NU5M_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NU5M_HUMAN
• UniProt AC: P03915
• Protein Name: NADH-ubiquinone oxidoreductase chain 5
• Gene Name: MT-ND5
• Organism: Homo sapiens (Human).
• Sequence Length: 603
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)..
• Protein Sequence: MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTMHTTMTT ------CCCCCCCCH	20.05	24043423
5	Phosphorylation	---MTMHTTMTTLTL ---CCCCCCCCHHHH	13.87	24043423
6	Phosphorylation	--MTMHTTMTTLTLT --CCCCCCCCHHHHH	9.61	24043423
8	Phosphorylation	MTMHTTMTTLTLTSL CCCCCCCCHHHHHHC	19.30	24043423
9	Phosphorylation	TMHTTMTTLTLTSLI CCCCCCCHHHHHHCC	13.61	24043423
11	Phosphorylation	HTTMTTLTLTSLIPP CCCCCHHHHHHCCCC	26.37	24043423
13	Phosphorylation	TMTTLTLTSLIPPIL CCCHHHHHHCCCCHH	19.09	24043423
14	Phosphorylation	MTTLTLTSLIPPILT CCHHHHHHCCCCHHH	27.67	24043423
21	Phosphorylation	SLIPPILTTLVNPNK HCCCCHHHHCCCCCC	20.85	24043423
22	Phosphorylation	LIPPILTTLVNPNKK CCCCHHHHCCCCCCC	25.84	24043423
77	Phosphorylation	TTQTTQLSLSFKLDY CCCCEEEEEEEECCH	16.49	23090842
79	Phosphorylation	QTTQLSLSFKLDYFS CCEEEEEEEECCHHH	19.57	24719451
244	Phosphorylation	MEGPTPVSALLHSST CCCCCCHHHHHHHHH	17.88	25332170
251	Phosphorylation	SALLHSSTMVVAGIF HHHHHHHHHHHHHHH	19.59	25332170
565	Phosphorylation	LEKLLPKTISQHQIS HHHHHCCCCCHHHCC	24.74	29978859
567	Phosphorylation	KLLPKTISQHQISTS HHHCCCCCHHHCCCH	27.17	29978859
572	Phosphorylation	TISQHQISTSIITST CCCHHHCCCHHHCCC	14.99	29978859
573	Phosphorylation	ISQHQISTSIITSTQ CCHHHCCCHHHCCCC	26.10	29978859
574	Phosphorylation	SQHQISTSIITSTQK CHHHCCCHHHCCCCC	12.76	29978859
587	Phosphorylation	QKGMIKLYFLSFFFP CCHHHHHHHHHHHHH	9.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NU5M_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NU5M_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NU5M_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAX_HUMAN	BAX	physical	25115399
BAK_HUMAN	BAK1	physical	25115399

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.