GL8D1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GL8D1_HUMAN
• UniProt AC: Q68CQ7
• Protein Name: Glycosyltransferase 8 domain-containing protein 1
• Gene Name: GLT8D1
• Organism: Homo sapiens (Human).
• Sequence Length: 371
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Sequence: MSFRKVNIIILVLAVALFLLVLHHNFLSLSSLLRNEVTDSGIVGPQPIDFVPNALRHAVDGRQEEIPVVIAASEDRLGGAIAAINSIQHNTRSNVIFYIVTLNNTADHLRSWLNSDSLKSIRYKIVNFDPKLLEGKVKEDPDQGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTALKPGHAAAFSEDCDSASTKVVIRGAGNQYNYIGYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNITNQLEKWMKLNVEEGLYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHLKPWGRTASYTDVWEKWYIPDPTGKFNLIRRYTEISNIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFRKVNII ------CCHHHHHHH	33.48	24719451
30	Phosphorylation	HHNFLSLSSLLRNEV HHHHHCHHHHHHCCC	18.63	24945436
31	Phosphorylation	HNFLSLSSLLRNEVT HHHHCHHHHHHCCCC	36.39	24719451
119	Ubiquitination	WLNSDSLKSIRYKIV HHCCCCHHHCEEEEE	48.03	-
131	Ubiquitination	KIVNFDPKLLEGKVK EEEECCHHHHCCCCC	68.50	-
165	Ubiquitination	PILVPSAKKAIYMDD EHHCCCCCEEEECCC	47.26	-
166	Ubiquitination	ILVPSAKKAIYMDDD HHCCCCCEEEECCCC	39.47	-
189	Acetylation	ALYNTALKPGHAAAF HHHCCCCCCCCHHHC	46.63	20167786
206	Acetylation	DCDSASTKVVIRGAG CCCCCCCEEEEECCC	31.82	20167786
225	Acetylation	YIGYLDYKKERIRKL EEEEEECCHHHHHHH	48.07	20167786
237	Phosphorylation	RKLSMKASTCSFNPG HHHHHCCCCCCCCCC	25.16	22210691
240	Phosphorylation	SMKASTCSFNPGVFV HHCCCCCCCCCCEEE	28.31	22210691
249	N-linked_Glycosylation	NPGVFVANLTEWKRQ CCCEEEEECCHHHHH	42.04	19159218
257	N-linked_Glycosylation	LTEWKRQNITNQLEK CCHHHHHCHHHHHHH	47.27	UniProtKB CARBOHYD
276	Phosphorylation	NVEEGLYSRTLAGSI CHHHCCCCCCCCCCC	24.67	24719451
278	O-linked_Glycosylation	EEGLYSRTLAGSITT HHCCCCCCCCCCCCC	18.28	29351928
282	O-linked_Glycosylation	YSRTLAGSITTPPLL CCCCCCCCCCCCCEE	15.91	29351928
365	O-linked_Glycosylation	FNLIRRYTEISNIK- CCHHHHHHCHHCCC-	25.65	55831345

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GL8D1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GL8D1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GL8D1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GL8D1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-249, AND MASSSPECTROMETRY.
PubMed: 19159218