NDUB9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUB9_HUMAN
• UniProt AC: Q9Y6M9
• Protein Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
• Gene Name: NDUFB9
• Organism: Homo sapiens (Human).
• Sequence Length: 179
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAFLASGPYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPPGGPLTEALPPARKEGDLPPLWWYIVTRPRERPM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAFLASGPY ------CCCCCCCCC	14.25	25944712
6	Phosphorylation	--MAFLASGPYLTHQ --CCCCCCCCCCHHH	42.31	20068231
9	Phosphorylation	AFLASGPYLTHQQKV CCCCCCCCCHHHHHH	27.97	20068231
11	Phosphorylation	LASGPYLTHQQKVLR CCCCCCCHHHHHHHH	16.28	20068231
15	Ubiquitination	PYLTHQQKVLRLYKR CCCHHHHHHHHHHHH	36.34	21890473
55	Acetylation	FEEHKNEKDMAKATQ HHHHCCHHHHHHHHH	63.30	25825284
59	Ubiquitination	KNEKDMAKATQLLKE CCHHHHHHHHHHHHH	45.38	21906983
59	2-Hydroxyisobutyrylation	KNEKDMAKATQLLKE CCHHHHHHHHHHHHH	45.38	-
65	Ubiquitination	AKATQLLKEAEEEFW HHHHHHHHHHHHHHH	64.57	21890473
73	Phosphorylation	EAEEEFWYRQHPQPY HHHHHHHHHCCCCCE	13.01	-
80	Phosphorylation	YRQHPQPYIFPDSPG HHCCCCCEECCCCCC	15.22	25884760
85	Phosphorylation	QPYIFPDSPGGTSYE CCEECCCCCCCCCCC	26.19	25159151
89	Phosphorylation	FPDSPGGTSYERYDC CCCCCCCCCCCCCCC	33.77	20068231
90	Phosphorylation	PDSPGGTSYERYDCY CCCCCCCCCCCCCCC	28.42	23186163
91	Phosphorylation	DSPGGTSYERYDCYK CCCCCCCCCCCCCCC	12.31	20068231
98	Acetylation	YERYDCYKVPEWCLD CCCCCCCCCCHHHCC	58.61	25825284
98	Ubiquitination	YERYDCYKVPEWCLD CCCCCCCCCCHHHCC	58.61	-
112	Ubiquitination	DDWHPSEKAMYPDYF CCCCHHHHHCCHHHH	42.67	-
115	Phosphorylation	HPSEKAMYPDYFAKR CHHHHHCCHHHHHHH	9.60	25348954
118	Phosphorylation	EKAMYPDYFAKREQW HHHCCHHHHHHHHHH	10.84	25348954
121	Ubiquitination	MYPDYFAKREQWKKL CCHHHHHHHHHHHHH	46.71	21890473
121	Acetylation	MYPDYFAKREQWKKL CCHHHHHHHHHHHHH	46.71	133291
121	2-Hydroxyisobutyrylation	MYPDYFAKREQWKKL CCHHHHHHHHHHHHH	46.71	-
132	Phosphorylation	WKKLRRESWEREVKQ HHHHHHHHHHHHHHH	32.21	23882029
138	Ubiquitination	ESWEREVKQLQEETP HHHHHHHHHHHHHCC	40.30	2190698
138	Malonylation	ESWEREVKQLQEETP HHHHHHHHHHHHHCC	40.30	32601280
169	Phosphorylation	DLPPLWWYIVTRPRE CCCCCEEEEECCCCC	3.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUB9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUB9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUB9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GDF9_HUMAN	GDF9	physical	16169070
FEZ1_HUMAN	FEZ1	physical	16169070
ELP1_HUMAN	IKBKAP	physical	16169070
SH3G3_HUMAN	SH3GL3	physical	16169070
HAP1_HUMAN	HAP1	physical	16169070
MIC60_HUMAN	IMMT	physical	16169070
NDUS1_HUMAN	NDUFS1	physical	22939629
NDUBA_HUMAN	NDUFB10	physical	22939629
SYNE2_HUMAN	SYNE2	physical	22939629
STX4_HUMAN	STX4	physical	22939629
RT28_HUMAN	MRPS28	physical	22939629
AT5F1_HUMAN	ATP5F1	physical	26344197
CLH1_HUMAN	CLTC	physical	26344197
ETFR1_HUMAN	LYRM5	physical	26344197
NDUAC_HUMAN	NDUFA12	physical	26344197
NDUA2_HUMAN	NDUFA2	physical	26344197
NDUA6_HUMAN	NDUFA6	physical	26344197
NDUA9_HUMAN	NDUFA9	physical	26344197
NDUB8_HUMAN	NDUFB8	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
VDAC2_HUMAN	VDAC2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, AND MASSSPECTROMETRY.
PubMed: 18691976