dbPTM

LMTK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LMTK2_HUMAN
UniProt AC	Q8IWU2
Protein Name	Serine/threonine-protein kinase LMTK2
Gene Name	LMTK2
Organism	Homo sapiens (Human).
Sequence Length	1503
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	Phosphorylates PPP1C, phosphorylase b and CFTR..
Protein Sequence	MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEESSTDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKPSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	FDDEIDFTPPAEDTP CCCCCCCCCCCCCCC	25.31	-
130	Phosphorylation	PSVEGLKSQVARHSL CCHHHHHHHHHHHHH	34.62	27067055
136	Phosphorylation	KSQVARHSLNYIQEI HHHHHHHHHHHHHHH	16.86	27067055
139	Phosphorylation	VARHSLNYIQEIGNG HHHHHHHHHHHHCCC	14.85	27067055
150	Ubiquitination	IGNGWFGKVLLGEIY HCCCCCCHHHCCEEC	21.89	-
177	Ubiquitination	LKASANPKEQDTFLK HHHCCCHHHHCCHHH	68.74	29967540
223	Ubiquitination	FCDLGDLKAYLRSEQ CCCHHHHHHHHHHHH	39.46	-
291	Phosphorylation	YGIGFSRYKEDYIET CCCCCCCCCCCEEEC	19.96	30576142
292	Ubiquitination	GIGFSRYKEDYIETD CCCCCCCCCCEEECC	42.89	29967540
295	Phosphorylation	FSRYKEDYIETDDKK CCCCCCCEEECCCCE	11.18	30576142
298	Phosphorylation	YKEDYIETDDKKVFP CCCCEEECCCCEEEC	39.68	30576142
300	Ubiquitination	EDYIETDDKKVFPLR CCEEECCCCEEECCC	61.16	27667366
302	Ubiquitination	YIETDDKKVFPLRWT EEECCCCEEECCCCC	56.98	27667366
418	Phosphorylation	RLQSQRDSEVDFEQQ HHHHCCCCCCCHHHH	41.53	27251275
428	Ubiquitination	DFEQQWNALKPNTNS CHHHHHHHCCCCCCC	17.63	22817900
430	Ubiquitination	EQQWNALKPNTNSRD HHHHHHCCCCCCCCC	33.54	22817900
438	Phosphorylation	PNTNSRDSSNNAAFP CCCCCCCCCCCCHHH	33.58	30266825
439	Phosphorylation	NTNSRDSSNNAAFPI CCCCCCCCCCCHHHH	38.09	30266825
473	Phosphorylation	TETSQGLSFEYVWEA EECCCCCCEEEHHHH	23.90	-
476	Phosphorylation	SQGLSFEYVWEAAKH CCCCCEEEHHHHHCC	14.62	25884760
490	Phosphorylation	HDHFDERSRGHLDEG CCCCCCCCCCCCCCC	40.33	24719451
500	Phosphorylation	HLDEGLSYTSIFYPV CCCCCCCCCEEEEEH	15.00	25884760
512	Phosphorylation	YPVEVFESSLSDPGP EEHHHHHCCCCCCCC	25.72	24275569
513	Phosphorylation	PVEVFESSLSDPGPG EHHHHHCCCCCCCCC	25.37	25627689
525	Phosphorylation	GPGKQDDSGQDVPLR CCCCCCCCCCCCCCC	46.79	25159151
546	Phosphorylation	VFDAHNLSVGSDYYI EEECCCCCCCCCEEE	29.74	27642862
549	Phosphorylation	AHNLSVGSDYYIQLE CCCCCCCCCEEEEEE	21.93	27642862
551	Phosphorylation	NLSVGSDYYIQLEEK CCCCCCCEEEEEEEC	12.26	27642862
552	Phosphorylation	LSVGSDYYIQLEEKS CCCCCCEEEEEEECC	6.28	27642862
559	Phosphorylation	YIQLEEKSGSNLELD EEEEEECCCCCCEEC	51.22	28857561
561	Phosphorylation	QLEEKSGSNLELDYP EEEECCCCCCEECCC	45.38	28857561
582	Phosphorylation	DMDNPERTGPELSQL CCCCCCCCCHHHHHH	56.26	22210691
587	Phosphorylation	ERTGPELSQLTALRS CCCCHHHHHHHHHHE	22.83	-
590	Phosphorylation	GPELSQLTALRSVEL CHHHHHHHHHHEEEC	18.93	24719451
594	Phosphorylation	SQLTALRSVELEESS HHHHHHHEEECCCCC	22.31	22199227
600	Phosphorylation	RSVELEESSTDEDFF HEEECCCCCCCHHHH	29.21	25159151
601	Phosphorylation	SVELEESSTDEDFFQ EEECCCCCCCHHHHH	43.06	25159151
602	Phosphorylation	VELEESSTDEDFFQS EECCCCCCCHHHHHC	53.33	25159151
609	Phosphorylation	TDEDFFQSSTDPKDS CCHHHHHCCCCCCCC	30.01	28102081
610	Phosphorylation	DEDFFQSSTDPKDSS CHHHHHCCCCCCCCC	26.50	28102081
611	Phosphorylation	EDFFQSSTDPKDSSL HHHHHCCCCCCCCCC	62.66	28102081
616	Phosphorylation	SSTDPKDSSLPGDLH CCCCCCCCCCCCCCE	39.64	23663014
617	Phosphorylation	STDPKDSSLPGDLHV CCCCCCCCCCCCCEE	49.03	23663014
625	Phosphorylation	LPGDLHVTSGPESPF CCCCCEECCCCCCCC	19.74	23663014
626	Phosphorylation	PGDLHVTSGPESPFN CCCCEECCCCCCCCC	51.79	23663014
630	Phosphorylation	HVTSGPESPFNNIFN EECCCCCCCCCCCCC	37.61	25159151
642	Phosphorylation	IFNDVDKSEDLPSHQ CCCCCCCCCCCCCHH	31.70	24144214
647	Phosphorylation	DKSEDLPSHQKIFDL CCCCCCCCHHHHHHH	45.94	24144214
668	Phosphorylation	QADFKPATLSSSLDN CCCCCCCCCCCCCCC	35.38	28348404
670	Phosphorylation	DFKPATLSSSLDNPK CCCCCCCCCCCCCCC	17.33	25850435
671	Phosphorylation	FKPATLSSSLDNPKE CCCCCCCCCCCCCCH	37.72	25850435
672	Phosphorylation	KPATLSSSLDNPKES CCCCCCCCCCCCCHH	36.04	25850435
679	Phosphorylation	SLDNPKESVITGHFE CCCCCCHHCCCCCCC	25.58	27251275
735	Phosphorylation	EKNLLKGSLSSKEHI HHCHHCCCCCCHHHH	24.40	28857561
737	Phosphorylation	NLLKGSLSSKEHIND CHHCCCCCCHHHHHH	40.85	28857561
738	Phosphorylation	LLKGSLSSKEHINDL HHCCCCCCHHHHHHH	47.56	23186163
788	Phosphorylation	SLLQENVSTKGDDTD HHHHHCCCCCCCCCC	35.66	25159151
789	Phosphorylation	LLQENVSTKGDDTDV HHHHCCCCCCCCCCE	34.46	25627689
805	Phosphorylation	LTGDTLSTSLQSSPE EECCCCCCCCCCCCC	36.25	-
806	Phosphorylation	TGDTLSTSLQSSPEV ECCCCCCCCCCCCCC	22.49	-
809	Phosphorylation	TLSTSLQSSPEVQVP CCCCCCCCCCCCCCC	53.83	22798277
810	Phosphorylation	LSTSLQSSPEVQVPP CCCCCCCCCCCCCCC	16.48	22798277
825	Phosphorylation	TSFETEETPRRVPPD CCCCCCCCCCCCCCC	18.83	22798277
876	Phosphorylation	ILSTDARTHSLDNRS EEECCCCCCCCCCCC	19.96	23312004
878	Phosphorylation	STDARTHSLDNRSQD ECCCCCCCCCCCCCC	36.48	23186163
883	Phosphorylation	THSLDNRSQDSPGES CCCCCCCCCCCCCCC	44.59	20873877
886	Phosphorylation	LDNRSQDSPGESEET CCCCCCCCCCCCHHH	27.45	28355574
890	Phosphorylation	SQDSPGESEETLRLT CCCCCCCCHHHHHHC	46.80	20873877
893	Phosphorylation	SPGESEETLRLTESD CCCCCHHHHHHCCCC	17.08	29396449
897	Phosphorylation	SEETLRLTESDSVLA CHHHHHHCCCCCCHH	27.32	27251275
899	Phosphorylation	ETLRLTESDSVLADD HHHHHCCCCCCHHHH	29.92	26471730
901	Phosphorylation	LRLTESDSVLADDIL HHHCCCCCCHHHHHH	28.45	28857561
955	Phosphorylation	ETLNQLNSKDAAKEA HHHHHHCCHHHHHHH	40.27	22817900
996	Phosphorylation	ASEPSLETPDSLESV CCCCCCCCCCCCCCC	37.38	24275569
1012	Phosphorylation	VHEALLDSLGSHTPQ HHHHHHHHHCCCCCC	34.30	24275569
1088	Phosphorylation	GHRGTEVTPETFTAG CCCCCCCCCCCCCCC	14.80	21815630
1100	Phosphorylation	TAGSQGSYRDSAYFS CCCCCCCCCCCCCCC	25.84	22817900
1103	Phosphorylation	SQGSYRDSAYFSDND CCCCCCCCCCCCCCC	18.83	27732954
1105	Phosphorylation	GSYRDSAYFSDNDSE CCCCCCCCCCCCCCC	13.94	28450419
1107	Phosphorylation	YRDSAYFSDNDSEPE CCCCCCCCCCCCCCC	23.87	25159151
1111	Phosphorylation	AYFSDNDSEPEKRSE CCCCCCCCCCCCCCC	62.40	25849741
1117	Phosphorylation	DSEPEKRSEEVPGTS CCCCCCCCCCCCCCC	49.53	-
1123	Phosphorylation	RSEEVPGTSPSALVL CCCCCCCCCCCCEEE	31.24	-
1124	Phosphorylation	SEEVPGTSPSALVLV CCCCCCCCCCCEEEE	23.83	25159151
1126	Phosphorylation	EVPGTSPSALVLVQE CCCCCCCCCEEEEEC	33.72	25159151
1171	Phosphorylation	CLSALHNSSDLELRA HHHHHHCCCCCCCCC	17.93	25159151
1172	Phosphorylation	LSALHNSSDLELRAT HHHHHCCCCCCCCCC	52.08	25159151
1246	Phosphorylation	TNSALDKSLSSHSEG HHHHHHHHHHCCCCC	32.90	25627689
1248	Phosphorylation	SALDKSLSSHSEGPK HHHHHHHHCCCCCCC	32.85	-
1251	Phosphorylation	DKSLSSHSEGPKLKE HHHHHCCCCCCCCCC	46.31	-
1291	Phosphorylation	ADEEDENSDDSDEDL CCCCCCCCCCCHHHH	40.52	-
1294	Phosphorylation	EDENSDDSDEDLRAF CCCCCCCCHHHHHHH	48.14	33259812
1305	Phosphorylation	LRAFNLHSLSSESED HHHHCHHHCCCCCCC	32.87	20873877
1307	Phosphorylation	AFNLHSLSSESEDET HHCHHHCCCCCCCCC	34.77	17081983
1308	Phosphorylation	FNLHSLSSESEDETE HCHHHCCCCCCCCCC	50.89	17081983
1310	Phosphorylation	LHSLSSESEDETEHP HHHCCCCCCCCCCCC	52.90	17081983
1314	Phosphorylation	SSESEDETEHPVPII CCCCCCCCCCCCCEE	52.49	20873877
1323	Phosphorylation	HPVPIILSNEDGRHL CCCCEEEECCCCHHH	27.97	20873877
1332	Phosphorylation	EDGRHLRSLLKPTAA CCCHHHHHHHCCCCC	44.40	24719451
1395	Phosphorylation	LSGPAPASGSPYLSR CCCCCCCCCCCCHHH	38.45	30576142
1397	Phosphorylation	GPAPASGSPYLSRCI CCCCCCCCCCHHHHH	14.10	25849741
1399	Phosphorylation	APASGSPYLSRCINS CCCCCCCCHHHHHCC	21.00	28985074
1401	Phosphorylation	ASGSPYLSRCINSES CCCCCCHHHHHCCCC	21.18	27080861
1408	Phosphorylation	SRCINSESSTDEEGG HHHHCCCCCCCCCCC	38.06	28348404
1409	Phosphorylation	RCINSESSTDEEGGG HHHCCCCCCCCCCCC	35.51	28348404
1410	Phosphorylation	CINSESSTDEEGGGF HHCCCCCCCCCCCCC	57.62	28348404
1438	Phosphorylation	KTTSNLLSSKPSLQT HHHHHHHCCCCCCCC	39.21	28555341
1439	Phosphorylation	TTSNLLSSKPSLQTS HHHHHHCCCCCCCCC	48.86	28555341
1445	Phosphorylation	SSKPSLQTSKYFSPP CCCCCCCCCCCCCCC	32.26	-
1446	Phosphorylation	SKPSLQTSKYFSPPP CCCCCCCCCCCCCCC	16.64	-
1448	Phosphorylation	PSLQTSKYFSPPPPA CCCCCCCCCCCCCCC	14.73	22322096
1450	Phosphorylation	LQTSKYFSPPPPARS CCCCCCCCCCCCCCC	33.15	30266825
1465	Phosphorylation	TEQSWPHSAPYSRFS CCCCCCCCCCCCCCC	27.19	-
1468	Phosphorylation	SWPHSAPYSRFSISP CCCCCCCCCCCCCCH	16.52	22817900
1469	Phosphorylation	WPHSAPYSRFSISPA CCCCCCCCCCCCCHH	26.28	21082442
1480	Phosphorylation	ISPANIASFSLTHLT CCHHHHHEEEEEECC	16.15	24144214
1482	Phosphorylation	PANIASFSLTHLTDS HHHHHEEEEEECCHH	29.84	24144214
1484	Phosphorylation	NIASFSLTHLTDSDI HHHEEEEEECCHHHH	17.40	24144214
1487	Phosphorylation	SFSLTHLTDSDIEQG EEEEEECCHHHHHCC	26.33	24144214
1489	Phosphorylation	SLTHLTDSDIEQGGS EEEECCHHHHHCCCC	34.94	29802988
1496	Phosphorylation	SDIEQGGSSEDGEKD HHHHCCCCCCCCCCC	37.06	29802988
1497	Phosphorylation	DIEQGGSSEDGEKD- HHHCCCCCCCCCCC-	42.87	29802988

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1450	S	Phosphorylation	Kinase	CDK5	Q00535	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LMTK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LMTK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMTK2_HUMAN	LMTK2	physical	12393858
PP1A_HUMAN	PPP1CA	physical	12393858
IPP2_HUMAN	PPP1R2	physical	12393858
MYO6_HUMAN	MYO6	physical	18029400
PP1A_HUMAN	PPP1CA	physical	28065597
PP1B_HUMAN	PPP1CB	physical	28065597
PP1G_HUMAN	PPP1CC	physical	28065597
PP2BB_HUMAN	PPP3CB	physical	28065597
PPM1A_HUMAN	PPM1A	physical	28065597
PPM1F_HUMAN	PPM1F	physical	28065597
PPM1K_HUMAN	PPM1K	physical	28065597
ILKAP_HUMAN	ILKAP	physical	28065597
PTPRR_HUMAN	PTPRR	physical	28065597
PTN6_HUMAN	PTPN6	physical	28065597
PTN12_HUMAN	PTPN12	physical	28065597
DUS6_HUMAN	DUSP6	physical	28065597
DUS14_HUMAN	DUSP14	physical	28065597
DUS19_HUMAN	DUSP19	physical	28065597
DUPD1_HUMAN	DUPD1	physical	28065597
STYX_HUMAN	STYX	physical	28065597
CC14A_HUMAN	CDC14A	physical	28065597
PTPC1_HUMAN	PTPDC1	physical	28065597
TPTE2_HUMAN	TPTE2	physical	28065597
MTMR6_HUMAN	MTMR6	physical	28065597
MPIP3_HUMAN	CDC25C	physical	28065597

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LMTK2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-955, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1305; SER-1307; SER-1308AND SER-1310, AND MASS SPECTROMETRY.	17081983 [Abstract]