NDUV2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUV2_HUMAN
• UniProt AC: P19404
• Protein Name: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
• Gene Name: NDUFV2
• Organism: Homo sapiens (Human).
• Sequence Length: 249
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)..
• Protein Sequence: MFFSAALRARAAGLTAHWGRHVRNLHKTVMQNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTAKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQAGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RARAAGLTAHWGRHV HHHHHCCHHHHHHHH	18.63	27251275
32	Ubiquitination	LHKTVMQNGAGGALF HHHHHHHCCCCCEEE	24.96	24816145
51	Phosphorylation	TPENNPDTPFDFTPE CCCCCCCCCCCCCHH	27.41	-
61	Acetylation	DFTPENYKRIEAIVK CCCHHHHHHHHHHHH	59.49	26051181
61	2-Hydroxyisobutyrylation	DFTPENYKRIEAIVK CCCHHHHHHHHHHHH	59.49	-
61	Ubiquitination	DFTPENYKRIEAIVK CCCHHHHHHHHHHHH	59.49	24816145
68	Malonylation	KRIEAIVKNYPEGHK HHHHHHHHHCCCCHH	44.65	26320211
70	Phosphorylation	IEAIVKNYPEGHKAA HHHHHHHCCCCHHCH	9.28	29496907
113	Phosphorylation	QVPPMRVYEVATFYT CCCCCEEEEEEEEEE	8.36	24043423
117	Phosphorylation	MRVYEVATFYTMYNR CEEEEEEEEEECCCC	23.50	24043423
119	Phosphorylation	VYEVATFYTMYNRKP EEEEEEEEECCCCCC	6.04	24043423
120	Phosphorylation	YEVATFYTMYNRKPV EEEEEEEECCCCCCC	14.69	25599653
122	Phosphorylation	VATFYTMYNRKPVGK EEEEEECCCCCCCCE	12.19	24043423
129	Acetylation	YNRKPVGKYHIQVCT CCCCCCCEEEEEEEC	33.61	25038526
147	Phosphorylation	CMLRNSDSILEAIQK HHCCCCHHHHHHHHH	28.97	27251275
154	Acetylation	SILEAIQKKLGIKVG HHHHHHHHHHCCCCC	43.80	25953088
154	2-Hydroxyisobutyrylation	SILEAIQKKLGIKVG HHHHHHHHHHCCCCC	43.80	-
163	Phosphorylation	LGIKVGETTPDKLFT HCCCCCCCCHHHEEE	37.39	20068231
164	Phosphorylation	GIKVGETTPDKLFTL CCCCCCCCHHHEEEE	25.78	20068231
193	Phosphorylation	VQINDNYYEDLTAKD EEECCCHHHCCCHHH	14.82	22823520
209	Acetylation	EEIIDELKAGKIPKP HHHHHHHHCCCCCCC	53.71	25038526
209	2-Hydroxyisobutyrylation	EEIIDELKAGKIPKP HHHHHHHHCCCCCCC	53.71	-
209	Ubiquitination	EEIIDELKAGKIPKP HHHHHHHHCCCCCCC	53.71	29967540
215	Acetylation	LKAGKIPKPGPRSGR HHCCCCCCCCCCCCC	67.11	2380383
220	Phosphorylation	IPKPGPRSGRFSCEP CCCCCCCCCCEECCC	37.14	-
233	Phosphorylation	EPAGGLTSLTEPPKG CCCCCCCCCCCCCCC	38.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
193	Y	Phosphorylation	Kinase	SRC	P12931	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUV2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUV2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SP110_HUMAN	SP110	physical	16169070
KAT5_HUMAN	KAT5	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
NDUV3_HUMAN	NDUFV3	physical	22939629
QCR1_HUMAN	UQCRC1	physical	22939629
NPTN_HUMAN	NPTN	physical	22939629
SURF1_HUMAN	SURF1	physical	22939629
PREP_HUMAN	PITRM1	physical	22939629
NOTC2_HUMAN	NOTCH2	physical	22939629
TMED9_HUMAN	TMED9	physical	22939629
NPC2_HUMAN	NPC2	physical	22939629
SUCB2_HUMAN	SUCLG2	physical	22939629
ZO1_HUMAN	TJP1	physical	22939629
SEPT9_HUMAN	SEPT9	physical	22939629
PCYOX_HUMAN	PCYOX1	physical	22939629
SVIL_HUMAN	SVIL	physical	22939629
COX2_HUMAN	COX2	physical	26344197
NU1M_HUMAN	ND1	physical	26344197
NDUA6_HUMAN	NDUFA6	physical	26344197
NDUS2_HUMAN	NDUFS2	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
NDUS1_HUMAN	NDUFS1	physical	24344204
NDUV1_HUMAN	NDUFV1	physical	24344204
NDUV3_HUMAN	NDUFV3	physical	24344204
NDUAD_HUMAN	NDUFA13	physical	24344204
NDUA9_HUMAN	NDUFA9	physical	24344204
NU5M_HUMAN	ND5	physical	24344204
NDUS2_HUMAN	NDUFS2	physical	24344204
NDUAC_HUMAN	NDUFA12	physical	24344204
NDUS3_HUMAN	NDUFS3	physical	24344204

Drug and Disease Associations

• Kegg Disease
• H00473: Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.