CF120_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CF120_HUMAN
• UniProt AC: Q7Z4R8
• Protein Name: UPF0669 protein C6orf120
• Gene Name: C6orf120
• Organism: Homo sapiens (Human).
• Sequence Length: 191
• Subcellular Localization: Secreted . Secreted by hepatocytes.
• Protein Description: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes..
• Protein Sequence: MAAPRGRAAPWTTALLLLLASQVLSPGSCADEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIVLRMRSLKGDADLYVSASSLHPSFDDYELQSATCGPDAVSIPAHFRRPVGIGVYGHPSHLESEFEMKVYYDGTVEQHPFGEAAYPADGADAGQKHAGAPEDASQEEESVLWTILISILKLVLEILF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	N-linked_Glycosylation	QGQIGAGNYSYLRLN ECCCCCCCCCEEEEC	23.26	19159218
64	Ubiquitination	LRLNHEGKIVLRMRS EEECCCCEEEEEEEC	27.02	-
72	N-linked_Glycosylation	IVLRMRSLKGDADLY EEEEEECCCCCCCEE	5.19	19159218
98	O-linked_Glycosylation	DYELQSATCGPDAVS CHHHCCCCCCCCCCC	24.20	OGP
127	Phosphorylation	GHPSHLESEFEMKVY CCHHHCCCCEEEEEE	54.68	-
138	O-linked_Glycosylation	MKVYYDGTVEQHPFG EEEEECCCEEECCCC	20.26	OGP
146	Phosphorylation	VEQHPFGEAAYPADG EEECCCCCCCCCCCC	30.42	-
181	Phosphorylation	VLWTILISILKLVLE HHHHHHHHHHHHHHH	20.58	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CF120_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CF120_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CF120_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CF120_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53, AND MASS SPECTROMETRY.
PubMed: 19159218