SPG7_HUMAN - dbPTM
SPG7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPG7_HUMAN
UniProt AC Q9UQ90
Protein Name Paraplegin {ECO:0000250|UniProtKB:Q3ULF4}
Gene Name SPG7 {ECO:0000312|HGNC:HGNC:11237}
Organism Homo sapiens (Human).
Sequence Length 795
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein .
Protein Description ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function. [PubMed: 26387735]
Protein Sequence MAVLLLLLRALRRGPGPGPRPLWGPGPAWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMRPGRLDRHVFIDLPTLQERREIFEQHLKSLKLTQSSTFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTLNFEYAVERVLAGTAKKSKILSKEEQKVVAFHESGHALVGWMLEHTEAVMKVSITPRTNAALGFAQMLPRDQHLFTKEQLFERMCMALGGRASEALSFNEVTSGAQDDLRKVTRIAYSMVKQFGMAPGIGPISFPEAQEGLMGIGRRPFSQGLQQMMDHEARLLVAKAYRHTEKVLQDNLDKLQALANALLEKEVINYEDIEALIGPPPHGPKKMIAPQRWIDAQREKQDLGEEETEETQQPPLGGEEPTWPK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30PhosphorylationWGPGPAWSPGFPARP
CCCCCCCCCCCCCCC		19.77-
166PhosphorylationSTSGGSISWNDFVHE
HCCCCCCCHHHHHHH		22.86-
195PhosphorylationESDVVEVYLHPGAVV
CCCEEEEEECCCCEE		5.93-
248PhosphorylationIPVSYKRTGFFGNAL
CCCCEECCCCCCHHH		33.9025867546
256PhosphorylationGFFGNALYSVGMTAV
CCCCHHHHHHHHHHH		10.0125867546
257PhosphorylationFFGNALYSVGMTAVG
CCCHHHHHHHHHHHH		17.0325867546
261PhosphorylationALYSVGMTAVGLAIL
HHHHHHHHHHHHHHH		16.5625867546
270PhosphorylationVGLAILWYVFRLAGM
HHHHHHHHHHHHHCC		6.0525867546
307PhosphorylationGKMGKGVSFKDVAGM
CCCCCCCCHHHHCCC		34.9429457462
318UbiquitinationVAGMHEAKLEVREFV
HCCCHHHHHHHHHHH		42.04-
330PhosphorylationEFVDYLKSPERFLQL
HHHHHHHCHHHHHHC		29.42-
340UbiquitinationRFLQLGAKVPKGALL
HHHHCCCCCCCCCEE		58.22-
392PhosphorylationLGAARVRSLFKEARA
CCHHHHHHHHHHHHH		34.9924719451
395MalonylationARVRSLFKEARARAP
HHHHHHHHHHHHHCC		56.6126320211
395UbiquitinationARVRSLFKEARARAP
HHHHHHHHHHHHHCC		56.61-
495PhosphorylationIFEQHLKSLKLTQSS
HHHHHHHHCCCCCCC		36.7823532336
499PhosphorylationHLKSLKLTQSSTFYS
HHHHCCCCCCCCHHH		25.4723532336
501PhosphorylationKSLKLTQSSTFYSQR
HHCCCCCCCCHHHHH		26.5525003641
502PhosphorylationSLKLTQSSTFYSQRL
HCCCCCCCCHHHHHH		16.8425003641
505NitrationLTQSSTFYSQRLAEL
CCCCCCHHHHHHHHH		12.18-
505Nitrated tyrosineLTQSSTFYSQRLAEL
CCCCCCHHHHHHHHH		12.18-
595PhosphorylationTEAVMKVSITPRTNA
CCCEEEEECCCCCCH		18.4124719451
619MalonylationRDQHLFTKEQLFERM
CCCCCCCHHHHHHHH		35.8126320211
619UbiquitinationRDQHLFTKEQLFERM
CCCCCCCHHHHHHHH		35.81-
635PhosphorylationMALGGRASEALSFNE
HHHCCCHHHHHCHHH		23.2622496350
709SuccinylationEARLLVAKAYRHTEK
HHHHHHHHHHHHHHH		38.1723954790
740PhosphorylationLEKEVINYEDIEALI
HHCCCCCHHHHHHHH		12.1227642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPG7_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPG7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPG7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KR412_HUMANKRTAP4-12physical
16189514
RALY_HUMANRALYphysical
16169070
LRIF1_HUMANLRIF1physical
16169070
STABP_HUMANSTAMBPphysical
21988832
PPIP1_HUMANPSTPIP1physical
25416956
PNMA1_HUMANPNMA1physical
25416956
PSME3_HUMANPSME3physical
25416956
RBPMS_HUMANRBPMSphysical
25416956
MTUS2_HUMANMTUS2physical
25416956
CCDB1_HUMANCCNDBP1physical
25416956
LZTS2_HUMANLZTS2physical
25416956
K1C40_HUMANKRT40physical
25416956
KHDR2_HUMANKHDRBS2physical
25416956
KR107_HUMANKRTAP10-7physical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
NDUB9_HUMANNDUFB9physical
26186194
PNMA1_HUMANPNMA1physical
21516116
NDUB9_HUMANNDUFB9physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPG7_HUMAN

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Related Literatures of Post-Translational Modification

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