dbPTM

ENPL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ENPL_HUMAN
UniProt AC	P14625
Protein Name	Endoplasmin
Gene Name	HSP90B1
Organism	Homo sapiens (Human).
Sequence Length	803
Subcellular Localization	Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Description	Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity..
Protein Sequence	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	VEEDLGKSREGSRTD EEHHHCCCCCCCCCC	33.49	24505115
42	Phosphorylation	LGKSREGSRTDDEVV HCCCCCCCCCCHHHH	27.53	25849741
44	Phosphorylation	KSREGSRTDDEVVQR CCCCCCCCCHHHHHH	49.88	25849741
62	N-linked_Glycosylation	AIQLDGLNASQIREL HHHCCCCCHHHHHHH	42.97	16263699
64	O-linked_Glycosylation	QLDGLNASQIRELRE HCCCCCHHHHHHHHH	25.68	30059200
64	Phosphorylation	QLDGLNASQIRELRE HCCCCCHHHHHHHHH	25.68	20873877
72	Ubiquitination	QIRELREKSEKFAFQ HHHHHHHHHHHHHHH	58.44	-
75	Acetylation	ELREKSEKFAFQAEV HHHHHHHHHHHHHHH	49.43	61151
75	Ubiquitination	ELREKSEKFAFQAEV HHHHHHHHHHHHHHH	49.43	21890473
92	Phosphorylation	MMKLIINSLYKNKEI HHHHHHHHHHCCHHH	23.75	20068231
94	Phosphorylation	KLIINSLYKNKEIFL HHHHHHHHCCHHHHH	16.61	20068231
95	Acetylation	LIINSLYKNKEIFLR HHHHHHHCCHHHHHH	67.83	25953088
95	Succinylation	LIINSLYKNKEIFLR HHHHHHHCCHHHHHH	67.83	23954790
95	Ubiquitination	LIINSLYKNKEIFLR HHHHHHHCCHHHHHH	67.83	21890473
97	Acetylation	INSLYKNKEIFLREL HHHHHCCHHHHHHHH	48.30	72623279
97	Succinylation	INSLYKNKEIFLREL HHHHHCCHHHHHHHH	48.30	23954790
97	Ubiquitination	INSLYKNKEIFLREL HHHHHCCHHHHHHHH	48.30	-
106	Phosphorylation	IFLRELISNASDALD HHHHHHHHCCHHHHH	38.68	20164059
107	N-linked_Glycosylation	FLRELISNASDALDK HHHHHHHCCHHHHHH	36.15	16263699
109	Phosphorylation	RELISNASDALDKIR HHHHHCCHHHHHHHE	27.89	20164059
114	Acetylation	NASDALDKIRLISLT CCHHHHHHHEEEEEC	30.49	23749302
114	Ubiquitination	NASDALDKIRLISLT CCHHHHHHHEEEEEC	30.49	21890473
127	Phosphorylation	LTDENALSGNEELTV ECCCCCCCCCCEEEE	36.84	25814448
133	Phosphorylation	LSGNEELTVKIKCDK CCCCCEEEEEEEECC	24.04	-
135	Ubiquitination	GNEELTVKIKCDKEK CCCEEEEEEEECCCC	31.08	-
140	Acetylation	TVKIKCDKEKNLLHV EEEEEECCCCCEEEE	78.89	11920951
142	Acetylation	KIKCDKEKNLLHVTD EEEECCCCCEEEEEC	59.65	25953088
142	Ubiquitination	KIKCDKEKNLLHVTD EEEECCCCCEEEEEC	59.65	21890473
148	Phosphorylation	EKNLLHVTDTGVGMT CCCEEEEECCCCCCC	19.66	20068231
150	Phosphorylation	NLLHVTDTGVGMTRE CEEEEECCCCCCCHH	25.13	20068231
154	Sulfoxidation	VTDTGVGMTREELVK EECCCCCCCHHHHHH	2.72	28183972
155	Phosphorylation	TDTGVGMTREELVKN ECCCCCCCHHHHHHH	29.06	20363803
161	Acetylation	MTREELVKNLGTIAK CCHHHHHHHHHHHHH	60.11	23236377
161	Succinylation	MTREELVKNLGTIAK CCHHHHHHHHHHHHH	60.11	27452117
161	Ubiquitination	MTREELVKNLGTIAK CCHHHHHHHHHHHHH	60.11	21890473
165	Phosphorylation	ELVKNLGTIAKSGTS HHHHHHHHHHHHCHH	22.41	21406692
168	Acetylation	KNLGTIAKSGTSEFL HHHHHHHHHCHHHHH	45.64	27452117
168	Ubiquitination	KNLGTIAKSGTSEFL HHHHHHHHHCHHHHH	45.64	21890473
169	Phosphorylation	NLGTIAKSGTSEFLN HHHHHHHHCHHHHHH	37.98	29691806
171	Phosphorylation	GTIAKSGTSEFLNKM HHHHHHCHHHHHHHH	31.97	29691806
172	Phosphorylation	TIAKSGTSEFLNKMT HHHHHCHHHHHHHHH	29.85	26657352
177	Methylation	GTSEFLNKMTEAQED CHHHHHHHHHHHHHC	49.71	-
179	Phosphorylation	SEFLNKMTEAQEDGQ HHHHHHHHHHHHCCC	29.76	21406692
187	Phosphorylation	EAQEDGQSTSELIGQ HHHHCCCCHHHHHHH	39.16	21406692
188	Phosphorylation	AQEDGQSTSELIGQF HHHCCCCHHHHHHHH	20.52	21406692
189	Phosphorylation	QEDGQSTSELIGQFG HHCCCCHHHHHHHHC	35.34	21406692
200	Phosphorylation	GQFGVGFYSAFLVAD HHHCCHHHHHHHEEC	7.99	21406692
201	Phosphorylation	QFGVGFYSAFLVADK HHCCHHHHHHHEECE	15.41	21406692
217	N-linked_Glycosylation	IVTSKHNNDTQHIWE EEEECCCCCCCCEEE	54.12	12754519
219	O-linked_Glycosylation	TSKHNNDTQHIWESD EECCCCCCCCEEECC	24.95	30059200
225	O-linked_Glycosylation	DTQHIWESDSNEFSV CCCCEEECCCCCEEE	31.20	30059200
225	Phosphorylation	DTQHIWESDSNEFSV CCCCEEECCCCCEEE	31.20	-
227	Phosphorylation	QHIWESDSNEFSVIA CCEEECCCCCEEEEE	47.76	-
246	Phosphorylation	NTLGRGTTITLVLKE CCCCCCCEEEEEECH	18.13	22817901
248	Phosphorylation	LGRGTTITLVLKEEA CCCCCEEEEEECHHH	14.55	22817901
252	Ubiquitination	TTITLVLKEEASDYL CEEEEEECHHHCCCC	46.13	21906983
256	Phosphorylation	LVLKEEASDYLELDT EEECHHHCCCCCHHH	30.02	-
258	Phosphorylation	LKEEASDYLELDTIK ECHHHCCCCCHHHHH	10.28	-
263	Phosphorylation	SDYLELDTIKNLVKK CCCCCHHHHHHHHHH	46.61	25338102
265	Acetylation	YLELDTIKNLVKKYS CCCHHHHHHHHHHHH	46.45	26822725
265	Ubiquitination	YLELDTIKNLVKKYS CCCHHHHHHHHHHHH	46.45	21890473
270	Acetylation	TIKNLVKKYSQFINF HHHHHHHHHHHHHCC	42.53	25038526
270	Ubiquitination	TIKNLVKKYSQFINF HHHHHHHHHHHHHCC	42.53	21890473
271	Phosphorylation	IKNLVKKYSQFINFP HHHHHHHHHHHHCCC	11.29	22210691
272	Phosphorylation	KNLVKKYSQFINFPI HHHHHHHHHHHCCCE	27.74	22210691
280	Phosphorylation	QFINFPIYVWSSKTE HHHCCCEEEEECCCE	8.98	-
286	Phosphorylation	IYVWSSKTETVEEPM EEEEECCCEECCCCC	38.54	23403867
288	Phosphorylation	VWSSKTETVEEPMEE EEECCCEECCCCCHH	38.15	23403867
293	Sulfoxidation	TETVEEPMEEEEAAK CEECCCCCHHHHHHH	13.16	28465586
303	Acetylation	EEAAKEEKEESDDEA HHHHHHHHHHCCHHH	68.80	26051181
306	Phosphorylation	AKEEKEESDDEAAVE HHHHHHHCCHHHHHH	51.99	29255136
320	Acetylation	EEEEEEKKPKTKKVE HHHHHHHCCCCCCCH	55.84	26051181
340	Ubiquitination	WELMNDIKPIWQRPS HHHHCCCCCHHCCCC	33.06	-
347	Phosphorylation	KPIWQRPSKEVEEDE CCHHCCCCCCCCHHH	43.57	22817900
348	Ubiquitination	PIWQRPSKEVEEDEY CHHCCCCCCCCHHHH	69.34	-
355	Phosphorylation	KEVEEDEYKAFYKSF CCCCHHHHHHHHHHH	21.68	28152594
356	Acetylation	EVEEDEYKAFYKSFS CCCHHHHHHHHHHHC	29.94	26822725
356	Succinylation	EVEEDEYKAFYKSFS CCCHHHHHHHHHHHC	29.94	23954790
356	Ubiquitination	EVEEDEYKAFYKSFS CCCHHHHHHHHHHHC	29.94	-
360	Succinylation	DEYKAFYKSFSKESD HHHHHHHHHHCCCCC	38.27	23954790
360	Ubiquitination	DEYKAFYKSFSKESD HHHHHHHHHHCCCCC	38.27	21890473
361	Phosphorylation	EYKAFYKSFSKESDD HHHHHHHHHCCCCCC	24.31	24719451
385	Phosphorylation	EGEVTFKSILFVPTS ECEEEEEEEEEEECC	21.97	24117733
391	Phosphorylation	KSILFVPTSAPRGLF EEEEEEECCCCCCCC	32.02	27050516
392	Phosphorylation	SILFVPTSAPRGLFD EEEEEECCCCCCCCH	30.15	25159151
395	Methylation	FVPTSAPRGLFDEYG EEECCCCCCCCHHCC	54.91	-
401	Phosphorylation	PRGLFDEYGSKKSDY CCCCCHHCCCCHHHH	28.66	29691806
403	Phosphorylation	GLFDEYGSKKSDYIK CCCHHCCCCHHHHHH	35.69	29691806
404	Acetylation	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	7696511
404	Succinylation	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	-
404	Succinylation	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	23954790
404	Ubiquitination	LFDEYGSKKSDYIKL CCHHCCCCHHHHHHE	52.51	-
405	Ubiquitination	FDEYGSKKSDYIKLY CHHCCCCHHHHHHEE	50.70	21890473
408	Phosphorylation	YGSKKSDYIKLYVRR CCCCHHHHHHEEEEE	13.67	28258704
410	Ubiquitination	SKKSDYIKLYVRRVF CCHHHHHHEEEEEEE	27.77	-
425	Sulfoxidation	ITDDFHDMMPKYLNF ECCCHHHHHHHHHHH	3.58	30846556
426	Sulfoxidation	TDDFHDMMPKYLNFV CCCHHHHHHHHHHHH	3.01	30846556
428	Acetylation	DFHDMMPKYLNFVKG CHHHHHHHHHHHHCC	44.46	25038526
429	Phosphorylation	FHDMMPKYLNFVKGV HHHHHHHHHHHHCCC	10.87	-
434	Acetylation	PKYLNFVKGVVDSDD HHHHHHHCCCCCCCC	41.68	27452117
434	Ubiquitination	PKYLNFVKGVVDSDD HHHHHHHCCCCCCCC	41.68	21906983
439	Phosphorylation	FVKGVVDSDDLPLNV HHCCCCCCCCCCCCC	22.78	30266825
445	N-linked_Glycosylation	DSDDLPLNVSRETLQ CCCCCCCCCCHHHHH	27.98	12754519
447	Phosphorylation	DDLPLNVSRETLQQH CCCCCCCCHHHHHHH	24.27	30266825
450	Phosphorylation	PLNVSRETLQQHKLL CCCCCHHHHHHHHHH	28.85	25627689
455	Acetylation	RETLQQHKLLKVIRK HHHHHHHHHHHHHHH	51.69	27178108
455	Ubiquitination	RETLQQHKLLKVIRK HHHHHHHHHHHHHHH	51.69	21906983
458	Acetylation	LQQHKLLKVIRKKLV HHHHHHHHHHHHHHH	46.16	21466224
458	Malonylation	LQQHKLLKVIRKKLV HHHHHHHHHHHHHHH	46.16	26320211
458	Ubiquitination	LQQHKLLKVIRKKLV HHHHHHHHHHHHHHH	46.16	-
467	Ubiquitination	IRKKLVRKTLDMIKK HHHHHHHHHHHHHHH	46.06	21906983
468	Phosphorylation	RKKLVRKTLDMIKKI HHHHHHHHHHHHHHH	19.89	20068231
473	Ubiquitination	RKTLDMIKKIADDKY HHHHHHHHHHHHCCC	31.33	21890473
479	Acetylation	IKKIADDKYNDTFWK HHHHHHCCCCHHHHH	46.64	25825284
479	Succinylation	IKKIADDKYNDTFWK HHHHHHCCCCHHHHH	46.64	23954790
479	Ubiquitination	IKKIADDKYNDTFWK HHHHHHCCCCHHHHH	46.64	-
480	Phosphorylation	KKIADDKYNDTFWKE HHHHHCCCCHHHHHH	25.84	28152594
481	N-linked_Glycosylation	KIADDKYNDTFWKEF HHHHCCCCHHHHHHH	47.81	UniProtKB CARBOHYD
483	Phosphorylation	ADDKYNDTFWKEFGT HHCCCCHHHHHHHCC	27.97	28152594
486	Methylation	KYNDTFWKEFGTNIK CCCHHHHHHHCCCCE	38.69	-
486	Ubiquitination	KYNDTFWKEFGTNIK CCCHHHHHHHCCCCE	38.69	21890473
490	O-linked_Glycosylation	TFWKEFGTNIKLGVI HHHHHHCCCCEEEEE	38.81	30059200
493	Ubiquitination	KEFGTNIKLGVIEDH HHHCCCCEEEEEECC	41.06	-
501	Phosphorylation	LGVIEDHSNRTRLAK EEEEECCCCHHHHHH	40.09	29514088
502	N-linked_Glycosylation	GVIEDHSNRTRLAKL EEEECCCCHHHHHHH	46.02	UniProtKB CARBOHYD
504	Phosphorylation	IEDHSNRTRLAKLLR EECCCCHHHHHHHHH	33.99	29514088
508	Acetylation	SNRTRLAKLLRFQSS CCHHHHHHHHHHHCC	53.28	25825284
511	Methylation	TRLAKLLRFQSSHHP HHHHHHHHHHCCCCC	37.69	-
514	Phosphorylation	AKLLRFQSSHHPTDI HHHHHHHCCCCCCCC	29.00	23607784
515	Phosphorylation	KLLRFQSSHHPTDIT HHHHHHCCCCCCCCC	18.29	20068231
519	Phosphorylation	FQSSHHPTDITSLDQ HHCCCCCCCCCHHHH	35.36	20068231
522	Phosphorylation	SHHPTDITSLDQYVE CCCCCCCCHHHHHHH	26.50	23607784
523	Phosphorylation	HHPTDITSLDQYVER CCCCCCCHHHHHHHH	30.22	23607784
527	Phosphorylation	DITSLDQYVERMKEK CCCHHHHHHHHHHHH	12.16	23607784
537	Acetylation	RMKEKQDKIYFMAGS HHHHHCCCEEEEECC	36.49	25038526
541	Sulfoxidation	KQDKIYFMAGSSRKE HCCCEEEEECCCCCH	2.01	30846556
544	Phosphorylation	KIYFMAGSSRKEAES CEEEEECCCCCHHHC	19.89	20068231
545	Phosphorylation	IYFMAGSSRKEAESS EEEEECCCCCHHHCC	46.59	21712546
551	Phosphorylation	SSRKEAESSPFVERL CCCCHHHCCHHHHHH	50.81	23911959
552	Phosphorylation	SRKEAESSPFVERLL CCCHHHCCHHHHHHH	17.54	25159151
561	Ubiquitination	FVERLLKKGYEVIYL HHHHHHHCCCEEEEE	67.69	-
576	Glutathionylation	TEPVDEYCIQALPEF CCCCCHHHHHHCCCC	1.42	22555962
586	Acetylation	ALPEFDGKRFQNVAK HCCCCCCHHHHHHHH	52.46	69983
586	Sumoylation	ALPEFDGKRFQNVAK HCCCCCCHHHHHHHH	52.46	-
586	Ubiquitination	ALPEFDGKRFQNVAK HCCCCCCHHHHHHHH	52.46	21906983
593	Ubiquitination	KRFQNVAKEGVKFDE HHHHHHHHHCCCCCC	51.20	21906983
597	Acetylation	NVAKEGVKFDESEKT HHHHHCCCCCCCHHC	58.93	25953088
597	Succinylation	NVAKEGVKFDESEKT HHHHHCCCCCCCHHC	58.93	23954790
604	Phosphorylation	KFDESEKTKESREAV CCCCCHHCHHHHHHH	35.67	18452278
607	Phosphorylation	ESEKTKESREAVEKE CCHHCHHHHHHHHHH	36.66	27130503
613	Acetylation	ESREAVEKEFEPLLN HHHHHHHHHHHHHHH	62.19	87869
613	Succinylation	ESREAVEKEFEPLLN HHHHHHHHHHHHHHH	62.19	23954790
613	Ubiquitination	ESREAVEKEFEPLLN HHHHHHHHHHHHHHH	62.19	-
622	Sulfoxidation	FEPLLNWMKDKALKD HHHHHHHHHHHHHHH	3.81	30846556
623	Acetylation	EPLLNWMKDKALKDK HHHHHHHHHHHHHHH	47.92	27452117
623	Ubiquitination	EPLLNWMKDKALKDK HHHHHHHHHHHHHHH	47.92	-
633	Acetylation	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	25953088
633	Succinylation	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	-
633	Succinylation	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	27452117
633	Ubiquitination	ALKDKIEKAVVSQRL HHHHHHHHHHHHHHC	50.37	21890473
641	Phosphorylation	AVVSQRLTESPCALV HHHHHHCCCCCCHHH	36.28	-
643	Phosphorylation	VSQRLTESPCALVAS HHHHCCCCCCHHHHH	21.75	28102081
650	Phosphorylation	SPCALVASQYGWSGN CCCHHHHHHHCCCCC	19.22	28102081
652	Phosphorylation	CALVASQYGWSGNME CHHHHHHHCCCCCHH	20.33	22817900
655	Phosphorylation	VASQYGWSGNMERIM HHHHHCCCCCHHHHH	18.87	28102081
658	Sulfoxidation	QYGWSGNMERIMKAQ HHCCCCCHHHHHHHH	4.12	28465586
663	Methylation	GNMERIMKAQAYQTG CCHHHHHHHHHHHHC	34.67	24129315
663	Ubiquitination	GNMERIMKAQAYQTG CCHHHHHHHHHHHHC	34.67	21890473
667	Phosphorylation	RIMKAQAYQTGKDIS HHHHHHHHHHCCCCC	8.43	-
669	O-linked_Glycosylation	MKAQAYQTGKDISTN HHHHHHHHCCCCCCC	33.26	OGP
669	Phosphorylation	MKAQAYQTGKDISTN HHHHHHHHCCCCCCC	33.26	-
671	Acetylation	AQAYQTGKDISTNYY HHHHHHCCCCCCCCC	56.10	26051181
671	Succinylation	AQAYQTGKDISTNYY HHHHHHCCCCCCCCC	56.10	23954790
671	Ubiquitination	AQAYQTGKDISTNYY HHHHHHCCCCCCCCC	56.10	21890473
674	Phosphorylation	YQTGKDISTNYYASQ HHHCCCCCCCCCCCC	22.27	28152594
675	Phosphorylation	QTGKDISTNYYASQK HHCCCCCCCCCCCCC	27.81	21406692
677	Nitration	GKDISTNYYASQKKT CCCCCCCCCCCCCCE	10.66	-
677	Phosphorylation	GKDISTNYYASQKKT CCCCCCCCCCCCCCE	10.66	28152594
678	Phosphorylation	KDISTNYYASQKKTF CCCCCCCCCCCCCEE	11.22	25884760
680	Phosphorylation	ISTNYYASQKKTFEI CCCCCCCCCCCEEEC	26.81	28152594
682	Acetylation	TNYYASQKKTFEINP CCCCCCCCCEEECCC	51.81	25953088
682	Succinylation	TNYYASQKKTFEINP CCCCCCCCCEEECCC	51.81	27452117
682	Ubiquitination	TNYYASQKKTFEINP CCCCCCCCCEEECCC	51.81	-
683	Acetylation	NYYASQKKTFEINPR CCCCCCCCEEECCCC	51.30	26822725
683	Ubiquitination	NYYASQKKTFEINPR CCCCCCCCEEECCCC	51.30	-
684	Phosphorylation	YYASQKKTFEINPRH CCCCCCCEEECCCCC	33.27	20068231
690	Methylation	KTFEINPRHPLIRDM CEEECCCCCHHHHHH	39.30	-
702	Acetylation	RDMLRRIKEDEDDKT HHHHHHHHCCCCCCC	58.25	26051181
702	Succinylation	RDMLRRIKEDEDDKT HHHHHHHHCCCCCCC	58.25	23954790
725	Phosphorylation	FETATLRSGYLLPDT HHHCCCCCCCCCCCC	34.60	28152594
727	Phosphorylation	TATLRSGYLLPDTKA HCCCCCCCCCCCCHH	13.30	28152594
733	Ubiquitination	GYLLPDTKAYGDRIE CCCCCCCHHHHHHHH	47.17	21890473
735	Phosphorylation	LLPDTKAYGDRIERM CCCCCHHHHHHHHHH	22.55	28152594
738	Methylation	DTKAYGDRIERMLRL CCHHHHHHHHHHHHH	28.45	-
744	Methylation	DRIERMLRLSLNIDP HHHHHHHHHHCCCCC	16.94	-
746	Phosphorylation	IERMLRLSLNIDPDA HHHHHHHHCCCCCCC	16.97	21815630
766	Phosphorylation	PEEEPEETAEDTTED CCCCCCCCCCCCCCC	33.41	28985074
770	Phosphorylation	PEETAEDTTEDTEQD CCCCCCCCCCCCCCC	24.48	20639409
771	Phosphorylation	EETAEDTTEDTEQDE CCCCCCCCCCCCCCC	44.15	20639409
774	Phosphorylation	AEDTTEDTEQDEDEE CCCCCCCCCCCCHHC	29.34	29496963
786	Phosphorylation	DEEMDVGTDEEEETA HHCCCCCCCHHHHHH	39.83	28355574
792	Phosphorylation	GTDEEEETAKESTAE CCCHHHHHHHHHHHH	46.43	22199227
796	Phosphorylation	EEETAKESTAEKDEL HHHHHHHHHHHHHCC	32.01	24275569
797	Phosphorylation	EETAKESTAEKDEL- HHHHHHHHHHHHCC-	39.67	28355574
800	Ubiquitination	AKESTAEKDEL---- HHHHHHHHHCC----	54.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
306	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
347	S	Phosphorylation	Kinase	CSNK1A1	P97633	GPS
669	T	Phosphorylation	Kinase	MAP3K7	O43318	GPS
674	S	Phosphorylation	Kinase	MAP3K7	O43318	GPS
675	T	Phosphorylation	Kinase	MAP3K7	O43318	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ENPL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ENPL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMCA4_HUMAN	SMARCA4	physical	11726552
SMRC2_HUMAN	SMARCC2	physical	11726552
SMRC1_HUMAN	SMARCC1	physical	11726552
CSK21_HUMAN	CSNK2A1	physical	11557039
CSK22_HUMAN	CSNK2A2	physical	11557039
ERBB2_HUMAN	ERBB2	physical	8617772
BIRC2_HUMAN	BIRC2	physical	18239673
OS9_HUMAN	OS9	physical	21559462
GRP78_HUMAN	HSPA5	physical	22939629
PDIA1_HUMAN	P4HB	physical	22939629
GLU2B_HUMAN	PRKCSH	physical	22939629
GANAB_HUMAN	GANAB	physical	22939629
PCNA_HUMAN	PCNA	physical	22939629
RACK1_HUMAN	GNB2L1	physical	22939629
AIMP1_HUMAN	AIMP1	physical	20510162
KCNQ4_HUMAN	KCNQ4	physical	23431407
AF9_HUMAN	MLLT3	physical	20159978
TXD11_HUMAN	TXNDC11	physical	21988832
CAP1_HUMAN	CAP1	physical	22863883
CD37L_HUMAN	CDC37L1	physical	22863883
K1468_HUMAN	KIAA1468	physical	22863883
MCM3_HUMAN	MCM3	physical	22863883
UBP25_HUMAN	USP25	physical	22863883
BIRC2_HUMAN	BIRC2	physical	25361076
OS9_HUMAN	OS9	physical	24899641
ACADM_HUMAN	ACADM	physical	26344197
CALR_HUMAN	CALR	physical	26344197
CLH1_HUMAN	CLTC	physical	26344197
OST48_HUMAN	DDOST	physical	26344197
IPO9_HUMAN	IPO9	physical	26344197
SYMC_HUMAN	MARS	physical	26344197
COX2_HUMAN	COX2	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
SRSF9_HUMAN	SRSF9	physical	26344197
USO1_HUMAN	USO1	physical	26344197
CLUS_HUMAN	CLU	physical	26496610
SE1L1_HUMAN	SEL1L	physical	26496610
EBP_HUMAN	EBP	physical	26496610
OS9_HUMAN	OS9	physical	26496610
SMG1_HUMAN	SMG1	physical	26496610
CO039_HUMAN	C15orf39	physical	26496610
DERL1_HUMAN	DERL1	physical	26496610
KLF16_HUMAN	KLF16	physical	26496610
BRNP1_HUMAN	BRINP1	physical	26496610
P53_HUMAN	TP53	physical	25637791
MDM2_HUMAN	MDM2	physical	25637791
KIT_HUMAN	KIT	physical	25737303
APAF_HUMAN	APAF1	physical	25737303
GBRA1_HUMAN	GABRA1	physical	26945068
STAT1_HUMAN	STAT1	physical	18662321
STAT3_HUMAN	STAT3	physical	18662321
SGT1_HUMAN	SUGT1	physical	27249023
CYBP_HUMAN	CACYBP	physical	27249023

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ENPL_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-62; ASN-107; ASN-217 ANDASN-445, AND MASS SPECTROMETRY.	19159218 [Abstract]
"Elucidation of N-glycosylation sites on human platelet proteins: aglycoproteomic approach."; Lewandrowski U., Moebius J., Walter U., Sickmann A.; Mol. Cell. Proteomics 5:226-233(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-107, AND MASSSPECTROMETRY.	16263699 [Abstract]
"Identification and quantification of N-linked glycoproteins usinghydrazide chemistry, stable isotope labeling and mass spectrometry."; Zhang H., Li X.-J., Martin D.B., Aebersold R.; Nat. Biotechnol. 21:660-666(2003). Cited for: GLYCOSYLATION AT ASN-217 AND ASN-445.	12754519 [Abstract]
Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-677, AND MASSSPECTROMETRY.	18083107 [Abstract]