NCPR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCPR_HUMAN
• UniProt AC: P16435
• Protein Name: NADPH--cytochrome P450 reductase {ECO:0000255|HAMAP-Rule:MF_03212}
• Gene Name: POR {ECO:0000255|HAMAP-Rule:MF_03212}
• Organism: Homo sapiens (Human).
• Sequence Length: 677
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side .
• Protein Description: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5..
• Protein Sequence: MGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDSHVDTS ------CCCCCCCCC	45.16	2513880
48	2-Hydroxyisobutyrylation	WFLFRKKKEEVPEFT HHHHHCCHHCCCCCC	63.24	-
51	Ubiquitination	FRKKKEEVPEFTKIQ HHCCHHCCCCCCCHH	6.04	24816145
56	Ubiquitination	EEVPEFTKIQTLTSS HCCCCCCCHHHHCHH	37.83	21890473
56	2-Hydroxyisobutyrylation	EEVPEFTKIQTLTSS HCCCCCCCHHHHCHH	37.83	-
59	Phosphorylation	PEFTKIQTLTSSVRE CCCCCHHHHCHHHHH	35.16	30266825
59	Ubiquitination	PEFTKIQTLTSSVRE CCCCCHHHHCHHHHH	35.16	27667366
61	Phosphorylation	FTKIQTLTSSVRESS CCCHHHHCHHHHHHH	23.49	30266825
62	Phosphorylation	TKIQTLTSSVRESSF CCHHHHCHHHHHHHH	29.92	30266825
63	Phosphorylation	KIQTLTSSVRESSFV CHHHHCHHHHHHHHH	21.69	30266825
65	Phosphorylation	QTLTSSVRESSFVEK HHHCHHHHHHHHHHH	39.77	-
66	Phosphorylation	TLTSSVRESSFVEKM HHCHHHHHHHHHHHH	48.88	32142685
67	Phosphorylation	LTSSVRESSFVEKMK HCHHHHHHHHHHHHH	20.64	20068231
68	Phosphorylation	TSSVRESSFVEKMKK CHHHHHHHHHHHHHH	28.67	25159151
71	Phosphorylation	VRESSFVEKMKKTGR HHHHHHHHHHHHHCC	45.48	-
72	Acetylation	RESSFVEKMKKTGRN HHHHHHHHHHHHCCE	51.20	25825284
75	Acetylation	SFVEKMKKTGRNIIV HHHHHHHHHCCEEEE	53.35	-
77	Ubiquitination	VEKMKKTGRNIIVFY HHHHHHHCCEEEEEE	29.53	24816145
100	2-Hydroxyisobutyrylation	EFANRLSKDAHRYGM HHHHHHHHHHHHHHC	64.62	-
177	Phosphorylation	VFGLGNKTYEHFNAM EEECCCCHHHHHHHH	37.84	26503892
178	Phosphorylation	FGLGNKTYEHFNAMG EECCCCHHHHHHHHH	14.71	26503892
186	2-Hydroxyisobutyrylation	EHFNAMGKYVDKRLE HHHHHHHHHHHHHHH	29.08	-
186	Acetylation	EHFNAMGKYVDKRLE HHHHHHHHHHHHHHH	29.08	27452117
189	Ubiquitination	NAMGKYVDKRLEQLG HHHHHHHHHHHHHHC	27.54	29967540
245	Phosphorylation	EESSIRQYELVVHTD CCCCCCEEEEEEECC	11.03	20068231
251	Phosphorylation	QYELVVHTDIDAAKV EEEEEEECCCHHHHH	24.04	20068231
254	Phosphorylation	LVVHTDIDAAKVYMG EEEECCCHHHHHHHH	43.19	-
259	Phosphorylation	DIDAAKVYMGEMGRL CCHHHHHHHHCCCCC	9.94	18083107
267	Methylation	MGEMGRLKSYENQKP HHCCCCCCCCCCCCC	50.02	115975411
268	Phosphorylation	GEMGRLKSYENQKPP HCCCCCCCCCCCCCC	42.12	26270265
269	Phosphorylation	EMGRLKSYENQKPPF CCCCCCCCCCCCCCC	19.81	26270265
270	Ubiquitination	MGRLKSYENQKPPFD CCCCCCCCCCCCCCC	61.34	29967540
270	Methylation	MGRLKSYENQKPPFD CCCCCCCCCCCCCCC	61.34	-
273	Malonylation	LKSYENQKPPFDAKN CCCCCCCCCCCCCCC	67.26	26320211
276	Ubiquitination	YENQKPPFDAKNPFL CCCCCCCCCCCCCHH	22.61	33845483
279	2-Hydroxyisobutyrylation	QKPPFDAKNPFLAAV CCCCCCCCCCHHEEH	67.98	-
282	Ubiquitination	PFDAKNPFLAAVTTN CCCCCCCHHEEHHCC	11.51	21963094
287	Phosphorylation	NPFLAAVTTNRKLNQ CCHHEEHHCCCCCCC	17.39	28857561
288	Phosphorylation	PFLAAVTTNRKLNQG CHHEEHHCCCCCCCC	26.82	20873877
294	Ubiquitination	TTNRKLNQGTERHLM HCCCCCCCCCHHHEE	71.29	33845483
296	Phosphorylation	NRKLNQGTERHLMHL CCCCCCCCHHHEEEE	21.78	20068231
299	Phosphorylation	LNQGTERHLMHLELD CCCCCHHHEEEEEEE	22.67	20068231
308	Phosphorylation	MHLELDISDSKIRYE EEEEEECCCCEEEEE	35.18	21406692
310	Phosphorylation	LELDISDSKIRYESG EEEECCCCEEEEECC	24.16	21406692
311	2-Hydroxyisobutyrylation	ELDISDSKIRYESGD EEECCCCEEEEECCC	35.87	-
314	Ubiquitination	ISDSKIRYESGDHVA CCCCEEEEECCCEEE	20.23	32015554
332	Ubiquitination	ANDSALVNQLGKILG CCHHHHHHHHHHHHC	32.01	33845483
358	Malonylation	LDEESNKKHPFPCPT CCHHHCCCCCCCCCC	61.84	26320211
358	Acetylation	LDEESNKKHPFPCPT CCHHHCCCCCCCCCC	61.84	27452117
373	Phosphorylation	SYRTALTYYLDITNP CHHCEEEEEECCCCC	11.68	18083107
374	Phosphorylation	YRTALTYYLDITNPP HHCEEEEEECCCCCC	7.83	18083107
383	Phosphorylation	DITNPPRTNVLYELA CCCCCCCCCHHHHHH	35.14	29978859
387	Phosphorylation	PPRTNVLYELAQYAS CCCCCHHHHHHHHCC	12.48	29978859
392	Phosphorylation	VLYELAQYASEPSEQ HHHHHHHHCCCCCHH	13.39	29978859
394	Phosphorylation	YELAQYASEPSEQEL HHHHHHCCCCCHHHH	45.14	29978859
397	Phosphorylation	AQYASEPSEQELLRK HHHCCCCCHHHHHHH	48.11	29978859
407	Phosphorylation	ELLRKMASSSGEGKE HHHHHHHHCCCCCCH	22.87	29978859
408	Phosphorylation	LLRKMASSSGEGKEL HHHHHHHCCCCCCHH	32.59	29978859
409	Phosphorylation	LRKMASSSGEGKELY HHHHHHCCCCCCHHH	38.07	29978859
416	Phosphorylation	SGEGKELYLSWVVEA CCCCCHHHHHHHHHH	10.36	-
434	Ubiquitination	ILAILQDCPSLRPPI HHHHHHCCCCCCCCH	1.27	33845483
455	Phosphorylation	LPRLQARYYSIASSS HHHHHHHHHHHHCCC	12.46	28152594
456	Phosphorylation	PRLQARYYSIASSSK HHHHHHHHHHHCCCC	6.50	22210691
457	Phosphorylation	RLQARYYSIASSSKV HHHHHHHHHHCCCCC	11.62	28152594
460	Phosphorylation	ARYYSIASSSKVHPN HHHHHHHCCCCCCCC	33.21	20068231
461	Phosphorylation	RYYSIASSSKVHPNS HHHHHHCCCCCCCCC	25.75	22210691
462	Phosphorylation	YYSIASSSKVHPNSV HHHHHCCCCCCCCCE	35.88	22210691
464	Phosphorylation	SIASSSKVHPNSVHI HHHCCCCCCCCCEEE	11.09	20068231
468	Phosphorylation	SSKVHPNSVHICAVV CCCCCCCCEEEEEEE	21.37	22210691
484	Ubiquitination	EYETKAGRINKGVAT EEECCCCCCCCCHHC	33.88	23000965
487	2-Hydroxyisobutyrylation	TKAGRINKGVATNWL CCCCCCCCCHHCCCH	53.01	-
487	Ubiquitination	TKAGRINKGVATNWL CCCCCCCCCHHCCCH	53.01	21890473
490	Ubiquitination	GRINKGVATNWLRAK CCCCCCHHCCCHHCC	12.13	21890473
490	Ubiquitination	GRINKGVATNWLRAK CCCCCCHHCCCHHCC	12.13	21890473
502	Ubiquitination	RAKEPAGENGGRALV HCCCCCCCCCCEEEE	55.60	33845483
523	Ubiquitination	SQFRLPFKATTPVIM HHCCCCCCCCCCEEE	42.77	-
525	Phosphorylation	FRLPFKATTPVIMVG CCCCCCCCCCEEEEC	32.02	-
526	Phosphorylation	RLPFKATTPVIMVGP CCCCCCCCCEEEECC	22.03	-
528	Phosphorylation	PFKATTPVIMVGPGT CCCCCCCEEEECCCC	4.07	-
529	Phosphorylation	FKATTPVIMVGPGTG CCCCCCEEEECCCCC	1.63	-
555	2-Hydroxyisobutyrylation	AWLRQQGKEVGETLL HHHHHCCCCHHCHHH	44.91	-
558	Ubiquitination	RQQGKEVGETLLYYG HHCCCCHHCHHHHCC	24.22	24816145
560	Phosphorylation	QGKEVGETLLYYGCR CCCCHHCHHHHCCCC	19.01	28152594
563	Phosphorylation	EVGETLLYYGCRRSD CHHCHHHHCCCCCCC	10.83	28152594
563	Ubiquitination	EVGETLLYYGCRRSD CHHCHHHHCCCCCCC	10.83	33845483
564	Phosphorylation	VGETLLYYGCRRSDE HHCHHHHCCCCCCCC	15.09	28152594
569	Phosphorylation	LYYGCRRSDEDYLYR HHCCCCCCCCHHCCH	26.46	28258704
573	Phosphorylation	CRRSDEDYLYREELA CCCCCCHHCCHHHHH	12.00	-
575	Phosphorylation	RSDEDYLYREELAQF CCCCHHCCHHHHHHH	15.11	28258704
576	Phosphorylation	SDEDYLYREELAQFH CCCHHCCHHHHHHHH	28.46	-
602	2-Hydroxyisobutyrylation	FSREQSHKVYVQHLL CCHHHHHHHHHHHHH	40.27	-
604	Phosphorylation	REQSHKVYVQHLLKQ HHHHHHHHHHHHHHH	10.13	28152594
607	Phosphorylation	SHKVYVQHLLKQDRE HHHHHHHHHHHHCHH	24.08	-
613	Ubiquitination	QHLLKQDREHLWKLI HHHHHHCHHHHHHHH	30.64	21963094
631	Ubiquitination	AHIYVCGDARNMARD CEEEEECCHHHHHHH	36.91	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCPR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCPR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCPR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP2CJ_HUMAN	CYP2C19	physical	9398194
CP2C9_HUMAN	CYP2C9	physical	9398194
CP2E1_HUMAN	CYP2E1	physical	9398194
CP1A2_HUMAN	CYP1A2	physical	9398194
PGRC1_HUMAN	PGRMC1	physical	21081644
CP1A2_HUMAN	CYP1A2	physical	15680923
CP2E1_HUMAN	CYP2E1	physical	15680923
CP2A6_HUMAN	CYP2A6	physical	15680923
CP2CJ_HUMAN	CYP2C19	physical	15680923
CP2D6_HUMAN	CYP2D6	physical	15680923
CP3A4_HUMAN	CYP3A4	physical	15680923
STAT1_HUMAN	STAT1	physical	21988832
ATLA3_HUMAN	ATL3	physical	26344197
NDUB9_HUMAN	NDUFB9	physical	26344197
NDUV1_HUMAN	NDUFV1	physical	26344197
XPO1_HUMAN	XPO1	physical	26344197
NCPR_HUMAN	POR	physical	15980100

Drug and Disease Associations

• Kegg Disease
• H00458: Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss synd
• H00599: 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adr
• H00608: 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenita
• OMIM Disease
• 201750: Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis (ABS1)
• 613571: Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00865: Benzphetamine
• DB00694: Daunorubicin
• DB00997: Doxorubicin
• DB01466: Ethylmorphine
• DB03147: Flavin adenine dinucleotide
• DB00166: Lipoic Acid
• DB00305: Mitomycin
• DB00665: Nilutamide
• DB00698: Nitrofurantoin