AP3S1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP3S1_HUMAN
• UniProt AC: Q92572
• Protein Name: AP-3 complex subunit sigma-1
• Gene Name: AP3S1
• Organism: Homo sapiens (Human).
• Sequence Length: 193
• Subcellular Localization: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
• Protein Description: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals..
• Protein Sequence: MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	LIFNNHGKPRLSKFY EEECCCCCCCHHHCC	21.29	21906983
18	Ubiquitination	HGKPRLSKFYQPYSE CCCCCHHHCCCCCCH	53.32	21890473
41	Ubiquitination	ETFHLVSKRDENVCN HHHHHHHCCCCCHHH	57.29	21906983
113	Ubiquitination	ELDLIFHVDKVHNIL HHHHHEEHHHHHHHH	5.47	21890473
118	Ubiquitination	FHVDKVHNILAEMVM EEHHHHHHHHHHHHH	33.68	21890473
141	Ubiquitination	MNEIVTQIDAQNKLE HHHHHHHHHHHHHHH	3.28	21890473
149	Ubiquitination	DAQNKLEKSEAGLAG HHHHHHHHCHHHHCC	65.12	21906983
149	Malonylation	DAQNKLEKSEAGLAG HHHHHHHHCHHHHCC	65.12	26320211
150	Phosphorylation	AQNKLEKSEAGLAGA HHHHHHHCHHHHCCC	24.25	20068231
163	Phosphorylation	GAPARAVSAVKNMNL CCCHHHHHHHHCCCC	26.76	24719451
166	Acetylation	ARAVSAVKNMNLPEI HHHHHHHHCCCCCCC	50.63	25953088
166	Ubiquitination	ARAVSAVKNMNLPEI HHHHHHHHCCCCCCC	50.63	21890473
168	Sulfoxidation	AVSAVKNMNLPEIPR HHHHHHCCCCCCCCC	4.52	21406390
183	Phosphorylation	NINIGDISIKVPNLP CCEECCCEEECCCCC	22.54	25159151
185	Ubiquitination	NIGDISIKVPNLPSF EECCCEEECCCCCCC	44.86	2190698
191	Phosphorylation	IKVPNLPSFK----- EECCCCCCCC-----	49.16	29514088
193	Methylation	VPNLPSFK------- CCCCCCCC-------	64.86	-
193	Ubiquitination	VPNLPSFK------- CCCCCCCC-------	64.86	-
193	Acetylation	VPNLPSFK------- CCCCCCCC-------	64.86	130605
249	Ubiquitination	--------------------------------------------------------------- ---------------------------------------------------------------		21890473
266	Ubiquitination	-------------------------------------------------------------------------------- --------------------------------------------------------------------------------		21890473
285	Ubiquitination	--------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP3S1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP3S1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP3S1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRS1_HUMAN	IRS1	physical	9792713
AP3D1_HUMAN	AP3D1	physical	22863883
AP3M1_HUMAN	AP3M1	physical	22863883
CDC73_HUMAN	CDC73	physical	26344197
AP3M1_HUMAN	AP3M1	physical	28514442
AP3M2_HUMAN	AP3M2	physical	28514442
AP3B2_HUMAN	AP3B2	physical	28514442
AP3B1_HUMAN	AP3B1	physical	28514442
RABL6_HUMAN	RABL6	physical	28514442
AP3D1_HUMAN	AP3D1	physical	28514442
RN167_HUMAN	RNF167	physical	28514442
DHRS2_HUMAN	DHRS2	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
AGO3_HUMAN	AGO3	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
AGK_HUMAN	AGK	physical	28514442
SPG7_HUMAN	SPG7	physical	28514442
FND3A_HUMAN	FNDC3A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.