PIHD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIHD1_HUMAN
• UniProt AC: Q9NWS0
• Protein Name: PIH1 domain-containing protein 1
• Gene Name: PIH1D1
• Organism: Homo sapiens (Human).
• Sequence Length: 290
• Protein Description: Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. [PubMed: 17636026 Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription]
• Protein Sequence: MANPKLLGMGLSEAEAIGADSARFEELLLQASKELQQAQTTRPESTQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MANPKLLGMGLS ---CCCHHHCCCCCC	57.03	-
5	Ubiquitination	---MANPKLLGMGLS ---CCCHHHCCCCCC	57.03	21890473
5	Ubiquitination	---MANPKLLGMGLS ---CCCHHHCCCCCC	57.03	21890473
12	Phosphorylation	KLLGMGLSEAEAIGA HHCCCCCCHHHHHCC	29.09	26714015
33	Ubiquitination	ELLLQASKELQQAQT HHHHHHHHHHHHHHH	66.51	29967540
46	Phosphorylation	QTTRPESTQIQPQPG HHCCCCCCCCCCCCC	28.20	28555341
57	Acetylation	PQPGFCIKTNSSEGK CCCCEEEEECCCCCE	42.72	26051181
57	Malonylation	PQPGFCIKTNSSEGK CCCCEEEEECCCCCE	42.72	26320211
87 (in isoform 2)	Ubiquitination	-	2.96	-
87	Ubiquitination	DVTEEELLQMLEEDQ CCCHHHHHHHHHHHC	2.96	21890473
144	Phosphorylation	FLRELVITIAREGLE HHHHHHHHHHHCCCH	10.91	24719451
153	Ubiquitination	AREGLEDKYNLQLNP HHCCCHHHHCCCCCH	27.02	30230243
166	Ubiquitination	NPEWRMMKNRPFMGS CHHHHHHHCCCCCCC	40.22	-
173	Phosphorylation	KNRPFMGSISQQNIR HCCCCCCCHHHHHCC	13.79	30108239
175	Phosphorylation	RPFMGSISQQNIRSE CCCCCCHHHHHCCCC	27.66	23186163
194	Phosphorylation	IQELGDLYTPAPGRA HHHHHCCCCCCCCCC	18.54	21945579
195	Phosphorylation	QELGDLYTPAPGRAE HHHHCCCCCCCCCCC	21.92	21945579
290	Phosphorylation	MPLLPVPS------- EECCCCCC-------	53.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIHD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIHD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIHD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
T22D4_HUMAN	TSC22D4	physical	16189514
RUVB1_HUMAN	RUVBL1	physical	17636026
RUVB2_HUMAN	RUVBL2	physical	17636026
FBRL_HUMAN	FBL	physical	17636026
RPAP3_HUMAN	RPAP3	physical	22939629
TELO2_HUMAN	TELO2	physical	22863883
TTI1_HUMAN	TTI1	physical	22863883
T22D4_HUMAN	TSC22D4	physical	25416956
RPB7_HUMAN	POLR2G	physical	26186194
PDRG1_HUMAN	PDRG1	physical	26186194
RUVB1_HUMAN	RUVBL1	physical	26186194
RPA1_HUMAN	POLR1A	physical	26186194
RPC1_HUMAN	POLR3A	physical	26186194
RPAP2_HUMAN	RPAP2	physical	26186194
RPC5_HUMAN	POLR3E	physical	26186194
UXT_HUMAN	UXT	physical	26186194
RPB1_HUMAN	POLR2A	physical	26186194
MYZAP_HUMAN	POLR2M	physical	26186194
GRL1A_HUMAN	POLR2M	physical	26186194
GL1AD_HUMAN	POLR2M	physical	26186194
RPAP3_HUMAN	RPAP3	physical	26186194
RPB4_HUMAN	POLR2D	physical	26186194
RPC2_HUMAN	POLR3B	physical	26186194
WDR92_HUMAN	WDR92	physical	26186194
RUVB2_HUMAN	RUVBL2	physical	26186194
RMP_HUMAN	URI1	physical	26186194
DOCK7_HUMAN	DOCK7	physical	26186194
RPB9_HUMAN	POLR2I	physical	26186194
RPB11_HUMAN	POLR2J	physical	26186194
RPC4_HUMAN	POLR3D	physical	26186194
RPAB1_HUMAN	POLR2E	physical	26186194
RPB3_HUMAN	POLR2C	physical	26186194
DCAF6_HUMAN	DCAF6	physical	26186194
LRCH3_HUMAN	LRCH3	physical	26186194
PP1A_HUMAN	PPP1CA	physical	26186194
PP1G_HUMAN	PPP1CC	physical	26186194
RPAB5_HUMAN	POLR2L	physical	26186194
KMT2A_HUMAN	KMT2A	physical	26186194
RPAB2_HUMAN	POLR2F	physical	26186194
RPC10_HUMAN	POLR3K	physical	26186194
TYK2_HUMAN	TYK2	physical	26186194
SPT6H_HUMAN	SUPT6H	physical	26186194
WDR92_HUMAN	WDR92	physical	21078300
ECD_HUMAN	ECD	physical	26711270
RPAP3_HUMAN	RPAP3	physical	26711270
RUVB1_HUMAN	RUVBL1	physical	26711270
RUVB2_HUMAN	RUVBL2	physical	26711270
PDRG1_HUMAN	PDRG1	physical	28514442
RMP_HUMAN	URI1	physical	28514442
RPAP2_HUMAN	RPAP2	physical	28514442
MYZAP_HUMAN	POLR2M	physical	28514442
GRL1A_HUMAN	POLR2M	physical	28514442
GL1AD_HUMAN	POLR2M	physical	28514442
RPAP3_HUMAN	RPAP3	physical	28514442
RPC1_HUMAN	POLR3A	physical	28514442
RPC10_HUMAN	POLR3K	physical	28514442
RPB4_HUMAN	POLR2D	physical	28514442
RPB1_HUMAN	POLR2A	physical	28514442
RPC4_HUMAN	POLR3D	physical	28514442
DOCK7_HUMAN	DOCK7	physical	28514442
RPB11_HUMAN	POLR2J	physical	28514442
WDR92_HUMAN	WDR92	physical	28514442
RPC5_HUMAN	POLR3E	physical	28514442
KMT2A_HUMAN	KMT2A	physical	28514442
SPT6H_HUMAN	SUPT6H	physical	28514442
RUVB1_HUMAN	RUVBL1	physical	28514442
RPB9_HUMAN	POLR2I	physical	28514442
PP1A_HUMAN	PPP1CA	physical	28514442
RUVB2_HUMAN	RUVBL2	physical	28514442
RPA1_HUMAN	POLR1A	physical	28514442
PP1G_HUMAN	PPP1CC	physical	28514442
GPN1_HUMAN	GPN1	physical	28514442
RPB3_HUMAN	POLR2C	physical	28514442
RPC2_HUMAN	POLR3B	physical	28514442
DCAF6_HUMAN	DCAF6	physical	28514442
RPB7_HUMAN	POLR2G	physical	28514442
RPAB5_HUMAN	POLR2L	physical	28514442
RPB2_HUMAN	POLR2B	physical	28514442
RPAP3_HUMAN	RPAP3	physical	25404746
RUVB1_HUMAN	RUVBL1	physical	25404746
RUVB2_HUMAN	RUVBL2	physical	25404746

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.