| UniProt ID | RABL6_HUMAN | |
|---|---|---|
| UniProt AC | Q3YEC7 | |
| Protein Name | Rab-like protein 6 | |
| Gene Name | RABL6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 729 | |
| Subcellular Localization |
Isoform 1: Cytoplasm . Predominantly cytoplasmic (PubMed:17962191). Isoform 3: Nucleus . Predominantly nuclear (PubMed:17962191). |
|
| Protein Description | May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.. | |
| Protein Sequence | MFSALKKLVGSDQAPGRDKNIPAGLQSMNQALQRRFAKGVQYNMKIVIRGDRNTGKTALWHRLQGRPFVEEYIPTQEIQVTSIHWSYKTTDDIVKVEVWDVVDKGKCKKRGDGLKMENDPQEAESEMALDAEFLDVYKNCNGVVMMFDITKQWTFNYILRELPKVPTHVPVCVLGNYRDMGEHRVILPDDVRDFIDNLDRPPGSSYFRYAESSMKNSFGLKYLHKFFNIPFLQLQRETLLRQLETNQLDMDATLEELSVQQETEDQNYGIFLEMMEARSRGHASPLAANGQSPSPGSQSPVVPAGAVSTGSSSPGTPQPAPQLPLNAAPPSSVPPVPPSEALPPPACPSAPAPRRSIISRLFGTSPATEAAPPPPEPVPAAEGPATVQSVEDFVPDDRLDRSFLEDTTPARDEKKVGAKAAQQDSDSDGEALGGNPMVAGFQDDVDLEDQPRGSPPLPAGPVPSQDITLSSEEEAEVAAPTKGPAPAPQQCSEPETKWSSIPASKPRRGTAPTRTAAPPWPGGVSVRTGPEKRSSTRPPAEMEPGKGEQASSSESDPEGPIAAQMLSFVMDDPDFESEGSDTQRRADDFPVRDDPSDVTDEDEGPAEPPPPPKLPLPAFRLKNDSDLFGLGLEEAGPKESSEEGKEGKTPSKEKKKKKKKGKEEEEKAAKKKSKHKKSKDKEEGKEERRRRQQRPPRSRERTAADELEAFLGGGAPGGRHPGGGDYEEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MFSALKKL -------CCHHHHHH | 22814378 | ||
| 6 | Ubiquitination | --MFSALKKLVGSDQ --CCHHHHHHHCCCC | 24816145 | ||
| 6 | Acetylation | --MFSALKKLVGSDQ --CCHHHHHHHCCCC | 25953088 | ||
| 7 (in isoform 2) | Ubiquitination | - | - | ||
| 11 | Phosphorylation | ALKKLVGSDQAPGRD HHHHHHCCCCCCCCC | 21815630 | ||
| 19 | Ubiquitination | DQAPGRDKNIPAGLQ CCCCCCCCCCCHHHH | 24816145 | ||
| 27 | Phosphorylation | NIPAGLQSMNQALQR CCCHHHHHHHHHHHH | 28857561 | ||
| 42 | Phosphorylation | RFAKGVQYNMKIVIR HHHHCCCCEEEEEEE | 24719451 | ||
| 54 | Phosphorylation | VIRGDRNTGKTALWH EEECCCCCCCCHHHH | 24719451 | ||
| 104 | Malonylation | EVWDVVDKGKCKKRG EEEEEEECCCCCCCC | 26320211 | ||
| 104 | Acetylation | EVWDVVDKGKCKKRG EEEEEEECCCCCCCC | 25953088 | ||
| 167 | Phosphorylation | RELPKVPTHVPVCVL HHCCCCCCCCCEEEE | 22210691 | ||
| 177 | Phosphorylation | PVCVLGNYRDMGEHR CEEEECCCCCCCCCE | 22210691 | ||
| 217 | Phosphorylation | AESSMKNSFGLKYLH HHHHCCCCCCHHHHH | - | ||
| 217 (in isoform 6) | Phosphorylation | - | - | ||
| 222 | Phosphorylation | KNSFGLKYLHKFFNI CCCCCHHHHHHHHCC | - | ||
| 222 (in isoform 6) | Phosphorylation | - | - | ||
| 356 | Phosphorylation | SAPAPRRSIISRLFG CCCCCHHHHHHHHHC | 20363803 | ||
| 357 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 359 | Phosphorylation | APRRSIISRLFGTSP CCHHHHHHHHHCCCC | 19664995 | ||
| 360 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 364 | Phosphorylation | IISRLFGTSPATEAA HHHHHHCCCCCCCCC | 27080861 | ||
| 365 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 365 | Phosphorylation | ISRLFGTSPATEAAP HHHHHCCCCCCCCCC | 27080861 | ||
| 368 | Phosphorylation | LFGTSPATEAAPPPP HHCCCCCCCCCCCCC | 29496963 | ||
| 386 | Phosphorylation | PAAEGPATVQSVEDF CCCCCCCEEECHHHH | 27251275 | ||
| 387 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 389 | Phosphorylation | EGPATVQSVEDFVPD CCCCEEECHHHHCCC | 27251275 | ||
| 402 | Phosphorylation | PDDRLDRSFLEDTTP CCCCCCHHHHCCCCC | 23401153 | ||
| 403 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 407 | Phosphorylation | DRSFLEDTTPARDEK CHHHHCCCCCCCCHH | 29255136 | ||
| 408 | Phosphorylation | RSFLEDTTPARDEKK HHHHCCCCCCCCHHH | 19664994 | ||
| 425 | Phosphorylation | AKAAQQDSDSDGEAL HHHHCCCCCCCCCHH | 30266825 | ||
| 426 (in isoform 2) | Phosphorylation | - | 21406692 | ||
| 427 | Phosphorylation | AAQQDSDSDGEALGG HHCCCCCCCCCHHCC | 30266825 | ||
| 428 (in isoform 2) | Phosphorylation | - | 21406692 | ||
| 454 | Phosphorylation | LEDQPRGSPPLPAGP CCCCCCCCCCCCCCC | 23927012 | ||
| 455 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 464 | Phosphorylation | LPAGPVPSQDITLSS CCCCCCCCCCCCCCC | 23927012 | ||
| 468 | Phosphorylation | PVPSQDITLSSEEEA CCCCCCCCCCCHHHH | 23927012 | ||
| 470 | Phosphorylation | PSQDITLSSEEEAEV CCCCCCCCCHHHHHH | 26503892 | ||
| 471 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 471 | Phosphorylation | SQDITLSSEEEAEVA CCCCCCCCHHHHHHC | 26503892 | ||
| 472 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 481 | Phosphorylation | EAEVAAPTKGPAPAP HHHHCCCCCCCCCCC | 23927012 | ||
| 492 | Phosphorylation | APAPQQCSEPETKWS CCCCCCCCCCCCCCC | 30266825 | ||
| 493 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 496 | Phosphorylation | QQCSEPETKWSSIPA CCCCCCCCCCCCCCC | 30266825 | ||
| 499 | Phosphorylation | SEPETKWSSIPASKP CCCCCCCCCCCCCCC | 27251275 | ||
| 500 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 500 | Phosphorylation | EPETKWSSIPASKPR CCCCCCCCCCCCCCC | 27251275 | ||
| 504 | Phosphorylation | KWSSIPASKPRRGTA CCCCCCCCCCCCCCC | 25159151 | ||
| 505 | Acetylation | WSSIPASKPRRGTAP CCCCCCCCCCCCCCC | 25953088 | ||
| 505 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 510 | Phosphorylation | ASKPRRGTAPTRTAA CCCCCCCCCCCCCCC | - | ||
| 513 | Phosphorylation | PRRGTAPTRTAAPPW CCCCCCCCCCCCCCC | - | ||
| 525 | Phosphorylation | PPWPGGVSVRTGPEK CCCCCCCCCCCCCCC | 28857561 | ||
| 525 | O-linked_Glycosylation | PPWPGGVSVRTGPEK CCCCCCCCCCCCCCC | 23301498 | ||
| 526 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 528 | Phosphorylation | PGGVSVRTGPEKRSS CCCCCCCCCCCCCCC | 24719451 | ||
| 529 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 534 | Phosphorylation | RTGPEKRSSTRPPAE CCCCCCCCCCCCCCC | 28555341 | ||
| 535 | Phosphorylation | TGPEKRSSTRPPAEM CCCCCCCCCCCCCCC | - | ||
| 551 | Phosphorylation | PGKGEQASSSESDPE CCCCCCCCCCCCCCC | 25137130 | ||
| 552 | Phosphorylation | GKGEQASSSESDPEG CCCCCCCCCCCCCCC | 25137130 | ||
| 553 | Phosphorylation | KGEQASSSESDPEGP CCCCCCCCCCCCCCH | 25137130 | ||
| 555 | Phosphorylation | EQASSSESDPEGPIA CCCCCCCCCCCCHHH | 25137130 | ||
| 567 | Phosphorylation | PIAAQMLSFVMDDPD HHHHHHHHHHCCCCC | 17081983 | ||
| 577 | Phosphorylation | MDDPDFESEGSDTQR CCCCCCCCCCCCCCC | 26657352 | ||
| 580 | Phosphorylation | PDFESEGSDTQRRAD CCCCCCCCCCCCCHH | 20363803 | ||
| 582 | Phosphorylation | FESEGSDTQRRADDF CCCCCCCCCCCHHCC | 17081983 | ||
| 596 | Phosphorylation | FPVRDDPSDVTDEDE CCCCCCHHCCCCCCC | 29255136 | ||
| 597 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 597 | Phosphorylation | PVRDDPSDVTDEDEG CCCCCHHCCCCCCCC | 32142685 | ||
| 599 | Phosphorylation | RDDPSDVTDEDEGPA CCCHHCCCCCCCCCC | 29255136 | ||
| 600 | Phosphorylation | DDPSDVTDEDEGPAE CCHHCCCCCCCCCCC | 32142685 | ||
| 600 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 625 | Phosphorylation | AFRLKNDSDLFGLGL CEECCCCHHHCCCCC | 23403867 | ||
| 626 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 640 | Phosphorylation | EEAGPKESSEEGKEG CCCCCCCCCCCCCCC | 29255136 | ||
| 641 | Phosphorylation | EAGPKESSEEGKEGK CCCCCCCCCCCCCCC | 29255136 | ||
| 641 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 642 | Phosphorylation | AGPKESSEEGKEGKT CCCCCCCCCCCCCCC | 32142685 | ||
| 642 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 662 | Acetylation | KKKKKKGKEEEEKAA HHHHHCCHHHHHHHH | 130827 | ||
| 698 | Phosphorylation | RQQRPPRSRERTAAD HHHCCCCHHHCHHHH | 33259812 | ||
| 699 | Phosphorylation | QQRPPRSRERTAADE HHCCCCHHHCHHHHH | 33259812 | ||
| 702 | Phosphorylation | PPRSRERTAADELEA CCCHHHCHHHHHHHH | 28555341 | ||
| 725 | Phosphorylation | GRHPGGGDYEEL--- CCCCCCCCCCCC--- | 17016520 | ||
| 726 | Phosphorylation | RHPGGGDYEEL---- CCCCCCCCCCC---- | 27273156 | ||
| 727 (in isoform 2) | Phosphorylation | - | 27642862 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RABL6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RABL6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RABL6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CS057_HUMAN | C19orf57 | physical | 16189514 | |
| P53_HUMAN | TP53 | physical | 23572512 | |
| AP3M1_HUMAN | AP3M1 | physical | 22863883 | |
| AP3S1_HUMAN | AP3S1 | physical | 22863883 | |
| ML12A_HUMAN | MYL12A | physical | 22863883 | |
| MDM2_HUMAN | MDM2 | physical | 23572512 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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