| UniProt ID | CNO10_HUMAN | |
|---|---|---|
| UniProt AC | Q9H9A5 | |
| Protein Name | CCR4-NOT transcription complex subunit 10 | |
| Gene Name | CNOT10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 744 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.. | |
| Protein Sequence | MAADKPADQGAEKHEGTGQSSGITDQEKELSTNAFQAFTSGNYDACLQHLACLQDINKDDYKIILNTAVAEFFKSNQTTTDNLRQTLNQLKNQVHSAVEEMDGLDDVENSMLYYNQAVILYHLRQYTEAISVGEKLYQFIEPFEEKFAQAVCFLLVDLYILTYQAEKALHLLAVLEKMISQGNNNKNGKNETGNNNNKDGSNHKAESGALIEAAKSKIHQYKVRAYIQMKSLKACKREIKSVMNTAGNSAPSLFLKSNFEYLRGNYRKAVKLLNSSNIAEHPGFMKTGECLRCMFWNNLGCIHFAMSKHNLGIFYFKKALQENDNVCAQLSAGSTDPGKKFSGRPMCTLLTNKRYELLYNCGIQLLHIGRPLAAFECLIEAVQVYHANPRLWLRLAECCIAANKGTSEQETKGLPSKKGIVQSIVGQGYHRKIVLASQSIQNTVYNDGQSSAIPVASMEFAAICLRNALLLLPEEQQDPKQENGAKNSNQLGGNTESSESSETCSSKSHDGDKFIPAPPSSPLRKQELENLKCSILACSAYVALALGDNLMALNHADKLLQQPKLSGSLKFLGHLYAAEALISLDRISDAITHLNPENVTDVSLGISSNEQDQGSDKGENEAMESSGKRAPQCYPSSVNSARTVMLFNLGSAYCLRSEYDKARKCLHQAASMIHPKEVPPEAILLAVYLELQNGNTQLALQIIKRNQLLPAVKTHSEVRKKPVFQPVHPIQPIQMPAFTTVQRK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAADKPADQ ------CCCCCCCCC | 19413330 | ||
| 20 | Phosphorylation | KHEGTGQSSGITDQE CCCCCCCCCCCCHHH | 25627689 | ||
| 21 | Phosphorylation | HEGTGQSSGITDQEK CCCCCCCCCCCHHHH | 25627689 | ||
| 28 | Ubiquitination | SGITDQEKELSTNAF CCCCHHHHHHCHHHH | 21963094 | ||
| 43 | Ubiquitination | QAFTSGNYDACLQHL HHHHCCCHHHHHHHH | 21890473 | ||
| 58 | Ubiquitination | ACLQDINKDDYKIIL HHHHCCCHHHHHHHH | 21963094 | ||
| 74 | Ubiquitination | TAVAEFFKSNQTTTD HHHHHHHHCCCCCHH | 21906983 | ||
| 74 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 74 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 74 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 88 | Ubiquitination | DNLRQTLNQLKNQVH HHHHHHHHHHHHHHH | 29967540 | ||
| 111 | Ubiquitination | LDDVENSMLYYNQAV CCHHHHHHHHHHHHH | 21963094 | ||
| 118 | Ubiquitination | MLYYNQAVILYHLRQ HHHHHHHHHHHHHHH | 29967540 | ||
| 134 | Ubiquitination | TEAISVGEKLYQFIE HCHHCHHHHHHHHHH | 21963094 | ||
| 134 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 162 | Phosphorylation | LVDLYILTYQAEKAL HHHHHHHHHHHHHHH | - | ||
| 176 | Ubiquitination | LHLLAVLEKMISQGN HHHHHHHHHHHHCCC | 21963094 | ||
| 177 | Acetylation | HLLAVLEKMISQGNN HHHHHHHHHHHCCCC | 20167786 | ||
| 184 | Ubiquitination | KMISQGNNNKNGKNE HHHHCCCCCCCCCCC | 27667366 | ||
| 189 | Ubiquitination | GNNNKNGKNETGNNN CCCCCCCCCCCCCCC | 27667366 | ||
| 190 | Ubiquitination | NNNKNGKNETGNNNN CCCCCCCCCCCCCCC | 21963094 | ||
| 203 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 204 | Ubiquitination | NKDGSNHKAESGALI CCCCCCCCHHHHHHH | 21906983 | ||
| 204 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 204 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 215 | Acetylation | GALIEAAKSKIHQYK HHHHHHHHHHHHHHH | 25953088 | ||
| 215 | Ubiquitination | GALIEAAKSKIHQYK HHHHHHHHHHHHHHH | 29967540 | ||
| 217 | Ubiquitination | LIEAAKSKIHQYKVR HHHHHHHHHHHHHHH | 27667366 | ||
| 230 | Ubiquitination | VRAYIQMKSLKACKR HHHHHHHHCHHHHHH | 29967540 | ||
| 240 | Malonylation | KACKREIKSVMNTAG HHHHHHHHHHHHCCC | 26320211 | ||
| 240 | Ubiquitination | KACKREIKSVMNTAG HHHHHHHHHHHHCCC | 29967540 | ||
| 241 | Phosphorylation | ACKREIKSVMNTAGN HHHHHHHHHHHCCCC | 22210691 | ||
| 245 | Phosphorylation | EIKSVMNTAGNSAPS HHHHHHHCCCCCCHH | 21659604 | ||
| 249 | Phosphorylation | VMNTAGNSAPSLFLK HHHCCCCCCHHHHHH | 21659604 | ||
| 255 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 256 | Acetylation | SAPSLFLKSNFEYLR CCHHHHHHHHHHHHC | 9854603 | ||
| 256 | Methylation | SAPSLFLKSNFEYLR CCHHHHHHHHHHHHC | - | ||
| 256 | Ubiquitination | SAPSLFLKSNFEYLR CCHHHHHHHHHHHHC | 21906983 | ||
| 256 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 256 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 258 | Ubiquitination | PSLFLKSNFEYLRGN HHHHHHHHHHHHCCC | 21963094 | ||
| 263 | Methylation | KSNFEYLRGNYRKAV HHHHHHHCCCHHHHH | - | ||
| 264 | Ubiquitination | SNFEYLRGNYRKAVK HHHHHHCCCHHHHHH | 21963094 | ||
| 264 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 270 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 271 | Acetylation | GNYRKAVKLLNSSNI CCHHHHHHHHCCCCC | 25953088 | ||
| 271 | Ubiquitination | GNYRKAVKLLNSSNI CCHHHHHHHHCCCCC | 29967540 | ||
| 271 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 271 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 275 | Ubiquitination | KAVKLLNSSNIAEHP HHHHHHCCCCCCCCC | 29967540 | ||
| 276 | Phosphorylation | AVKLLNSSNIAEHPG HHHHHCCCCCCCCCC | 24972180 | ||
| 277 | Ubiquitination | VKLLNSSNIAEHPGF HHHHCCCCCCCCCCC | 27667366 | ||
| 286 | Ubiquitination | AEHPGFMKTGECLRC CCCCCCCCCCCHHHH | 21963094 | ||
| 287 | Phosphorylation | EHPGFMKTGECLRCM CCCCCCCCCCHHHHH | 25247763 | ||
| 290 | Ubiquitination | GFMKTGECLRCMFWN CCCCCCCHHHHHHHC | 29967540 | ||
| 300 | Ubiquitination | CMFWNNLGCIHFAMS HHHHCCCCHHHHHHH | 29967540 | ||
| 316 | Ubiquitination | HNLGIFYFKKALQEN HCCCHHHHHHHHHHC | 21963094 | ||
| 316 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 318 | Ubiquitination | LGIFYFKKALQENDN CCHHHHHHHHHHCCC | 29967540 | ||
| 331 | Ubiquitination | DNVCAQLSAGSTDPG CCCCCHHCCCCCCCC | 21890473 | ||
| 331 | Ubiquitination | DNVCAQLSAGSTDPG CCCCCHHCCCCCCCC | 21890473 | ||
| 331 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 339 | Ubiquitination | AGSTDPGKKFSGRPM CCCCCCCCCCCCCCC | 21963094 | ||
| 346 | Ubiquitination | KKFSGRPMCTLLTNK CCCCCCCCCHHHCCC | 21963094 | ||
| 378 | Ubiquitination | PLAAFECLIEAVQVY CHHHHHHHHHHHHHH | 29967540 | ||
| 389 | Ubiquitination | VQVYHANPRLWLRLA HHHHHCCHHHHHHHH | 21963094 | ||
| 399 | Ubiquitination | WLRLAECCIAANKGT HHHHHHHHHHHCCCC | 21963094 | ||
| 400 | Ubiquitination | LRLAECCIAANKGTS HHHHHHHHHHCCCCC | 21963094 | ||
| 404 | Ubiquitination | ECCIAANKGTSEQET HHHHHHCCCCCHHHH | 21963094 | ||
| 412 | Ubiquitination | GTSEQETKGLPSKKG CCCHHHHCCCCCCCC | 27667366 | ||
| 416 | Phosphorylation | QETKGLPSKKGIVQS HHHCCCCCCCCCHHH | 24719451 | ||
| 417 | Ubiquitination | ETKGLPSKKGIVQSI HHCCCCCCCCCHHHH | 27667366 | ||
| 418 | Ubiquitination | TKGLPSKKGIVQSIV HCCCCCCCCCHHHHH | 21963094 | ||
| 437 | Phosphorylation | HRKIVLASQSIQNTV CHHEEEEECHHCCCC | 28111955 | ||
| 439 | Phosphorylation | KIVLASQSIQNTVYN HEEEEECHHCCCCCC | 23403867 | ||
| 443 | Phosphorylation | ASQSIQNTVYNDGQS EECHHCCCCCCCCCC | 23403867 | ||
| 445 | Phosphorylation | QSIQNTVYNDGQSSA CHHCCCCCCCCCCCC | 23403867 | ||
| 450 | Phosphorylation | TVYNDGQSSAIPVAS CCCCCCCCCCCCHHH | 28111955 | ||
| 451 | Phosphorylation | VYNDGQSSAIPVASM CCCCCCCCCCCHHHH | 23403867 | ||
| 457 | Phosphorylation | SSAIPVASMEFAAIC CCCCCHHHHHHHHHH | 23403867 | ||
| 464 | Ubiquitination | SMEFAAICLRNALLL HHHHHHHHHHHHHHH | 21963094 | ||
| 472 | Ubiquitination | LRNALLLLPEEQQDP HHHHHHHCCHHHCCC | 27667366 | ||
| 477 | Ubiquitination | LLLPEEQQDPKQENG HHCCHHHCCCCCCCC | 27667366 | ||
| 478 | Ubiquitination | LLPEEQQDPKQENGA HCCHHHCCCCCCCCC | 21963094 | ||
| 480 | Ubiquitination | PEEQQDPKQENGAKN CHHHCCCCCCCCCCC | 29967540 | ||
| 486 | Ubiquitination | PKQENGAKNSNQLGG CCCCCCCCCCCCCCC | 21963094 | ||
| 492 | Ubiquitination | AKNSNQLGGNTESSE CCCCCCCCCCCCCCC | 21963094 | ||
| 497 | Phosphorylation | QLGGNTESSESSETC CCCCCCCCCCCCCCC | 30576142 | ||
| 501 | Phosphorylation | NTESSESSETCSSKS CCCCCCCCCCCCCCC | 30576142 | ||
| 503 | Phosphorylation | ESSESSETCSSKSHD CCCCCCCCCCCCCCC | 30576142 | ||
| 513 | Ubiquitination | SKSHDGDKFIPAPPS CCCCCCCCCCCCCCC | 29967540 | ||
| 520 | Phosphorylation | KFIPAPPSSPLRKQE CCCCCCCCCHHCHHH | 29255136 | ||
| 521 | Phosphorylation | FIPAPPSSPLRKQEL CCCCCCCCHHCHHHH | 29255136 | ||
| 525 | Ubiquitination | PPSSPLRKQELENLK CCCCHHCHHHHHHCC | 29967540 | ||
| 537 | Ubiquitination | NLKCSILACSAYVAL HCCHHHHHHHHHHHH | 29967540 | ||
| 540 | Ubiquitination | CSILACSAYVALALG HHHHHHHHHHHHHHC | 29967540 | ||
| 546 | Ubiquitination | SAYVALALGDNLMAL HHHHHHHHCCHHHHH | 21963094 | ||
| 564 | Ubiquitination | DKLLQQPKLSGSLKF HHHHHCCCCCCCHHH | 29967540 | ||
| 566 | Phosphorylation | LLQQPKLSGSLKFLG HHHCCCCCCCHHHHH | 23909892 | ||
| 568 | Phosphorylation | QQPKLSGSLKFLGHL HCCCCCCCHHHHHHH | 23909892 | ||
| 573 | Ubiquitination | SGSLKFLGHLYAAEA CCCHHHHHHHHHHHH | 29967540 | ||
| 580 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 585 | Ubiquitination | AEALISLDRISDAIT HHHHHCHHHHHHHHH | 29967540 | ||
| 590 | Ubiquitination | SLDRISDAITHLNPE CHHHHHHHHHHCCCC | 21963094 | ||
| 601 | Ubiquitination | LNPENVTDVSLGISS CCCCCCCEEEEECCC | 21963094 | ||
| 607 | Phosphorylation | TDVSLGISSNEQDQG CEEEEECCCCCCCCC | 26471730 | ||
| 608 | Phosphorylation | DVSLGISSNEQDQGS EEEEECCCCCCCCCC | 26471730 | ||
| 615 | Phosphorylation | SNEQDQGSDKGENEA CCCCCCCCCCCHHHH | 30576142 | ||
| 616 | Ubiquitination | NEQDQGSDKGENEAM CCCCCCCCCCHHHHH | 21963094 | ||
| 617 | Ubiquitination | EQDQGSDKGENEAME CCCCCCCCCHHHHHH | 21963094 | ||
| 624 | Ubiquitination | KGENEAMESSGKRAP CCHHHHHHHCCCCCC | 29967540 | ||
| 625 | Phosphorylation | GENEAMESSGKRAPQ CHHHHHHHCCCCCCC | 26471730 | ||
| 626 | Phosphorylation | ENEAMESSGKRAPQC HHHHHHHCCCCCCCC | 26471730 | ||
| 627 | Ubiquitination | NEAMESSGKRAPQCY HHHHHHCCCCCCCCC | 21963094 | ||
| 628 | Ubiquitination | EAMESSGKRAPQCYP HHHHHCCCCCCCCCC | 21963094 | ||
| 637 | Ubiquitination | APQCYPSSVNSARTV CCCCCCCCCCCCCEE | 29967540 | ||
| 650 | Ubiquitination | TVMLFNLGSAYCLRS EEEEEECCHHHHHHH | 21963094 | ||
| 661 | Ubiquitination | CLRSEYDKARKCLHQ HHHHHHHHHHHHHHH | 21963094 | ||
| 664 | Ubiquitination | SEYDKARKCLHQAAS HHHHHHHHHHHHHHH | 29967540 | ||
| 676 | Ubiquitination | AASMIHPKEVPPEAI HHHCCCCCCCCHHHH | 21963094 | ||
| 677 | Ubiquitination | ASMIHPKEVPPEAIL HHCCCCCCCCHHHHH | 21963094 | ||
| 681 | Ubiquitination | HPKEVPPEAILLAVY CCCCCCHHHHHHHHH | 21963094 | ||
| 686 | Ubiquitination | PPEAILLAVYLELQN CHHHHHHHHHHHHHC | 29967540 | ||
| 687 | Ubiquitination | PEAILLAVYLELQNG HHHHHHHHHHHHHCC | 21963094 | ||
| 688 | Ubiquitination | EAILLAVYLELQNGN HHHHHHHHHHHHCCC | 21963094 | ||
| 693 | Ubiquitination | AVYLELQNGNTQLAL HHHHHHHCCCHHHHH | 21963094 | ||
| 694 | Ubiquitination | VYLELQNGNTQLALQ HHHHHHCCCHHHHHH | 29967540 | ||
| 707 | Ubiquitination | LQIIKRNQLLPAVKT HHHHHHCCCCCCHHC | 21963094 | ||
| 708 | Ubiquitination | QIIKRNQLLPAVKTH HHHHHCCCCCCHHCC | 21963094 | ||
| 713 | Ubiquitination | NQLLPAVKTHSEVRK CCCCCCHHCCCHHHC | 29967540 | ||
| 719 | Ubiquitination | VKTHSEVRKKPVFQP HHCCCHHHCCCCCCC | 21963094 | ||
| 720 | Ubiquitination | KTHSEVRKKPVFQPV HCCCHHHCCCCCCCC | 21963094 | ||
| 721 | Ubiquitination | THSEVRKKPVFQPVH CCCHHHCCCCCCCCC | 29967540 | ||
| 724 | Ubiquitination | EVRKKPVFQPVHPIQ HHHCCCCCCCCCCCC | 29967540 | ||
| 753 | Ubiquitination | ---------------- ---------------- | 21963094 | ||
| 768 | Ubiquitination | ------------------------------- ------------------------------- | 21963094 | ||
| 773 | Ubiquitination | ------------------------------------ ------------------------------------ | 29967540 | ||
| 779 | Ubiquitination | ------------------------------------------ ------------------------------------------ | 21963094 | ||
| 780 | Ubiquitination | ------------------------------------------- ------------------------------------------- | 21963094 | ||
| 781 | Ubiquitination | -------------------------------------------- -------------------------------------------- | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CNO10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CNO10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CNO10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CNO10_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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