DCAF6_HUMAN - dbPTM
DCAF6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DCAF6_HUMAN
UniProt AC Q58WW2
Protein Name DDB1- and CUL4-associated factor 6
Gene Name DCAF6
Organism Homo sapiens (Human).
Sequence Length 860
Subcellular Localization Nucleus .
Protein Description Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
Protein Sequence MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENENEDEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Methylation-----MSRGGSYPHL
-----CCCCCCCCHH		52.79115368173
6Phosphorylation--MSRGGSYPHLLWD
--CCCCCCCCHHHHH		38.0127251275
6 (in isoform 3)Phosphorylation-38.0127251275
18PhosphorylationLWDVRKRSLGLEDPS
HHHHHHHHCCCCCHH		29.8020068231
25PhosphorylationSLGLEDPSRLRSRYL
HCCCCCHHHHHHHHH		57.1620068231
101UbiquitinationRANIFSAKFLPCTND
CCEEEEEEEEECCCC		46.35-
101 (in isoform 3)Ubiquitination-46.35-
144UbiquitinationFTCHYGTTYEIMTVP
EEEECCCEEEEEECC		18.1333845483
183UbiquitinationSCTKEDCKDDILINC
CCCCHHHCCCEEECC		71.41-
196PhosphorylationNCRRAATSVAICPPI
CCCCCCCEEEECCCC		12.5730576142
212PhosphorylationYYLAVGCSDSSVRIY
EEEEECCCCCCCEEE		34.3030576142
214PhosphorylationLAVGCSDSSVRIYDR
EEECCCCCCCEEEEC		17.90-
215PhosphorylationAVGCSDSSVRIYDRR
EECCCCCCCEEEECC		22.0224667141
229PhosphorylationRMLGTRATGNYAGRG
CCCCCCCCCCCCCCC		23.7524719451
229 (in isoform 3)Phosphorylation-23.7524719451
232PhosphorylationGTRATGNYAGRGTTG
CCCCCCCCCCCCCHH		16.2724719451
232 (in isoform 3)Phosphorylation-16.2724719451
235MethylationATGNYAGRGTTGMVA
CCCCCCCCCCHHHHH		30.9880701857
257PhosphorylationNNKSCRVTSLCYSED
CCCCCEEEEEEECCC		9.1630576142
260UbiquitinationSCRVTSLCYSEDGQE
CCEEEEEEECCCCCE		3.3532015554
271PhosphorylationDGQEILVSYSSDYIY
CCCEEEEEECCCEEE		18.8230576142
276PhosphorylationLVSYSSDYIYLFDPK
EEEECCCEEEEECCC		8.0730576142
286PhosphorylationLFDPKDDTARELKTP
EECCCCCCHHHCCCC		37.4324719451
286 (in isoform 3)Phosphorylation-37.4324719451
291UbiquitinationDDTARELKTPSAEER
CCCHHHCCCCCHHHH		54.3532015554
291 (in isoform 3)Ubiquitination-54.35-
292PhosphorylationDTARELKTPSAEERR
CCHHHCCCCCHHHHH		34.7925394399
292 (in isoform 3)Phosphorylation-34.7927251275
294PhosphorylationARELKTPSAEERREE
HHHCCCCCHHHHHHH		54.2527794612
308UbiquitinationELRQPPVKRLRLRGD
HHHCCCCCEEEECCC		52.03-
308 (in isoform 3)Ubiquitination-52.03-
313MethylationPVKRLRLRGDWSDTG
CCCEEEECCCCCCCC		34.29115483911
317PhosphorylationLRLRGDWSDTGPRAR
EEECCCCCCCCCCCC		29.9928555341
319PhosphorylationLRGDWSDTGPRARPE
ECCCCCCCCCCCCCH		43.5028555341
336PhosphorylationRERDGEQSPNVSLMQ
HHCCCCCCCCHHHHH		17.7223927012
336 (in isoform 3)Phosphorylation-17.7224719451
340PhosphorylationGEQSPNVSLMQRMSD
CCCCCCHHHHHHHHH		25.4323663014
364MethylationSEVAQSNRGRGRSRP
HHHHHHCCCCCCCCC		41.2454557467
366MethylationVAQSNRGRGRSRPRG
HHHHCCCCCCCCCCC		33.8354557459
367UbiquitinationAQSNRGRGRSRPRGG
HHHCCCCCCCCCCCC		34.4421963094
368MethylationQSNRGRGRSRPRGGT
HHCCCCCCCCCCCCC		28.2954557475
387UbiquitinationISTLPTVPSSPDLEV
HCCCCCCCCCCCCCC		31.4121963094
388PhosphorylationSTLPTVPSSPDLEVS
CCCCCCCCCCCCCCC		50.6024275569
402UbiquitinationSETAMEVDTPAEQFL
CCCEEECCCCHHHHC		33.4033845483
422UbiquitinationSTMSAQAHSTSSPTE
CCCCCCCCCCCCCCC		21.3833845483
424PhosphorylationMSAQAHSTSSPTESP
CCCCCCCCCCCCCCC		24.2926074081
424UbiquitinationMSAQAHSTSSPTESP
CCCCCCCCCCCCCCC		24.2933845483
425PhosphorylationSAQAHSTSSPTESPH
CCCCCCCCCCCCCCC		37.0226074081
426PhosphorylationAQAHSTSSPTESPHS
CCCCCCCCCCCCCCC		35.6126074081
428PhosphorylationAHSTSSPTESPHSTP
CCCCCCCCCCCCCCC		51.5526074081
428UbiquitinationAHSTSSPTESPHSTP
CCCCCCCCCCCCCCC		51.5533845483
430PhosphorylationSTSSPTESPHSTPLL
CCCCCCCCCCCCCCC		30.3226657352
444UbiquitinationLSSPDSEQRQSVEAS
CCCCCHHHHHHHHHC		53.3021963094
447 (in isoform 2)Phosphorylation-24.9026330541
448UbiquitinationDSEQRQSVEASGHHT
CHHHHHHHHHCCCCC		5.5833845483
451 (in isoform 2)Phosphorylation-25.7526330541
455 (in isoform 2)Phosphorylation-18.5126330541
457UbiquitinationASGHHTHHQSDNNNE
HCCCCCCCCCCCCCC		29.9633845483
459UbiquitinationGHHTHHQSDNNNEKL
CCCCCCCCCCCCCCC		37.6433845483
459 (in isoform 2)Phosphorylation-37.6423927012
461 (in isoform 2)Phosphorylation-59.4826330541
467PhosphorylationDNNNEKLSPKPGTGE
CCCCCCCCCCCCCCC		41.7825056879
472 (in isoform 2)Phosphorylation-47.0722673903
474 (in isoform 2)Phosphorylation-31.8822673903
477UbiquitinationPGTGEPVLSLHYSTE
CCCCCCEEEEEEECC		7.0733845483
479UbiquitinationTGEPVLSLHYSTEGT
CCCCEEEEEEECCCE		3.7233845483
481PhosphorylationEPVLSLHYSTEGTTT
CCEEEEEEECCCEEE		23.6825627689
487 (in isoform 2)Phosphorylation-29.6125159151
498 (in isoform 4)Phosphorylation-46.3222673903
500 (in isoform 4)Phosphorylation-15.1522673903
501UbiquitinationNFTDEWSSIASSSRG
ECCCCHHHHHHCCCC		24.2122817900
505UbiquitinationEWSSIASSSRGIGSH
CHHHHHHCCCCCCCC		18.2921890473
513 (in isoform 4)Phosphorylation-5.7825159151
514UbiquitinationRGIGSHCKSEGQEES
CCCCCCCCCCCCCCC		46.2321963094
529 (in isoform 3)Phosphorylation-50.1822673903
531 (in isoform 3)Phosphorylation-40.9022673903
534UbiquitinationSVQPPEGDSETKAPE
HCCCCCCCCCCCCCC		41.4621963094
536UbiquitinationQPPEGDSETKAPEES
CCCCCCCCCCCCCCC		60.1023503661
544UbiquitinationTKAPEESSEDVTKYQ
CCCCCCCCCHHHHHH		40.8923503661
544 (in isoform 3)Phosphorylation-40.8925159151
547UbiquitinationPEESSEDVTKYQEGV
CCCCCCHHHHHHCCC		4.3433845483
549UbiquitinationESSEDVTKYQEGVSA
CCCCHHHHHHCCCCC		44.8033845483
560UbiquitinationGVSAENPVENHINIT
CCCCCCCCCCCCCCC		20.3021963094
564UbiquitinationENPVENHINITQSDK
CCCCCCCCCCCCCCC		6.3423503661
567PhosphorylationVENHINITQSDKFTA
CCCCCCCCCCCCEEC		19.9628555341
567UbiquitinationVENHINITQSDKFTA
CCCCCCCCCCCCEEC		19.9633845483
569UbiquitinationNHINITQSDKFTAKP
CCCCCCCCCCEECCC		33.8333845483
571UbiquitinationINITQSDKFTAKPLD
CCCCCCCCEECCCCC		50.2733845483
575UbiquitinationQSDKFTAKPLDSNSG
CCCCEECCCCCCCCC		42.9522817900
575 (in isoform 1)Ubiquitination-42.9521890473
579PhosphorylationFTAKPLDSNSGERND
EECCCCCCCCCCCCC		40.3525627689
581PhosphorylationAKPLDSNSGERNDLN
CCCCCCCCCCCCCCC		46.0825627689
591UbiquitinationRNDLNLDRSCGVPEE
CCCCCCCCCCCCCHH		36.6921963094
592PhosphorylationNDLNLDRSCGVPEES
CCCCCCCCCCCCHHH		18.1925159151
595UbiquitinationNLDRSCGVPEESASS
CCCCCCCCCHHHCCC		6.7322817900
595 (in isoform 2)Ubiquitination-6.7321890473
604UbiquitinationEESASSEKAKEPETS
HHHCCCHHCCCCCCC		67.7033845483
606UbiquitinationSASSEKAKEPETSDQ
HCCCHHCCCCCCCCC		82.1533845483
606 (in isoform 1)Ubiquitination-82.1521890473
617UbiquitinationTSDQTSTESATNENN
CCCCCCCCCCCCCCC		37.8433845483
621UbiquitinationTSTESATNENNTNPE
CCCCCCCCCCCCCCC		50.1121890473
621UbiquitinationTSTESATNENNTNPE
CCCCCCCCCCCCCCC		50.1122817900
624UbiquitinationESATNENNTNPEPQF
CCCCCCCCCCCCCCC		34.7533845483
626UbiquitinationATNENNTNPEPQFQT
CCCCCCCCCCCCCCC		40.8533845483
626 (in isoform 2)Ubiquitination-40.8521890473
635UbiquitinationEPQFQTEATGPSAHE
CCCCCCCCCCCCCCC		22.6523503661
638UbiquitinationFQTEATGPSAHEETS
CCCCCCCCCCCCCCC		24.8023503661
648UbiquitinationHEETSTRDSALQDTD
CCCCCCCCHHCCCCC		38.0533845483
649PhosphorylationEETSTRDSALQDTDD
CCCCCCCHHCCCCCC		27.8229255136
650UbiquitinationETSTRDSALQDTDDS
CCCCCCHHCCCCCCC		17.3333845483
652UbiquitinationSTRDSALQDTDDSDD
CCCCHHCCCCCCCCC		51.8022817900
652 (in isoform 3)Ubiquitination-51.8021890473
653UbiquitinationTRDSALQDTDDSDDD
CCCHHCCCCCCCCCC		53.6122053931
654PhosphorylationRDSALQDTDDSDDDP
CCHHCCCCCCCCCCC		28.8429255136
657PhosphorylationALQDTDDSDDDPVLI
HCCCCCCCCCCCCEE		45.8329255136
673UbiquitinationGARYRAGPGDRRSAV
CCCCCCCCCCHHHHH		40.2922053931
681UbiquitinationGDRRSAVARIQEFFR
CCHHHHHHHHHHHHH		11.5433845483
683UbiquitinationRRSAVARIQEFFRRR
HHHHHHHHHHHHHHH		3.1233845483
683 (in isoform 3)Ubiquitination-3.1221890473
691UbiquitinationQEFFRRRKERKEMEE
HHHHHHHHHHHHHHH		61.1223503661
694UbiquitinationFRRRKERKEMEELDT
HHHHHHHHHHHHHHH		63.6133845483
703PhosphorylationMEELDTLNIRRPLVK
HHHHHHHCCCHHHHH		28.0132645325
705UbiquitinationELDTLNIRRPLVKMV
HHHHHCCCHHHHHHH		32.8423503661
708UbiquitinationTLNIRRPLVKMVYKG
HHCCCHHHHHHHHCC		5.6923503661
711UbiquitinationIRRPLVKMVYKGHRN
CCHHHHHHHHCCCCC		2.8823503661
714UbiquitinationPLVKMVYKGHRNSRT
HHHHHHHCCCCCCCC		36.5132015554
714 (in isoform 2)Ubiquitination-36.51-
723PhosphorylationHRNSRTMIKEANFWG
CCCCCCEEEECCCCC		3.4532645325
725UbiquitinationNSRTMIKEANFWGAN
CCCCEEEECCCCCCC		37.6123503661
728UbiquitinationTMIKEANFWGANFVM
CEEEECCCCCCCEEE		9.0823503661
731 (in isoform 3)Phosphorylation-9.2524719451
734 (in isoform 3)Phosphorylation-2.7524719451
744UbiquitinationGSDCGHIFIWDRHTA
CCCCCCEEEEECCHH		3.7122053931
751UbiquitinationFIWDRHTAEHLMLLE
EEEECCHHHHHHHHE		8.9723503661
754UbiquitinationDRHTAEHLMLLEADN
ECCHHHHHHHHEECC		1.6232015554
768UbiquitinationNHVVNCLQPHPFDPI
CCEEECCCCCCCCHH		36.1323503661
771UbiquitinationVNCLQPHPFDPILAS
EECCCCCCCCHHHHC		41.8633845483
782UbiquitinationILASSGIDYDIKIWS
HHHCCCCCCEEEEEC		38.2823503661
785UbiquitinationSSGIDYDIKIWSPLE
CCCCCCEEEEECCCH		2.5832015554
785 (in isoform 3)Ubiquitination-2.58-
800UbiquitinationESRIFNRKLADEVIT
HHCHHCHHHHHHHHH		49.4833845483
814UbiquitinationTRNELMLEETRNTIT
HHCHHHHHHHCCCCC		43.2722053931
820UbiquitinationLEETRNTITVPASFM
HHHHCCCCCCCHHHH		4.1122053931
833PhosphorylationFMLRMLASLNHIRAD
HHHHHHHHCCCCCHH		26.2428555341
834UbiquitinationMLRMLASLNHIRADR
HHHHHHHCCCCCHHH		4.4922053931
847PhosphorylationDRLEGDRSEGSGQEN
HHCCCCCCCCCCCCC		51.5630278072
850PhosphorylationEGDRSEGSGQENENE
CCCCCCCCCCCCCCC		33.0028355574
860UbiquitinationENENEDEE-------
CCCCCCCC-------		77.5522053931
870Phosphorylation-----------------
-----------------		32645325
877Ubiquitination------------------------
------------------------		22053931
891Ubiquitination--------------------------------------
--------------------------------------		22053931
891 (in isoform 3)Ubiquitination--
910Phosphorylation---------------------------------------------------------
---------------------------------------------------------		32645325
927Phosphorylation--------------------------------------------------------------------------
--------------------------------------------------------------------------		32645325
938 (in isoform 3)Phosphorylation-24719451
941Phosphorylation----------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------		32645325
941 (in isoform 3)Phosphorylation-24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DCAF6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DCAF6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DCAF6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ANDR_HUMANARphysical
15784617
DCAF6_HUMANDCAF6physical
15784617
GCR_HUMANNR3C1physical
15784617
ACACA_HUMANACACAphysical
22863883
IMA5_HUMANKPNA1physical
22863883
USP9X_HUMANUSP9Xphysical
22863883
DDB1_HUMANDDB1physical
16949367
CUL4A_HUMANCUL4Aphysical
16949367
CUL4B_HUMANCUL4Bphysical
16949367
DDB1_HUMANDDB1physical
28212551
CUL4A_HUMANCUL4Aphysical
28212551
ANDR_HUMANARphysical
28212551
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DCAF6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336 AND SER-657, ANDMASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; THR-654; SER-657;SER-847 AND SER-850, AND MASS SPECTROMETRY.

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