dbPTM

PP1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PP1A_HUMAN
UniProt AC	P62136
Protein Name	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Gene Name	PPP1CA
Organism	Homo sapiens (Human).
Sequence Length	330
Subcellular Localization	Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this pr
Protein Description	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. [PubMed: 23396208 Dephosphorylates CENPA]
Protein Sequence	MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDSEKLNL ------CCHHHHCCH	50.25	22617229
2	Acetylation	------MSDSEKLNL ------CCHHHHCCH	50.25	22814378
4	Phosphorylation	----MSDSEKLNLDS ----CCHHHHCCHHH	29.35	28464451
6	Ubiquitination	--MSDSEKLNLDSII --CCHHHHCCHHHHH	46.78	-
11	Phosphorylation	SEKLNLDSIIGRLLE HHHCCHHHHHHHHHH	21.19	20164059
22	Phosphorylation	RLLEVQGSRPGKNVQ HHHHHCCCCCCCCEE	20.43	20068231
25 (in isoform 3)	Phosphorylation	-	32.81	27732954
26	Ubiquitination	VQGSRPGKNVQLTEN HCCCCCCCCEECCHH	57.54	21890473
26	Malonylation	VQGSRPGKNVQLTEN HCCCCCCCCEECCHH	57.54	26320211
26 (in isoform 3)	Phosphorylation	-	57.54	27732954
26	Acetylation	VQGSRPGKNVQLTEN HCCCCCCCCEECCHH	57.54	26051181
36	Methylation	QLTENEIRGLCLKSR ECCHHHHHHHHHHCC	26.33	115488367
41	Ubiquitination	EIRGLCLKSREIFLS HHHHHHHHCCHHHHC	46.61	-
42	Phosphorylation	IRGLCLKSREIFLSQ HHHHHHHCCHHHHCC	23.38	28450419
48	Phosphorylation	KSREIFLSQPILLEL HCCHHHHCCCEEEEE	24.14	28450419
54	Ubiquitination	LSQPILLELEAPLKI HCCCEEEEEHHHHHH	40.91	21890473
59	Phosphorylation	LLELEAPLKICGDIH EEEEHHHHHHCCCCC	8.23	27251275
60	Ubiquitination	LELEAPLKICGDIHG EEEHHHHHHCCCCCC	34.59	-
69	Phosphorylation	CGDIHGQYYDLLRLF CCCCCCHHHHHHHHH	11.98	28152594
69	Ubiquitination	CGDIHGQYYDLLRLF CCCCCCHHHHHHHHH	11.98	21890473
70	Phosphorylation	GDIHGQYYDLLRLFE CCCCCHHHHHHHHHH	7.70	28152594
93	Phosphorylation	NYLFLGDYVDRGKQS CEEECHHHCHHCHHH	11.49	-
98	Ubiquitination	GDYVDRGKQSLETIC HHHCHHCHHHHHHHH	37.29	21890473
103	Acetylation	RGKQSLETICLLLAY HCHHHHHHHHHHHHH	23.45	19608861
103	Ubiquitination	RGKQSLETICLLLAY HCHHHHHHHHHHHHH	23.45	19608861
103	Ubiquitination	RGKQSLETICLLLAY HCHHHHHHHHHHHHH	23.45	21890473
109	Ubiquitination	ETICLLLAYKIKYPE HHHHHHHHHHCCCCC	11.98	21890473
113	Ubiquitination	LLLAYKIKYPENFFL HHHHHHCCCCCCEEE	51.07	21890473
114	Phosphorylation	LLAYKIKYPENFFLL HHHHHCCCCCCEEEE	21.17	28152594
122	Methylation	PENFFLLRGNHECAS CCCEEEECCCCHHHH	46.12	-
124	Ubiquitination	NFFLLRGNHECASIN CEEEECCCCHHHHHH	22.73	21890473
129	Phosphorylation	RGNHECASINRIYGF CCCCHHHHHHHHEEE	31.86	30576142
132	Methylation	HECASINRIYGFYDE CHHHHHHHHEEEHHH	23.10	-
134	Phosphorylation	CASINRIYGFYDECK HHHHHHHEEEHHHHH	9.65	28152594
137	Phosphorylation	INRIYGFYDECKRRY HHHHEEEHHHHHHHH	13.38	28152594
140	Glutathionylation	IYGFYDECKRRYNIK HEEEHHHHHHHHCCC	3.67	22555962
141	Ubiquitination	YGFYDECKRRYNIKL EEEHHHHHHHHCCCC	37.55	21906983
141	Acetylation	YGFYDECKRRYNIKL EEEHHHHHHHHCCCC	37.55	68941
147	Ubiquitination	CKRRYNIKLWKTFTD HHHHHCCCCCHHHHH	44.66	19608861
147	Acetylation	CKRRYNIKLWKTFTD HHHHHCCCCCHHHHH	44.66	22637287
150	Ubiquitination	RYNIKLWKTFTDCFN HHCCCCCHHHHHHCC	44.17	-
158	Glutathionylation	TFTDCFNCLPIAAIV HHHHHCCCCHHHHHC	2.10	22555962
158	Ubiquitination	TFTDCFNCLPIAAIV HHHHHCCCCHHHHHC	2.10	21890473
177	Phosphorylation	FCCHGGLSPDLQSME EECCCCCCCCHHHHH	21.46	30622161
182	Phosphorylation	GLSPDLQSMEQIRRI CCCCCHHHHHHHHHH	31.42	26437602
194	Ubiquitination	RRIMRPTDVPDQGLL HHHHCCCCCCCCCCC	53.27	21890473
216	Ubiquitination	PDKDVQGWGENDRGV CCCCCCCCCCCCCCC	8.20	21890473
238	Acetylation	VVAKFLHKHDLDLIC HHHHHHCCCCHHHHH	40.75	44499823
238	Ubiquitination	VVAKFLHKHDLDLIC HHHHHHCCCCHHHHH	40.75	21890473
245	Glutathionylation	KHDLDLICRAHQVVE CCCHHHHHHHHHHHH	4.01	22555962
249	Ubiquitination	DLICRAHQVVEDGYE HHHHHHHHHHHHCHH	39.71	21890473
255	Phosphorylation	HQVVEDGYEFFAKRQ HHHHHHCHHHHHHCC	23.14	28796482
255	Nitration	HQVVEDGYEFFAKRQ HHHHHHCHHHHHHCC	23.14	-
260	Acetylation	DGYEFFAKRQLVTLF HCHHHHHHCCEEECC	35.20	19809605
260	Ubiquitination	DGYEFFAKRQLVTLF HCHHHHHHCCEEECC	35.20	21890473
261	Ubiquitination	GYEFFAKRQLVTLFS CHHHHHHCCEEECCC	31.47	21890473
271	Ubiquitination	VTLFSAPNYCGEFDN EECCCCCCCCCCCCC	44.43	21890473
305	Malonylation	PADKNKGKYGQFSGL CCCCCCCCCCCCCCC	48.06	26320211
305	Ubiquitination	PADKNKGKYGQFSGL CCCCCCCCCCCCCCC	48.06	21890473
305	Acetylation	PADKNKGKYGQFSGL CCCCCCCCCCCCCCC	48.06	23749302
306	Phosphorylation	ADKNKGKYGQFSGLN CCCCCCCCCCCCCCC	25.48	21945579
310	Phosphorylation	KGKYGQFSGLNPGGR CCCCCCCCCCCCCCC	34.19	21945579
316	Ubiquitination	FSGLNPGGRPITPPR CCCCCCCCCCCCCCC	33.19	21890473
317	Phosphorylation	SGLNPGGRPITPPRN CCCCCCCCCCCCCCC	25.93	27642862
320	Dephosphorylation	NPGGRPITPPRNSAK CCCCCCCCCCCCCCC	29.89	17274640
320	Phosphorylation	NPGGRPITPPRNSAK CCCCCCCCCCCCCCC	29.89	29255136
325	Phosphorylation	PITPPRNSAKAKK-- CCCCCCCCCCCCC--	32.21	22617229
329	Methylation	PRNSAKAKK------ CCCCCCCCC------	59.31	-
331	Phosphorylation	NSAKAKK-------- CCCCCCC--------		27251275
336	Phosphorylation	KK------------- CC-------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
320	T	Phosphorylation	Kinase	AKT1	P31749	PSP
320	T	Phosphorylation	Kinase	CDK1	P06493	PSP
320	T	Phosphorylation	Kinase	CDK2	P24941	PSP
320	T	Phosphorylation	Kinase	CDK5	Q02399	PSP
320	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
320	T	Phosphorylation	Kinase	LMTK2	Q8IWU2	GPS
320	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
320	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
320	T	Phosphorylation		16732323
Dephosphorylated at Thr-320 in the presence of ionizing radiation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PP1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHAR1_HUMAN	PHACTR1	physical	15107502
ACTS_HUMAN	ACTA1	physical	15107502
PHAR3_HUMAN	PHACTR3	physical	12925532
EED_HUMAN	EED	physical	12788942
PP1R8_HUMAN	PPP1R8	physical	12788942
GSK3B_HUMAN	GSK3B	physical	12147701
AKA11_HUMAN	AKAP11	physical	12147701
SNF5_HUMAN	SMARCB1	genetic	12016208
E2AK2_HUMAN	EIF2AK2	physical	12138106
AKA11_HUMAN	AKAP11	physical	10209101
PP1RA_HUMAN	PPP1R10	physical	10637318
NOC2L_HUMAN	NOC2L	physical	10637318
RRP1B_HUMAN	RRP1B	physical	10637318
PP1R8_HUMAN	PPP1R8	physical	10637318
HCFC1_HUMAN	HCFC1	physical	10637318
LMTK2_HUMAN	LMTK2	physical	12393858
BRCA1_HUMAN	BRCA1	physical	17511879
NCOR1_HUMAN	NCOR1	physical	12410313
CREB1_HUMAN	CREB1	physical	20498639
TIF1B_HUMAN	TRIM28	physical	20424263
WDR82_HUMAN	WDR82	physical	20516061
TOX4_HUMAN	TOX4	physical	20516061
PP1RA_HUMAN	PPP1R10	physical	20516061
EI2BE_RAT	Eif2b5	physical	12624094
NONO_HUMAN	NONO	physical	21566083
SFPQ_HUMAN	SFPQ	physical	21566083
LMTK1_HUMAN	AATK	physical	22321011
CSRN1_HUMAN	CSRNP1	physical	22321011
C1QA_HUMAN	C1QA	physical	22321011
CNST_HUMAN	CNST	physical	22321011
TPRN_HUMAN	TPRN	physical	22321011
PPR18_HUMAN	PPP1R18	physical	22321011
TOIP1_HUMAN	TOR1AIP1	physical	22321011
NEK2_HUMAN	NEK2	physical	22321011
PHAR3_HUMAN	PHACTR3	physical	22321011
IPP2_HUMAN	PPP1R2	physical	22321011
PPR3C_HUMAN	PPP1R3C	physical	22321011
PPR3D_HUMAN	PPP1R3D	physical	22321011
PPR3E_HUMAN	PPP1R3E	physical	22321011
NEB2_HUMAN	PPP1R9B	physical	22321011
ASPP2_HUMAN	TP53BP2	physical	22321011
ASPP1_HUMAN	PPP1R13B	physical	22321011
PP13G_HUMAN	PPP1R3G	physical	22321011
IASPP_HUMAN	PPP1R13L	physical	22321011
PP16A_HUMAN	PPP1R16A	physical	22321011
RANB9_HUMAN	RANBP9	physical	22321011
RIF1_HUMAN	RIF1	physical	22321011
SH3R2_HUMAN	SH3RF2	physical	22321011
STAU1_HUMAN	STAU1	physical	22321011
WBP11_HUMAN	WBP11	physical	22321011
YLPM1_HUMAN	YLPM1	physical	22321011
ZFYV9_HUMAN	ZFYVE9	physical	22321011
KANK1_HUMAN	KANK1	physical	22321011
BTBDA_HUMAN	BTBD10	physical	22321011
CLCN2_HUMAN	CLCN2	physical	22321011
CE170_HUMAN	CEP170	physical	22321011
CLH1_HUMAN	CLTC	physical	22321011
KCRB_HUMAN	CKB	physical	22321011
CN37_HUMAN	CNP	physical	22321011
CNTN1_HUMAN	CNTN1	physical	22321011
CRK_HUMAN	CRK	physical	22321011
CXXC1_HUMAN	CXXC1	physical	22321011
DCTN1_HUMAN	DCTN1	physical	22321011
DEAF1_HUMAN	DEAF1	physical	22321011
FRPD4_HUMAN	FRMPD4	physical	22321011
GRPL2_HUMAN	GLIPR1L2	physical	22321011
NOP53_HUMAN	GLTSCR2	physical	22321011
IBTK_HUMAN	IBTK	physical	22321011
MIIP_HUMAN	MIIP	physical	22321011
JPH3_HUMAN	JPH3	physical	22321011
KCD20_HUMAN	KCTD20	physical	22321011
RPRD2_HUMAN	RPRD2	physical	22321011
CE126_HUMAN	KIAA1377	physical	22321011
LPIN2_HUMAN	LPIN2	physical	22321011
MAFG_HUMAN	MAFG	physical	22321011
MAL2_HUMAN	MAL2	physical	22321011
M4K4_HUMAN	MAP4K4	physical	22321011
NDP_HUMAN	NDP	physical	22321011
PHC1_HUMAN	PHC1	physical	22321011
PIAS1_HUMAN	PIAS1	physical	22321011
PIAS3_HUMAN	PIAS3	physical	22321011
PREX1_HUMAN	PREX1	physical	22321011
LARGN_HUMAN	PRR16	physical	22321011
SNCAP_HUMAN	SNCAIP	physical	22321011
SORL_HUMAN	SORL1	physical	22321011
SPRE1_HUMAN	SPRED1	physical	22321011
UBE2Z_HUMAN	UBE2Z	physical	22321011
ULK1_HUMAN	ULK1	physical	22321011
ZBT11_HUMAN	ZBTB11	physical	22321011
ZN827_HUMAN	ZNF827	physical	22321011
HSP7C_HUMAN	HSPA8	physical	17683050
TFG_HUMAN	TFG	physical	17683050
ACTB_HUMAN	ACTB	physical	17683050
AINX_HUMAN	INA	physical	17683050
PPR1B_HUMAN	PPP1R1B	physical	17683050
ATM_HUMAN	ATM	physical	17274640
AURKB_HUMAN	AURKB	physical	17274640
BCL2_HUMAN	BCL2	physical	17274640
FAK1_HUMAN	PTK2	physical	17274640
LBR_HUMAN	LBR	physical	17274640
RB_HUMAN	RB1	physical	17274640
B2CL1_HUMAN	BCL2L1	physical	17274640
CDK1_HUMAN	CDK1	physical	17274640
CDK2_HUMAN	CDK2	physical	17274640
CDK4_HUMAN	CDK4	physical	17274640
CCNB1_HUMAN	CCNB1	physical	17274640
CCND3_HUMAN	CCND3	physical	17274640
HSP74_HUMAN	HSPA4	physical	17274640
MAX_HUMAN	MAX	physical	17274640
SKP1_HUMAN	SKP1	physical	17274640
STX1A_HUMAN	STX1A	physical	17274640
APAF_HUMAN	APAF1	physical	17274640
CCNA1_HUMAN	CCNA1	physical	17274640
PTPA_HUMAN	PPP2R4	physical	17274640
CADH1_HUMAN	CDH1	physical	17274640
PTEN_HUMAN	PTEN	physical	17274640
CUL1_HUMAN	CUL1	physical	17274640
WWTR1_HUMAN	WWTR1	physical	21189257
ASPP2_HUMAN	TP53BP2	physical	21189257
BRCA1_HUMAN	BRCA1	physical	12438214
BTBDA_MOUSE	Btbd10	physical	18160256
NEB2_HUMAN	PPP1R9B	physical	19094064
KI13B_HUMAN	KIF13B	physical	19094064
DCX_HUMAN	DCX	physical	19094064
CAV1_HUMAN	CAV1	physical	14645548
AKT1_HUMAN	AKT1	physical	14645548
AURKA_HUMAN	AURKA	physical	11551964
PP1B_HUMAN	PPP1CB	physical	22939629
PP1R8_HUMAN	PPP1R8	physical	22939629
SRSF7_HUMAN	SRSF7	physical	22939629
SRSF5_HUMAN	SRSF5	physical	22939629
SRS11_HUMAN	SRSF11	physical	22939629
VTNC_HUMAN	VTN	physical	22939629
SON_HUMAN	SON	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
TPBG_HUMAN	TPBG	physical	22939629
ZN326_HUMAN	ZNF326	physical	22939629
SMCA5_HUMAN	SMARCA5	physical	22939629
MDM4_HUMAN	MDM4	physical	23277204
AXIN1_HUMAN	AXIN1	physical	17318175
KC1E_HUMAN	CSNK1E	physical	17318175
KPCB_HUMAN	PRKCB	physical	8749392
PP1RA_HUMAN	PPP1R10	physical	12574161
TC1D4_HUMAN	TCTEX1D4	physical	21382349
SFRP1_HUMAN	SFRP1	physical	21382349
PPR32_HUMAN	PPP1R32	physical	21382349
RANB9_HUMAN	RANBP9	physical	21382349
WBP11_HUMAN	WBP11	physical	22365833
PP1R8_HUMAN	PPP1R8	physical	22365833
CD2B2_HUMAN	CD2BP2	physical	22365833
TOE1_HUMAN	TOE1	physical	22365833
GPKOW_HUMAN	GPKOW	physical	22365833
MPP10_HUMAN	MPHOSPH10	physical	15231748
PR15A_HUMAN	PPP1R15A	physical	15231748
PPR37_HUMAN	PPP1R37	physical	15231748
ZFYV9_HUMAN	ZFYVE9	physical	15231748
STAU1_HUMAN	STAU1	physical	15231748
P53_HUMAN	TP53	physical	15231748
PP1R8_HUMAN	PPP1R8	physical	15231748
TUSC3_HUMAN	TUSC3	physical	15231748
ASPP2_HUMAN	TP53BP2	physical	15231748
NOM1_HUMAN	NOM1	physical	15231748
PPR26_HUMAN	PPP1R26	physical	15231748
CC181_HUMAN	CCDC181	physical	15231748
ZFY16_HUMAN	ZFYVE16	physical	15231748
SPRE1_HUMAN	SPRED1	physical	15231748
PPR3B_HUMAN	PPP1R3B	physical	15231748
TPRN_HUMAN	TPRN	physical	15231748
KNL1_HUMAN	CASC5	physical	15231748
KI18A_HUMAN	KIF18A	physical	15231748
STAM1_HUMAN	STAM	physical	15231748
ASPP1_HUMAN	PPP1R13B	physical	15231748
PP1RA_HUMAN	PPP1R10	physical	15231748
NEB2_HUMAN	PPP1R9B	physical	15231748
CSRN2_HUMAN	CSRNP2	physical	15231748
SYTL2_HUMAN	SYTL2	physical	15231748
HEYL_HUMAN	HEYL	physical	15231748
PLCL2_HUMAN	PLCL2	physical	15231748
RON_HUMAN	MST1R	physical	14505491
TAT_HV1H2	tat	physical	12036313
IKKB_HUMAN	IKBKB	physical	18949366
IKKA_HUMAN	CHUK	physical	18949366
RPB1_HUMAN	POLR2A	physical	12052871
RB_HUMAN	RB1	physical	8384581
YAP1_HUMAN	YAP1	physical	24255178
MAT2B_HUMAN	MAT2B	physical	22863883
KPYM_HUMAN	PKM	physical	22863883
RISC_HUMAN	SCPEP1	physical	22863883
TMOD3_HUMAN	TMOD3	physical	22863883
XPO1_HUMAN	XPO1	physical	22863883
KCD20_MOUSE	Kctd20	physical	24156551
CSRN1_HUMAN	CSRNP1	physical	25416956
CSRN2_HUMAN	CSRNP2	physical	25416956
AKT1_HUMAN	AKT1	physical	20186153
RORG_HUMAN	RORC	physical	23555304
2A5E_HUMAN	PPP2R5E	physical	23555304
CLOCK_HUMAN	CLOCK	physical	23555304
BMAL1_HUMAN	ARNTL	physical	23555304
PP1R8_HUMAN	PPP1R8	physical	26186194
ASPP1_HUMAN	PPP1R13B	physical	26186194
ASPP2_HUMAN	TP53BP2	physical	26186194
PDRG1_HUMAN	PDRG1	physical	26186194
PLCL2_HUMAN	PLCL2	physical	26186194
IASPP_HUMAN	PPP1R13L	physical	26186194
RIF1_HUMAN	RIF1	physical	26186194
ZFYV9_HUMAN	ZFYVE9	physical	26186194
NEB2_HUMAN	PPP1R9B	physical	26186194
NEB1_HUMAN	PPP1R9A	physical	26186194
GYS2_HUMAN	GYS2	physical	26186194
GYS1_HUMAN	GYS1	physical	26186194
PPR18_HUMAN	PPP1R18	physical	26186194
CDCA2_HUMAN	CDCA2	physical	26186194
UXT_HUMAN	UXT	physical	26186194
RPAP3_HUMAN	RPAP3	physical	26186194
RPC1_HUMAN	POLR3A	physical	26186194
SCRIB_HUMAN	SCRIB	physical	26186194
LRRC1_HUMAN	LRRC1	physical	26186194
C10_HUMAN	C12orf57	physical	26186194
PPR37_HUMAN	PPP1R37	physical	26186194
KBP_HUMAN	KIAA1279	physical	26186194
KI67_HUMAN	MKI67	physical	26186194
YLPM1_HUMAN	YLPM1	physical	26186194
KNL1_HUMAN	CASC5	physical	26186194
PEAK1_HUMAN	PEAK1	physical	26186194
WBP11_HUMAN	WBP11	physical	26186194
ZFY16_HUMAN	ZFYVE16	physical	26186194
ERBIN_HUMAN	ERBB2IP	physical	26186194
E2AK4_HUMAN	EIF2AK4	physical	26186194
IPP2_HUMAN	PPP1R2	physical	26186194
RMP_HUMAN	URI1	physical	26186194
RUVB1_HUMAN	RUVBL1	physical	26186194
SHOC2_HUMAN	SHOC2	physical	26186194
NU153_HUMAN	NUP153	physical	26186194
PP1B_HUMAN	PPP1CB	physical	26186194
CT027_HUMAN	C20orf27	physical	26186194
KI18A_HUMAN	KIF18A	physical	26186194
RPAB1_HUMAN	POLR2E	physical	26186194
CC85C_HUMAN	CCDC85C	physical	26186194
RASF8_HUMAN	RASSF8	physical	26186194
GLYG_HUMAN	GYG1	physical	26186194
PP1RA_HUMAN	PPP1R10	physical	26186194
TANC2_HUMAN	TANC2	physical	26186194
PHAR4_HUMAN	PHACTR4	physical	26186194
TPRN_HUMAN	TPRN	physical	26186194
CSRN2_HUMAN	CSRNP2	physical	26186194
CNST_HUMAN	CNST	physical	26186194
PP1RB_HUMAN	PPP1R11	physical	26186194
CC85B_HUMAN	CCDC85B	physical	26186194
RPC5_HUMAN	POLR3E	physical	26186194
CSRN1_HUMAN	CSRNP1	physical	26186194
RPC2_HUMAN	POLR3B	physical	26186194
PPR3D_HUMAN	PPP1R3D	physical	26186194
RASF7_HUMAN	RASSF7	physical	26186194
HOMEZ_HUMAN	HOMEZ	physical	26186194
SPT6H_HUMAN	SUPT6H	physical	26186194
PP1B_HUMAN	PPP1CB	physical	26344197
PP1G_HUMAN	PPP1CC	physical	26344197
DPYL2_HUMAN	DPYSL2	physical	17683050
AKT1_HUMAN	AKT1	physical	16186112
HDAC6_HUMAN	HDAC6	physical	16186112
HDAC3_HUMAN	HDAC3	physical	16186112
HDAC1_HUMAN	HDAC1	physical	16186112
ANDR_HUMAN	AR	physical	26636645
MDM2_HUMAN	MDM2	physical	26636645
SKP2_HUMAN	SKP2	physical	26636645
LATS1_HUMAN	LATS1	physical	26116754
WWTR1_HUMAN	WWTR1	physical	26116754
PARD3_HUMAN	PARD3	physical	26116754
PTN7_HUMAN	PTPN7	physical	14613483
CT027_HUMAN	C20orf27	physical	27880917
KNL1_HUMAN	CASC5	physical	27880917
CC85C_HUMAN	CCDC85C	physical	27880917
CD2B2_HUMAN	CD2BP2	physical	27880917
E2AK4_HUMAN	EIF2AK4	physical	27880917
ERBIN_HUMAN	ERBB2IP	physical	27880917
GSK3A_HUMAN	GSK3A	physical	27880917
GSK3B_HUMAN	GSK3B	physical	27880917
KI18A_HUMAN	KIF18A	physical	27880917
LEO1_HUMAN	LEO1	physical	27880917
LRRC1_HUMAN	LRRC1	physical	27880917
KI67_HUMAN	MKI67	physical	27880917
PEAK1_HUMAN	PEAK1	physical	27880917
PFD2_HUMAN	PFDN2	physical	27880917
PFD6_HUMAN	PFDN6	physical	27880917
PIHD1_HUMAN	PIH1D1	physical	27880917
PLCL2_HUMAN	PLCL2	physical	27880917
RPAB1_HUMAN	POLR2E	physical	27880917
PP1RA_HUMAN	PPP1R10	physical	27880917
PP1RB_HUMAN	PPP1R11	physical	27880917
ASPP1_HUMAN	PPP1R13B	physical	27880917
IASPP_HUMAN	PPP1R13L	physical	27880917
PPR18_HUMAN	PPP1R18	physical	27880917
IPP2_HUMAN	PPP1R2	physical	27880917
PPR37_HUMAN	PPP1R37	physical	27880917
PPR3D_HUMAN	PPP1R3D	physical	27880917
PP1R7_HUMAN	PPP1R7	physical	27880917
PP1R8_HUMAN	PPP1R8	physical	27880917
NEB1_HUMAN	PPP1R9A	physical	27880917
NEB2_HUMAN	PPP1R9B	physical	27880917
RIF1_HUMAN	RIF1	physical	27880917
RPAP3_HUMAN	RPAP3	physical	27880917
RL13_HUMAN	RPL13	physical	27880917
SCRIB_HUMAN	SCRIB	physical	27880917
SHOC2_HUMAN	SHOC2	physical	27880917
TERF2_HUMAN	TERF2	physical	27880917
TOX4_HUMAN	TOX4	physical	27880917
ASPP2_HUMAN	TP53BP2	physical	27880917
TPRN_HUMAN	TPRN	physical	27880917
RMP_HUMAN	URI1	physical	27880917
UXT_HUMAN	UXT	physical	27880917
WBP11_HUMAN	WBP11	physical	27880917
WDR82_HUMAN	WDR82	physical	27880917
WDR92_HUMAN	WDR92	physical	27880917
YLPM1_HUMAN	YLPM1	physical	27880917
ZFY16_HUMAN	ZFYVE16	physical	27880917
ZFYV9_HUMAN	ZFYVE9	physical	27880917
PPR18_HUMAN	PPP1R18	physical	28514442
PPR37_HUMAN	PPP1R37	physical	28514442
PP1R8_HUMAN	PPP1R8	physical	28514442
TPRN_HUMAN	TPRN	physical	28514442
PP1RB_HUMAN	PPP1R11	physical	28514442
ZFYV9_HUMAN	ZFYVE9	physical	28514442
NEB1_HUMAN	PPP1R9A	physical	28514442
IASPP_HUMAN	PPP1R13L	physical	28514442
SHOC2_HUMAN	SHOC2	physical	28514442
PLCL2_HUMAN	PLCL2	physical	28514442
RASF8_HUMAN	RASSF8	physical	28514442
TANC2_HUMAN	TANC2	physical	28514442
ASPP1_HUMAN	PPP1R13B	physical	28514442
CDCA2_HUMAN	CDCA2	physical	28514442
E2AK4_HUMAN	EIF2AK4	physical	28514442
IPP2_HUMAN	PPP1R2	physical	28514442
PPR3D_HUMAN	PPP1R3D	physical	28514442
RASF7_HUMAN	RASSF7	physical	28514442
PEAK1_HUMAN	PEAK1	physical	28514442
ERBIN_HUMAN	ERBB2IP	physical	28514442
KI18A_HUMAN	KIF18A	physical	28514442
CC85C_HUMAN	CCDC85C	physical	28514442
YLPM1_HUMAN	YLPM1	physical	28514442
ASPP2_HUMAN	TP53BP2	physical	28514442
WBP11_HUMAN	WBP11	physical	28514442
CT027_HUMAN	C20orf27	physical	28514442
HOMEZ_HUMAN	HOMEZ	physical	28514442
C10_HUMAN	C12orf57	physical	28514442
CSRN2_HUMAN	CSRNP2	physical	28514442
PP1RA_HUMAN	PPP1R10	physical	28514442
ZFY16_HUMAN	ZFYVE16	physical	28514442
CNST_HUMAN	CNST	physical	28514442
CC85B_HUMAN	CCDC85B	physical	28514442
KBP_HUMAN	KIAA1279	physical	28514442
SCRIB_HUMAN	SCRIB	physical	28514442
KNL1_HUMAN	CASC5	physical	28514442
PHAR4_HUMAN	PHACTR4	physical	28514442
RMP_HUMAN	URI1	physical	28514442
RIF1_HUMAN	RIF1	physical	28514442
PDRG1_HUMAN	PDRG1	physical	28514442
KI67_HUMAN	MKI67	physical	28514442
RPC1_HUMAN	POLR3A	physical	28514442
GYS1_HUMAN	GYS1	physical	28514442
NEB2_HUMAN	PPP1R9B	physical	28514442
RPAP3_HUMAN	RPAP3	physical	28514442
LRRC1_HUMAN	LRRC1	physical	28514442
PP1B_HUMAN	PPP1CB	physical	28514442
SPT6H_HUMAN	SUPT6H	physical	28514442
NU153_HUMAN	NUP153	physical	28514442
RPC5_HUMAN	POLR3E	physical	28514442
RUVB1_HUMAN	RUVBL1	physical	28514442
GYS2_HUMAN	GYS2	physical	28514442
CSRN1_HUMAN	CSRNP1	physical	28514442
SFRP2_HUMAN	SFRP2	physical	17123353
SFRP1_HUMAN	SFRP1	physical	17123353
SFRP5_HUMAN	SFRP5	physical	17123353
PAK1_HUMAN	PAK1	physical	18586681
PP1R7_HUMAN	PPP1R7	physical	27173435
PDRG1_HUMAN	PDRG1	physical	27173435
KI18A_HUMAN	KIF18A	physical	27173435
RIF1_HUMAN	RIF1	physical	27173435
CT027_HUMAN	C20orf27	physical	27173435
PP1RB_HUMAN	PPP1R11	physical	27173435
RMP_HUMAN	URI1	physical	27173435
WDR92_HUMAN	WDR92	physical	27173435
RPAB1_HUMAN	POLR2E	physical	27173435
IASPP_HUMAN	PPP1R13L	physical	27173435
WBP11_HUMAN	WBP11	physical	27173435
PP1R8_HUMAN	PPP1R8	physical	27173435
RPAP3_HUMAN	RPAP3	physical	27173435
IPP2_HUMAN	PPP1R2	physical	27173435
PIHD1_HUMAN	PIH1D1	physical	27173435
GYS1_HUMAN	GYS1	physical	27173435
PACS1_HUMAN	PACS1	physical	27173435
HS71L_HUMAN	HSPA1L	physical	27173435
MARE2_HUMAN	MAPRE2	physical	27173435
MARE1_HUMAN	MAPRE1	physical	27173435
2A5G_HUMAN	PPP2R5C	physical	25487150
2A5D_HUMAN	PPP2R5D	physical	25487150
MCR_HUMAN	NR3C2	physical	28454724

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PP1A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-320, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-320, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-320, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Downregulation of Fer induces PP1 activation and cell-cycle arrest inmalignant cells."; Pasder O., Shpungin S., Salem Y., Makovsky A., Vilchick S.,Michaeli S., Malovani H., Nir U.; Oncogene 25:4194-4206(2006). Cited for: INTERACTION WITH FER, AND PHOSPHORYLATION AT THR-320.	16732323 [Abstract]

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