DUS6_HUMAN - dbPTM
DUS6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DUS6_HUMAN
UniProt AC Q16828
Protein Name Dual specificity protein phosphatase 6
Gene Name DUSP6
Organism Homo sapiens (Human).
Sequence Length 381
Subcellular Localization Cytoplasm .
Protein Description Inactivates MAP kinases. Has a specificity for the ERK family. [PubMed: 9858808 Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity]
Protein Sequence MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
68UbiquitinationIMLRRLQKGNLPVRA
HHHHHHHCCCCCCEE		55.12-
159PhosphorylationDGSCSSSSPPLPVLG
CCCCCCCCCCCCEEE		32.2715632084
173PhosphorylationGLGGLRISSDSSSDI
EECCEEECCCCCCHH		22.9725850435
174PhosphorylationLGGLRISSDSSSDIE
ECCEEECCCCCCHHH		38.8629255136
176PhosphorylationGLRISSDSSSDIESD
CEEECCCCCCHHHHH		33.4229255136
177PhosphorylationLRISSDSSSDIESDL
EEECCCCCCHHHHHC		36.7029255136
178 (in isoform 2)Ubiquitination-46.7021906983
178PhosphorylationRISSDSSSDIESDLD
EECCCCCCHHHHHCC		46.7029255136
181 (in isoform 2)Ubiquitination-43.1021906983
182PhosphorylationDSSSDIESDLDRDPN
CCCCHHHHHCCCCCC		43.7520230923
197PhosphorylationSATDSDGSPLSNSQP
CCCCCCCCCCCCCCC		27.8815632084
205PhosphorylationPLSNSQPSFPVEILP
CCCCCCCCCCCHHHH		34.2519664994
254 (in isoform 1)Ubiquitination-47.4321906983
254UbiquitinationFENAGEFKYKQIPIS
HCCCCCCCCEECCCC		47.4321906983
255PhosphorylationENAGEFKYKQIPISD
CCCCCCCCEECCCCH		17.28-
300PhosphorylationCLAGISRSVTVTVAY
HHHCCCHHHHHHHHH		18.4922817900
324UbiquitinationNDAYDIVKMKKSNIS
CCHHHHHHHHHCCCC		45.392190698
324 (in isoform 1)Ubiquitination-45.3921906983
327UbiquitinationYDIVKMKKSNISPNF
HHHHHHHHCCCCCCC		45.28-
327 (in isoform 1)Ubiquitination-45.2821906983
328PhosphorylationDIVKMKKSNISPNFN
HHHHHHHCCCCCCCC		33.6028176443
331PhosphorylationKMKKSNISPNFNFMG
HHHHCCCCCCCCHHH		20.3125159151
346PhosphorylationQLLDFERTLGLSSPC
HHHCHHHHHCCCCCC		20.2728102081
350PhosphorylationFERTLGLSSPCDNRV
HHHHHCCCCCCCCCC		30.3629116813
351PhosphorylationERTLGLSSPCDNRVP
HHHHCCCCCCCCCCC		34.2919664994
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
159SPhosphorylationKinaseMAPK1P28482
GPS
159SPhosphorylationKinaseMAPK3P27361
GPS
174SPhosphorylationKinaseMAPK3P27361
GPS
174SPhosphorylationKinasePDGFR-FAMILY-GPS
197SPhosphorylationKinaseMAPK1P28482
GPS
197SPhosphorylationKinaseMAPK3P27361
GPS
300SPhosphorylationKinaseMAPK3P27361
GPS
300SPhosphorylationKinasePDGFR-FAMILY-GPS
-KUbiquitinationE3 ubiquitin ligaseFBXL14Q8N1E6
PMID:24658274
-KUbiquitinationE3 ubiquitin ligaseSPOPO43791
PMID:24656772
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DUS6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DUS6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MDFI_HUMANMDFIphysical
16189514
TEX11_HUMANTEX11physical
16189514
MK03_HUMANMAPK3physical
9535927
MK01_HUMANMAPK1physical
9535927
MK03_HUMANMAPK3physical
25515236
MK01_HUMANMAPK1physical
25515236
TAGL_HUMANTAGLNphysical
25515236
MK01_HUMANMAPK1physical
27880917
MK03_HUMANMAPK3physical
27880917
DUS6_HUMANDUSP6physical
27432908
WRB_HUMANWRBphysical
27432908
MK03_HUMANMAPK3physical
27432908
T126A_HUMANTMEM126Aphysical
27432908
KBRS2_HUMANNKIRAS2physical
27432908
VPS4A_HUMANVPS4Aphysical
27432908
NDUF4_HUMANNDUFAF4physical
27432908
MGRN1_HUMANMGRN1physical
27432908
PARK7_HUMANPARK7physical
27432908
PTH2_HUMANPTRH2physical
27432908
CHP1_HUMANCHP1physical
27432908
MBLC2_HUMANMBLAC2physical
27432908
FDFT_HUMANFDFT1physical
27432908
MIC27_HUMANAPOOLphysical
27432908
TIM21_HUMANTIMM21physical
27432908
ARF5_HUMANARF5physical
27432908
CQ062_HUMANC17orf62physical
27432908
MK01_HUMANMAPK1physical
27432908
GL8D1_HUMANGLT8D1physical
27432908
AURKB_HUMANAURKBphysical
27432908
RDH14_HUMANRDH14physical
27432908
TI17B_HUMANTIMM17Bphysical
27432908
AP3S1_HUMANAP3S1physical
27432908
HDDC2_HUMANHDDC2physical
27432908
PTPM1_HUMANPTPMT1physical
27432908
RAB5B_HUMANRAB5Bphysical
27432908
UB2G2_HUMANUBE2G2physical
27432908
SGMR2_HUMANTMEM97physical
27432908
MAIP1_HUMANC2orf47physical
27432908
UBXN1_HUMANUBXN1physical
27432908
TMCO1_HUMANTMCO1physical
27432908
DUS8_HUMANDUSP8physical
27432908
PIN1_HUMANPIN1physical
27432908
TIDC1_HUMANTIMMDC1physical
27432908
SPEE_HUMANSRMphysical
27432908
ARPC3_HUMANARPC3physical
27432908
TMM11_HUMANTMEM11physical
27432908
TPC_HUMANSLC25A19physical
27432908
CNO10_HUMANCNOT10physical
27432908
SRPRA_HUMANSRPRphysical
27432908
RAB13_HUMANRAB13physical
27432908
TF2B_HUMANGTF2Bphysical
27432908
NDK3_HUMANNME3physical
27432908
COX41_HUMANCOX4I1physical
27432908
HUMMR_HUMANMGARPphysical
27432908
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615269Hypogonadotropic hypogonadism 19 with or without anosmia (HH19)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DUS6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, AND MASSSPECTROMETRY.
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, AND MASSSPECTROMETRY.

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