GBRA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRA1_HUMAN
• UniProt AC: P14867
• Protein Name: Gamma-aminobutyric acid receptor subunit alpha-1
• Gene Name: GABRA1
• Organism: Homo sapiens (Human).
• Sequence Length: 456
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .
• Protein Description: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity)..
• Protein Sequence: MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	ILLLSTLTGRSYGQP HHHHHHHHCCCCCCC	30.55	-
38	N-linked_Glycosylation	LQDELKDNTTVFTRI CCHHHCCCCHHHHHH	35.74	UniProtKB CARBOHYD
53	Phosphorylation	LDRLLDGYDNRLRPG HHHHHCCCCCCCCCC	15.09	22817900
87	Phosphorylation	VSDHDMEYTIDVFFR CCCCCCEEEEEEEEE	11.45	-
88	Phosphorylation	SDHDMEYTIDVFFRQ CCCCCEEEEEEEEEC	9.44	-
138	N-linked_Glycosylation	GKKSVAHNMTMPNKL CCCCCCCCCCCCCCE	20.20	UniProtKB CARBOHYD
149	Phosphorylation	PNKLLRITEDGTLLY CCCEEEECCCCCEEE	22.91	24043423
153	Phosphorylation	LRITEDGTLLYTMRL EEECCCCCEEEEEEE	26.38	24043423
156	Phosphorylation	TEDGTLLYTMRLTVR CCCCCEEEEEEEEEE	11.12	24043423
157	Phosphorylation	EDGTLLYTMRLTVRA CCCCEEEEEEEEEEE	8.86	24043423
232	Phosphorylation	VDSGIVQSSTGEYVV CCCCEEECCCCCEEE	20.97	-
237	Phosphorylation	VQSSTGEYVVMTTHF EECCCCCEEEEEEEE	10.33	-
278	Phosphorylation	SFWLNRESVPARTVF HHHHCCCCCCHHHCC	30.11	-
368	Phosphorylation	LIKKNNTYAPTATSY CCCCCCCCCCCCCCC	16.83	19060867
371	Phosphorylation	KNNTYAPTATSYTPN CCCCCCCCCCCCCCC	34.10	30576142
373	Phosphorylation	NTYAPTATSYTPNLA CCCCCCCCCCCCCCC	25.41	30576142
374	Phosphorylation	TYAPTATSYTPNLAR CCCCCCCCCCCCCCC	25.25	30576142
375	Phosphorylation	YAPTATSYTPNLARG CCCCCCCCCCCCCCC	23.12	19060867
376	Phosphorylation	APTATSYTPNLARGD CCCCCCCCCCCCCCC	12.88	24076635
388	Phosphorylation	RGDPGLATIAKSATI CCCCCCCHHHHCCCC	26.89	30243723
392	Phosphorylation	GLATIAKSATIEPKE CCCHHHHCCCCCCCC	22.94	30243723
404	Phosphorylation	PKEVKPETKPPEPKK CCCCCCCCCCCCCCC	58.33	26546556

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBRA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPCG_HUMAN	PRKCG	physical	12091471
KPCD_HUMAN	PRKCD	physical	12091471
OS9_HUMAN	OS9	physical	26945068
ENPL_HUMAN	HSP90B1	physical	26945068
CALX_HUMAN	CANX	physical	26945068
TERA_HUMAN	VCP	physical	26945068
SYVN1_HUMAN	SYVN1	physical	26945068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.