dbPTM

EED_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EED_HUMAN
UniProt AC	O75530
Protein Name	Polycomb protein EED {ECO:0000305}
Gene Name	EED {ECO:0000312\|HGNC:HGNC:3188}
Organism	Homo sapiens (Human).
Sequence Length	441
Subcellular Localization	Nucleus. Chromosome. Transiently colocalizes with XIST at inactive X chromosomes.
Protein Description	Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A..
Protein Sequence	MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEREVSTA ------CCCCCCCCC	45.41	22199227
2	Acetylation	------MSEREVSTA ------CCCCCCCCC	45.41	19413330
7	Phosphorylation	-MSEREVSTAPAGTD -CCCCCCCCCCCCCC	17.69	22199227
8	Phosphorylation	MSEREVSTAPAGTDM CCCCCCCCCCCCCCC	41.66	23186163
15	Sulfoxidation	TAPAGTDMPAAKKQK CCCCCCCCCHHHHHC	2.15	21406390
19 (in isoform 3)	Ubiquitination	-	58.82	21890473
19 (in isoform 2)	Ubiquitination	-	58.82	21890473
19	Acetylation	GTDMPAAKKQKLSSD CCCCCHHHHHCCCCC	58.82	25953088
19 (in isoform 1)	Ubiquitination	-	58.82	21890473
19	Ubiquitination	GTDMPAAKKQKLSSD CCCCCHHHHHCCCCC	58.82	-
24	Phosphorylation	AAKKQKLSSDENSNP HHHHHCCCCCCCCCC	42.66	25022875
25	Phosphorylation	AKKQKLSSDENSNPD HHHHCCCCCCCCCCC	60.42	30278072
29	Phosphorylation	KLSSDENSNPDLSGD CCCCCCCCCCCCCCC	47.92	23898821
34	Phosphorylation	ENSNPDLSGDENDDA CCCCCCCCCCCCCCC	52.13	30278072
43	Phosphorylation	DENDDAVSIESGTNT CCCCCCEEECCCCCC	23.51	30278072
46	Phosphorylation	DDAVSIESGTNTERP CCCEEECCCCCCCCC	49.61	25022875
48	Phosphorylation	AVSIESGTNTERPDT CEEECCCCCCCCCCC	48.52	30576142
50	Phosphorylation	SIESGTNTERPDTPT EECCCCCCCCCCCCC	32.96	30278072
55	Phosphorylation	TNTERPDTPTNTPNA CCCCCCCCCCCCCCC	34.39	30278072
57	Phosphorylation	TERPDTPTNTPNAPG CCCCCCCCCCCCCCC	54.54	30278072
59	Phosphorylation	RPDTPTNTPNAPGRK CCCCCCCCCCCCCCC	22.01	30576142
66	"N6,N6,N6-trimethyllysine"	TPNAPGRKSWGKGKW CCCCCCCCCCCCCCC	57.38	-
66	Methylation	TPNAPGRKSWGKGKW CCCCCCCCCCCCCCC	57.38	20974918
81	Phosphorylation	KSKKCKYSFKCVNSL CCCCCCCEEEEHHHC	12.06	29496963
83	Ubiquitination	KKCKYSFKCVNSLKE CCCCCEEEEHHHCCC	31.19	-
83	Acetylation	KKCKYSFKCVNSLKE CCCCCEEEEHHHCCC	31.19	25953088
115	Phosphorylation	GDPLVFATVGSNRVT CCCEEEEEECCCEEE	17.59	20068231
118	Phosphorylation	LVFATVGSNRVTLYE EEEEEECCCEEEEEE	19.68	21406692
197	Ubiquitination	GNAINELKFHPRDPN CHHHCEECCCCCCCC	35.13	20974918
197 (in isoform 2)	Ubiquitination	-	35.13	-
197	"N6,N6,N6-trimethyllysine"	GNAINELKFHPRDPN CHHHCEECCCCCCCC	35.13	-
197	Methylation	GNAINELKFHPRDPN CHHHCEECCCCCCCC	35.13	20974918
208	Phosphorylation	RDPNLLLSVSKDHAL CCCCEEEEEEHHHHH	25.06	24719451
211	Acetylation	NLLLSVSKDHALRLW CEEEEEEHHHHHHHH	51.91	26051181
211 (in isoform 2)	Ubiquitination	-	51.91	-
211	Ubiquitination	NLLLSVSKDHALRLW CEEEEEEHHHHHHHH	51.91	-
224	Phosphorylation	LWNIQTDTLVAIFGG HHCCCCCCEEEEECC	26.90	24275569
253	Phosphorylation	LLGEKIMSCGMDHSL HHHHHHHHCCCCHHH	15.82	22210691
259	Phosphorylation	MSCGMDHSLKLWRIN HHCCCCHHHHHHHCC	23.96	22210691
267	Phosphorylation	LKLWRINSKRMMNAI HHHHHCCHHHHHHHH	21.19	24260401
268	Methylation	KLWRINSKRMMNAIK HHHHCCHHHHHHHHH	39.56	20974918
268	"N6,N6,N6-trimethyllysine"	KLWRINSKRMMNAIK HHHHCCHHHHHHHHH	39.56	-
275	Ubiquitination	KRMMNAIKESYDYNP HHHHHHHHHHHCCCC	37.89	-
275 (in isoform 2)	Ubiquitination	-	37.89	21890473
275 (in isoform 3)	Ubiquitination	-	37.89	21890473
275 (in isoform 1)	Ubiquitination	-	37.89	21890473
277	Phosphorylation	MMNAIKESYDYNPNK HHHHHHHHHCCCCCC	20.50	-
278	Phosphorylation	MNAIKESYDYNPNKT HHHHHHHHCCCCCCC	24.44	-
280	Phosphorylation	AIKESYDYNPNKTNR HHHHHHCCCCCCCCC	25.04	-
284 (in isoform 2)	Ubiquitination	-	48.73	21890473
284 (in isoform 1)	Ubiquitination	-	48.73	21890473
284	"N6,N6,N6-trimethyllysine"	SYDYNPNKTNRPFIS HHCCCCCCCCCCCCC	48.73	-
284 (in isoform 3)	Ubiquitination	-	48.73	21890473
284	Ubiquitination	SYDYNPNKTNRPFIS HHCCCCCCCCCCCCC	48.73	20974918
284	Methylation	SYDYNPNKTNRPFIS HHCCCCCCCCCCCCC	48.73	20974918
293	Acetylation	NRPFISQKIHFPDFS CCCCCCCEECCCCCC	31.21	26051181
332	Acetylation	ENAIVCWKPGKMEDD CCEEEEECCCCCHHC	38.47	26051181
340 (in isoform 2)	Phosphorylation	-	10.07	20860994
344 (in isoform 3)	Ubiquitination	-	48.51	21890473
344 (in isoform 1)	Ubiquitination	-	48.51	21890473
344	Ubiquitination	EDDIDKIKPSESNVT HHCHHHCCCCCCCEE	48.51	-
348 (in isoform 2)	Phosphorylation	-	40.72	25850435
369 (in isoform 2)	Ubiquitination	-	13.69	21890473
398	Ubiquitination	LEVEDPHKAKCTTLT CCCCCCCCCCCEECC	55.73	-
398	Acetylation	LEVEDPHKAKCTTLT CCCCCCCCCCCEECC	55.73	25953088
408	Ubiquitination	CTTLTHHKCGAAIRQ CEECCCCCCCHHHHC	27.10	-
433 (in isoform 2)	Ubiquitination	-	29.67	-
433	Phosphorylation	IAVCDDASIWRWDRL EEEECCCCCCCCHHC	29.67	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EED_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
26	K	Methylation		20974918
Binding to histone H1 'Lys-26' promotes mono-, di-, and trimethylation of internal lysines.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EED_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC2_HUMAN	HDAC2	physical	10581039
TGS1_HUMAN	TGS1	physical	12943661
PP1R8_HUMAN	PPP1R8	physical	12788942
EZH2_HUMAN	EZH2	physical	9584197
EZH2_HUMAN	EZH2	physical	10581039
HDAC1_HUMAN	HDAC1	physical	10581039
EZH2_HUMAN	EZH2	physical	9742080
ITB7_HUMAN	ITGB7	physical	9765275
EZH2_HUMAN	EZH2	physical	15385962
SUZ12_HUMAN	SUZ12	physical	15385962
RBBP4_HUMAN	RBBP4	physical	15385962
EZH2_HUMAN	EZH2	physical	15225548
SUZ12_HUMAN	SUZ12	physical	15225548
AEBP2_HUMAN	AEBP2	physical	15225548
EZH1_HUMAN	EZH1	physical	19026781
EZH2_HUMAN	EZH2	physical	19026781
SUZ12_HUMAN	SUZ12	physical	19026781
EED_HUMAN	EED	physical	19026781
SUZ12_HUMAN	SUZ12	physical	19026780
EZH2_HUMAN	EZH2	physical	19026780
DDB1_HUMAN	DDB1	physical	17041588
DNMT1_HUMAN	DNMT1	physical	16357870
DNM3A_HUMAN	DNMT3A	physical	16357870
DNM3B_HUMAN	DNMT3B	physical	16357870
EPC1_HUMAN	EPC1	physical	15536069
E2F6_HUMAN	E2F6	physical	15536069
EZH2_HUMAN	EZH2	physical	18285464
SUZ12_HUMAN	SUZ12	physical	18285464
EZH2_HUMAN	EZH2	physical	17937919
H31T_HUMAN	HIST3H3	physical	20974918
GAG_HV1H2	gag	physical	9880543
EHMT1_HUMAN	EHMT1	physical	22659877
SMYD3_HUMAN	SMYD3	physical	22659877
EPC2_HUMAN	EPC2	physical	22659877
EZH2_HUMAN	EZH2	physical	11158321
TYY1_HUMAN	YY1	physical	11158321
PHO_DROME	pho	physical	11158321
EZH2_HUMAN	EZH2	physical	9584199
ADA17_HUMAN	ADAM17	physical	23317503
EED_HUMAN	EED	physical	24457600
RING2_HUMAN	RNF2	physical	24457600
BMI1_HUMAN	BMI1	physical	24457600
FBX11_HUMAN	FBXO11	physical	24457600
RU17_HUMAN	SNRNP70	physical	24457600
RING1_HUMAN	RING1	physical	24457600
CBX8_HUMAN	CBX8	physical	24457600
SNRPA_HUMAN	SNRPA	physical	24457600
EIF3A_HUMAN	EIF3A	physical	24457600
ABC3B_HUMAN	APOBEC3B	physical	24457600
PRDX4_HUMAN	PRDX4	physical	24457600
PHC1_HUMAN	PHC1	physical	24457600
PCGF2_HUMAN	PCGF2	physical	24457600
HDAC2_HUMAN	HDAC2	physical	24457600
PHC3_HUMAN	PHC3	physical	24457600
RB12B_HUMAN	RBM12B	physical	24457600
SRRM2_HUMAN	SRRM2	physical	24457600
LC7L3_HUMAN	LUC7L3	physical	24457600
MGAP_HUMAN	MGA	physical	24457600
UTP20_HUMAN	UTP20	physical	24457600
PHC2_HUMAN	PHC2	physical	24457600
RYBP_HUMAN	RYBP	physical	24457600
ENPL_HUMAN	HSP90B1	physical	24457600
CBX7_HUMAN	CBX7	physical	24457600
MINT_HUMAN	SPEN	physical	24457600
ELYS_HUMAN	AHCTF1	physical	24457600
CHD2_HUMAN	CHD2	physical	24457600
NXF1_HUMAN	NXF1	physical	24457600
RL1D1_HUMAN	RSL1D1	physical	24457600
PAWR_HUMAN	PAWR	physical	24457600
CTCF_HUMAN	CTCF	physical	24457600
KDM2A_HUMAN	KDM2A	physical	24457600
TXND5_HUMAN	TXNDC5	physical	24457600
TF3C3_HUMAN	GTF3C3	physical	24457600
PCGF1_HUMAN	PCGF1	physical	24457600
ABCF1_HUMAN	ABCF1	physical	24457600
PPWD1_HUMAN	PPWD1	physical	24457600
SPB1_HUMAN	FTSJ3	physical	24457600
EIF3B_HUMAN	EIF3B	physical	24457600
RAB7A_HUMAN	RAB7A	physical	24457600
PCGF6_HUMAN	PCGF6	physical	24457600
RFC5_HUMAN	RFC5	physical	24457600
NU188_HUMAN	NUP188	physical	24457600
NUP98_HUMAN	NUP98	physical	24457600
PRP6_HUMAN	PRPF6	physical	24457600
BCOR_HUMAN	BCOR	physical	24457600
RPN2_HUMAN	RPN2	physical	24457600
DSG2_HUMAN	DSG2	physical	24457600
KCMA1_HUMAN	KCNMA1	physical	24457600
CRNL1_HUMAN	CRNKL1	physical	24457600
SBP1_HUMAN	SELENBP1	physical	24457600
CUL1_HUMAN	CUL1	physical	24457600
DDX52_HUMAN	DDX52	physical	24457600
CBX4_HUMAN	CBX4	physical	24457600
PNO1_HUMAN	PNO1	physical	24457600
CBX3_HUMAN	CBX3	physical	24457600
STAG1_HUMAN	STAG1	physical	24457600
NSMA3_HUMAN	SMPD4	physical	24457600
MYH9_HUMAN	MYH9	physical	24457600
ENOA_HUMAN	ENO1	physical	24457600
CLK3_HUMAN	CLK3	physical	24457600
ZMYM2_HUMAN	ZMYM2	physical	24457600
RBM15_HUMAN	RBM15	physical	24457600
DCA13_HUMAN	DCAF13	physical	24457600
PR38A_HUMAN	PRPF38A	physical	24457600
SKP1_HUMAN	SKP1	physical	24457600
RM20_HUMAN	MRPL20	physical	24457600
CPSF7_HUMAN	CPSF7	physical	24457600
SMCA1_HUMAN	SMARCA1	physical	24457600
RS3_HUMAN	RPS3	physical	24457600
GRP78_HUMAN	HSPA5	physical	24457600
BPTF_HUMAN	BPTF	physical	24457600
EP400_HUMAN	EP400	physical	24457600
SIN3A_HUMAN	SIN3A	physical	24457600
RIF1_HUMAN	RIF1	physical	24457600
RAB5B_HUMAN	RAB5B	physical	24457600
UBP7_HUMAN	USP7	physical	24457600
NRDE2_HUMAN	NRDE2	physical	24457600
BAZ2A_HUMAN	BAZ2A	physical	24457600
POGZ_HUMAN	POGZ	physical	24457600
BAZ1B_HUMAN	BAZ1B	physical	24457600
CWC22_HUMAN	CWC22	physical	24457600
ACINU_HUMAN	ACIN1	physical	24457600
EHMT1_HUMAN	EHMT1	physical	24457600
CLK2_HUMAN	CLK2	physical	24457600
NOM1_HUMAN	NOM1	physical	24457600
RRP12_HUMAN	RRP12	physical	24457600
SLTM_HUMAN	SLTM	physical	24457600
BRX1_HUMAN	BRIX1	physical	24457600
DDX47_HUMAN	DDX47	physical	24457600
CENPV_HUMAN	CENPV	physical	24457600
NAA40_HUMAN	NAA40	physical	24457600
SPF27_HUMAN	BCAS2	physical	24457600
RCL1_HUMAN	RCL1	physical	24457600
RL18A_HUMAN	RPL18A	physical	24457600
ADT2_HUMAN	SLC25A5	physical	24457600
MK67I_HUMAN	NIFK	physical	24457600
RL9_HUMAN	RPL9	physical	24457600
RS11_HUMAN	RPS11	physical	24457600
SF3B6_HUMAN	SF3B6	physical	24457600
DIDO1_HUMAN	DIDO1	physical	24457600
TRA2B_HUMAN	TRA2B	physical	24457600
SRRT_HUMAN	SRRT	physical	24457600
HNRL1_HUMAN	HNRNPUL1	physical	24457600
K1C19_HUMAN	KRT19	physical	24457600
RS8_HUMAN	RPS8	physical	24457600
HNRH2_HUMAN	HNRNPH2	physical	24457600
PRP19_HUMAN	PRPF19	physical	24457600
MYH10_HUMAN	MYH10	physical	24457600
H10_HUMAN	H1F0	physical	24457600
SRSF8_HUMAN	SRSF8	physical	24457600
ANDR_HUMAN	AR	physical	24457600
RL23_HUMAN	RPL23	physical	24457600
TRIPC_HUMAN	TRIP12	physical	24457600
PDS5B_HUMAN	PDS5B	physical	24457600
RL14_HUMAN	RPL14	physical	24457600
SRSF2_HUMAN	SRSF2	physical	24457600
PB1_HUMAN	PBRM1	physical	24457600
MAGT1_HUMAN	MAGT1	physical	24457600
NOC2L_HUMAN	NOC2L	physical	24457600
NUP85_HUMAN	NUP85	physical	24457600
RL31_HUMAN	RPL31	physical	24457600
DDX27_HUMAN	DDX27	physical	24457600
ERG24_HUMAN	TM7SF2	physical	24457600
NOLC1_HUMAN	NOLC1	physical	24457600
DDX50_HUMAN	DDX50	physical	24457600
DYL1_HUMAN	DYNLL1	physical	24457600
RAC1_HUMAN	RAC1	physical	24457600
FAS_HUMAN	FASN	physical	24457600
INT1_HUMAN	INTS1	physical	24457600
NOG1_HUMAN	GTPBP4	physical	24457600
EHMT2_HUMAN	EHMT2	physical	24457600
NOL11_HUMAN	NOL11	physical	24457600
NCBP1_HUMAN	NCBP1	physical	24457600
RBM28_HUMAN	RBM28	physical	24457600
RL3_HUMAN	RPL3	physical	24457600
MPCP_HUMAN	SLC25A3	physical	24457600
RL29_HUMAN	RPL29	physical	24457600
RL7A_HUMAN	RPL7A	physical	24457600
RU2A_HUMAN	SNRPA1	physical	24457600
CLH1_HUMAN	CLTC	physical	24457600
CASZ1_HUMAN	CASZ1	physical	24457600
KI20A_HUMAN	KIF20A	physical	24457600
NDRG1_HUMAN	NDRG1	physical	24457600
HXB13_HUMAN	HOXB13	physical	24457600
DDX6_HUMAN	DDX6	physical	24457600
U2AF2_HUMAN	U2AF2	physical	24457600
ROAA_HUMAN	HNRNPAB	physical	24457600
DDX18_HUMAN	DDX18	physical	24457600
MGN2_HUMAN	MAGOHB	physical	24457600
RL12_HUMAN	RPL12	physical	24457600
KIF4A_HUMAN	KIF4A	physical	24457600
TCRG1_HUMAN	TCERG1	physical	24457600
SPT6H_HUMAN	SUPT6H	physical	24457600
FUBP3_HUMAN	FUBP3	physical	24457600
NOL10_HUMAN	NOL10	physical	24457600
GRN_HUMAN	GRN	physical	24457600
SF01_HUMAN	SF1	physical	24457600
NOL6_HUMAN	NOL6	physical	24457600
SEPT9_HUMAN	SEPT9	physical	24457600
RBM4_HUMAN	RBM4	physical	24457600
API5_HUMAN	API5	physical	24457600
STRBP_HUMAN	STRBP	physical	24457600
MBB1A_HUMAN	MYBBP1A	physical	24457600
NU205_HUMAN	NUP205	physical	24457600
SMD1_HUMAN	SNRPD1	physical	24457600
CEBPZ_HUMAN	CEBPZ	physical	24457600
NU133_HUMAN	NUP133	physical	24457600
RS4X_HUMAN	RPS4X	physical	24457600
OSTC_HUMAN	OSTC	physical	24457600
H2AW_HUMAN	H2AFY2	physical	24457600
TF3C1_HUMAN	GTF3C1	physical	24457600
VTNC_HUMAN	VTN	physical	24457600
RS28_HUMAN	RPS28	physical	24457600
RL30_HUMAN	RPL30	physical	24457600
MEN1_HUMAN	MEN1	physical	24457600
INT3_HUMAN	INTS3	physical	24457600
TF3C4_HUMAN	GTF3C4	physical	24457600
NU107_HUMAN	NUP107	physical	24457600
SMCA2_HUMAN	SMARCA2	physical	24457600
RL24_HUMAN	RPL24	physical	24457600
RL22_HUMAN	RPL22	physical	24457600
ZN638_HUMAN	ZNF638	physical	24457600
CI114_HUMAN	C9orf114	physical	24457600
NFIB_HUMAN	NFIB	physical	24457600
RL23A_HUMAN	RPL23A	physical	24457600
NEP1_HUMAN	EMG1	physical	24457600
RS7_HUMAN	RPS7	physical	24457600
H1X_HUMAN	H1FX	physical	24457600
RS24_HUMAN	RPS24	physical	24457600
RS26_HUMAN	RPS26	physical	24457600
SK2L2_HUMAN	SKIV2L2	physical	24457600
DDX42_HUMAN	DDX42	physical	24457600
EXOS4_HUMAN	EXOSC4	physical	24457600
P66B_HUMAN	GATAD2B	physical	24457600
DEST_HUMAN	DSTN	physical	24457600
G3P_HUMAN	GAPDH	physical	24457600
RAB14_HUMAN	RAB14	physical	24457600
HS90B_HUMAN	HSP90AB1	physical	24457600
MAP1B_HUMAN	MAP1B	physical	24457600
UT14A_HUMAN	UTP14A	physical	24457600
MDC1_HUMAN	MDC1	physical	24457600
RBM25_HUMAN	RBM25	physical	24457600
TP53B_HUMAN	TP53BP1	physical	24457600
GLYR1_HUMAN	GLYR1	physical	24457600
CKAP5_HUMAN	CKAP5	physical	24457600
GNL3_HUMAN	GNL3	physical	24457600
SF3A1_HUMAN	SF3A1	physical	24457600
RAD21_HUMAN	RAD21	physical	24457600
HMGB2_HUMAN	HMGB2	physical	24457600
RUVB2_HUMAN	RUVBL2	physical	24457600
SRP14_HUMAN	SRP14	physical	24457600
RBP56_HUMAN	TAF15	physical	24457600
SMD3_HUMAN	SNRPD3	physical	24457600
SMD2_HUMAN	SNRPD2	physical	24457600
SAFB1_HUMAN	SAFB	physical	24457600
NAT10_HUMAN	NAT10	physical	24457600
SAFB2_HUMAN	SAFB2	physical	24457600
TRRAP_HUMAN	TRRAP	physical	24457600
SMHD1_HUMAN	SMCHD1	physical	24457600
WDR3_HUMAN	WDR3	physical	24457600
SFR15_HUMAN	SCAF4	physical	24457600
TBL3_HUMAN	TBL3	physical	24457600
ZN687_HUMAN	ZNF687	physical	24457600
OST48_HUMAN	DDOST	physical	24457600
PUF60_HUMAN	PUF60	physical	24457600
PUM3_HUMAN	KIAA0020	physical	24457600
NPM3_HUMAN	NPM3	physical	24457600
RAB1B_HUMAN	RAB1B	physical	24457600
WIZ_HUMAN	WIZ	physical	24457600
MYEF2_HUMAN	MYEF2	physical	24457600
XRCC1_HUMAN	XRCC1	physical	24457600
XRCC5_HUMAN	XRCC5	physical	24457600
PSPC1_HUMAN	PSPC1	physical	24457600
PNKP_HUMAN	PNKP	physical	24457600
CDC5L_HUMAN	CDC5L	physical	24457600
CCD71_HUMAN	CCDC71	physical	24457600
CH60_HUMAN	HSPD1	physical	24457600
CPSF6_HUMAN	CPSF6	physical	24457600
EF1B_HUMAN	EEF1B2	physical	24457600
RUXF_HUMAN	SNRPF	physical	24457600
TBA1B_HUMAN	TUBA1B	physical	24457600
RL8_HUMAN	RPL8	physical	24457600
PLAK_HUMAN	JUP	physical	24457600
NIPBL_HUMAN	NIPBL	physical	24457600
RAD50_HUMAN	RAD50	physical	24457600
MTA1_HUMAN	MTA1	physical	24457600
FBRL_HUMAN	FBL	physical	24457600
NUP93_HUMAN	NUP93	physical	24457600
RL27A_HUMAN	RPL27A	physical	24457600
DAD1_HUMAN	DAD1	physical	24457600
DYL2_HUMAN	DYNLL2	physical	24457600
THOC4_HUMAN	ALYREF	physical	24457600
FOXA1_HUMAN	FOXA1	physical	24457600
TFAM_HUMAN	TFAM	physical	24457600
EF1D_HUMAN	EEF1D	physical	24457600
SF3A3_HUMAN	SF3A3	physical	24457600
EBP2_HUMAN	EBNA1BP2	physical	24457600
C1QB_HUMAN	C1QB	physical	24457600
K2C6A_HUMAN	KRT6A	physical	24457600
LBR_HUMAN	LBR	physical	24457600
PCBP1_HUMAN	PCBP1	physical	24457600
PKP2_HUMAN	PKP2	physical	24457600
PWP2_HUMAN	PWP2	physical	24457600
HEAT1_HUMAN	HEATR1	physical	24457600
RL13A_HUMAN	RPL13A	physical	24457600
ARGL1_HUMAN	ARGLU1	physical	24457600
HNRDL_HUMAN	HNRNPDL	physical	24457600
MRE11_HUMAN	MRE11A	physical	24457600
PHB2_HUMAN	PHB2	physical	24457600
FUBP1_HUMAN	FUBP1	physical	24457600
SRS10_HUMAN	SRSF10	physical	24457600
U5S1_HUMAN	EFTUD2	physical	24457600
SF3B1_HUMAN	SF3B1	physical	24457600
HCFC1_HUMAN	HCFC1	physical	24457600
IF4A3_HUMAN	EIF4A3	physical	24457600
RAN_HUMAN	RAN	physical	24457600
RS23_HUMAN	RPS23	physical	24457600
CPSF1_HUMAN	CPSF1	physical	24457600
COF1_HUMAN	CFL1	physical	24457600
RS16_HUMAN	RPS16	physical	24457600
RPN1_HUMAN	RPN1	physical	24457600
PR40A_HUMAN	PRPF40A	physical	24457600
NH2L1_HUMAN	NHP2L1	physical	24457600
SMRC1_HUMAN	SMARCC1	physical	24457600
TRA2A_HUMAN	TRA2A	physical	24457600
SRSF6_HUMAN	SRSF6	physical	24457600
TOP1_HUMAN	TOP1	physical	24457600
RBM14_HUMAN	RBM14	physical	24457600
RS14_HUMAN	RPS14	physical	24457600
XRCC6_HUMAN	XRCC6	physical	24457600
ERH_HUMAN	ERH	physical	24457600
TPR_HUMAN	TPR	physical	24457600
TCOF_HUMAN	TCOF1	physical	24457600
PABP2_HUMAN	PABPN1	physical	24457600
ARI1A_HUMAN	ARID1A	physical	24457600
DEK_HUMAN	DEK	physical	24457600
RUVB1_HUMAN	RUVBL1	physical	24457600
PRP8_HUMAN	PRPF8	physical	24457600
NU160_HUMAN	NUP160	physical	24457600
ROA0_HUMAN	HNRNPA0	physical	24457600
RL18_HUMAN	RPL18	physical	24457600
ZN326_HUMAN	ZNF326	physical	24457600
RBP2_HUMAN	RANBP2	physical	24457600
IMB1_HUMAN	KPNB1	physical	24457600
PHB_HUMAN	PHB	physical	24457600
IMP3_HUMAN	IMP3	physical	24457600
TADBP_HUMAN	TARDBP	physical	24457600
RPB1_HUMAN	POLR2A	physical	24457600
DKC1_HUMAN	DKC1	physical	24457600
CHD4_HUMAN	CHD4	physical	24457600
SYVC_HUMAN	VARS	physical	24457600
SON_HUMAN	SON	physical	24457600
NUCL_HUMAN	NCL	physical	24457600
PP1B_HUMAN	PPP1CB	physical	24457600
LMNB2_HUMAN	LMNB2	physical	24457600
LAP2A_HUMAN	TMPO	physical	24457600
LAP2B_HUMAN	TMPO	physical	24457600
H12_HUMAN	HIST1H1C	physical	24457600
SMCA4_HUMAN	SMARCA4	physical	24457600
RL11_HUMAN	RPL11	physical	24457600
PPIB_HUMAN	PPIB	physical	24457600
LMNA_HUMAN	LMNA	physical	24457600
GRP75_HUMAN	HSPA9	physical	24457600
SRSF9_HUMAN	SRSF9	physical	24457600
PDS5A_HUMAN	PDS5A	physical	24457600
ROA3_HUMAN	HNRNPA3	physical	24457600
THOC2_HUMAN	THOC2	physical	24457600
RL7_HUMAN	RPL7	physical	24457600
RALY_HUMAN	RALY	physical	24457600
PTBP1_HUMAN	PTBP1	physical	24457600
KDM1A_HUMAN	KDM1A	physical	24457600
SMRC2_HUMAN	SMARCC2	physical	24457600
NOP2_HUMAN	NOP2	physical	24457600
PKP3_HUMAN	PKP3	physical	24457600
HP1B3_HUMAN	HP1BP3	physical	24457600
SRSF3_HUMAN	SRSF3	physical	24457600
DDX3X_HUMAN	DDX3X	physical	24457600
SMC3_HUMAN	SMC3	physical	24457600
HNRL2_HUMAN	HNRNPUL2	physical	24457600
ROA1_HUMAN	HNRNPA1	physical	24457600
FUBP2_HUMAN	KHSRP	physical	24457600
PCBP2_HUMAN	PCBP2	physical	24457600
DNLI3_HUMAN	LIG3	physical	24457600
DDX5_HUMAN	DDX5	physical	24457600
SSRP1_HUMAN	SSRP1	physical	24457600
NOP58_HUMAN	NOP58	physical	24457600
RRP5_HUMAN	PDCD11	physical	24457600
HNRH3_HUMAN	HNRNPH3	physical	24457600
HNRPL_HUMAN	HNRNPL	physical	24457600
H2AY_HUMAN	H2AFY	physical	24457600
SP16H_HUMAN	SUPT16H	physical	24457600
RBM39_HUMAN	RBM39	physical	24457600
SRSF7_HUMAN	SRSF7	physical	24457600
NOP56_HUMAN	NOP56	physical	24457600
SF3B3_HUMAN	SF3B3	physical	24457600
ADNP_HUMAN	ADNP	physical	24457600
SRSF1_HUMAN	SRSF1	physical	24457600
HNRPQ_HUMAN	SYNCRIP	physical	24457600
U520_HUMAN	SNRNP200	physical	24457600
SMC1A_HUMAN	SMC1A	physical	24457600
PLEC_HUMAN	PLEC	physical	24457600
SMCA5_HUMAN	SMARCA5	physical	24457600
DX39B_HUMAN	DDX39B	physical	24457600
DSRAD_HUMAN	ADAR	physical	24457600
GTF2I_HUMAN	GTF2I	physical	24457600
HSP7C_HUMAN	HSPA8	physical	24457600
TIF1B_HUMAN	TRIM28	physical	24457600
ACTG_HUMAN	ACTG1	physical	24457600
PO210_HUMAN	NUP210	physical	24457600
RS27A_HUMAN	RPS27A	physical	24457600
HNRPD_HUMAN	HNRNPD	physical	24457600
DX39A_HUMAN	DDX39A	physical	24457600
K22E_HUMAN	KRT2	physical	24457600
HNRPF_HUMAN	HNRNPF	physical	24457600
ELAV1_HUMAN	ELAVL1	physical	24457600
DHX15_HUMAN	DHX15	physical	24457600
ILF2_HUMAN	ILF2	physical	24457600
K1C18_HUMAN	KRT18	physical	24457600
ILF3_HUMAN	ILF3	physical	24457600
MATR3_HUMAN	MATR3	physical	24457600
HNRPK_HUMAN	HNRNPK	physical	24457600
DDX17_HUMAN	DDX17	physical	24457600
ROA2_HUMAN	HNRNPA2B1	physical	24457600
SFPQ_HUMAN	SFPQ	physical	24457600
EF1G_HUMAN	EEF1G	physical	24457600
HNRPR_HUMAN	HNRNPR	physical	24457600
NONO_HUMAN	NONO	physical	24457600
LMNB1_HUMAN	LMNB1	physical	24457600
RBMX_HUMAN	RBMX	physical	24457600
FLOT2_HUMAN	FLOT2	physical	24457600
DDX21_HUMAN	DDX21	physical	24457600
FLOT1_HUMAN	FLOT1	physical	24457600
K2C8_HUMAN	KRT8	physical	24457600
HNRPC_HUMAN	HNRNPC	physical	24457600
HNRPU_HUMAN	HNRNPU	physical	24457600
HNRH1_HUMAN	HNRNPH1	physical	24457600
DHX9_HUMAN	DHX9	physical	24457600
K2C1_HUMAN	KRT1	physical	24457600
HNRPM_HUMAN	HNRNPM	physical	24457600
PRKDC_HUMAN	PRKDC	physical	24457600
NUMA1_HUMAN	NUMA1	physical	24457600
DESP_HUMAN	DSP	physical	24457600
EZH2_HUMAN	EZH2	physical	24457600
SUZ12_HUMAN	SUZ12	physical	24457600
EZH2_HUMAN	EZH2	physical	26344197
ABCF1_HUMAN	ABCF1	physical	26496610
DDX10_HUMAN	DDX10	physical	26496610
EZH2_HUMAN	EZH2	physical	26496610
JARD2_HUMAN	JARID2	physical	26496610
NOP2_HUMAN	NOP2	physical	26496610
PHF1_HUMAN	PHF1	physical	26496610
RBBP4_HUMAN	RBBP4	physical	26496610
RBBP7_HUMAN	RBBP7	physical	26496610
RL9_HUMAN	RPL9	physical	26496610
TCEA1_HUMAN	TCEA1	physical	26496610
AP2A_HUMAN	TFAP2A	physical	26496610
U3IP2_HUMAN	RRP9	physical	26496610
DDX21_HUMAN	DDX21	physical	26496610
MTF2_HUMAN	MTF2	physical	26496610
SUZ12_HUMAN	SUZ12	physical	26496610
NOG1_HUMAN	GTPBP4	physical	26496610
PHF19_HUMAN	PHF19	physical	26496610
LCOR_HUMAN	C10orf12	physical	26496610
NOC2L_HUMAN	NOC2L	physical	26496610
AEBP2_HUMAN	AEBP2	physical	26496610
EPOP_HUMAN	C17orf96	physical	26496610
PRD14_HUMAN	PRDM14	physical	23280602
EZH2_HUMAN	EZH2	physical	23280602
SUZ12_HUMAN	SUZ12	physical	23280602
HNF4A_HUMAN	HNF4A	physical	25391650
NSMA2_HUMAN	SMPD3	physical	20080539
RACK1_HUMAN	GNB2L1	physical	20080539
EZH2_HUMAN	EZH2	physical	27338022
SUZ12_HUMAN	SUZ12	physical	27338022
DDX5_HUMAN	DDX5	physical	27338022

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EED_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; THR-55 AND THR-57,AND MASS SPECTROMETRY.	18669648 [Abstract]

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