BRNP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRNP1_HUMAN
• UniProt AC: O60477
• Protein Name: BMP/retinoic acid-inducible neural-specific protein 1
• Gene Name: BRINP1
• Organism: Homo sapiens (Human).
• Sequence Length: 761
• Subcellular Localization: Cytoplasm .
• Protein Description: Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway..
• Protein Sequence: MNWRFVELLYFLFIWGRISVQPSHQEPAGTDQHVSKEFDWLISDRGPFHHSRSYLSFVERHRQGFTTRYKIYREFARWKVRNTAIERRDLVRHPVPLMPEFQRSIRLLGRRPTTQQFIDTIIKKYGTHLLISATLGGEEALTMYMDKSRLDRKSGNATQSVEALHQLASSYFVDRDGTMRRLHEIQISTGAIKVTETRTGPLGCNSYDNLDSVSSVLLQSTESKLHLQGLQIIFPQYLQEKFVQSALSYIMCNGEGEYLCQNSQCRCQCAEEFPQCNCPITDIQIMEYTLANMAKSWAEAYKDLENSDEFKSFMKRLPSNHFLTIGSIHQHWGNDWDLQNRYKLLQSATEAQRQKIQRTARKLFGLSVRCRHNPNHQLPRERTIQQWLARVQSLLYCNENGFWGTFLESQRSCVCHGSTTLCQRPIPCVIGGNNSCAMCSLANISLCGSCNKGYKLYRGRCEPQNVDSERSEQFISFETDLDFQDLELKYLLQKMDSRLYVHTTFISNEIRLDTFFDPRWRKRMSLTLKSNKNRMDFIHMVIGMSMRICQMRNSSLDPMFFVYVNPFSGSHSEGWNMPFGEFGYPRWEKIRLQNSQCYNWTLLLGNRWKTFFETVHIYLRSRTRLPTLLRNETGQGPVDLSDPSKRQFYIKISDVQVFGYSLRFNADLLRSAVQQVNQSYTQGGQFYSSSSVMLLLLDIRDRINRLAPPVAPGKPQLDLFSCMLKHRLKLTNSEIIRVNHALDLYNTEILKQSDQMTAKLC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	ERHRQGFTTRYKIYR HHHCCCCCHHHHHHH		-
104	O-linked_Glycosylation	LMPEFQRSIRLLGRR CCHHHHHHHHHHCCC		30379171
132	Phosphorylation	YGTHLLISATLGGEE HCCEEEEEEEECCHH		23532336
142	Phosphorylation	LGGEEALTMYMDKSR ECCHHHHHHHHCHHH		23532336
156	N-linked_Glycosylation	RLDRKSGNATQSVEA HCCCCCCCHHHHHHH		UniProtKB CARBOHYD
281	Phosphorylation	PQCNCPITDIQIMEY CCCCCCCCCHHHHHH		24043423
288	Phosphorylation	TDIQIMEYTLANMAK CCHHHHHHHHHHHHH		24043423
289	Phosphorylation	DIQIMEYTLANMAKS CHHHHHHHHHHHHHH		24043423
358	Dimethylation	AQRQKIQRTARKLFG HHHHHHHHHHHHHHC		-
367	Phosphorylation	ARKLFGLSVRCRHNP HHHHHCCCCCCCCCC		24719451
433	N-linked_Glycosylation	IPCVIGGNNSCAMCS CCEEECCCCCCCHHC		UniProtKB CARBOHYD
443	N-linked_Glycosylation	CAMCSLANISLCGSC CCHHCCCCEEECCCC		UniProtKB CARBOHYD
525	Phosphorylation	PRWRKRMSLTLKSNK HHHHHHHEEEECCCC		24719451
553	N-linked_Glycosylation	MRICQMRNSSLDPMF HHHHHHCCCCCCCEE		UniProtKB CARBOHYD
599	N-linked_Glycosylation	LQNSQCYNWTLLLGN ECCCCEECEEEEECC		UniProtKB CARBOHYD
623	Phosphorylation	HIYLRSRTRLPTLLR HHHHHCCCCCCCCCC		23403867
627	O-linked_Glycosylation	RSRTRLPTLLRNETG HCCCCCCCCCCCCCC		30379171
627	Phosphorylation	RSRTRLPTLLRNETG HCCCCCCCCCCCCCC		23403867
631	N-linked_Glycosylation	RLPTLLRNETGQGPV CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
661	Phosphorylation	DVQVFGYSLRFNADL CEEEEEEEEEECHHH		24719451
677	N-linked_Glycosylation	RSAVQQVNQSYTQGG HHHHHHHHHHHHCCC		UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRNP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRNP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRNP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUV91_HUMAN	SUV39H1	physical	19218236
RPB1_HUMAN	POLR2A	physical	22446626
ROA1_HUMAN	HNRNPA1	physical	22446626
SIR1_HUMAN	SIRT1	physical	22446626
SIR1_HUMAN	SIRT1	physical	18235501
RAC1_HUMAN	RAC1	physical	21988832
PBIP1_HUMAN	PBXIP1	physical	26186194
P53_HUMAN	TP53	physical	25732823

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.