NEK8_HUMAN - dbPTM
NEK8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEK8_HUMAN
UniProt AC Q86SG6
Protein Name Serine/threonine-protein kinase Nek8
Gene Name NEK8
Organism Homo sapiens (Human).
Sequence Length 692
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium. Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.
Protein Description Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway..
Protein Sequence MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
131PhosphorylationILHRDLKTQNILLDK
HHCCCHHHCCEEECC		33.8618491316
138UbiquitinationTQNILLDKHRMVVKI
HCCEEECCCCEEEEE		32.8329967540
151PhosphorylationKIGDFGISKILSSKS
EECCCCHHHHHCCCC		17.6423312004
152UbiquitinationIGDFGISKILSSKSK
ECCCCHHHHHCCCCC		45.83-
155PhosphorylationFGISKILSSKSKAYT
CCHHHHHCCCCCCEE		38.9123403867
156PhosphorylationGISKILSSKSKAYTV
CHHHHHCCCCCCEEE		37.1923403867
158PhosphorylationSKILSSKSKAYTVVG
HHHHCCCCCCEEEEC		25.19-
162PhosphorylationSSKSKAYTVVGTPCY
CCCCCCEEEECCCCC		17.3611864968
198PhosphorylationCVLYELASLKRAFEA
HHHHHHHHHHHHHHH		47.2323532336
625PhosphorylationVACGDAFTVAIGAES
EECCCEEEEEEECCE		15.6822210691
635PhosphorylationIGAESEVYSWGKGAR
EECCEEEEECCCCCC		8.4822210691
639UbiquitinationSEVYSWGKGARGRLG
EEEEECCCCCCCCCC		43.04-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NEK8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEK8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEK8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AIP_HUMANAIPphysical
26638075
ANKS6_HUMANANKS6physical
26638075
CYBP_HUMANCACYBPphysical
26638075
CDC37_HUMANCDC37physical
26638075
CDKAL_HUMANCDKAL1physical
26638075
FKBP4_HUMANFKBP4physical
26638075
HS71L_HUMANHSPA1Lphysical
26638075
HSP76_HUMANHSPA6physical
26638075
METH_HUMANMTRphysical
26638075
NUDC_HUMANNUDCphysical
26638075
NUDC2_HUMANNUDCD2physical
26638075
NUDC3_HUMANNUDCD3physical
26638075
STIP1_HUMANSTIP1physical
26638075
SGT1_HUMANSUGT1physical
26638075
TTC1_HUMANTTC1physical
26638075
TBA1A_HUMANTUBA1Aphysical
26638075
UN45A_HUMANUNC45Aphysical
26638075
PHOCN_HUMANMOB4physical
26638075
PIHD1_HUMANPIH1D1physical
26638075
RPAP3_HUMANRPAP3physical
26638075
TTC4_HUMANTTC4physical
26638075
UXT_HUMANUXTphysical
26638075
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613824Nephronophthisis 9 (NPHP9)
615415Renal-hepatic-pancreatic dysplasia 2 (RHPD2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NEK8_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory