NDUV1_HUMAN - dbPTM
NDUV1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NDUV1_HUMAN
UniProt AC P49821
Protein Name NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Gene Name NDUFV1
Organism Homo sapiens (Human).
Sequence Length 464
Subcellular Localization Mitochondrion inner membrane
Peripheral membrane protein
Matrix side.
Protein Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)..
Protein Sequence MLATRRLLGWSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGSLSRGDWYKTKEILLKGPDWILGEIKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREILRHDPHKLLEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQHQARQAAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationTRRLLGWSLPARVSV
CHHHHCCCCCEEEEE		23.7624719451
29UbiquitinationGDTTAPKKTSFGSLK
CCCCCCCCCCCCCCC		48.63-
30PhosphorylationDTTAPKKTSFGSLKD
CCCCCCCCCCCCCCC		35.1026437602
31PhosphorylationTTAPKKTSFGSLKDE
CCCCCCCCCCCCCCC		36.1728348404
34PhosphorylationPKKTSFGSLKDEDRI
CCCCCCCCCCCCCCE		30.1826437602
40MethylationGSLKDEDRIFTNLYG
CCCCCCCCEEHHCCC		24.71115484763
46PhosphorylationDRIFTNLYGRHDWRL
CCEEHHCCCCCCCCC		17.7429496907
57 (in isoform 2)Ubiquitination-5.73-
62 (in isoform 2)Ubiquitination-10.1921906983
64AcetylationLSRGDWYKTKEILLK
ECCCCCEEEEEEHCC		49.192402805
66MalonylationRGDWYKTKEILLKGP
CCCCEEEEEEHCCCC		38.3126320211
66AcetylationRGDWYKTKEILLKGP
CCCCEEEEEEHCCCC		38.3125038526
66UbiquitinationRGDWYKTKEILLKGP
CCCCEEEEEEHCCCC		38.31-
71 (in isoform 1)Ubiquitination-66.0221906983
71UbiquitinationKTKEILLKGPDWILG
EEEEEHCCCCCEEEE		66.0221906983
72 (in isoform 2)Ubiquitination-25.9321906983
81 (in isoform 1)Ubiquitination-32.1321906983
81SuccinylationDWILGEIKTSGLRGR
CEEEEEECCCCCCCC		32.132190698
81AcetylationDWILGEIKTSGLRGR
CEEEEEECCCCCCCC		32.1325038526
81SuccinylationDWILGEIKTSGLRGR
CEEEEEECCCCCCCC		32.13-
81UbiquitinationDWILGEIKTSGLRGR
CEEEEEECCCCCCCC		32.13-
88MethylationKTSGLRGRGGAGFPT
CCCCCCCCCCCCCCC		33.66115484757
104AcetylationLKWSFMNKPSDGRPK
CCEEECCCCCCCCCC		33.8323236377
104MalonylationLKWSFMNKPSDGRPK
CCEEECCCCCCCCCC		33.8326320211
111UbiquitinationKPSDGRPKYLVVNAD
CCCCCCCCEEEEECC		50.27-
112PhosphorylationPSDGRPKYLVVNADE
CCCCCCCEEEEECCC		13.8629496907
124PhosphorylationADEGEPGTCKDREIL
CCCCCCCCCCCHHHH		27.39-
126UbiquitinationEGEPGTCKDREILRH
CCCCCCCCCHHHHHC		60.71-
137UbiquitinationILRHDPHKLLEGCLV
HHHCCHHHHHCCCEE		61.22-
137AcetylationILRHDPHKLLEGCLV
HHHCCHHHHHCCCEE		61.2226051181
251PhosphorylationNVETVAVSPTICRRG
CCEEEEECCEEECCC		13.4427251275
257MethylationVSPTICRRGGTWFAG
ECCEEECCCCCEEEE		43.4054557533
297UbiquitinationEEMSVPLKELIEKHA
CHHCCCHHHHHHHHC		44.39-
323PhosphorylationAVIPGGSSTPLIPKS
EEECCCCCCCCCCHH		37.00-
324PhosphorylationVIPGGSSTPLIPKSV
EECCCCCCCCCCHHH		24.66-
365UbiquitinationDRSTDIVKAIARLIE
ECCHHHHHHHHHHHH		34.12-
375AcetylationARLIEFYKHESCGQC
HHHHHHHHHCCCCCC		46.3321466224
375UbiquitinationARLIEFYKHESCGQC
HHHHHHHHHCCCCCC		46.33-
383PhosphorylationHESCGQCTPCREGVD
HCCCCCCCCCHHCHH		19.96-
385 (in isoform 2)Ubiquitination-3.13-
394UbiquitinationEGVDWMNKVMARFVR
HCHHHHHHHHHHHHC		19.79-
464PhosphorylationHQARQAAS-------
HHHHHHHC-------		43.7120068231
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
383TPhosphorylationKinaseCDK1P06493
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NDUV1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NDUV1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NDUV2_HUMANNDUFV2physical
22939629
TCOF_HUMANTCOF1physical
22939629
VPS29_HUMANVPS29physical
22939629
TM189_HUMANTMEM189physical
22939629
RIR1_HUMANRRM1physical
22939629
NOTC2_HUMANNOTCH2physical
22939629
STMN1_HUMANSTMN1physical
22939629
TIM9_HUMANTIMM9physical
22939629
PNPH_HUMANPNPphysical
22939629
THTM_HUMANMPSTphysical
22939629
TOIP1_HUMANTOR1AIP1physical
22939629
PUR6_HUMANPAICSphysical
22939629
PALLD_HUMANPALLDphysical
22939629
RNT2_HUMANRNASET2physical
22939629
COX5A_HUMANCOX5Aphysical
26344197
EF2_HUMANEEF2physical
26344197
NDUS1_HUMANNDUFS1physical
26344197
NDUV2_HUMANNDUFV2physical
26344197
ODPA_HUMANPDHA1physical
26344197
PHB2_HUMANPHB2physical
26344197
PSMD7_HUMANPSMD7physical
26344197
SDHB_HUMANSDHBphysical
26344197
STXB1_HUMANSTXBP1physical
26344197
UCRI_HUMANUQCRFS1physical
26344197
SCOT1_HUMANOXCT1physical
24344204
NDUV2_HUMANNDUFV2physical
24344204
NDUS1_HUMANNDUFS1physical
24344204
NDUAC_HUMANNDUFA12physical
24344204
NDUV3_HUMANNDUFV3physical
24344204
NDUA9_HUMANNDUFA9physical
24344204
NU1M_HUMANND1physical
24344204
NDUA2_HUMANNDUFA2physical
24344204
NDUS3_HUMANNDUFS3physical
24344204
NDUS8_HUMANNDUFS8physical
24344204
NDUS2_HUMANNDUFS2physical
24344204
NU5M_HUMANND5physical
24344204
NDUB4_HUMANNDUFB4physical
24344204
Drug and Disease Associations
Kegg Disease
H00473 Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
OMIM Disease
256000Leigh syndrome (LS)
252010Mitochondrial complex I deficiency (MT-C1D)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NDUV1_HUMAN

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Related Literatures of Post-Translational Modification

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