dbPTM

SMG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SMG1_HUMAN
UniProt AC	Q96Q15
Protein Name	Serine/threonine-protein kinase SMG1
Gene Name	SMG1
Organism	Homo sapiens (Human).
Sequence Length	3661
Subcellular Localization	Nucleus . Cytoplasm .
Protein Description	Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ..
Protein Sequence	MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSPEFTSVQHGSRALATKDMRKSQERSMSYSDESRLSNLLRRITREDDRDRRLATVKQLKEFIQQPENKLVLVKQLDNILAAVHDVLNESSKLLQELRQEGACCLGLLCASLSYEAEKIFKWIFSKFSSSAKDEVKLLYLCATYKALETVGEKKAFSSVMQLVMTSLQSILENVDTPELLCKCVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPSLTQQVSGWLQSLEPFWVADLAFSTTLLGQFLEDMEAYAEDLSHVASGESVDEDVPPPSVSLPKLAALLRVFSTVVRSIGERFSPIRGPPITEAYVTDVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGSLDPSMTIHCDMVITYGLDQLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSSKLLFLRYHKEKEVVAVAHAVYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIKHEAFKNHVFNVDNAKFVVIFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSIILNLLGILLKKDNLNQDTRKLLMTWALEAAVLMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQACSSLHALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSIPLDVVLSNNNHTEIQEISLALRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQSTIPRNLLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTTADNDEGHGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEALCELHCPEAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSFDKSVLTLANAGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACECYISIADWAAVQEWQNAIHDLKKSTSSTSLNLKADFNYIKSLSSFESGKFVECTEQLELLPGENINLLAGGSKEKIDMKKLLPNMLSPDPRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITENVVKYLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSEALRSCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNVSLATRLLAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHAMEMLSSCAISFCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQVYRAQHQQNFTGLSTLSKNILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSWAALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQAVCRPAGIQDEDITLQITESEDNEEDDMVDVIWRQLISSCPWLSELDESATEGVIKVWRKVVDRIFSLYKLSCSAYFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDDMIVMATLRLLRLLVKHAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPHLILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGLNEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWFQDNYGDAIENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEEISPWLAAMTNTEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEGVDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHYATVALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGELIQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREARSTQVNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQVEAKDFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTGLEHPIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMGQVRSQEHVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRRAPGSR ------CCCCCCCCC	41.60	24719451
3 (in isoform 2)	Phosphorylation	-	51.11	22210691
8	Phosphorylation	MSRRAPGSRLSSGGG CCCCCCCCCCCCCCC	29.05	24719451
11	Phosphorylation	RAPGSRLSSGGGGGG CCCCCCCCCCCCCCC	26.31	30576142
12	Phosphorylation	APGSRLSSGGGGGGT CCCCCCCCCCCCCCC	46.15	24532841
17	Ubiquitination	LSSGGGGGGTKYPRS CCCCCCCCCCCCCCC	43.82	24816145
19	Phosphorylation	SGGGGGGTKYPRSWN CCCCCCCCCCCCCCC	30.58	20068231
21	Phosphorylation	GGGGGTKYPRSWNDW CCCCCCCCCCCCCCC	12.06	20068231
32	Phosphorylation	WNDWQPRTDSASADP CCCCCCCCCCCCCCC	40.77	25850435
34	Phosphorylation	DWQPRTDSASADPDN CCCCCCCCCCCCCCC	24.42	25159151
36	Phosphorylation	QPRTDSASADPDNLK CCCCCCCCCCCCCCC	36.84	25850435
43	Methylation	SADPDNLKYSSSRDR CCCCCCCCCCCCCCC	49.71	115980883
43	Ubiquitination	SADPDNLKYSSSRDR CCCCCCCCCCCCCCC	49.71	24816145
44	Phosphorylation	ADPDNLKYSSSRDRG CCCCCCCCCCCCCCC	19.56	-
50	Methylation	KYSSSRDRGGSSSYG CCCCCCCCCCCCCCC	50.71	115368545
53	Phosphorylation	SSRDRGGSSSYGLQP CCCCCCCCCCCCCCC	20.95	29255136
54	Phosphorylation	SRDRGGSSSYGLQPS CCCCCCCCCCCCCCC	30.74	29255136
55	Phosphorylation	RDRGGSSSYGLQPSN CCCCCCCCCCCCCCC	25.56	29255136
56	Phosphorylation	DRGGSSSYGLQPSNS CCCCCCCCCCCCCCC	24.65	28555341
61	Phosphorylation	SSYGLQPSNSAVVSR CCCCCCCCCCEEEEE	30.38	29255136
63	Phosphorylation	YGLQPSNSAVVSRQR CCCCCCCCEEEEECC	27.12	29255136
67	Phosphorylation	PSNSAVVSRQRHDDT CCCCEEEEECCCCCC	18.98	29255136
94	Phosphorylation	GYSVNGGSGENTYGR CCCCCCCCCCCCCCC	44.31	25159151
98	Phosphorylation	NGGSGENTYGRKSLG CCCCCCCCCCCCCCC	24.05	30257219
99	Phosphorylation	GGSGENTYGRKSLGQ CCCCCCCCCCCCCCC	26.89	30257219
103	Phosphorylation	ENTYGRKSLGQELRV CCCCCCCCCCCEEEE	36.05	21815630
114	Phosphorylation	ELRVNNVTSPEFTSV EEEECCCCCCCCCCC	40.46	22199227
115	Phosphorylation	LRVNNVTSPEFTSVQ EEECCCCCCCCCCCC	20.39	25159151
119	Phosphorylation	NVTSPEFTSVQHGSR CCCCCCCCCCCCCCC	26.73	29978859
120	Phosphorylation	VTSPEFTSVQHGSRA CCCCCCCCCCCCCCE	25.71	29396449
125	Phosphorylation	FTSVQHGSRALATKD CCCCCCCCCEECCHH	16.56	27251275
130	Phosphorylation	HGSRALATKDMRKSQ CCCCEECCHHHHHHH	28.55	-
131	Acetylation	GSRALATKDMRKSQE CCCEECCHHHHHHHH	43.87	178226545
136	Phosphorylation	ATKDMRKSQERSMSY CCHHHHHHHHHHCCC	27.23	-
140	Phosphorylation	MRKSQERSMSYSDES HHHHHHHHCCCCCHH	16.01	19276368
142	Phosphorylation	KSQERSMSYSDESRL HHHHHHCCCCCHHHH	23.80	28985074
143	Phosphorylation	SQERSMSYSDESRLS HHHHHCCCCCHHHHH	16.11	24043423
144	Phosphorylation	QERSMSYSDESRLSN HHHHCCCCCHHHHHH	27.82	24043423
147	Phosphorylation	SMSYSDESRLSNLLR HCCCCCHHHHHHHHH	43.44	24043423
157	Phosphorylation	SNLLRRITREDDRDR HHHHHHHHCCCHHHH	26.62	-
170	Ubiquitination	DRRLATVKQLKEFIQ HHHHHHHHHHHHHHH	45.63	29967540
173	Acetylation	LATVKQLKEFIQQPE HHHHHHHHHHHHCCC	48.35	19608861
173	Malonylation	LATVKQLKEFIQQPE HHHHHHHHHHHHCCC	48.35	26320211
173	Ubiquitination	LATVKQLKEFIQQPE HHHHHHHHHHHHCCC	48.35	19608861
182	Ubiquitination	FIQQPENKLVLVKQL HHHCCCCCEEHHHHH	38.01	29967540
238	Phosphorylation	KIFKWIFSKFSSSAK HHHHHHHHHCCCCCC	24.53	24719451
252	Phosphorylation	KDEVKLLYLCATYKA CHHHHHHHHHHHHHH	15.35	20068231
256	Phosphorylation	KLLYLCATYKALETV HHHHHHHHHHHHHHH	25.26	19835603
257	Phosphorylation	LLYLCATYKALETVG HHHHHHHHHHHHHHC	3.92	19835603
258	Acetylation	LYLCATYKALETVGE HHHHHHHHHHHHHCC	41.98	26051181
262	Phosphorylation	ATYKALETVGEKKAF HHHHHHHHHCCHHHH	34.36	19835603
270	Phosphorylation	VGEKKAFSSVMQLVM HCCHHHHHHHHHHHH	27.21	22210691
271	Phosphorylation	GEKKAFSSVMQLVMT CCHHHHHHHHHHHHH	18.37	22210691
389 (in isoform 2)	Ubiquitination	-	47.62	21890473
407	Phosphorylation	ALLRVFSTVVRSIGE HHHHHHHHHHHHHHH	16.14	24719451
411	Phosphorylation	VFSTVVRSIGERFSP HHHHHHHHHHHHCCC	24.28	23403867
425	Phosphorylation	PIRGPPITEAYVTDV CCCCCCCCHHHHHHH	21.97	20068231
458 (in isoform 2)	Ubiquitination	-	26.34	21890473
468 (in isoform 2)	Ubiquitination	-	34.62	21890473
477	Ubiquitination	SMTIHCDMVITYGLD CCEEEECEEEEECHH	2.60	21890473
485	Ubiquitination	VITYGLDQLENCQTC EEEECHHHHHCCCCC	56.57	20639865
503	Ubiquitination	YIISVLNLLTLIVEQ HHHHHHHHHHHHHHH	3.19	21890473
511	Ubiquitination	LTLIVEQINTKLPSS HHHHHHHHHCCCCHH	4.47	20639865
517	Phosphorylation	QINTKLPSSFVEKLF HHHCCCCHHHHHHHH	47.01	25850435
518	Phosphorylation	INTKLPSSFVEKLFI HHCCCCHHHHHHHHC	31.22	25850435
529	Ubiquitination	KLFIPSSKLLFLRYH HHHCCHHHEEEEECC	54.25	21963094
529 (in isoform 1)	Ubiquitination	-	54.25	21890473
537	Ubiquitination	LLFLRYHKEKEVVAV EEEEECCCCCHHHHH	62.64	20639865
541	Ubiquitination	RYHKEKEVVAVAHAV ECCCCCHHHHHHHHH	5.05	22817900
546	Ubiquitination	KEVVAVAHAVYQAVL CHHHHHHHHHHHHHH	14.77	21890473
549	Phosphorylation	VAVAHAVYQAVLSLK HHHHHHHHHHHHHCC	7.49	-
554	Phosphorylation	AVYQAVLSLKNIPVL HHHHHHHHCCCCCHH	30.60	24719451
567	Ubiquitination	VLETAYKLILGEMTC HHHHHHHHHHHHHHH	2.26	22817900
572	Ubiquitination	YKLILGEMTCALNNL HHHHHHHHHHHHHHH	3.37	21890473
593	Ubiquitination	PEACSEIKHEAFKNH CHHHHHHCHHHHHCC	31.20	22817900
598	Ubiquitination	EIKHEAFKNHVFNVD HHCHHHHHCCCCCCC	53.87	27667366
598 (in isoform 1)	Ubiquitination	-	53.87	21890473
602	Ubiquitination	EAFKNHVFNVDNAKF HHHHCCCCCCCCCCE	6.00	27667366
602 (in isoform 3)	Ubiquitination	-	6.00	21906983
608	Ubiquitination	VFNVDNAKFVVIFDL CCCCCCCCEEEEEEH	44.97	21906983
635	Phosphorylation	LIGMWALSPTVFALL CHHHHCCCHHHHHHH	15.69	-
637	Phosphorylation	GMWALSPTVFALLSK HHHCCCHHHHHHHCC	25.53	-
643	Phosphorylation	PTVFALLSKNLMIVH HHHHHHHCCCCEEEE	21.98	-
708	Phosphorylation	TATKKHFSIILNLLG HHCHHHHHHHHHHHH	14.40	29396449
720 (in isoform 4)	Ubiquitination	-	52.39	21906983
753	Phosphorylation	ETYAPLFSLPSFHKF CCCHHHCCCHHHHHH	47.24	-
819	Acetylation	RIRQAFGKLLKSIPL HHHHHHHHHHHHCCC	44.16	25953088
819	Ubiquitination	RIRQAFGKLLKSIPL HHHHHHHHHHHHCCC	44.16	-
823	Phosphorylation	AFGKLLKSIPLDVVL HHHHHHHHCCCEEEE	29.43	22210691
847	Phosphorylation	EISLALRSHMSKAPS HHHHHHHHHHCCCCC	25.13	22210691
850	Phosphorylation	LALRSHMSKAPSNTF HHHHHHHCCCCCCCC	21.90	22210691
879	Ubiquitination	GNSHRTGKDNWLERL CCCCCCCCCCHHHHH	47.47	-
899	Phosphorylation	RLDKRDQSTIPRNLL HCCCCCCCCCCHHHH	32.37	23312004
900	Phosphorylation	LDKRDQSTIPRNLLK CCCCCCCCCCHHHHH	29.39	23312004
995	Phosphorylation	ENLEKLMYNAYEGCA HHHHHHHHHHHHHHH	13.69	-
998	Phosphorylation	EKLMYNAYEGCANAL HHHHHHHHHHHHHHH	14.82	-
1002	Ubiquitination	YNAYEGCANALTSPP HHHHHHHHHHHCCCC	18.39	24816145
1005 (in isoform 2)	Phosphorylation	-	4.96	21406692
1006	Phosphorylation	EGCANALTSPPKVIR HHHHHHHCCCCCHHE	36.46	-
1007	Phosphorylation	GCANALTSPPKVIRT HHHHHHCCCCCHHEE	39.80	-
1047	Phosphorylation	LAGQPAVTVRHGFDL HCCCCEEEEECCHHH	17.58	-
1092 (in isoform 2)	Ubiquitination	-	1.28	21890473
1145	Phosphorylation	CISSFDKSVLTLANA EHHCCCHHHHHHHHC	24.97	21406692
1148	Phosphorylation	SFDKSVLTLANAGRN CCCHHHHHHHHCCCC	22.97	21406692
1156	Phosphorylation	LANAGRNSASPKHSL HHHCCCCCCCCCCCC	28.85	24719451
1158	Phosphorylation	NAGRNSASPKHSLNG HCCCCCCCCCCCCCC	34.01	28985074
1169	Ubiquitination	SLNGESRKTVLSKPT CCCCCCCCEECCCCC	52.87	29967540
1174	Ubiquitination	SRKTVLSKPTDSSPE CCCEECCCCCCCCHH	48.02	29967540
1180	Ubiquitination	SKPTDSSPEVINYLG CCCCCCCHHHHHHHC	43.77	27667366
1206	Ubiquitination	DWAAVQEWQNAIHDL HHHHHHHHHHHHHHH	4.61	27667366
1215	Ubiquitination	NAIHDLKKSTSSTSL HHHHHHHHCCCCCCC	67.28	29967540
1218	Phosphorylation	HDLKKSTSSTSLNLK HHHHHCCCCCCCEEE	38.42	25159151
1221	Phosphorylation	KKSTSSTSLNLKADF HHCCCCCCCEEEECH	19.74	-
1232	Ubiquitination	KADFNYIKSLSSFES EECHHHHHCHHHHCC	34.68	21906983
1232 (in isoform 1)	Ubiquitination	-	34.68	21890473
1241	Ubiquitination	LSSFESGKFVECTEQ HHHHCCCCEEEECCC	56.36	29967540
1265	Ubiquitination	NLLAGGSKEKIDMKK EECCCCCHHHCCHHH	67.32	29967540
1279	Phosphorylation	KLLPNMLSPDPRELQ HHCCCCCCCCHHHHH	19.25	28348404
1287	Acetylation	PDPRELQKSIEVQLL CCHHHHHHHHHHHHH	67.06	12650533
1287	Ubiquitination	PDPRELQKSIEVQLL CCHHHHHHHHHHHHH	67.06	33845483
1325	Acetylation	ENVVKYLKQTSRIAI HHHHHHHHHCCCEEE	48.73	25953088
1359	Ubiquitination	LQLYCSSALENTVSN HHHHHHHHHHHHHHC	11.55	24816145
1359 (in isoform 3)	Ubiquitination	-	11.55	21906983
1411	Ubiquitination	NQLLEKIKEQTVPIR HHHHHHHHHCCCCCH	55.63	29967540
1455	Ubiquitination	CSEVQLGKTTTAQDL CCCCCCCCCCCHHHH	51.82	29967540
1467	Ubiquitination	QDLVQHFKKLSTQGQ HHHHHHHHHHHCCCC	51.16	29967540
1468	Ubiquitination	DLVQHFKKLSTQGQV HHHHHHHHHHCCCCC	46.88	29967540
1478	Ubiquitination	TQGQVDEKWGPELDI CCCCCCCCCCCCCCH	53.65	29967540
1488	Phosphorylation	PELDIEKTKLLYTAG CCCCHHHHEEEEECC	17.71	25022875
1492	Phosphorylation	IEKTKLLYTAGQSTH HHHHEEEEECCCCHH	12.65	25022875
1493	Phosphorylation	EKTKLLYTAGQSTHA HHHEEEEECCCCHHH	25.04	25022875
1497	Phosphorylation	LLYTAGQSTHAMEML EEEECCCCHHHHHHH	22.65	25022875
1498	Phosphorylation	LYTAGQSTHAMEMLS EEECCCCHHHHHHHH	13.03	25022875
1505	Phosphorylation	THAMEMLSSCAISFC HHHHHHHHHHHHHHH	23.28	25022875
1506	Phosphorylation	HAMEMLSSCAISFCK HHHHHHHHHHHHHHH	12.01	25022875
1510	Phosphorylation	MLSSCAISFCKSVKA HHHHHHHHHHHHHHH	13.18	25022875
1513	Acetylation	SCAISFCKSVKAEYA HHHHHHHHHHHHHHH	57.16	11688505
1514	Phosphorylation	CAISFCKSVKAEYAV HHHHHHHHHHHHHHH	29.99	25022875
1516	Acetylation	ISFCKSVKAEYAVAK HHHHHHHHHHHHHHH	42.46	11688515
1516	Ubiquitination	ISFCKSVKAEYAVAK HHHHHHHHHHHHHHH	42.46	29967540
1519	Phosphorylation	CKSVKAEYAVAKSIL HHHHHHHHHHHHHHH	15.96	-
1523	Acetylation	KAEYAVAKSILTLAK HHHHHHHHHHHHHHH	31.28	19413330
1527	Phosphorylation	AVAKSILTLAKWIQA HHHHHHHHHHHHHHH	24.01	19413330
1537	Acetylation	KWIQAEWKEISGQLK HHHHHHHHHHHHHHH	36.35	25953088
1544	Ubiquitination	KEISGQLKQVYRAQH HHHHHHHHHHHHHHH	29.81	29967540
1580	Ubiquitination	SVNTMEEEYPRIESE CCCCCCHHCCCCCCC	47.75	24816145
1602	Ubiquitination	GEPDFILGQLYHLSS CCCCCHHHHHHHHHC	15.61	23503661
1606	Ubiquitination	FILGQLYHLSSVQAP CHHHHHHHHHCCCCH	28.03	24816145
1624	Phosphorylation	KSWAALASWAYRWGR HHHHHHHHHHHHCCC	17.06	30206219
1627	Phosphorylation	AALASWAYRWGRKVV HHHHHHHHHCCCCHH	10.71	30206219
1632	Ubiquitination	WAYRWGRKVVDNASQ HHHHCCCCHHCCCCC	42.55	24816145
1638	Phosphorylation	RKVVDNASQGEGVRL CCHHCCCCCCCCCEE	45.00	-
1650	Ubiquitination	VRLLPREKSEVQNLL CEECCCCHHHHHHHC	53.87	29967540
1660	Phosphorylation	VQNLLPDTITEEEKE HHHHCCCCCCHHHHH	28.05	-
1666	Ubiquitination	DTITEEEKERIYGIL CCCCHHHHHHHHHHH	56.42	29967540
1789	Phosphorylation	DDMIVMATLRLLRLL CHHHHHHHHHHHHHH	8.36	-
1798	Ubiquitination	RLLRLLVKHAGELRQ HHHHHHHHHHHHHHH	27.92	-
1806	Phosphorylation	HAGELRQYLEHGLET HHHHHHHHHHHCCCC	13.97	24043423
1813	Phosphorylation	YLEHGLETTPTAPWR HHHHCCCCCCCCCCC	43.02	24043423
1814	Phosphorylation	LEHGLETTPTAPWRG HHHCCCCCCCCCCCC	14.85	24043423
1816	Phosphorylation	HGLETTPTAPWRGII HCCCCCCCCCCCCHH	43.17	24043423
1849 (in isoform 2)	Ubiquitination	-	6.52	21890473
1879	Phosphorylation	QASGNKFSTAIPTLL CCCCCCCCCHHHHHH	20.66	30177828
1880	Phosphorylation	ASGNKFSTAIPTLLG CCCCCCCCHHHHHHH	31.57	30177828
1884	Phosphorylation	KFSTAIPTLLGNIQG CCCCHHHHHHHCCCC	28.62	28348404
1897	Phosphorylation	QGEELLVSECEGGSP CCCEEEEEECCCCCC	36.18	20873877
1903	Phosphorylation	VSECEGGSPPASQDS EEECCCCCCCCCCCC	38.27	20873877
1907	Phosphorylation	EGGSPPASQDSNKDE CCCCCCCCCCCCCCC	40.05	20873877
1910	Phosphorylation	SPPASQDSNKDEPKS CCCCCCCCCCCCCCC	37.84	20873877
1917	Phosphorylation	SNKDEPKSGLNEDQA CCCCCCCCCCCHHHH	60.26	25159151
1937	Ubiquitination	YSKIVDKLSSANPTM HHHHHHHHHCCCCCH	4.18	24816145
1963	Ubiquitination	RRVTVLWDELWLGVL HHHHHHHHHHHHHHH	36.63	24816145
1989	Ubiquitination	QQLEDEVKRVQNNNT HHHHHHHHHHHCCCC	44.82	24816145
1989 (in isoform 1)	Ubiquitination	-	44.82	21890473
2038	Ubiquitination	PAETPHEKWFQDNYG CCCCCCHHHCCCCHH	50.72	29967540
2063	Ubiquitination	KTPLNPAKPGSSWIP CCCCCCCCCCCCCCC	51.69	29967540
2087	Phosphorylation	QRAQKRASYILRLEE HHHHHHHHHHHHHHH	19.42	24719451
2092 (in isoform 2)	Ubiquitination	-	6.58	-
2138	Acetylation	LPTKTKPKKLLFLGS ECCCCCCCEEEEECC	58.57	30583779
2139	Acetylation	PTKTKPKKLLFLGSD CCCCCCCEEEEECCC	59.97	30583785
2139	Ubiquitination	PTKTKPKKLLFLGSD CCCCCCCEEEEECCC	59.97	29967540
2145	Phosphorylation	KKLLFLGSDGKSYPY CEEEEECCCCCCCCC	45.39	26074081
2148	Acetylation	LFLGSDGKSYPYLFK EEECCCCCCCCCCCC	52.38	30583791
2149	Phosphorylation	FLGSDGKSYPYLFKG EECCCCCCCCCCCCC	36.55	25884760
2150	Phosphorylation	LGSDGKSYPYLFKGL ECCCCCCCCCCCCCH	10.20	25884760
2152	Phosphorylation	SDGKSYPYLFKGLED CCCCCCCCCCCCHHH	19.28	28152594
2171	Phosphorylation	ERIMQFLSIVNTMFA HHHHHHHHHHHHHHH	26.27	29978859
2175	Phosphorylation	QFLSIVNTMFATINR HHHHHHHHHHHHCCC	11.63	29978859
2179	Phosphorylation	IVNTMFATINRQETP HHHHHHHHCCCCCCC	13.91	29978859
2180	Ubiquitination	VNTMFATINRQETPR HHHHHHHCCCCCCCC	3.43	23503661
2185	Phosphorylation	ATINRQETPRFHARH HHCCCCCCCCCEECC	16.07	29978859
2193	Phosphorylation	PRFHARHYSVTPLGT CCCEECCCEECCCCC	10.17	25599653
2194	Phosphorylation	RFHARHYSVTPLGTR CCEECCCEECCCCCC	17.25	25599653
2200	Phosphorylation	YSVTPLGTRSGLIQW CEECCCCCCCCHHHH	29.37	25599653
2206	Ubiquitination	GTRSGLIQWVDGATP CCCCCHHHHCCCCCC	38.90	23503661
2232	Ubiquitination	EAALQAQKAQDSYQT HHHHHHHHHHHHCCC	51.54	23503661
2239	Phosphorylation	KAQDSYQTPQNPGIV HHHHHCCCCCCCCCC	20.71	27251275
2250	Phosphorylation	PGIVPRPSELYYSKI CCCCCCCHHHCCCCH	41.32	30177828
2253	Phosphorylation	VPRPSELYYSKIGPA CCCCHHHCCCCHHHH	11.14	30177828
2254	Phosphorylation	PRPSELYYSKIGPAL CCCHHHCCCCHHHHH	18.99	30177828
2255	Phosphorylation	RPSELYYSKIGPALK CCHHHCCCCHHHHHH	12.30	30177828
2256	Ubiquitination	PSELYYSKIGPALKT CHHHCCCCHHHHHHH	35.24	29967540
2262	Ubiquitination	SKIGPALKTVGLSLD CCHHHHHHHCCEEEE	43.18	33845483
2263	Phosphorylation	KIGPALKTVGLSLDV CHHHHHHHCCEEEEC	22.21	27251275
2267	Phosphorylation	ALKTVGLSLDVSRRD HHHHCCEEEECCCCC	19.32	20873877
2370	Ubiquitination	KSLRVPEKVPFRMTQ CCCCCCCCCCCCCCC	49.49	-
2459	Phosphorylation	REMEREITRSLFSSR HHHHHHHHHHHHHHC	14.95	22210691
2461	Phosphorylation	MEREITRSLFSSRVA HHHHHHHHHHHHCCE	25.72	22210691
2471	Ubiquitination	SSRVAEIKVNWFKNR HHCCEEEEEEECCCC	22.48	-
2507	Ubiquitination	EQLTDVEKLQGKLLE HHHCCHHHHHHHHHH	46.06	29967540
2511	Ubiquitination	DVEKLQGKLLEEIEF CHHHHHHHHHHHHHH	36.62	29967540
2536	Phosphorylation	SHTLQHRYSEHTQLQ HHHHHHCCCCHHHHH	19.11	28331001
2537	Phosphorylation	HTLQHRYSEHTQLQT HHHHHCCCCHHHHHH	23.90	28331001
2658	Ubiquitination	YPKAIFQKHRIEQWK CHHHHHHHHHHHHHH	24.89	29967540
2713	Phosphorylation	TEMTLQRYAADINSR HHHHHHHHHHHHHHH	7.99	21253578
2729	Ubiquitination	IRQVERLKQEAVTVP HHHHHHHHHHCCCCC	52.92	-
2776	Phosphorylation	ISALCTLTRRNLMME HHHHHHHHHHHHHHH	14.94	-
2787	Phosphorylation	LMMEGAASSAGEQLV HHHHCCCCCCCCHHH	21.86	26074081
2788	Phosphorylation	MMEGAASSAGEQLVD HHHCCCCCCCCHHHH	35.25	26074081
2797	Phosphorylation	GEQLVDLTSRDGAWF CCHHHHCCCCCCCHH	19.77	26074081
2798	Phosphorylation	EQLVDLTSRDGAWFL CHHHHCCCCCCCHHH	35.35	26074081
2910	Phosphorylation	LVESLQAYLRNAAMG HHHHHHHHHHHHHHC	8.01	20068231
2955	Phosphorylation	VDETPKMSAGQMLLV CCCCCCCCHHHEEEH	35.06	-
3030	Ubiquitination	LKRLQTIKEFFRLCG HHHHHHHHHHHHHHC	52.43	-
3065	Ubiquitination	PVQIVNVKTLFRNSC CEEEEEHHHHHCCCC	34.02	-
3140	Ubiquitination	SVDDLCKKAVEHNIQ CHHHHHHHHHHCCCC	57.58	29967540
3152	Phosphorylation	NIQIGKFSQLVMNRA CCCHHHHHHHHHHHH	26.54	30387612
3156	Sulfoxidation	GKFSQLVMNRATVLA HHHHHHHHHHHHHHH	3.70	21406390
3164	Phosphorylation	NRATVLASSYDTAWK HHHHHHHHCCCCHHH	25.85	25627689
3165	Phosphorylation	RATVLASSYDTAWKK HHHHHHHCCCCHHHH	22.78	25627689
3166	Phosphorylation	ATVLASSYDTAWKKH HHHHHHCCCCHHHHH	18.15	25627689
3168	Phosphorylation	VLASSYDTAWKKHDL HHHHCCCCHHHHHHH	26.61	25627689
3181	Phosphorylation	DLVRRLETSISSCKT HHHHHHHHHHHHCHH	35.63	-
3182	Phosphorylation	LVRRLETSISSCKTS HHHHHHHHHHHCHHH	15.88	29449344
3184	Phosphorylation	RRLETSISSCKTSLQ HHHHHHHHHCHHHHH	29.47	29449344
3185	Phosphorylation	RLETSISSCKTSLQR HHHHHHHHCHHHHHH	20.26	29449344
3216	Phosphorylation	INRPQAMSVTPPPRS CCCCCCCCCCCCCHH	26.34	21949786
3218	Phosphorylation	RPQAMSVTPPPRSAI CCCCCCCCCCCHHHH	23.83	21949786
3223	Phosphorylation	SVTPPPRSAILTSMK CCCCCCHHHHHHHHH	25.99	21949786
3227	Phosphorylation	PPRSAILTSMKKKLH CCHHHHHHHHHHHHH	22.21	21949786
3228	Phosphorylation	PRSAILTSMKKKLHT CHHHHHHHHHHHHHH	25.76	27282143
3232	Malonylation	ILTSMKKKLHTLSQI HHHHHHHHHHHHHHH	39.73	26320211
3235	Phosphorylation	SMKKKLHTLSQIETS HHHHHHHHHHHHHHH	38.24	20068231
3237	Phosphorylation	KKKLHTLSQIETSIA HHHHHHHHHHHHHHH	30.21	20068231
3241	Phosphorylation	HTLSQIETSIATVQE HHHHHHHHHHHHHHH	27.36	20068231
3242	Phosphorylation	TLSQIETSIATVQEK HHHHHHHHHHHHHHH	9.46	20068231
3245	Phosphorylation	QIETSIATVQEKLAA HHHHHHHHHHHHHHH	22.50	20068231
3255	Phosphorylation	EKLAALESSIEQRLK HHHHHHHHHHHHHHH	37.15	20068231
3256	Phosphorylation	KLAALESSIEQRLKW HHHHHHHHHHHHHHH	22.29	20068231
3338	Phosphorylation	KRCQQMCSFASQFNS HHHHHHHHHHHHCCC	20.64	30631047
3341	Phosphorylation	QQMCSFASQFNSSVS HHHHHHHHHCCCCHH	33.04	30631047
3380	Phosphorylation	LSAHKQLTQDMSTQR HHHHHHHHHHHHHHH	21.74	24043423
3384	Phosphorylation	KQLTQDMSTQRAIQT HHHHHHHHHHHHHHH	29.67	24043423
3385	Phosphorylation	QLTQDMSTQRAIQTE HHHHHHHHHHHHHHH	18.55	24043423
3410 (in isoform 2)	Phosphorylation	-	30.12	21406692
3416 (in isoform 2)	Phosphorylation	-	31.87	21406692
3426	Ubiquitination	NRQLGDVKHLLKAMA CCHHHCHHHHHHHHH	33.02	29967540
3429 (in isoform 2)	Phosphorylation	-	3.12	21406692
3430 (in isoform 2)	Phosphorylation	-	42.34	21406692
3433 (in isoform 2)	Phosphorylation	-	22.47	21406692
3436 (in isoform 2)	Phosphorylation	-	49.15	21406692
3459	Phosphorylation	VRQFLGEYKSWQDNI HHHHHHHCHHHHHHH	14.44	27794612
3482	Phosphorylation	QAMGQVRSQEHVEML HHHCCCCCHHHHHHH	40.85	20873877
3505	Phosphorylation	ELKTQSQSIYNNLVS HHHHHCHHHHHHHHH	32.08	27080861
3512	Phosphorylation	SIYNNLVSFASPLVT HHHHHHHHHHHCCCC	20.47	27080861
3515	Phosphorylation	NNLVSFASPLVTDAT HHHHHHHHCCCCCCC	19.43	27080861
3519	Phosphorylation	SFASPLVTDATNECS HHHHCCCCCCCCCCC	27.83	27080861
3522	Phosphorylation	SPLVTDATNECSSPT HCCCCCCCCCCCCCC	34.07	26657352
3526	Phosphorylation	TDATNECSSPTSSAT CCCCCCCCCCCCCCC	32.92	26657352
3527	Phosphorylation	DATNECSSPTSSATY CCCCCCCCCCCCCCC	43.80	28464451
3529	Phosphorylation	TNECSSPTSSATYQP CCCCCCCCCCCCCCC	36.94	27080861
3530	Phosphorylation	NECSSPTSSATYQPS CCCCCCCCCCCCCCC	22.74	28464451
3531	Phosphorylation	ECSSPTSSATYQPSF CCCCCCCCCCCCCCH	27.40	27080861
3533	Phosphorylation	SSPTSSATYQPSFAA CCCCCCCCCCCCHHH	25.33	27080861
3534	Phosphorylation	SPTSSATYQPSFAAA CCCCCCCCCCCHHHH	20.38	26074081
3537	Phosphorylation	SSATYQPSFAAAVRS CCCCCCCCHHHHHHC	16.40	26074081
3544	Phosphorylation	SFAAAVRSNTGQKTQ CHHHHHHCCCCCCCC	31.95	23403867
3546	Phosphorylation	AAAVRSNTGQKTQPD HHHHHCCCCCCCCCC	42.08	17525332
3550	Phosphorylation	RSNTGQKTQPDVMSQ HCCCCCCCCCCHHCH	37.13	17525332
3552	Phosphorylation	NTGQKTQPDVMSQNA CCCCCCCCCHHCHHH	41.20	17525332
3556	Phosphorylation	KTQPDVMSQNARKLI CCCCCHHCHHHHHHH	21.82	17525332
3566	Phosphorylation	ARKLIQKNLATSADT HHHHHHHHHCCCCCC	20.66	18669648
3569	Phosphorylation	LIQKNLATSADTPPS HHHHHHCCCCCCCCC	27.84	29255136
3570	Phosphorylation	IQKNLATSADTPPST HHHHHCCCCCCCCCC	20.66	29255136
3572	Phosphorylation	KNLATSADTPPSTVP HHHCCCCCCCCCCCC	60.56	18669648
3573	Phosphorylation	NLATSADTPPSTVPG HHCCCCCCCCCCCCC	36.49	19664994
3576	Phosphorylation	TSADTPPSTVPGTGK CCCCCCCCCCCCCCC	43.15	29255136
3577	Phosphorylation	SADTPPSTVPGTGKS CCCCCCCCCCCCCCC	36.17	30266825
3581	Phosphorylation	PPSTVPGTGKSVACS CCCCCCCCCCCCCCC	35.05	22167270
3584	O-linked_Glycosylation	TVPGTGKSVACSPKK CCCCCCCCCCCCCCC	19.11	30379171
3588	Phosphorylation	TGKSVACSPKKAVRD CCCCCCCCCCCHHCC	29.98	28985074
3619	Methylation	VWKRVKAKLEGRDVD HHHHHHHHHCCCCCC	41.16	116253547
3632	Phosphorylation	VDPNRRMSVAEQVDY CCCCCCCCHHHHHHH	19.16	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SMG1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SMG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SMG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMG1_HUMAN	SMG1	physical	11544179
RENT1_HUMAN	UPF1	physical	11544179
SMG8_HUMAN	SMG8	physical	19417104
SMG9_HUMAN	SMG9	physical	19417104
RENT1_HUMAN	UPF1	physical	19417104
RENT2_HUMAN	UPF2	physical	18256688
RENT1_HUMAN	UPF1	physical	18256688
REN3B_HUMAN	UPF3B	physical	18256688
NCBP2_HUMAN	NCBP2	physical	16452507
RBM8A_HUMAN	RBM8A	physical	16452507
PABP1_HUMAN	PABPC1	physical	16452507
RENT1_HUMAN	UPF1	physical	16452507
RENT2_HUMAN	UPF2	physical	16452507
SMG7_HUMAN	SMG7	physical	16452507
IF4A3_HUMAN	EIF4A3	physical	16452507
REN3B_HUMAN	UPF3B	physical	16452507
REN3A_HUMAN	UPF3A	physical	16452507
MGN_HUMAN	MAGOH	physical	16452507
ERF3B_HUMAN	GSPT2	physical	16452507
ERF3A_HUMAN	GSPT1	physical	16452507
SMG8_HUMAN	SMG8	physical	20371770
SMG9_HUMAN	SMG9	physical	20371770
RENT1_HUMAN	UPF1	physical	20371770
RENT2_HUMAN	UPF2	physical	20371770
IF4A3_HUMAN	EIF4A3	physical	20371770
RBM8A_HUMAN	RBM8A	physical	20371770
MGN_HUMAN	MAGOH	physical	20371770
EF2_HUMAN	EEF2	physical	20371770
HS90A_HUMAN	HSP90AA1	physical	20371770
HSP74_HUMAN	HSPA4	physical	20371770
RUVB1_HUMAN	RUVBL1	physical	20371770
RUVB2_HUMAN	RUVBL2	physical	20371770
TTI1_HUMAN	TTI1	physical	20371770
RPAB1_HUMAN	POLR2E	physical	20371770
TBA1A_HUMAN	TUBA1A	physical	20371770
TBG1_HUMAN	TUBG1	physical	20371770

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SMG1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-173, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3570; THR-3573; SER-3576AND THR-3577, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3570 AND SER-3576, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3550 AND SER-3556, ANDMASS SPECTROMETRY.	17525332 [Abstract]