CP2CJ_HUMAN - dbPTM
CP2CJ_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CP2CJ_HUMAN
UniProt AC P33261
Protein Name Cytochrome P450 2C19
Gene Name CYP2C19
Organism Homo sapiens (Human).
Sequence Length 490
Subcellular Localization Endoplasmic reticulum membrane
Peripheral membrane protein. Microsome membrane
Peripheral membrane protein.
Protein Description Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine..
Protein Sequence MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationVVLVLCLSCLLLLSI
HHHHHHHHHHHHHHH		11.1718491316
18PhosphorylationLSCLLLLSIWRQSSG
HHHHHHHHHHHHCCC		21.7824719451
55PhosphorylationKDVSKSLTNLSKIYG
HHHHHHHHHHHHHHH		41.0019413330
95PhosphorylationIDLGEEFSGRGHFPL
HHHCHHHCCCCCCCH		30.75-
127PhosphorylationWKEIRRFSLMTLRNF
HHHHHHHHHHHHHHC		18.5420166139
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CP2CJ_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CP2CJ_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CP2CJ_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CP2CJ_HUMAN !!
Drug and Disease Associations
Kegg Disease
H01171 Poor drug metabolism (PM)
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00066 Progesterone (JP16/USP/INN); Crinone (TN); Prometrium (TN)
D00104 Chloramphenicol (JP16/USP/INN); CP; Amphicol (TN); Chloromycetin (TN); Econochlor (TN)
D00140 Erythromycin (JP16/USP/INN); EM; Akne-mycin (TN); Eryc (TN); Erygel (TN); Pce (TN); Staticin (TN); T
D00141 Indometacin (JP16/INN); Indomethacin (USP); Aconip (TN); Indocin (TN)
D00182 Norethisterone (JP16); Norethindrone (USP); Camila (TN); Micronor (TN); Primolut-N (TN)
D00211 Rifampicin (JP16/INN); Rifampin (USP); Rifadin (TN); Rimactane (TN)
D00228 Amoxapine (JP16/USP/INN); Asendin (TN)
D00252 Carbamazepine (JP16/USP/INN); Equetro (TN); Tegretol (TN)
D00293 Diazepam (JP16/USP/INN); Diastat (TN); Valium (TN)
D00322 Fluconazole (JP16/USAN/INN); Diflucan (TN)
D00326 Fluoxetine (USAN/INN); Fluoxetine (TN)
D00329 Flurazepam (JAN/INN); Insumin (TN)
D00351 Ketoconazole (JP16/USP); Nizoral (TN); Xolegel (TN)
D00355 Lansoprazole (JAN/USP/INN); Prevacid (TN)
D00375 Mephenytoin (USP/INN); Mesantoin (TN)
D00455 Omeprazole (JP16/USP/INN); Prilosec (TN)
D00473 Prednisone (USP); Prednisone monohydrate; Deltasone (TN); Meticorten (TN); Rayos (TN)
D00474 Primidone (JP16/USP/INN); Mysoline (TN)
D00475 Probenecid (JP16/USP/INN); Benemid (TN)
D00483 Propranolol hydrochloride (JP16/USP); Inderal (TN); Innopran XL (TN)
D00506 Phenobarbital (JP16/USP/INN); Luminal (TN)
D00512 Phenytoin (JP16/USP/INN); Dilantin (TN)
D00533 Oxcarbazepine (USAN/INN); Oxtellar (TN); Trileptal (TN)
D00536 Felbamate (USAN/INN); Felbatol (TN)
D00537 Topiramate (JAN/USAN/INN); Topamax (TN); Trokendi xr (TN)
D00578 Voriconazole (JAN/USAN/INN); Vfend (TN)
D00695 Flurazepam hydrochloride (USP); Flurazepam dihydrochloride; Dalmane (TN)
D00700 Mephobarbital (JAN/USP); Methylphenobarbital (INN); Mebaral (TN)
D00701 Phenobarbital sodium (JAN/USP/INN); Luminal sodium (TN)
D00724 Sodium rabeprazole (JP16); Rabeprazole sodium (USAN); Aciphex (TN); Pariet (TN)
D00749 Leflunomide (JAN/USAN/INN); Arava (TN)
D00768 Carisoprodol (JAN/USP/INN); Soma (TN)
D00769 Clopidogrel sulfate (JAN); Clopidogrel bisulfate (USAN); Isocover (TN); Plavix (TN)
D00809 Amitriptyline hydrochloride (JP16/USP); Elavil (TN)
D00811 Clomipramine hydrochloride (JP16/USP); Anafranil (TN)
D00815 Imipramine hydrochloride (JP16/USP); Tofranil (TN)
D00822 Citalopram hydrobromide (USAN); Celexa (TN)
D00823 Fluoxetine hydrochloride (JAN/USP); Prozac (TN)
D00824 Fluvoxamine maleate (JP16/USAN); Luvox (TN)
D00825 Sertraline hydrochloride (JAN/USAN); Zoloft (TN)
D00851 Erythromycin estorate (JAN); Erythromycin estolate (USP); Ilosone (TN)
D00895 Delavirdine mesilate (JAN); Delavirdine mesylate (USAN); Rescriptor (TN)
D00899 Nelfinavir mesilate (JAN); Nelfinavir mesylate (USAN/INN); Viracept (TN)
D00953 Norethisterone acetate (JAN); Norethindrone acetate (USP); Aygestin (TN)
D00965 Nilutamide (USAN/INN); Nilandron (TN)
D01028 Ticlopidine hydrochloride (JP16/USAN); Ticlid (TN)
D01071 Hexobarbital (JAN/INN)
D01072 Chloramphenicol palmitate (JP16/USP); Chloromycetin palmitate (TN)
D01173 Cilnidipine (JAN/INN); Atelec (TN)
D01207 Omeprazole sodium (USAN); Losec sodium (TN)
D01227 Bosentan hydrate (JAN); Bosentan (USAN); Tracleer (TN)
D01253 Clobazam (JAN/USAN/INN); Mystan (TN); Onfi (TN)
D01358 Mianserin hydrochloride (JAN/USAN); Tetramide (TN)
D01361 Erythromycin ethylsuccinate (JP16/USP); E.E.S. (TN); Eryped (TN); Erythrocin W (TN)
D01408 Flurazepam hydrochloride (JP16); Flurazepam monohydrochloride; Dalmate (TN)
D01429 Fosfluconazole (JAN/INN); Prodif (TN)
D01624 Sarpogrelate hydrochloride (JP16); Anplag (TN)
D01832 Modafinil (JAN/USAN/INN); Provigil (TN)
D01896 Cilostazol (JP16/USAN/INN); Pletal (TN)
D01984 Esomeprazole magnesium hydrate (JAN); Esomeprazole magnesium (USAN); Nexium (TN)
D02009 Erythromycin lactobionate (JP16/USP); EML; Erythrocin (TN)
D02103 Phenytoin sodium for injection (JP16); Phenytoin sodium (USP); Aleviatin (TN); Dilantin (TN)
D02110 Indometacin sodium (JAN); Indomethacin sodium (USP); Indomethacin sodium trihydrate; Indocin I.V. (T
D02184 Erythromycin stearate (JP16/USP); ES; Bristamycin (TN)
D02219 Terbinafine hydrochloride (JP16/USP); Lamisil (TN)
D02360 Sertraline (INN)
D02375 Terbinafine (USAN/INN); Lamasil (TN)
D02481 Artemisinin (INN); Qing Hau Sau
D02487 Proguanil hydrochloride (JAN); Chloroguanide hydrochloride; Paludrine (TN)
D02523 Erythromycin acistrate (USAN); EA; Erasis (TN)
D02524 Erythromycin gluceptate (USP); Erythromycin glucoheptonate; Ilotycin gluceptate (TN)
D02525 Erythromycin propionate (USAN)
D02561 Moclobemide (USAN/INN); Aurorix (TN)
D02567 Escitalopram oxalate (JAN/USAN); Lexapro (TN)
D02593 Pantoprazole Sodium Hydrate (JAN); Pantoprazole sodium (USAN); Protonix (TN)
D02691 Somatropin (genetical recombination) (JAN); Human growth hormone (JAN); Somatropin (USP/INN); Asella
D02698 Teniposide (USAN/INN); Vumon (TN)
D02731 Vardenafil dihydrochoride (USAN); Levitra (TN)
D03150 Bortezomib (JAN/USAN/INN); Velcade (TN)
D03215 Armodafinil (USAN/INN); Nuvigil (TN)
D03461 Chloramphenicol pantothenate complex (USAN/INN); Pantofenicol (TN)
D03729 Dexpropranolol hydrochloride (USAN)
D03844 Phenytoin - phenobarbital - caffeine and sodium benzoate; Hydantol F (TN)
D04054 Erythromycin salnacedin (USAN)
D04056 Esomeprazole sodium (USAN); Nexium IV (TN)
D04112 Etravirine (JAN/USAN/INN); Intelence (TN)
D05259 Omeprazole magnesium (USAN); Prilosec OTC (TN)
D05261 Omeprazole sodium injection (JAN); Omeprazole sodium hydrate; Omepral (TN)
D05353 Pantoprazole (USAN/INN)
D05597 Prasugrel hydrochloride (JAN/USAN); Effient (TN)
D05928 Stiripentol (JAN/USAN/INN)
D07448 Amitriptyline (INN); Laroxyl (TN)
D07538 Bosentan (INN)
D07583 Phenytoin - phenobarbital mixt; Aleviatin with phenobarbital (TN)
D07595 Fosphenytoin sodium hydrate (JAN); Fostoin (TN)
D07704 Citalopram (USP/INN); Citadur (TN)
D07705 Citalopram hydrochloride; Seropram (TN)
D07727 Clomipramine (INN); Anafranil (TN)
D07729 Clopidogrel (INN); Clopidogrel (TN); Plavix (TN)
D07782 Delavirdine (INN)
D07909 Erythromycin thiocyanate; Erythrocin (TN)
D07910 Erythromycin stinoprate (INN); Erysec (TN)
D07913 Escitalopram (INN); Esertia (TN)
D07917 Esomeprazole (INN); Inexium paranova (TN)
D07984 Fluvoxamine (INN)
D08070 Imipramine (INN); Tofranil (TN)
D08071 Imipramine embonate; Tofranil-pm (TN)
D08216 Mianserin (INN); Tolvon (TN)
D08259 Nelfinavir (INN); Viracept (TN)
D08283 Nordazepam (INN); Calmday (TN)
D08356 Phenobarbital diethylamine; Gratusminal (TN)
D08428 Proguanil (INN)
D08443 Propranolol (INN); Propranolol (TN)
D08463 Rabeprazole (INN); Eraloc (TN)
D08479 Rifampicin sodium; Rifadine (TN)
D08508 Sarpogrelate (INN)
D08594 Ticlopidine (INN); Ticlopidin-Puren (TN)
D08774 Amoxicillin hydrate - clarithromycin - lansoprazole mixt; Lansap (TN)
D08903 Dexlansoprazole (INN/USAN)
D09017 Ticagrelor (USAN/INN); Brilinta (TN)
D09339 Esomeprazole potassium (USAN)
D09741 Drospirenone - ethinylestradiol betadex mixt; Drospirenone - ethinylestradiol mixt; Angeliq (TN); Ya
D10120 Esomeprazole strontium (USAN); Esomeprazole strontium tetrahydrate
DrugBank
DB01418Acenocoumarol
DB00945Acetylsalicylic acid
DB00546Adinazolam
DB00918Almotriptan
DB00357Aminoglutethimide
DB01424Aminophenazone
DB01118Amiodarone
DB00321Amitriptyline
DB01060Amoxicillin
DB00701Amprenavir
DB01435Antipyrine
DB06605Apixaban
DB00673Aprepitant
DB01274Arformoterol
DB06697Artemether
DB00289Atomoxetine
DB01076Atorvastatin
DB06626Axitinib
DB00972Azelastine
DB00245Benzatropine
DB01128Bicalutamide
DB04794Bifonazole
DB00188Bortezomib
DB01558Bromazepam
DB00835Brompheniramine
DB00297Bupivacaine
DB00921Buprenorphine
DB00564Carbamazepine
DB00748Carbinoxamine
DB00395Carisoprodol
DB00446Chloramphenicol
DB00672Chlorpropamide
DB00169Cholecalciferol
DB01166Cilostazol
DB00501Cimetidine
DB00604Cisapride
DB00215Citalopram
DB01211Clarithromycin
DB04920Clevidipine
DB00349Clobazam
DB01242Clomipramine
DB00758Clopidogrel
DB01559Clotiazepam
DB00257Clotrimazole
DB00363Clozapine
DB00531Cyclophosphamide
DB00091Cyclosporine
DB00250Dapsone
DB00705Delavirdine
DB01151Desipramine
DB00967Desloratadine
DB01234Dexamethasone
DB01191Dexfenfluramine
DB00514Dextromethorphan
DB00829Diazepam
DB00586Diclofenac
DB00343Diltiazem
DB01093Dimethyl sulfoxide
DB01075Diphenhydramine
DB00988Dopamine
DB00590Doxazosin
DB01142Doxepin
DB00470Dronabinol
DB00625Efavirenz
DB00216Eletriptan
DB00109Enfuvirtide
DB08899Enzalutamide
DB01175Escitalopram
DB00736Esomeprazole
DB00783Estradiol
DB00898Ethanol
DB00754Ethotoin
DB01628Etoricoxib
DB06414Etravirine
DB00927Famotidine
DB00949Felbamate
DB00196Fluconazole
DB01544Flunitrazepam
DB00472Fluoxetine
DB00499Flutamide
DB01095Fluvastatin
DB00176Fluvoxamine
DB00983Formoterol
DB01320Fosphenytoin
DB00317Gefitinib
DB01241Gemfibrozil
DB01120Gliclazide
DB01296Glucosamine
DB01016Glyburide
DB01018Guanfacine
DB00502Haloperidol
DB01355Hexobarbital
DB01050Ibuprofen
DB01181Ifosfamide
DB00619Imatinib
DB00458Imipramine
DB00224Indinavir
DB00328Indomethacin
DB00951Isoniazid
DB06738Ketobemidone
DB01026Ketoconazole
DB00448Lansoprazole
DB01259Lapatinib
DB08918Levomilnacipran
DB01601Lopinavir
DB00455Loratadine
DB04871Lorcaserin
DB00678Losartan
DB00227Lovastatin
DB08933LULICONAZOLE
DB01283Lumiracoxib
DB08932MACITENTAN
DB01065Melatonin
DB01043Memantine
DB00371Meprobamate
DB00333Methadone
DB00703Methazolamide
DB00763Methimazole
DB05246Methsuximide
DB00849Methylphenobarbital
DB00264Metoprolol
DB01110Miconazole
DB01171Moclobemide
DB00745Modafinil
DB00220Nelfinavir
DB00622Nicardipine
DB00184Nicotine
DB00665Nilutamide
DB06712Nilvadipine
DB00717Norethindrone
DB00540Nortriptyline
DB00334Olanzapine
DB00338Omeprazole
DB04938Ospemifene
DB00776Oxcarbazepine
DB00239Oxiconazole
DB00213Pantoprazole
DB00082Pegvisomant
DB00738Pentamidine
DB00312Pentobarbital
DB00850Perphenazine
DB00454Pethidine
DB00780Phenelzine
DB01174Phenobarbital
DB00832Phensuximide
DB00252Phenytoin
DB01100Pimozide
DB01132Pioglitazone
DB01621Pipotiazine
DB01179Podofilox
DB06209Prasugrel
DB01058Praziquantel
DB00635Prednisone
DB00794Primidone
DB01032Probenecid
DB00396Progesterone
DB01131Proguanil
DB00420Promazine
DB00818Propofol
DB00571Propranolol
DB01589Quazepam
DB01224Quetiapine
DB00468Quinine
DB01129Rabeprazole
DB00980Ramelteon
DB00863Ranitidine
DB08896Regorafenib
DB01045Rifampicin
DB08864Rilpivirine
DB00503Ritonavir
DB00412Rosiglitazone
DB01098Rosuvastatin
DB01232Saquinavir
DB01037Selegiline
DB01104Sertraline
DB00203Sildenafil
DB00641Simvastatin
DB06268Sitaxentan
DB00398Sorafenib
DB00259Sulfanilamide
DB00675Tamoxifen
DB06204Tapentadol
DB00966Telmisartan
DB00231Temazepam
DB00444Teniposide
DB00857Terbinafine
DB00624Testosterone
DB01041Thalidomide
DB00679Thioridazine
DB00208Ticlopidine
DB00373Timolol
DB01007Tioconazole
DB00932Tipranavir
DB08895Tofacitinib
DB01124Tolbutamide
DB01036Tolterodine
DB00273Topiramate
DB00214Torasemide
DB05109Trabectedin
DB00752Tranylcypromine
DB00347Trimethadione
DB00726Trimipramine
DB01361Troleandomycin
DB00313Valproic Acid
DB00285Venlafaxine
DB00661Verapamil
DB08828Vismodegib
DB00582Voriconazole
DB00682Warfarin
DB00549Zafirlukast
DB00495Zidovudine
DB00425Zolpidem
DB00909Zonisamide
Regulatory Network of CP2CJ_HUMAN

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