| UniProt ID | HS90A_HUMAN | |
|---|---|---|
| UniProt AC | P07900 | |
| Protein Name | Heat shock protein HSP 90-alpha | |
| Gene Name | HSP90AA1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 732 | |
| Subcellular Localization | Nucleus . Cytoplasm . Melanosome . Cell membrane . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. | |
| Protein Description | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. [PubMed: 11274138] | |
| Protein Sequence | MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MPEETQTQDQPM ---CCCCCCCCCCCC | 34.94 | 2507541 | |
| 7 | Phosphorylation | -MPEETQTQDQPMEE -CCCCCCCCCCCCCH | 41.34 | 2507541 | |
| 19 | Phosphorylation | MEEEEVETFAFQAEI CCHHHHHHHHHHHHH | 25.99 | 21406692 | |
| 31 | Phosphorylation | AEIAQLMSLIINTFY HHHHHHHHHHHHHHC | 25.63 | 21406692 | |
| 36 | Phosphorylation | LMSLIINTFYSNKEI HHHHHHHHHCCCHHH | 17.34 | 21945579 | |
| 38 | Phosphorylation | SLIINTFYSNKEIFL HHHHHHHCCCHHHHH | 14.86 | 21945579 | |
| 39 | Phosphorylation | LIINTFYSNKEIFLR HHHHHHCCCHHHHHH | 36.92 | 21945579 | |
| 41 | Acetylation | INTFYSNKEIFLREL HHHHCCCHHHHHHHH | 46.37 | 25825284 | |
| 41 | Ubiquitination | INTFYSNKEIFLREL HHHHCCCHHHHHHHH | 46.37 | 21906983 | |
| 50 | Phosphorylation | IFLRELISNSSDALD HHHHHHHHCCCHHHH | 43.19 | 20873877 | |
| 52 | Phosphorylation | LRELISNSSDALDKI HHHHHHCCCHHHHHH | 23.86 | 25159151 | |
| 53 | Phosphorylation | RELISNSSDALDKIR HHHHHCCCHHHHHHC | 31.02 | 23403867 | |
| 58 | Acetylation | NSSDALDKIRYESLT CCCHHHHHHCHHHCC | 29.90 | 23954790 | |
| 58 | Ubiquitination | NSSDALDKIRYESLT CCCHHHHHHCHHHCC | 29.90 | 21890473 | |
| 58 (in isoform 1) | Ubiquitination | - | 29.90 | 21890473 | |
| 59 (in isoform 2) | Phosphorylation | - | 5.91 | 30622161 | |
| 61 | Phosphorylation | DALDKIRYESLTDPS HHHHHHCHHHCCCHH | 17.22 | 27273156 | |
| 63 | Phosphorylation | LDKIRYESLTDPSKL HHHHCHHHCCCHHHC | 27.86 | 25159151 | |
| 65 | Phosphorylation | KIRYESLTDPSKLDS HHCHHHCCCHHHCCC | 55.96 | 25159151 | |
| 68 | Phosphorylation | YESLTDPSKLDSGKE HHHCCCHHHCCCCCE | 48.97 | 21815630 | |
| 69 | Acetylation | ESLTDPSKLDSGKEL HHCCCHHHCCCCCEE | 62.80 | 23954790 | |
| 69 | Ubiquitination | ESLTDPSKLDSGKEL HHCCCHHHCCCCCEE | 62.80 | 6983 | |
| 69 (in isoform 1) | Ubiquitination | - | 62.80 | 21890473 | |
| 72 | Phosphorylation | TDPSKLDSGKELHIN CCHHHCCCCCEEEEE | 63.30 | 20873877 | |
| 73 (in isoform 2) | Phosphorylation | - | 27.42 | - | |
| 74 | Acetylation | PSKLDSGKELHINLI HHHCCCCCEEEEEEC | 62.14 | 26051181 | |
| 74 | Malonylation | PSKLDSGKELHINLI HHHCCCCCEEEEEEC | 62.14 | 26320211 | |
| 74 | Sumoylation | PSKLDSGKELHINLI HHHCCCCCEEEEEEC | 62.14 | - | |
| 74 | Ubiquitination | PSKLDSGKELHINLI HHHCCCCCEEEEEEC | 62.14 | - | |
| 74 (in isoform 1) | Ubiquitination | - | 62.14 | 21890473 | |
| 75 (in isoform 2) | Phosphorylation | - | 49.45 | - | |
| 84 | Acetylation | HINLIPNKQDRTLTI EEEECCCCCCCCEEE | 48.50 | 23954790 | |
| 84 | Ubiquitination | HINLIPNKQDRTLTI EEEECCCCCCCCEEE | 48.50 | 21890473 | |
| 88 | Phosphorylation | IPNKQDRTLTIVDTG CCCCCCCCEEEEECC | 36.22 | 21712546 | |
| 90 | Phosphorylation | NKQDRTLTIVDTGIG CCCCCCEEEEECCCC | 20.52 | 23911959 | |
| 94 | Phosphorylation | RTLTIVDTGIGMTKA CCEEEEECCCCCCHH | 21.58 | 23911959 | |
| 98 | Sulfoxidation | IVDTGIGMTKADLIN EEECCCCCCHHHHHH | 3.08 | 21406390 | |
| 99 | Phosphorylation | VDTGIGMTKADLINN EECCCCCCHHHHHHH | 20.19 | 23911959 | |
| 100 | Acetylation | DTGIGMTKADLINNL ECCCCCCHHHHHHHH | 30.89 | 5768605 | |
| 100 | Succinylation | DTGIGMTKADLINNL ECCCCCCHHHHHHHH | 30.89 | 23954790 | |
| 100 | Ubiquitination | DTGIGMTKADLINNL ECCCCCCHHHHHHHH | 30.89 | - | |
| 109 | Phosphorylation | DLINNLGTIAKSGTK HHHHHHHHHHHHHHH | 22.41 | 25159151 | |
| 112 | Acetylation | NNLGTIAKSGTKAFM HHHHHHHHHHHHHHH | 45.64 | 23236377 | |
| 112 | Ubiquitination | NNLGTIAKSGTKAFM HHHHHHHHHHHHHHH | 45.64 | 21906983 | |
| 112 (in isoform 1) | Ubiquitination | - | 45.64 | 21890473 | |
| 113 | Phosphorylation | NLGTIAKSGTKAFME HHHHHHHHHHHHHHH | 42.55 | 30624053 | |
| 115 | Phosphorylation | GTIAKSGTKAFMEAL HHHHHHHHHHHHHHH | 26.70 | 28464451 | |
| 116 | Ubiquitination | TIAKSGTKAFMEALQ HHHHHHHHHHHHHHH | 43.05 | - | |
| 119 | Sulfoxidation | KSGTKAFMEALQAGA HHHHHHHHHHHHCCC | 3.35 | 30846556 | |
| 127 (in isoform 2) | Phosphorylation | - | 32.36 | 2507541 | |
| 129 | Phosphorylation | LQAGADISMIGQFGV HHCCCCEEEEECCCC | 12.61 | - | |
| 129 (in isoform 2) | Phosphorylation | - | 12.61 | 2507541 | |
| 130 | Sulfoxidation | QAGADISMIGQFGVG HCCCCEEEEECCCCH | 4.00 | 30846556 | |
| 153 | Ubiquitination | EKVTVITKHNDDEQY EEEEEEECCCCCCCE | 29.32 | - | |
| 160 | Phosphorylation | KHNDDEQYAWESSAG CCCCCCCEEEECCCC | 16.19 | 28152594 | |
| 164 | Phosphorylation | DEQYAWESSAGGSFT CCCEEEECCCCCEEE | 18.13 | 28348404 | |
| 165 | Phosphorylation | EQYAWESSAGGSFTV CCEEEECCCCCEEEE | 21.29 | 28348404 | |
| 169 | Phosphorylation | WESSAGGSFTVRTDT EECCCCCEEEEEECC | 19.47 | 25693802 | |
| 171 | Phosphorylation | SSAGGSFTVRTDTGE CCCCCEEEEEECCCC | 15.69 | 24719451 | |
| 180 (in isoform 2) | Ubiquitination | - | 5.07 | 21890473 | |
| 185 | Ubiquitination | EPMGRGTKVILHLKE CCCCCCEEEEEEECC | 30.06 | 21139048 | |
| 185 (in isoform 1) | Ubiquitination | - | 30.06 | 21890473 | |
| 191 | Sumoylation | TKVILHLKEDQTEYL EEEEEEECCCHHHHH | 48.80 | - | |
| 191 | Acetylation | TKVILHLKEDQTEYL EEEEEEECCCHHHHH | 48.80 | 23749302 | |
| 191 | Methylation | TKVILHLKEDQTEYL EEEEEEECCCHHHHH | 48.80 | 30583259 | |
| 191 | Sumoylation | TKVILHLKEDQTEYL EEEEEEECCCHHHHH | 48.80 | - | |
| 191 | Ubiquitination | TKVILHLKEDQTEYL EEEEEEECCCHHHHH | 48.80 | 21906983 | |
| 191 (in isoform 1) | Ubiquitination | - | 48.80 | 21890473 | |
| 191 (in isoform 2) | Ubiquitination | - | 48.80 | 21890473 | |
| 195 | Phosphorylation | LHLKEDQTEYLEERR EEECCCHHHHHHHHH | 38.63 | 28152594 | |
| 196 (in isoform 2) | Ubiquitination | - | 42.35 | 21890473 | |
| 197 | Phosphorylation | LKEDQTEYLEERRIK ECCCHHHHHHHHHHH | 23.85 | 27273156 | |
| 201 | Methylation | QTEYLEERRIKEIVK HHHHHHHHHHHHHHH | 35.93 | - | |
| 204 | Sumoylation | YLEERRIKEIVKKHS HHHHHHHHHHHHHHH | 39.31 | - | |
| 204 | Ubiquitination | YLEERRIKEIVKKHS HHHHHHHHHHHHHHH | 39.31 | - | |
| 206 (in isoform 2) | Ubiquitination | - | 4.71 | - | |
| 208 | Acetylation | RRIKEIVKKHSQFIG HHHHHHHHHHHHHCC | 50.89 | 25953088 | |
| 209 | Acetylation | RIKEIVKKHSQFIGY HHHHHHHHHHHHCCC | 37.28 | 26051181 | |
| 209 | Ubiquitination | RIKEIVKKHSQFIGY HHHHHHHHHHHHCCC | 37.28 | 21890473 | |
| 211 | Phosphorylation | KEIVKKHSQFIGYPI HHHHHHHHHHCCCCE | 35.35 | 28152594 | |
| 216 | Nitration | KHSQFIGYPITLFVE HHHHHCCCCEEEEEE | 6.14 | - | |
| 216 | Phosphorylation | KHSQFIGYPITLFVE HHHHHCCCCEEEEEE | 6.14 | 28152594 | |
| 219 | Phosphorylation | QFIGYPITLFVEKER HHCCCCEEEEEEHHH | 15.05 | 28152594 | |
| 222 (in isoform 2) | Ubiquitination | - | 13.29 | - | |
| 224 | Acetylation | PITLFVEKERDKEVS CEEEEEEHHHCCCCC | 53.39 | 23236377 | |
| 224 | Ubiquitination | PITLFVEKERDKEVS CEEEEEEHHHCCCCC | 53.39 | 21890473 | |
| 224 (in isoform 1) | Ubiquitination | - | 53.39 | 21890473 | |
| 228 | Ubiquitination | FVEKERDKEVSDDEA EEEHHHCCCCCHHHH | 67.26 | 21906983 | |
| 228 (in isoform 1) | Ubiquitination | - | 67.26 | 21890473 | |
| 231 | Phosphorylation | KERDKEVSDDEAEEK HHHCCCCCHHHHHHH | 40.20 | 29255136 | |
| 234 (in isoform 2) | Ubiquitination | - | 64.07 | 21890473 | |
| 238 | Ubiquitination | SDDEAEEKEDKEEEK CHHHHHHHHHHHHHH | 63.82 | - | |
| 245 | Ubiquitination | KEDKEEEKEKEEKES HHHHHHHHHHHHHHC | 76.88 | - | |
| 252 | Phosphorylation | KEKEEKESEDKPEIE HHHHHHHCCCCCCCC | 63.26 | 25159151 | |
| 255 | Ubiquitination | EEKESEDKPEIEDVG HHHHCCCCCCCCCCC | 40.26 | - | |
| 263 | Phosphorylation | PEIEDVGSDEEEEKK CCCCCCCCHHHHHHC | 41.52 | 29255136 | |
| 274 | Acetylation | EEKKDGDKKKKKKIK HHHCCCCHHHHHHHH | 72.52 | 20167786 | |
| 275 | Ubiquitination | EKKDGDKKKKKKIKE HHCCCCHHHHHHHHH | 74.66 | - | |
| 276 | Acetylation | KKDGDKKKKKKIKEK HCCCCHHHHHHHHHH | 75.47 | 20167786 | |
| 281 | Acetylation | KKKKKKIKEKYIDQE HHHHHHHHHHHCCHH | 57.97 | 25953088 | |
| 281 | Ubiquitination | KKKKKKIKEKYIDQE HHHHHHHHHHHCCHH | 57.97 | - | |
| 283 | Acetylation | KKKKIKEKYIDQEEL HHHHHHHHHCCHHHH | 42.37 | 23954790 | |
| 283 | Methylation | KKKKIKEKYIDQEEL HHHHHHHHHCCHHHH | 42.37 | 19608861 | |
| 283 | Ubiquitination | KKKKIKEKYIDQEEL HHHHHHHHHCCHHHH | 42.37 | 21890473 | |
| 283 (in isoform 1) | Ubiquitination | - | 42.37 | 21890473 | |
| 284 | Phosphorylation | KKKIKEKYIDQEELN HHHHHHHHCCHHHHH | 15.72 | 25159151 | |
| 292 | Acetylation | IDQEELNKTKPIWTR CCHHHHHCCCCCCCC | 71.23 | 21466224 | |
| 292 | Malonylation | IDQEELNKTKPIWTR CCHHHHHCCCCCCCC | 71.23 | 26320211 | |
| 292 | Ubiquitination | IDQEELNKTKPIWTR CCHHHHHCCCCCCCC | 71.23 | 19608861 | |
| 292 (in isoform 1) | Ubiquitination | - | 71.23 | 21890473 | |
| 293 | Phosphorylation | DQEELNKTKPIWTRN CHHHHHCCCCCCCCC | 40.76 | 23401153 | |
| 294 | Acetylation | QEELNKTKPIWTRNP HHHHHCCCCCCCCCC | 35.79 | 21466224 | |
| 294 | Methylation | QEELNKTKPIWTRNP HHHHHCCCCCCCCCC | 35.79 | 183419 | |
| 294 | Ubiquitination | QEELNKTKPIWTRNP HHHHHCCCCCCCCCC | 35.79 | - | |
| 294 (in isoform 1) | Ubiquitination | - | 35.79 | 21890473 | |
| 298 | Phosphorylation | NKTKPIWTRNPDDIT HCCCCCCCCCCCCCC | 22.68 | 29978859 | |
| 299 | Methylation | KTKPIWTRNPDDITN CCCCCCCCCCCCCCH | 37.37 | 115367701 | |
| 305 | Phosphorylation | TRNPDDITNEEYGEF CCCCCCCCHHHHHHH | 43.50 | 28152594 | |
| 307 (in isoform 2) | Ubiquitination | - | 43.90 | 21890473 | |
| 309 | Phosphorylation | DDITNEEYGEFYKSL CCCCHHHHHHHHHHH | 18.77 | 28152594 | |
| 313 | Nitration | NEEYGEFYKSLTNDW HHHHHHHHHHHCCCH | 8.72 | - | |
| 313 | Phosphorylation | NEEYGEFYKSLTNDW HHHHHHHHHHHCCCH | 8.72 | 28152594 | |
| 313 (in isoform 2) | Ubiquitination | - | 8.72 | 21890473 | |
| 314 | Acetylation | EEYGEFYKSLTNDWE HHHHHHHHHHCCCHH | 44.29 | 26822725 | |
| 314 | Succinylation | EEYGEFYKSLTNDWE HHHHHHHHHHCCCHH | 44.29 | 23954790 | |
| 314 | Sumoylation | EEYGEFYKSLTNDWE HHHHHHHHHHCCCHH | 44.29 | - | |
| 314 | Ubiquitination | EEYGEFYKSLTNDWE HHHHHHHHHHCCCHH | 44.29 | - | |
| 314 (in isoform 1) | Ubiquitination | - | 44.29 | 21890473 | |
| 315 | Phosphorylation | EYGEFYKSLTNDWED HHHHHHHHHCCCHHH | 29.10 | 30266825 | |
| 317 | Phosphorylation | GEFYKSLTNDWEDHL HHHHHHHCCCHHHCE | 37.92 | 30266825 | |
| 327 | Acetylation | WEDHLAVKHFSVEGQ HHHCEEEEEEEEECE | 33.07 | 21466224 | |
| 327 | Ubiquitination | WEDHLAVKHFSVEGQ HHHCEEEEEEEEECE | 33.07 | 21906983 | |
| 327 (in isoform 1) | Ubiquitination | - | 33.07 | 21890473 | |
| 330 | Phosphorylation | HLAVKHFSVEGQLEF CEEEEEEEEECEEEE | 20.98 | 27251275 | |
| 331 (in isoform 2) | Ubiquitination | - | 10.54 | - | |
| 345 | Methylation | RALLFVPRRAPFDLF EEEEECCCCCCCCCC | 41.93 | 115479795 | |
| 346 (in isoform 2) | Ubiquitination | - | 40.31 | 21890473 | |
| 350 (in isoform 2) | Ubiquitination | - | 49.76 | 21890473 | |
| 355 | Methylation | PFDLFENRKKKNNIK CCCCCCCCCCCCCCE | 45.00 | 115479825 | |
| 357 | Sumoylation | DLFENRKKKNNIKLY CCCCCCCCCCCCEEE | 58.45 | - | |
| 358 | Sumoylation | LFENRKKKNNIKLYV CCCCCCCCCCCEEEE | 59.26 | - | |
| 358 | Ubiquitination | LFENRKKKNNIKLYV CCCCCCCCCCCEEEE | 59.26 | - | |
| 362 | Acetylation | RKKKNNIKLYVRRVF CCCCCCCEEEEEEEE | 35.57 | 23954790 | |
| 362 | Ubiquitination | RKKKNNIKLYVRRVF CCCCCCCEEEEEEEE | 35.57 | 21890473 | |
| 362 (in isoform 1) | Ubiquitination | - | 35.57 | 21890473 | |
| 371 | Sulfoxidation | YVRRVFIMDNCEELI EEEEEECCCCHHHHH | 1.74 | 30846556 | |
| 391 | Phosphorylation | FIRGVVDSEDLPLNI HHHCCCCCCCCCCCC | 22.77 | 20873877 | |
| 399 | Phosphorylation | EDLPLNISREMLQQS CCCCCCCCHHHHHHH | 22.55 | 30266825 | |
| 402 | Sulfoxidation | PLNISREMLQQSKIL CCCCCHHHHHHHHHH | 3.88 | 30846556 | |
| 405 (in isoform 2) | Ubiquitination | - | 42.61 | 21890473 | |
| 406 | Phosphorylation | SREMLQQSKILKVIR CHHHHHHHHHHHHHH | 14.54 | 29116813 | |
| 407 | Sumoylation | REMLQQSKILKVIRK HHHHHHHHHHHHHHH | 47.95 | - | |
| 407 | Acetylation | REMLQQSKILKVIRK HHHHHHHHHHHHHHH | 47.95 | 23954790 | |
| 407 | Malonylation | REMLQQSKILKVIRK HHHHHHHHHHHHHHH | 47.95 | 26320211 | |
| 407 | Sumoylation | REMLQQSKILKVIRK HHHHHHHHHHHHHHH | 47.95 | 19608861 | |
| 407 | Ubiquitination | REMLQQSKILKVIRK HHHHHHHHHHHHHHH | 47.95 | 19608861 | |
| 407 (in isoform 1) | Ubiquitination | - | 47.95 | 21890473 | |
| 410 | Acetylation | LQQSKILKVIRKNLV HHHHHHHHHHHHHHH | 38.80 | 21466224 | |
| 414 | Acetylation | KILKVIRKNLVKKCL HHHHHHHHHHHHHHH | 43.43 | - | |
| 414 (in isoform 2) | Ubiquitination | - | 43.43 | 21890473 | |
| 416 (in isoform 2) | Ubiquitination | - | 7.20 | 21890473 | |
| 419 | Acetylation | IRKNLVKKCLELFTE HHHHHHHHHHHHHHH | 36.25 | 26051181 | |
| 419 | Ubiquitination | IRKNLVKKCLELFTE HHHHHHHHHHHHHHH | 36.25 | 21890473 | |
| 420 | S-nitrosocysteine | RKNLVKKCLELFTEL HHHHHHHHHHHHHHH | 2.71 | - | |
| 420 | Glutathionylation | RKNLVKKCLELFTEL HHHHHHHHHHHHHHH | 2.71 | 22555962 | |
| 420 | S-nitrosylation | RKNLVKKCLELFTEL HHHHHHHHHHHHHHH | 2.71 | 22178444 | |
| 420 | S-palmitoylation | RKNLVKKCLELFTEL HHHHHHHHHHHHHHH | 2.71 | 26865113 | |
| 425 | Phosphorylation | KKCLELFTELAEDKE HHHHHHHHHHHHCHH | 42.59 | 28152594 | |
| 431 | Acetylation | FTELAEDKENYKKFY HHHHHHCHHHHHHHH | 39.09 | 25953088 | |
| 431 | Ubiquitination | FTELAEDKENYKKFY HHHHHHCHHHHHHHH | 39.09 | - | |
| 434 | Phosphorylation | LAEDKENYKKFYEQF HHHCHHHHHHHHHHH | 19.35 | 28152594 | |
| 435 | Acetylation | AEDKENYKKFYEQFS HHCHHHHHHHHHHHH | 48.24 | 25953088 | |
| 436 | Acetylation | EDKENYKKFYEQFSK HCHHHHHHHHHHHHH | 42.70 | 21466224 | |
| 436 | Succinylation | EDKENYKKFYEQFSK HCHHHHHHHHHHHHH | 42.70 | 23954790 | |
| 436 | Ubiquitination | EDKENYKKFYEQFSK HCHHHHHHHHHHHHH | 42.70 | - | |
| 436 (in isoform 1) | Ubiquitination | - | 42.70 | 21890473 | |
| 436 (in isoform 2) | Ubiquitination | - | 42.70 | 21890473 | |
| 438 | Phosphorylation | KENYKKFYEQFSKNI HHHHHHHHHHHHHHC | 20.08 | 28152594 | |
| 442 | Phosphorylation | KKFYEQFSKNIKLGI HHHHHHHHHHCCCCC | 25.20 | 23911959 | |
| 443 | Acetylation | KFYEQFSKNIKLGIH HHHHHHHHHCCCCCC | 65.07 | 19608861 | |
| 443 | Methylation | KFYEQFSKNIKLGIH HHHHHHHHHCCCCCC | 65.07 | 22631459 | |
| 443 | Ubiquitination | KFYEQFSKNIKLGIH HHHHHHHHHCCCCCC | 65.07 | 21890473 | |
| 443 (in isoform 1) | Ubiquitination | - | 65.07 | 21890473 | |
| 446 | Acetylation | EQFSKNIKLGIHEDS HHHHHHCCCCCCCCC | 50.48 | 25953088 | |
| 446 | Ubiquitination | EQFSKNIKLGIHEDS HHHHHHCCCCCCCCC | 50.48 | 21890473 | |
| 446 (in isoform 1) | Ubiquitination | - | 50.48 | 21890473 | |
| 449 (in isoform 2) | Ubiquitination | - | 4.69 | 21890473 | |
| 453 | Phosphorylation | KLGIHEDSQNRKKLS CCCCCCCCHHHHHHH | 26.77 | 23401153 | |
| 457 | Acetylation | HEDSQNRKKLSELLR CCCCHHHHHHHHHHH | 66.66 | 25953088 | |
| 457 | Ubiquitination | HEDSQNRKKLSELLR CCCCHHHHHHHHHHH | 66.66 | - | |
| 458 | Acetylation | EDSQNRKKLSELLRY CCCHHHHHHHHHHHH | 54.75 | 19608861 | |
| 458 | Malonylation | EDSQNRKKLSELLRY CCCHHHHHHHHHHHH | 54.75 | 26320211 | |
| 458 | Ubiquitination | EDSQNRKKLSELLRY CCCHHHHHHHHHHHH | 54.75 | 19608861 | |
| 460 | Phosphorylation | SQNRKKLSELLRYYT CHHHHHHHHHHHHHH | 34.77 | 23898821 | |
| 464 | Methylation | KKLSELLRYYTSASG HHHHHHHHHHHCCCC | 34.73 | 115384095 | |
| 465 | Phosphorylation | KLSELLRYYTSASGD HHHHHHHHHHCCCCC | 15.86 | 28152594 | |
| 466 | Phosphorylation | LSELLRYYTSASGDE HHHHHHHHHCCCCCC | 6.44 | 28152594 | |
| 467 | Phosphorylation | SELLRYYTSASGDEM HHHHHHHHCCCCCCC | 14.64 | 28152594 | |
| 468 | Phosphorylation | ELLRYYTSASGDEMV HHHHHHHCCCCCCCE | 12.33 | 23403867 | |
| 470 | Phosphorylation | LRYYTSASGDEMVSL HHHHHCCCCCCCEEH | 46.69 | 23403867 | |
| 474 | Sulfoxidation | TSASGDEMVSLKDYC HCCCCCCCEEHHHHH | 2.70 | 28465586 | |
| 476 | Phosphorylation | ASGDEMVSLKDYCTR CCCCCCEEHHHHHHH | 28.52 | 25159151 | |
| 478 | Acetylation | GDEMVSLKDYCTRMK CCCCEEHHHHHHHHH | 38.86 | 25953088 | |
| 478 | Ubiquitination | GDEMVSLKDYCTRMK CCCCEEHHHHHHHHH | 38.86 | - | |
| 480 | Phosphorylation | EMVSLKDYCTRMKEN CCEEHHHHHHHHHHH | 8.30 | 28152594 | |
| 481 | S-nitrosocysteine | MVSLKDYCTRMKENQ CEEHHHHHHHHHHHC | 2.52 | - | |
| 481 | Glutathionylation | MVSLKDYCTRMKENQ CEEHHHHHHHHHHHC | 2.52 | 22555962 | |
| 481 | S-nitrosylation | MVSLKDYCTRMKENQ CEEHHHHHHHHHHHC | 2.52 | 22178444 | |
| 482 | Phosphorylation | VSLKDYCTRMKENQK EEHHHHHHHHHHHCC | 27.80 | 28152594 | |
| 484 (in isoform 2) | Ubiquitination | - | 3.26 | 21890473 | |
| 485 | Acetylation | KDYCTRMKENQKHIY HHHHHHHHHHCCEEE | 50.66 | 23749302 | |
| 485 | Ubiquitination | KDYCTRMKENQKHIY HHHHHHHHHHCCEEE | 50.66 | - | |
| 489 | Acetylation | TRMKENQKHIYYITG HHHHHHCCEEEEEEC | 43.48 | 19608861 | |
| 489 | Malonylation | TRMKENQKHIYYITG HHHHHHCCEEEEEEC | 43.48 | 26320211 | |
| 489 | Methylation | TRMKENQKHIYYITG HHHHHHCCEEEEEEC | 43.48 | 156665 | |
| 489 | Ubiquitination | TRMKENQKHIYYITG HHHHHHCCEEEEEEC | 43.48 | 19608861 | |
| 489 (in isoform 1) | Ubiquitination | - | 43.48 | 21890473 | |
| 492 | Phosphorylation | KENQKHIYYITGETK HHHCCEEEEEECCCH | 6.63 | 27273156 | |
| 493 | Phosphorylation | ENQKHIYYITGETKD HHCCEEEEEECCCHH | 7.45 | 28152594 | |
| 495 | Phosphorylation | QKHIYYITGETKDQV CCEEEEEECCCHHHH | 16.91 | 28152594 | |
| 498 | Phosphorylation | IYYITGETKDQVANS EEEEECCCHHHHHHH | 41.06 | 28152594 | |
| 499 | Acetylation | YYITGETKDQVANSA EEEECCCHHHHHHHH | 41.69 | 23954790 | |
| 499 | Ubiquitination | YYITGETKDQVANSA EEEECCCHHHHHHHH | 41.69 | 21890473 | |
| 499 (in isoform 1) | Ubiquitination | - | 41.69 | 21890473 | |
| 505 | Phosphorylation | TKDQVANSAFVERLR CHHHHHHHHHHHHHH | 17.22 | 28152594 | |
| 510 | Methylation | ANSAFVERLRKHGLE HHHHHHHHHHHCCCE | 34.19 | 115479805 | |
| 513 | "N6,N6-dimethyllysine" | AFVERLRKHGLEVIY HHHHHHHHCCCEEEE | 46.76 | - | |
| 513 | Acetylation | AFVERLRKHGLEVIY HHHHHHHHCCCEEEE | 46.76 | 25825284 | |
| 513 | Methylation | AFVERLRKHGLEVIY HHHHHHHHCCCEEEE | 46.76 | 23644510 | |
| 513 | Ubiquitination | AFVERLRKHGLEVIY HHHHHHHHCCCEEEE | 46.76 | - | |
| 520 | Phosphorylation | KHGLEVIYMIEPIDE HCCCEEEEEECCCCH | 9.38 | 22817901 | |
| 521 | Sulfoxidation | HGLEVIYMIEPIDEY CCCEEEEEECCCCHH | 1.60 | 30846556 | |
| 528 | Phosphorylation | MIEPIDEYCVQQLKE EECCCCHHHHHHHHH | 8.32 | 25884760 | |
| 529 | Glutathionylation | IEPIDEYCVQQLKEF ECCCCHHHHHHHHHC | 1.78 | 22555962 | |
| 529 (in isoform 2) | Ubiquitination | - | 1.78 | 21890473 | |
| 534 | Acetylation | EYCVQQLKEFEGKTL HHHHHHHHHCCCCEE | 56.89 | 26051181 | |
| 539 | Acetylation | QLKEFEGKTLVSVTK HHHHCCCCEEEEEEH | 31.33 | 23236377 | |
| 539 | Succinylation | QLKEFEGKTLVSVTK HHHHCCCCEEEEEEH | 31.33 | 23954790 | |
| 539 | Sumoylation | QLKEFEGKTLVSVTK HHHHCCCCEEEEEEH | 31.33 | - | |
| 539 | Ubiquitination | QLKEFEGKTLVSVTK HHHHCCCCEEEEEEH | 31.33 | - | |
| 539 (in isoform 1) | Ubiquitination | - | 31.33 | 21890473 | |
| 540 | Phosphorylation | LKEFEGKTLVSVTKE HHHCCCCEEEEEEHH | 43.16 | 23312004 | |
| 541 (in isoform 2) | Ubiquitination | - | 2.85 | - | |
| 543 | Phosphorylation | FEGKTLVSVTKEGLE CCCCEEEEEEHHCCC | 27.47 | 23312004 | |
| 545 | Phosphorylation | GKTLVSVTKEGLELP CCEEEEEEHHCCCCC | 18.83 | 23312004 | |
| 546 | Acetylation | KTLVSVTKEGLELPE CEEEEEEHHCCCCCC | 47.86 | 23236377 | |
| 546 | Succinylation | KTLVSVTKEGLELPE CEEEEEEHHCCCCCC | 47.86 | 23954790 | |
| 546 | Ubiquitination | KTLVSVTKEGLELPE CEEEEEEHHCCCCCC | 47.86 | - | |
| 546 (in isoform 1) | Ubiquitination | - | 47.86 | 21890473 | |
| 558 | Acetylation | LPEDEEEKKKQEEKK CCCCHHHHHHHHHHH | 69.42 | 23954790 | |
| 558 | Succinylation | LPEDEEEKKKQEEKK CCCCHHHHHHHHHHH | 69.42 | 23954790 | |
| 558 | Ubiquitination | LPEDEEEKKKQEEKK CCCCHHHHHHHHHHH | 69.42 | 19608861 | |
| 558 (in isoform 1) | Ubiquitination | - | 69.42 | 21890473 | |
| 558 (in isoform 2) | Ubiquitination | - | 69.42 | 21890473 | |
| 559 | Acetylation | PEDEEEKKKQEEKKT CCCHHHHHHHHHHHH | 64.07 | 23749302 | |
| 559 | Ubiquitination | PEDEEEKKKQEEKKT CCCHHHHHHHHHHHH | 64.07 | - | |
| 565 | Acetylation | KKKQEEKKTKFENLC HHHHHHHHHHHHHHH | 61.29 | 23749302 | |
| 565 | Ubiquitination | KKKQEEKKTKFENLC HHHHHHHHHHHHHHH | 61.29 | - | |
| 565 (in isoform 2) | Ubiquitination | - | 61.29 | 21890473 | |
| 566 | Phosphorylation | KKQEEKKTKFENLCK HHHHHHHHHHHHHHH | 52.62 | 21406692 | |
| 567 | Acetylation | KQEEKKTKFENLCKI HHHHHHHHHHHHHHH | 60.61 | 23749302 | |
| 567 | Malonylation | KQEEKKTKFENLCKI HHHHHHHHHHHHHHH | 60.61 | 26320211 | |
| 567 | Ubiquitination | KQEEKKTKFENLCKI HHHHHHHHHHHHHHH | 60.61 | - | |
| 568 (in isoform 2) | Ubiquitination | - | 10.22 | 21890473 | |
| 573 | Acetylation | TKFENLCKIMKDILE HHHHHHHHHHHHHHH | 49.34 | 23954790 | |
| 573 | Malonylation | TKFENLCKIMKDILE HHHHHHHHHHHHHHH | 49.34 | 26320211 | |
| 573 | Methylation | TKFENLCKIMKDILE HHHHHHHHHHHHHHH | 49.34 | 66726823 | |
| 573 | Ubiquitination | TKFENLCKIMKDILE HHHHHHHHHHHHHHH | 49.34 | 19608861 | |
| 575 | Sulfoxidation | FENLCKIMKDILEKK HHHHHHHHHHHHHHH | 1.63 | 21406390 | |
| 576 | Acetylation | ENLCKIMKDILEKKV HHHHHHHHHHHHHHC | 45.12 | 23954790 | |
| 576 | Malonylation | ENLCKIMKDILEKKV HHHHHHHHHHHHHHC | 45.12 | 26320211 | |
| 576 | Succinylation | ENLCKIMKDILEKKV HHHHHHHHHHHHHHC | 45.12 | 23954790 | |
| 576 | Ubiquitination | ENLCKIMKDILEKKV HHHHHHHHHHHHHHC | 45.12 | 19608861 | |
| 579 (in isoform 2) | Ubiquitination | - | 13.00 | - | |
| 580 (in isoform 2) | Ubiquitination | - | 51.68 | - | |
| 581 | Acetylation | IMKDILEKKVEKVVV HHHHHHHHHCCEEEE | 59.69 | 23749302 | |
| 581 | Malonylation | IMKDILEKKVEKVVV HHHHHHHHHCCEEEE | 59.69 | 26320211 | |
| 581 | Ubiquitination | IMKDILEKKVEKVVV HHHHHHHHHCCEEEE | 59.69 | - | |
| 582 | Acetylation | MKDILEKKVEKVVVS HHHHHHHHCCEEEEC | 46.37 | 25953088 | |
| 582 | Ubiquitination | MKDILEKKVEKVVVS HHHHHHHHCCEEEEC | 46.37 | - | |
| 585 | Acetylation | ILEKKVEKVVVSNRL HHHHHCCEEEECCCC | 43.23 | 19608861 | |
| 585 | Ubiquitination | ILEKKVEKVVVSNRL HHHHHCCEEEECCCC | 43.23 | - | |
| 589 | Phosphorylation | KVEKVVVSNRLVTSP HCCEEEECCCCCCCC | 12.48 | 20068231 | |
| 594 | Phosphorylation | VVSNRLVTSPCCIVT EECCCCCCCCEEEEE | 31.38 | 21945579 | |
| 595 | Phosphorylation | VSNRLVTSPCCIVTS ECCCCCCCCEEEEEE | 14.41 | 21945579 | |
| 597 | S-nitrosocysteine | NRLVTSPCCIVTSTY CCCCCCCEEEEEECC | 2.18 | - | |
| 597 | S-nitrosylation | NRLVTSPCCIVTSTY CCCCCCCEEEEEECC | 2.18 | 22178444 | |
| 598 | S-nitrosocysteine | RLVTSPCCIVTSTYG CCCCCCEEEEEECCC | 2.96 | - | |
| 598 | Glutathionylation | RLVTSPCCIVTSTYG CCCCCCEEEEEECCC | 2.96 | 22555962 | |
| 598 | S-nitrosylation | RLVTSPCCIVTSTYG CCCCCCEEEEEECCC | 2.96 | 15937123 | |
| 600 (in isoform 2) | Ubiquitination | - | 1.84 | - | |
| 601 | Phosphorylation | TSPCCIVTSTYGWTA CCCEEEEEECCCCHH | 8.74 | 21945579 | |
| 602 | Phosphorylation | SPCCIVTSTYGWTAN CCEEEEEECCCCHHC | 14.56 | 21945579 | |
| 603 | Phosphorylation | PCCIVTSTYGWTANM CEEEEEECCCCHHCH | 19.38 | 21945579 | |
| 604 | Phosphorylation | CCIVTSTYGWTANME EEEEEECCCCHHCHH | 15.50 | 21945579 | |
| 607 | Phosphorylation | VTSTYGWTANMERIM EEECCCCHHCHHHHH | 12.09 | 21945579 | |
| 607 (in isoform 2) | Ubiquitination | - | 12.09 | - | |
| 610 | Sulfoxidation | TYGWTANMERIMKAQ CCCCHHCHHHHHHHH | 3.21 | 30846556 | |
| 611 (in isoform 2) | Ubiquitination | - | 38.57 | 21890473 | |
| 615 | Acetylation | ANMERIMKAQALRDN HCHHHHHHHHHHHCC | 34.67 | 25825284 | |
| 615 | Methylation | ANMERIMKAQALRDN HCHHHHHHHHHHHCC | 34.67 | 23644510 | |
| 615 | Ubiquitination | ANMERIMKAQALRDN HCHHHHHHHHHHHCC | 34.67 | 21890473 | |
| 615 (in isoform 1) | Ubiquitination | - | 34.67 | 21890473 | |
| 621 (in isoform 2) | Ubiquitination | - | 55.04 | 21890473 | |
| 623 | Phosphorylation | AQALRDNSTMGYMAA HHHHHCCCHHHHHHH | 24.86 | 21945579 | |
| 624 | Phosphorylation | QALRDNSTMGYMAAK HHHHCCCHHHHHHHH | 22.37 | 21945579 | |
| 625 | Sulfoxidation | ALRDNSTMGYMAAKK HHHCCCHHHHHHHHH | 3.48 | 30846556 | |
| 627 | Phosphorylation | RDNSTMGYMAAKKHL HCCCHHHHHHHHHHC | 3.46 | 21945579 | |
| 628 | Sulfoxidation | DNSTMGYMAAKKHLE CCCHHHHHHHHHHCC | 2.12 | 30846556 | |
| 631 | Acetylation | TMGYMAAKKHLEINP HHHHHHHHHHCCCCC | 31.05 | 23749302 | |
| 631 | Succinylation | TMGYMAAKKHLEINP HHHHHHHHHHCCCCC | 31.05 | 23954790 | |
| 631 | Ubiquitination | TMGYMAAKKHLEINP HHHHHHHHHHCCCCC | 31.05 | - | |
| 631 (in isoform 1) | Ubiquitination | - | 31.05 | 21890473 | |
| 632 | Acetylation | MGYMAAKKHLEINPD HHHHHHHHHCCCCCC | 49.01 | 25825284 | |
| 632 | Malonylation | MGYMAAKKHLEINPD HHHHHHHHHCCCCCC | 49.01 | 26320211 | |
| 632 | Ubiquitination | MGYMAAKKHLEINPD HHHHHHHHHCCCCCC | 49.01 | - | |
| 632 (in isoform 1) | Ubiquitination | - | 49.01 | 21890473 | |
| 641 | Phosphorylation | LEINPDHSIIETLRQ CCCCCCCHHHHHHHH | 32.42 | 15937123 | |
| 645 | Phosphorylation | PDHSIIETLRQKAEA CCCHHHHHHHHHHHH | 19.48 | 23403867 | |
| 657 | Ubiquitination | AEADKNDKSVKDLVI HHHCCCCCCHHHHHH | 67.55 | - | |
| 658 | Phosphorylation | EADKNDKSVKDLVIL HHCCCCCCHHHHHHH | 36.94 | 20068231 | |
| 661 (in isoform 2) | Ubiquitination | - | 43.97 | 21890473 | |
| 667 | Phosphorylation | KDLVILLYETALLSS HHHHHHHHHHHHHHC | 14.05 | 20068231 | |
| 668 (in isoform 2) | Ubiquitination | - | 27.81 | 21890473 | |
| 669 | Phosphorylation | LVILLYETALLSSGF HHHHHHHHHHHHCCC | 14.73 | 20068231 | |
| 673 | Phosphorylation | LYETALLSSGFSLED HHHHHHHHCCCCCCC | 29.30 | 20068231 | |
| 674 | Phosphorylation | YETALLSSGFSLEDP HHHHHHHCCCCCCCH | 43.77 | 20068231 | |
| 677 | Phosphorylation | ALLSSGFSLEDPQTH HHHHCCCCCCCHHHH | 34.08 | 20068231 | |
| 680 (in isoform 2) | Ubiquitination | - | 45.99 | 21890473 | |
| 683 | Phosphorylation | FSLEDPQTHANRIYR CCCCCHHHHHHHHHH | 28.48 | 20068231 | |
| 689 | Phosphorylation | QTHANRIYRMIKLGL HHHHHHHHHHHHHCC | 7.29 | 22210691 | |
| 689 (in isoform 2) | Ubiquitination | - | 7.29 | - | |
| 698 (in isoform 2) | Ubiquitination | - | 6.70 | - | |
| 703 (in isoform 2) | Ubiquitination | - | 41.63 | - | |
| 704 | Phosphorylation | GIDEDDPTADDTSAA CCCCCCCCCCCCCCC | 50.11 | 20068231 | |
| 704 (in isoform 2) | Ubiquitination | - | 50.11 | - | |
| 707 (in isoform 2) | Ubiquitination | - | 39.85 | - | |
| 708 | Phosphorylation | DDPTADDTSAAVTEE CCCCCCCCCCCCCCC | 22.32 | 25159151 | |
| 709 | Phosphorylation | DPTADDTSAAVTEEM CCCCCCCCCCCCCCC | 22.64 | 25159151 | |
| 713 | Phosphorylation | DDTSAAVTEEMPPLE CCCCCCCCCCCCCCC | 22.85 | 20068231 | |
| 716 | Sulfoxidation | SAAVTEEMPPLEGDD CCCCCCCCCCCCCCC | 3.18 | 28465586 | |
| 725 | Phosphorylation | PLEGDDDTSRMEEVD CCCCCCCCCCCCCCC | 25.81 | 25159151 | |
| 726 | Phosphorylation | LEGDDDTSRMEEVD- CCCCCCCCCCCCCC- | 36.30 | 25159151 | |
| 728 | Sulfoxidation | GDDDTSRMEEVD--- CCCCCCCCCCCC--- | 5.29 | 30846556 | |
| 737 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 753 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 754 (in isoform 2) | Ubiquitination | - | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 5 | T | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| 5 | T | Phosphorylation | Kinase | DNAPK | P78527 | PSP |
| 7 | T | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| 7 | T | Phosphorylation | Kinase | DNAPK | P78527 | PSP |
| 36 | T | Phosphorylation | Kinase | CSNK2A1 | P68400 | GPS |
| 38 | Y | Phosphorylation | Kinase | WEE1 | P30291 | PSP |
| 90 | T | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 115 | T | Phosphorylation | Kinase | TTK | P33981 | PSP |
| 115 | T | Phosphorylation | Kinase | PRKCG | P05129 | GPS |
| 197 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 231 | S | Phosphorylation | Kinase | CK2_GROUP | - | PhosphoELM |
| 231 | S | Phosphorylation | Kinase | CK2-FAMILY | - | GPS |
| 263 | S | Phosphorylation | Kinase | CSNK2A1 | P33674 | GPS |
| 263 | S | Phosphorylation | Kinase | CSK21 | P68400 | PhosphoELM |
| 263 | S | Phosphorylation | Kinase | CK2-FAMILY | - | GPS |
| 263 | S | Phosphorylation | Kinase | CK2_GROUP | - | PhosphoELM |
| 391 | S | Phosphorylation | Kinase | PNCK | Q6P2M8 | GPS |
| 425 | T | Phosphorylation | Kinase | PRKCG | P05129 | GPS |
| 595 | S | Phosphorylation | Kinase | P38G | P53778 | PSP |
| 603 | T | Phosphorylation | Kinase | PRKCG | P05129 | GPS |
| 624 | T | Phosphorylation | Kinase | PNCK | Q6P2M8 | GPS |
| 725 | T | Phosphorylation | Kinase | CK1A | P48729 | PSP |
| 725 | T | Phosphorylation | Kinase | GSK3B | P49841 | PSP |
| 725 | T | Phosphorylation | Kinase | CK2A1 | P68400 | PSP |
| 726 | S | Phosphorylation | Kinase | CK1A | P48729 | PSP |
| 726 | S | Phosphorylation | Kinase | GSK3B | P49841 | PSP |
| 726 | S | Phosphorylation | Kinase | CK2A1 | P68400 | PSP |
| - | K | Ubiquitination | E3 ubiquitin ligase | STUB1 | Q9UNE7 | PMID:19913553 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HS90A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HS90A_HUMAN !! | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-224; LYS-410; LYS-443;LYS-458; LYS-489; LYS-576 AND LYS-585, AND MASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399, AND MASSSPECTROMETRY. | |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND MASSSPECTROMETRY. | |
| "Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-263, ANDMASS SPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND MASSSPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND MASSSPECTROMETRY. | |
| "Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND MASSSPECTROMETRY. | |
| "Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-252 ANDSER-263, AND MASS SPECTROMETRY. | |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-263, ANDMASS SPECTROMETRY. | |
| "Phosphoproteomic analysis of the human pituitary."; Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F.; Pituitary 9:109-120(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND MASSSPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-252 ANDSER-263, AND MASS SPECTROMETRY. | |
| "Phosphoproteomic analysis of synaptosomes from human cerebralcortex."; DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P.,Pant H.C., Dosemeci A.; J. Proteome Res. 4:306-315(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-263, ANDMASS SPECTROMETRY. | |
| "The human double-stranded DNA-activated protein kinase phosphorylatesthe 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminalthreonine residues."; Lees-Miller S.P., Anderson C.W.; J. Biol. Chem. 264:17275-17280(1989). Cited for: PHOSPHORYLATION AT THR-5 AND THR-7. | |
| S-nitrosylation | |
| Reference | PubMed |
| "S-nitrosylation of Hsp90 promotes the inhibition of its ATPase andendothelial nitric oxide synthase regulatory activities."; Martinez-Ruiz A., Villanueva L., Gonzalez de Orduna C.,Lopez-Ferrer D., Higueras M.A., Tarin C., Rodriguez-Crespo I.,Vazquez J., Lamas S.; Proc. Natl. Acad. Sci. U.S.A. 102:8525-8530(2005). Cited for: PROTEIN SEQUENCE OF 592-612, FUNCTION, CATALYTIC ACTIVITY, MUTAGENESISOF CYS-598, AND S-NITROSYLATION AT CYS-598. | |
