RT28_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RT28_HUMAN
• UniProt AC: Q9Y2Q9
• Protein Name: 28S ribosomal protein S28, mitochondrial
• Gene Name: MRPS28
• Organism: Homo sapiens (Human).
• Sequence Length: 187
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MAALCRTRAVAAESHFLRVFLFFRPFRGVGTESGSESGSSNAKEPKTRAGGFASALERHSELLQKVEPLQKGSPKNVESFASMLRHSPLTQMGPAKDKLVIGRIFHIVENDLYIDFGGKFHCVCRRPEVDGEKYQKGTRVRLRLLDLELTSRFLGATTDTTVLEANAVLLGIQESKDSRSKEEHHEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Ubiquitination	ESGSSNAKEPKTRAG CCCCCCCCCCCCCHH	77.97	-
47	Phosphorylation	SNAKEPKTRAGGFAS CCCCCCCCCHHHHHH	36.15	-
54	Phosphorylation	TRAGGFASALERHSE CCHHHHHHHHHHHHH	31.00	23917254
65	Ubiquitination	RHSELLQKVEPLQKG HHHHHHHHHCCCCCC	48.84	21890473
73	Phosphorylation	VEPLQKGSPKNVESF HCCCCCCCCCCHHHH	39.47	24719451
75	Ubiquitination	PLQKGSPKNVESFAS CCCCCCCCCHHHHHH	75.27	2189047
79	Phosphorylation	GSPKNVESFASMLRH CCCCCHHHHHHHHHC	23.10	20068231
82	Phosphorylation	KNVESFASMLRHSPL CCHHHHHHHHHCCCC	19.15	25159151
83	Sulfoxidation	NVESFASMLRHSPLT CHHHHHHHHHCCCCH	3.23	21406390
87	Phosphorylation	FASMLRHSPLTQMGP HHHHHHCCCCHHCCC	18.38	25159151
90	Phosphorylation	MLRHSPLTQMGPAKD HHHCCCCHHCCCCCC	21.64	29449344
98	2-Hydroxyisobutyrylation	QMGPAKDKLVIGRIF HCCCCCCCEEEEEEE	43.90	-
133	Acetylation	RPEVDGEKYQKGTRV CCCCCCCCCCCCCEE	59.52	19608861
133	2-Hydroxyisobutyrylation	RPEVDGEKYQKGTRV CCCCCCCCCCCCCEE	59.52	-
150	Phosphorylation	RLLDLELTSRFLGAT EEECHHHHHHHCCCC	14.42	28387310
151	Phosphorylation	LLDLELTSRFLGATT EECHHHHHHHCCCCC	33.39	28387310

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RT28_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RT28_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RT28_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRPRB_HUMAN	SRPRB	physical	22939629
TIAR_HUMAN	TIAL1	physical	22939629
RT22_HUMAN	MRPS22	physical	26344197
RT27_HUMAN	MRPS27	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-133, AND MASS SPECTROMETRY.
PubMed: 19608861