KLHL6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLHL6_HUMAN
• UniProt AC: Q8WZ60
• Protein Name: Kelch-like protein 6
• Gene Name: KLHL6
• Organism: Homo sapiens (Human).
• Sequence Length: 621
• Protein Description: Involved in B-lymphocyte antigen receptor signaling and germinal center formation..
• Protein Sequence: MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Ubiquitination	TMGDVVEKSLEGPLA EHHHHHHHHCCCCCC	49.05	-
19	Phosphorylation	MGDVVEKSLEGPLAP HHHHHHHHCCCCCCC	20.39	22468782
27	Phosphorylation	LEGPLAPSTDEPSQK CCCCCCCCCCCCCCC	42.77	22468782
32	Phosphorylation	APSTDEPSQKTGDLV CCCCCCCCCCCCCEE	42.11	22468782
34	Ubiquitination	STDEPSQKTGDLVEI CCCCCCCCCCCEEHH	59.83	29967540
46	Ubiquitination	VEILNGEKVKFDDAG EHHHCCCEEECCHHH	52.72	29967540
48	Ubiquitination	ILNGEKVKFDDAGLS HHCCCEEECCHHHHH	54.89	-
55	Phosphorylation	KFDDAGLSLILQNGL ECCHHHHHHHHHCHH	16.67	-
64	Phosphorylation	ILQNGLETLRMENAL HHHCHHHHHHHHCCC	25.38	-
106	Ubiquitination	AMFCNDLKEKYEKRI HHHCHHHHHHHHHCE	55.83	-
108	Acetylation	FCNDLKEKYEKRIII HCHHHHHHHHHCEEE	58.06	-
116	Ubiquitination	YEKRIIIKGVDAETM HHHCEEEECCCHHHH	42.34	-
134	Ubiquitination	LDYTYTSKALITKQN HHHHHCCCCCCCHHH	39.14	22817900
139	Ubiquitination	TSKALITKQNVQRVL CCCCCCCHHHHHHHH	32.64	21906983
190	Ubiquitination	THSLDSLKKQVQSYI CCCHHHHHHHHHHHH	45.15	-
191	Ubiquitination	HSLDSLKKQVQSYII CCHHHHHHHHHHHHH	62.08	-
256	Phosphorylation	ERLCLLPYVLENVRL HHCCHHHHHHHCCCC	20.03	26074081
297	Phosphorylation	LLQEARMYHLSGNEI HHHHHHHHHHCCCCH	8.28	26074081
300	Phosphorylation	EARMYHLSGNEIISE HHHHHHHCCCCHHCC	26.68	26074081
306	Phosphorylation	LSGNEIISERTKPRM HCCCCHHCCCCCCCC	27.04	26074081
309	Phosphorylation	NEIISERTKPRMHEF CCHHCCCCCCCCHHC	41.15	26074081
352	Ubiquitination	RSRLEVAKLPLTEHE HHHCEEECCCCCHHH	56.67	29967540
353	Ubiquitination	SRLEVAKLPLTEHEL HHCEEECCCCCHHHH	2.79	22817900
358	Ubiquitination	AKLPLTEHELESENK ECCCCCHHHHHHCCC	39.44	22817900
385	Ubiquitination	EVYISGGKETQHDVW EEEEECCCCCCCCHH	62.20	29967540
393	Ubiquitination	ETQHDVWKYNSSINK CCCCCHHHCCCHHCC	34.11	29967540
424	Phosphorylation	VVLGGKVYVIGGFDG EEECCEEEEECCCCC	6.99	22817900
480	Ubiquitination	IGGGPNGKLATDKTQ ECCCCCCCCCCCCCC	41.40	22817900
485	Ubiquitination	NGKLATDKTQCYDPS CCCCCCCCCCEECCC	35.82	22817900
486	Phosphorylation	GKLATDKTQCYDPST CCCCCCCCCEECCCC	27.04	29083192
489	Phosphorylation	ATDKTQCYDPSTNKW CCCCCCEECCCCCCE	22.52	29083192
492	Phosphorylation	KTQCYDPSTNKWSLK CCCEECCCCCCEEEE	41.54	29083192
493	Phosphorylation	TQCYDPSTNKWSLKA CCEECCCCCCEEEEE	46.32	29083192
495	Ubiquitination	CYDPSTNKWSLKAAM EECCCCCCEEEEEEC	37.94	-
497	Phosphorylation	DPSTNKWSLKAAMPV CCCCCCEEEEEECCC	22.92	29083192
499	Ubiquitination	STNKWSLKAAMPVEA CCCCEEEEEECCCCE	28.69	29967540
507	Ubiquitination	AAMPVEAKCINAVSF EECCCCEEEEEEEEC	23.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLHL6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLHL6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLHL6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLHL7_HUMAN	KLHL7	physical	28514442
RC3H2_HUMAN	RC3H2	physical	28514442
NUDC3_HUMAN	NUDCD3	physical	28514442
DHRS4_HUMAN	DHRS4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.