
| Protein Description | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.. | |
| Protein Sequence | MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MEIPNPPTSKCITYW CCCCCCCCHHHHHHH | 41.92 | 23403867 | |
| 9 | Phosphorylation | EIPNPPTSKCITYWK CCCCCCCHHHHHHHH | 31.16 | 23403867 | |
| 52 | Ubiquitination | NFAKVQEKTQILNEE HHHHHHHHHHHHCHH | 28.74 | - | |
| 72 | Ubiquitination | VQPVQSMKPVSGHPF CCCCCCCCCCCCCCH | 47.73 | - | |
| 81 | Ubiquitination | VSGHPFLKKCTIESI CCCCCHHHCCCHHHH | 46.30 | - | |
| 186 | Phosphorylation | LVDALNQYSDEEEEG HHHHHHHCCCCCCCC | 19.60 | 24275569 | |
| 290 | Phosphorylation | KSVQREQSLHSFHTL CHHHHHHHHHHHHHH | 24.24 | 30108239 | |
| 293 | Phosphorylation | QREQSLHSFHTLFCR HHHHHHHHHHHHHHH | 24.82 | 30108239 | |
| 305 | Phosphorylation | FCRRCFKYDCFLHPF HHHHHHCCCCCCCCC | 9.55 | - | |
| 319 | Phosphorylation | FHATPNVYKRKNKEI CCCCCCHHHCCCCCC | 16.24 | - | |
| 327 | Sumoylation | KRKNKEIKIEPEPCG HCCCCCCCCCCCCCC | 41.95 | 28112733 | |
| 388 | Phosphorylation | AETKEGDSDRDTGND EECCCCCCCCCCCCC | 45.46 | 28450419 | |
| 392 | Phosphorylation | EGDSDRDTGNDWASS CCCCCCCCCCCCCCC | 38.49 | 28450419 | |
| 400 | Phosphorylation | GNDWASSSSEANSRC CCCCCCCCHHHHHCC | 29.69 | 24247654 | |
| 416 | Phosphorylation | TPTKQKASPAPPQLC CCCCCCCCCCCCCEE | 28.73 | 26657352 | |
| 483 | Phosphorylation | SLILKLPTDELMNPS HHEEECCHHHHCCHH | 53.17 | 27282143 | |
| 490 | Phosphorylation | TDELMNPSQKKKRKH HHHHCCHHHHHHHHH | 50.02 | 21815630 | |
| 570 | Ubiquitination | CKTQCNTKQCPCYLA EECCCCCCCCCEEEE | 35.59 | - | |
| 576 (in isoform 2) | Ubiquitination | - | 4.53 | - | |
| 597 (in isoform 5) | Ubiquitination | - | 2.80 | 21890473 | |
| 665 | Phosphorylation | VYDKYMSSFLFNLNN HHHHHHHHHHHHCCC | 14.94 | - | |
| 666 (in isoform 4) | Ubiquitination | - | 7.67 | 21890473 | |
| 691 | Phosphorylation | KIRFANHSVNPNCYA EEEECCCCCCCCCEE | 24.32 | - | |
| 696 (in isoform 3) | Ubiquitination | - | 3.54 | 21890473 | |
| 697 | Phosphorylation | HSVNPNCYAKVVMVN CCCCCCCEEEEEEEC | 18.98 | - | |
| 714 | Ubiquitination | HRIGIFAKRAIQAGE CEEEEEHHHHHHHCC | 31.45 | - | |
| 720 (in isoform 2) | Ubiquitination | - | 16.73 | - | |
| 729 | Phosphorylation | ELFFDYRYSQADALK HHEEEECCCHHHHHH | 10.02 | 20068231 | |
| 730 | Phosphorylation | LFFDYRYSQADALKY HEEEECCCHHHHHHH | 15.19 | 20068231 | |
| 736 | Ubiquitination | YSQADALKYVGIERE CCHHHHHHHCCEECC | 39.34 | 21906983 | |
| 736 (in isoform 1) | Ubiquitination | - | 39.34 | 21890473 | |
| 736 | Methylation | YSQADALKYVGIERE CCHHHHHHHCCEECC | 39.34 | - | |
| 742 (in isoform 2) | Ubiquitination | - | 50.63 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EZH1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EZH1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EZH1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| EZH1_HUMAN | EZH1 | physical | 19026781 | |
| EZH2_HUMAN | EZH2 | physical | 19026781 | |
| SUZ12_HUMAN | SUZ12 | physical | 19026781 | |
| EED_HUMAN | EED | physical | 19026781 | |
| EED_HUMAN | EED | physical | 19026780 | |
| SUZ12_HUMAN | SUZ12 | physical | 19026780 | |
| EZH2_HUMAN | EZH2 | physical | 19026780 | |
| EED_HUMAN | EED | physical | 9566901 | |
| ESC_DROME | esc | physical | 9566901 | |
| EED_HUMAN | EED | physical | 9584197 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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