CP2A6_HUMAN - dbPTM
CP2A6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CP2A6_HUMAN
UniProt AC P11509
Protein Name Cytochrome P450 2A6
Gene Name CYP2A6
Organism Homo sapiens (Human).
Sequence Length 494
Subcellular Localization Endoplasmic reticulum membrane
Peripheral membrane protein. Microsome membrane
Peripheral membrane protein.
Protein Description Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity..
Protein Sequence MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MLASGMLLVAL
----CCHHHHHHHHH		22.3024719451
16PhosphorylationVALLVCLTVMVLMSV
HHHHHHHHHHHHHHH		11.0524719451
22PhosphorylationLTVMVLMSVWQQRKS
HHHHHHHHHHHHHHH		18.9524043423
131PhosphorylationAKQLRRFSIATLRDF
HHHHHHCCHHHHHHC		14.9720166139
134PhosphorylationLRRFSIATLRDFGVG
HHHCCHHHHHHCCCC		22.2124275569
148DimethylationGKRGIEERIQEEAGF
CHHCHHHHHHHHHHH		24.09-
161DimethylationGFLIDALRGTGGANI
HHHHHHHHCCCCCCC		42.20-
163PhosphorylationLIDALRGTGGANIDP
HHHHHHCCCCCCCCH		26.47-
175PhosphorylationIDPTFFLSRTVSNVI
CCHHHHHCHHHHHHH		22.28-
177PhosphorylationPTFFLSRTVSNVISS
HHHHHCHHHHHHHHH		25.55-
183PhosphorylationRTVSNVISSIVFGDR
HHHHHHHHHHHHCCC		15.10-
184PhosphorylationTVSNVISSIVFGDRF
HHHHHHHHHHHCCCC		16.20-
295PhosphorylationLKNLVMTTLNLFIGG
HHHHHHHHHHHHCCC		8.78-
389PhosphorylationDFFLPKGTEVFPMLG
CCCCCCCCCCCCCCC		34.7923403867
403PhosphorylationGSVLRDPSFFSNPQD
CHHHCCHHHCCCCCC		43.1224275569
436AcetylationFVPFSIGKRNCFGEG
CCCCCCCCCCCCCHH		38.4724889741
464PhosphorylationMQNFRLKSSQSPKDI
HHHHCCCCCCCCCCC		37.9028787133
482PhosphorylationPKHVGFATIPRNYTM
CCCCEEEECCCCCEE		29.29-
488PhosphorylationATIPRNYTMSFLPR-
EECCCCCEECCCCC-		15.1928258704
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CP2A6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CP2A6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference
163Phosphorylation160 (3)L ⇒ Hrs1801272
  • Smoking behavior
23049750
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NCPR_HUMANPORphysical
15680923
PRAF1_HUMANRABAC1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00139 Methoxsalen (JP16/USP); Oxsoralen (TN)
D00217 Acetaminophen (JP16/USP); Paracetamol (INN); Tylenol (TN)
D00287 Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP); Cytoxan (TN); Neosar (TN)
D00525 Pilocarpine (JAN/USP); Ocusert pilo-20 (TN)
D00964 Letrozole (JAN/USP/INN); Femara (TN)
D02200 Pilocarpine hydrochloride (JP16/USP); Isopto carpine (TN); Pilopine HS (TN); Sanpilo (TN)
D03365 Nicotine (USP); Habitrol (TN)
D05478 Pilocarpine nitrate (USP); Pilagan (TN)
D07760 Cyclophosphamide (INN); Cyclophosphamide (TN); Cytoxan (TN)
D08376 Pilocarpine borate; pilolarpin ophtha (TN)
DrugBank
DB00316Acetaminophen
DB01118Amiodarone
DB00381Amlodipine
DB01351Amobarbital
DB00182Amphetamine
DB01435Antipyrine
DB01274Arformoterol
DB00972Azelastine
DB00207Azithromycin
DB00921Buprenorphine
DB01156Bupropion
DB00356Chlorzoxazone
DB00568Cinnarizine
DB00604Cisapride
DB00636Clofibrate
DB00882Clomifene
DB00257Clotrimazole
DB00363Clozapine
DB00531Cyclophosphamide
DB06292Dapagliflozin
DB01151Desipramine
DB01234Dexamethasone
DB01191Dexfenfluramine
DB00255Diethylstilbestrol
DB00470Dronabinol
DB00216Eletriptan
DB04953Ezogabine
DB04841Flunarizine
DB01544Flunitrazepam
DB00544Fluorouracil
DB00690Flurazepam
DB01213Fomepizole
DB00983Formoterol
DB01159Halothane
DB01181Ifosfamide
DB00951Isoniazid
DB01026Ketoconazole
DB01006Letrozole
DB00281Lidocaine
DB04871Lorcaserin
DB01043Memantine
DB00170Menadione
DB00763Methimazole
DB00553Methoxsalen
DB01028Methoxyflurane
DB01011Metyrapone
DB01110Miconazole
DB00471Montelukast
DB00238Nevirapine
DB00184Nicotine
DB01115Nifedipine
DB06712Nilvadipine
DB01059Norfloxacin
DB00312Pentobarbital
DB01174Phenobarbital
DB01085Pilocarpine
DB00860Prednisolone
DB00396Progesterone
DB00818Propofol
DB01045Rifampicin
DB00412Rosiglitazone
DB01037Selegiline
DB01236Sevoflurane
DB06729Sulfaphenazole
DB00675Tamoxifen
DB00752Tranylcypromine
DB00755Tretinoin
DB01361Troleandomycin
DB00313Valproic Acid
DB00495Zidovudine
Regulatory Network of CP2A6_HUMAN

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Related Literatures of Post-Translational Modification

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