| UniProt ID | SRPRB_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y5M8 | |
| Protein Name | Signal recognition particle receptor subunit beta | |
| Gene Name | SRPRB | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 271 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass membrane protein. |
|
| Protein Description | Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).. | |
| Protein Sequence | MASADSRRVADGGGAGGTFQPYLDTLRQELQQTDPTLLSVVVAVLAVLLTLVFWKLIRSRRSSQRAVLLVGLCDSGKTLLFVRLLTGLYRDTQTSITDSCAVYRVNNNRGNSLTLIDLPGHESLRLQFLERFKSSARAIVFVVDSAAFQREVKDVAEFLYQVLIDSMGLKNTPSFLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTRSAAPSTLDSSSTAPAQLGKKGKEFEFSQLPLKVEFLECSAKGGRGDVGSADIQDLEKWLAKIA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Phosphorylation | DGGGAGGTFQPYLDT CCCCCCCCHHHHHHH | 20.41 | 22210691 | |
| 18 | O-linked_Glycosylation | DGGGAGGTFQPYLDT CCCCCCCCHHHHHHH | 20.41 | 29237092 | |
| 25 | Phosphorylation | TFQPYLDTLRQELQQ CHHHHHHHHHHHHHH | 22.65 | 22210691 | |
| 92 | Phosphorylation | LTGLYRDTQTSITDS HHHHCCCCCCCCCCC | 25.42 | 26126808 | |
| 94 | Phosphorylation | GLYRDTQTSITDSCA HHCCCCCCCCCCCEE | 24.96 | 26126808 | |
| 95 | Phosphorylation | LYRDTQTSITDSCAV HCCCCCCCCCCCEEE | 17.42 | 26126808 | |
| 97 | Phosphorylation | RDTQTSITDSCAVYR CCCCCCCCCCEEEEE | 22.94 | 26126808 | |
| 99 | Phosphorylation | TQTSITDSCAVYRVN CCCCCCCCEEEEEEE | 8.70 | 26126808 | |
| 103 | Phosphorylation | ITDSCAVYRVNNNRG CCCCEEEEEEECCCC | 7.13 | 26126808 | |
| 109 | Methylation | VYRVNNNRGNSLTLI EEEEECCCCCEEEEE | 48.03 | 115917825 | |
| 112 | Phosphorylation | VNNNRGNSLTLIDLP EECCCCCEEEEEECC | 26.09 | 29255136 | |
| 114 | Phosphorylation | NNRGNSLTLIDLPGH CCCCCEEEEEECCCC | 22.84 | 29255136 | |
| 123 | Phosphorylation | IDLPGHESLRLQFLE EECCCCHHHHHHHHH | 17.08 | 23927012 | |
| 134 | Phosphorylation | QFLERFKSSARAIVF HHHHHHHHCCCEEEE | 26.90 | 27732954 | |
| 135 | Phosphorylation | FLERFKSSARAIVFV HHHHHHHCCCEEEEE | 23.51 | 27732954 | |
| 145 | Phosphorylation | AIVFVVDSAAFQREV EEEEEEEHHHHHHHH | 15.19 | 27732954 | |
| 174 | Phosphorylation | MGLKNTPSFLIACNK CCCCCCCCEEEEECH | 30.55 | 27499020 | |
| 181 | 2-Hydroxyisobutyrylation | SFLIACNKQDIAMAK CEEEEECHHHHHHHH | 49.59 | - | |
| 181 | Ubiquitination | SFLIACNKQDIAMAK CEEEEECHHHHHHHH | 49.59 | - | |
| 188 | Ubiquitination | KQDIAMAKSAKLIQQ HHHHHHHHHHHHHHH | 37.55 | - | |
| 191 | Acetylation | IAMAKSAKLIQQQLE HHHHHHHHHHHHHHH | 53.89 | 25953088 | |
| 191 | Malonylation | IAMAKSAKLIQQQLE HHHHHHHHHHHHHHH | 53.89 | 26320211 | |
| 191 | Ubiquitination | IAMAKSAKLIQQQLE HHHHHHHHHHHHHHH | 53.89 | 21890473 | |
| 199 | Acetylation | LIQQQLEKELNTLRV HHHHHHHHHHCHHHH | 75.89 | 23954790 | |
| 199 | Ubiquitination | LIQQQLEKELNTLRV HHHHHHHHHHCHHHH | 75.89 | 21890473 | |
| 199 | 2-Hydroxyisobutyrylation | LIQQQLEKELNTLRV HHHHHHHHHHCHHHH | 75.89 | - | |
| 207 | Phosphorylation | ELNTLRVTRSAAPST HHCHHHHHCCCCCCC | 16.69 | 28258704 | |
| 209 | Phosphorylation | NTLRVTRSAAPSTLD CHHHHHCCCCCCCCC | 21.29 | 28258704 | |
| 213 | Phosphorylation | VTRSAAPSTLDSSST HHCCCCCCCCCCCCC | 36.55 | 20068231 | |
| 214 | Phosphorylation | TRSAAPSTLDSSSTA HCCCCCCCCCCCCCC | 33.26 | 25159151 | |
| 217 | Phosphorylation | AAPSTLDSSSTAPAQ CCCCCCCCCCCCCHH | 29.33 | 28258704 | |
| 218 | Phosphorylation | APSTLDSSSTAPAQL CCCCCCCCCCCCHHH | 31.23 | 20068231 | |
| 219 | Phosphorylation | PSTLDSSSTAPAQLG CCCCCCCCCCCHHHC | 32.32 | 28985074 | |
| 220 | Phosphorylation | STLDSSSTAPAQLGK CCCCCCCCCCHHHCC | 38.31 | 20068231 | |
| 227 | 2-Hydroxyisobutyrylation | TAPAQLGKKGKEFEF CCCHHHCCCCCEEEC | 67.93 | - | |
| 227 | Malonylation | TAPAQLGKKGKEFEF CCCHHHCCCCCEEEC | 67.93 | 26320211 | |
| 227 | Acetylation | TAPAQLGKKGKEFEF CCCHHHCCCCCEEEC | 67.93 | 26051181 | |
| 227 | Ubiquitination | TAPAQLGKKGKEFEF CCCHHHCCCCCEEEC | 67.93 | 21906983 | |
| 228 | Ubiquitination | APAQLGKKGKEFEFS CCHHHCCCCCEEECC | 73.71 | - | |
| 230 | 2-Hydroxyisobutyrylation | AQLGKKGKEFEFSQL HHHCCCCCEEECCCC | 69.02 | - | |
| 230 | Malonylation | AQLGKKGKEFEFSQL HHHCCCCCEEECCCC | 69.02 | 26320211 | |
| 230 | Ubiquitination | AQLGKKGKEFEFSQL HHHCCCCCEEECCCC | 69.02 | 21890473 | |
| 235 | Phosphorylation | KGKEFEFSQLPLKVE CCCEEECCCCCEEEE | 24.49 | 25599653 | |
| 240 | Ubiquitination | EFSQLPLKVEFLECS ECCCCCEEEEEEECC | 37.47 | - | |
| 247 | Phosphorylation | KVEFLECSAKGGRGD EEEEEECCCCCCCCC | 24.52 | 21406692 | |
| 249 | 2-Hydroxyisobutyrylation | EFLECSAKGGRGDVG EEEECCCCCCCCCCC | 45.67 | - | |
| 249 | Ubiquitination | EFLECSAKGGRGDVG EEEECCCCCCCCCCC | 45.67 | 21890473 | |
| 257 | Phosphorylation | GGRGDVGSADIQDLE CCCCCCCCCCHHHHH | 23.71 | 29255136 | |
| 265 | Ubiquitination | ADIQDLEKWLAKIA- CCHHHHHHHHHHHC- | 55.60 | 21890473 | |
| 269 | Ubiquitination | DLEKWLAKIA----- HHHHHHHHHC----- | 36.68 | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SRPRB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SRPRB_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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