dbPTM

SVIL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SVIL_HUMAN
UniProt AC	O95425
Protein Name	Supervillin {ECO:0000303\|PubMed:9867483}
Gene Name	SVIL {ECO:0000303\|PubMed:9867483}
Organism	Homo sapiens (Human).
Sequence Length	2214
Subcellular Localization	Cell membrane Peripheral membrane protein Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody . Cleavage furrow . Tightly associated with both actin filaments and plasma membranes.
Protein Description	Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. [PubMed: 12711699 Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function]
Protein Sequence	MKRKERIARRLEGIENDTQPILLQSCTGLVTHRLLEEDTPRYMRASDPASPHIGRSNEEEETSDSSLEKQTRSKYCTETSGVHGDSPYGSGTMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYTKSRKEPDAVEKRGGKSDKQEESSRDASSLYPGTETMGLRTCAGESKDYALHVGDGSSDPEVLLNIENQRRGQELSATRQAHDLSPAAESSSTFSFSGRDSSFTEVPRSPKHAHSSSLQQAASRSPSFGDPQLSPEARPSTGKPKHEWFLQKDSEGDTPSLINWPSRVKVREKLVKEESARNSPELASESVTQRRHQPAPVHYVSFQSEHSAFDRVPSKAAGSTRQPIRGYVQPADTGHTAKLVTPETPENASECSWVASATQNVPKPPSLTVLEGDGRDSPVLHVCESKAEEEEGEGEGEEKEEDVCFTEALEQSKKTLLALEGDGLVRSPEDPSRNEDFGKPAVSTVTLEHQKELENVAQPPQAPHQPTERTGRSEMVLYIQSEPVSQDAKPTGHNREASKKRKVRTRSLSDFTGPPQLQALKYKDPASRRELELPSSKTEGPYGEISMLDTKVSVAQLRSAFLASANACRRPELKSRVERSAEGPGLPTGVERERGSRKPRRYFSPGESRKTSERFRTQPITSAERKESDRCTSHSETPTVDDEEKVDERAKLSVAAKRLLFREMEKSFDEQNVPKRRSRNTAVEQRLRRLQDRSLTQPITTEEVVIAATEPIPASCSGGTHPVMARLPSPTVARSAVQPARLQASAHQKALAKDQTNEGKELAEQGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDTRQRRMNARYQTQPVTLGEVEQVQSGKLIPFSPAVNTSVSTVASTVAPMYAGDLRTKPPLDHNASATDYKFSSSIENSDSPVRSILKSQAWQPLVEGSENKGMLREYGETESKRALTGRDSGMEKYGSFEEAEASYPILNRAREGDSHKESKYAVPRRGSLERANPPITHLGDEPKEFSMAKMNAQGNLDLRDRLPFEEKVEVENVMKRKFSLRAAEFGEPTSEQTGTAAGKTIAQTTAPVSWKPQDSSEQPQEKLCKNPCAMFAAGEIKTPTGEGLLDSPSKTMSIKERLALLKKSGEEDWRNRLSRRQEGGKAPASSLHTQEAGRSLIKKRVTESRESQMTIEERKQLITVREEAWKTRGRGAANDSTQFTVAGRMVKKGLASPTAITPVASPICGKTRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVGGMHETVLTVTGKSVKEVMKPDDDETFAKFYRSVDYNMPRSPVEMDEDFDVIFDPYAPKLTSSVAEHKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAKGLF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	TQPILLQSCTGLVTH CCCHHHHHCCHHHHH	17.39	-
46	Phosphorylation	TPRYMRASDPASPHI CCCCCCCCCCCCCCC	33.49	29255136
50	Phosphorylation	MRASDPASPHIGRSN CCCCCCCCCCCCCCC	23.54	23401153
50 (in isoform 2)	Phosphorylation	-	23.54	18669648
56	Phosphorylation	ASPHIGRSNEEEETS CCCCCCCCCCCCCCC	43.30	24732914
62	Phosphorylation	RSNEEEETSDSSLEK CCCCCCCCCCCHHHH	40.91	25159151
63	Phosphorylation	SNEEEETSDSSLEKQ CCCCCCCCCCHHHHH	38.48	25159151
63 (in isoform 2)	Phosphorylation	-	38.48	18669648
65	Phosphorylation	EEEETSDSSLEKQTR CCCCCCCCHHHHHHH	36.27	25159151
65 (in isoform 2)	Phosphorylation	-	36.27	18669648
66	Phosphorylation	EEETSDSSLEKQTRS CCCCCCCHHHHHHHH	45.60	23927012
66 (in isoform 2)	Phosphorylation	-	45.60	18669648
74	Acetylation	LEKQTRSKYCTETSG HHHHHHHCCCCCCCC	40.84	26051181
77	Phosphorylation	QTRSKYCTETSGVHG HHHHCCCCCCCCCCC	38.93	20068231
79	Phosphorylation	RSKYCTETSGVHGDS HHCCCCCCCCCCCCC	16.78	20068231
80	Phosphorylation	SKYCTETSGVHGDSP HCCCCCCCCCCCCCC	32.36	29496963
86	Phosphorylation	TSGVHGDSPYGSGTM CCCCCCCCCCCCCCC	25.31	25159151
88	Phosphorylation	GVHGDSPYGSGTMDT CCCCCCCCCCCCCCC	28.07	20068231
90	Phosphorylation	HGDSPYGSGTMDTHS CCCCCCCCCCCCCCC	25.83	25159151
92	Phosphorylation	DSPYGSGTMDTHSLE CCCCCCCCCCCCCHH	17.36	25159151
95	Phosphorylation	YGSGTMDTHSLESKA CCCCCCCCCCHHHHH	11.53	27732954
97	Phosphorylation	SGTMDTHSLESKAER CCCCCCCCHHHHHHH	35.60	25159151
100	Phosphorylation	MDTHSLESKAERIAR CCCCCHHHHHHHHHH	42.32	27732954
120	Phosphorylation	RRQLAEKYGLTLDPE HHHHHHHHCCCCCHH	14.63	22817900
123	Phosphorylation	LAEKYGLTLDPEADS HHHHHCCCCCHHCCH	25.42	27251275
132	Phosphorylation	DPEADSEYLSRYTKS CHHCCHHHHHHHHHC	17.58	22817900
134	Phosphorylation	EADSEYLSRYTKSRK HCCHHHHHHHHHCCC	23.49	25106551
136	Phosphorylation	DSEYLSRYTKSRKEP CHHHHHHHHHCCCCC	18.36	-
167	Phosphorylation	SRDASSLYPGTETMG HCCHHHCCCCCCCCC	11.10	22817900
182	Phosphorylation	LRTCAGESKDYALHV CEECCCCCCCEEEEC	29.88	-
185	Phosphorylation	CAGESKDYALHVGDG CCCCCCCEEEECCCC	18.14	22617229
193	Phosphorylation	ALHVGDGSSDPEVLL EEECCCCCCCHHHHH	35.99	26657352
194	Phosphorylation	LHVGDGSSDPEVLLN EECCCCCCCHHHHHH	63.81	30266825
212	Phosphorylation	QRRGQELSATRQAHD HHCCCCCCHHHCCCC	27.17	28857561
214	Phosphorylation	RGQELSATRQAHDLS CCCCCCHHHCCCCCC	21.67	28102081
221	Phosphorylation	TRQAHDLSPAAESSS HHCCCCCCCCCCCCC	20.67	29255136
221 (in isoform 2)	Phosphorylation	-	20.67	18669648
226	Phosphorylation	DLSPAAESSSTFSFS CCCCCCCCCCCEEEC	25.51	22167270
227	Phosphorylation	LSPAAESSSTFSFSG CCCCCCCCCCEEECC	25.54	26329039
228	Phosphorylation	SPAAESSSTFSFSGR CCCCCCCCCEEECCC	42.63	26329039
229	Phosphorylation	PAAESSSTFSFSGRD CCCCCCCCEEECCCC	25.83	26329039
231	Phosphorylation	AESSSTFSFSGRDSS CCCCCCEEECCCCCC	20.70	26329039
233	Phosphorylation	SSSTFSFSGRDSSFT CCCCEEECCCCCCCC	31.55	19691289
237	Phosphorylation	FSFSGRDSSFTEVPR EEECCCCCCCCCCCC	26.45	23927012
238	Phosphorylation	SFSGRDSSFTEVPRS EECCCCCCCCCCCCC	40.24	23927012
238 (in isoform 2)	Phosphorylation	-	40.24	18669648
240	Phosphorylation	SGRDSSFTEVPRSPK CCCCCCCCCCCCCCC	37.71	23401153
245	Phosphorylation	SFTEVPRSPKHAHSS CCCCCCCCCCCCCCH	32.03	29255136
245 (in isoform 2)	Phosphorylation	-	32.03	18669648
251	Phosphorylation	RSPKHAHSSSLQQAA CCCCCCCCHHHHHHH	23.54	29496963
251 (in isoform 2)	Phosphorylation	-	23.54	21955146
251 (in isoform 3)	Phosphorylation	-	23.54	21955146
252	Phosphorylation	SPKHAHSSSLQQAAS CCCCCCCHHHHHHHH	25.79	22496350
252 (in isoform 2)	Phosphorylation	-	25.79	21955146
252 (in isoform 3)	Phosphorylation	-	25.79	21955146
253	Phosphorylation	PKHAHSSSLQQAASR CCCCCCHHHHHHHHC	32.96	25159151
253 (in isoform 2)	Phosphorylation	-	32.96	21955146
253 (in isoform 3)	Phosphorylation	-	32.96	21955146
259	Phosphorylation	SSLQQAASRSPSFGD HHHHHHHHCCCCCCC	35.99	21082442
259 (in isoform 2)	Phosphorylation	-	35.99	21955146
259 (in isoform 3)	Phosphorylation	-	35.99	21955146
261	Phosphorylation	LQQAASRSPSFGDPQ HHHHHHCCCCCCCCC	23.54	30266825
261 (in isoform 2)	Phosphorylation	-	23.54	30266825
261 (in isoform 3)	Phosphorylation	-	23.54	30266825
263	Phosphorylation	QAASRSPSFGDPQLS HHHHCCCCCCCCCCC	43.01	30266825
263 (in isoform 2)	Phosphorylation	-	43.01	30266825
263 (in isoform 3)	Phosphorylation	-	43.01	30266825
270	Phosphorylation	SFGDPQLSPEARPST CCCCCCCCCCCCCCC	18.56	19664994
270 (in isoform 2)	Phosphorylation	-	18.56	19664994
270 (in isoform 3)	Phosphorylation	-	18.56	30266825
276	Phosphorylation	LSPEARPSTGKPKHE CCCCCCCCCCCCCCC	44.21	23403867
277	Phosphorylation	SPEARPSTGKPKHEW CCCCCCCCCCCCCCE	52.48	23403867
278 (in isoform 2)	Phosphorylation	-	48.91	29116813
279 (in isoform 2)	Phosphorylation	-	51.48	25849741
281 (in isoform 2)	Phosphorylation	-	58.61	29116813
283 (in isoform 2)	Phosphorylation	-	46.15	25056879
294	Phosphorylation	QKDSEGDTPSLINWP CCCCCCCCCHHHCCC	26.15	28857561
296	Phosphorylation	DSEGDTPSLINWPSR CCCCCCCHHHCCCCH	43.93	26437602
315	Phosphorylation	EKLVKEESARNSPEL HHHHHHHHHCCCHHH	33.35	26437602
319	Phosphorylation	KEESARNSPELASES HHHHHCCCHHHHHHH	17.75	19691289
324	Phosphorylation	RNSPELASESVTQRR CCCHHHHHHHHHHHC	42.92	24532841
339	Phosphorylation	HQPAPVHYVSFQSEH CCCCCEEEEEEECCC	9.68	-
340 (in isoform 2)	Phosphorylation	-	2.52	30206219
341	Phosphorylation	PAPVHYVSFQSEHSA CCCEEEEEEECCCCC	15.48	26437602
342 (in isoform 2)	Phosphorylation	-	7.08	25159151
346 (in isoform 2)	Phosphorylation	-	29.67	27174698
347 (in isoform 2)	Phosphorylation	-	26.95	27174698
355 (in isoform 2)	Phosphorylation	-	35.86	22210691
359 (in isoform 2)	Phosphorylation	-	18.71	27174698
360	Phosphorylation	PSKAAGSTRQPIRGY CCCCCCCCCCCCCCE	32.19	20860994
455	Phosphorylation	ALEQSKKTLLALEGD HHHHHHHHHHHHCCC	30.64	22199227
467	Phosphorylation	EGDGLVRSPEDPSRN CCCCCCCCCCCCCCC	25.76	26657352
472	Phosphorylation	VRSPEDPSRNEDFGK CCCCCCCCCCCCCCC	61.12	28857561
538	Phosphorylation	TGHNREASKKRKVRT CCCCHHHHHHCCCCC	33.68	20068231
545	Phosphorylation	SKKRKVRTRSLSDFT HHHCCCCCCCHHHCC	27.83	23403867
547	Phosphorylation	KRKVRTRSLSDFTGP HCCCCCCCHHHCCCC	31.45	30266825
549	Phosphorylation	KVRTRSLSDFTGPPQ CCCCCCHHHCCCCHH	31.74	30266825
552	Phosphorylation	TRSLSDFTGPPQLQA CCCHHHCCCCHHHHH	54.49	30266825
620	Phosphorylation	LKSRVERSAEGPGLP HHHHHHHHCCCCCCC	19.71	28857561
628	Phosphorylation	AEGPGLPTGVERERG CCCCCCCCCCCCCCC	59.92	23898821
636	Phosphorylation	GVERERGSRKPRRYF CCCCCCCCCCCCCCC	43.27	23898821
642	Phosphorylation	GSRKPRRYFSPGESR CCCCCCCCCCCCCCC	15.08	26657352
644	Phosphorylation	RKPRRYFSPGESRKT CCCCCCCCCCCCCCC	24.06	22617229
648	Phosphorylation	RYFSPGESRKTSERF CCCCCCCCCCCCHHH	45.02	27251275
651	Phosphorylation	SPGESRKTSERFRTQ CCCCCCCCCHHHHCC	34.41	20068231
652	Phosphorylation	PGESRKTSERFRTQP CCCCCCCCHHHHCCC	29.79	26437602
657	Phosphorylation	KTSERFRTQPITSAE CCCHHHHCCCCCHHH	35.67	30266825
662	Phosphorylation	FRTQPITSAERKESD HHCCCCCHHHHHHHC	28.93	28674419
672	Phosphorylation	RKESDRCTSHSETPT HHHHCCCCCCCCCCC	30.30	23927012
673	Phosphorylation	KESDRCTSHSETPTV HHHCCCCCCCCCCCC	28.74	23927012
675	Phosphorylation	SDRCTSHSETPTVDD HCCCCCCCCCCCCCC	42.82	23927012
677	Phosphorylation	RCTSHSETPTVDDEE CCCCCCCCCCCCCHH	27.55	23927012
679	Phosphorylation	TSHSETPTVDDEEKV CCCCCCCCCCCHHHH	43.94	23927012
693	O-linked_Glycosylation	VDERAKLSVAAKRLL HCHHHHHHHHHHHHH	14.70	30379171
694 (in isoform 2)	O-linked_Glycosylation	-	9.71	30379171
707	Phosphorylation	LFREMEKSFDEQNVP HHHHHHHHCCCCCCC	25.32	25159151
734	Phosphorylation	LRRLQDRSLTQPITT HHHHHCCCCCCCCCC	44.02	20873877
734 (in isoform 4)	Phosphorylation	-	44.02	30206219
736	Phosphorylation	RLQDRSLTQPITTEE HHHCCCCCCCCCCCE	33.28	17525332
736 (in isoform 4)	Phosphorylation	-	33.28	25159151
740	Phosphorylation	RSLTQPITTEEVVIA CCCCCCCCCCEEEEE	34.53	20873877
740 (in isoform 4)	Phosphorylation	-	34.53	27174698
741	Phosphorylation	SLTQPITTEEVVIAA CCCCCCCCCEEEEEE	30.76	20873877
741 (in isoform 4)	Phosphorylation	-	30.76	27174698
749	Phosphorylation	EEVVIAATEPIPASC CEEEEEECCCCCCCC	33.02	20873877
749 (in isoform 4)	Phosphorylation	-	33.02	22210691
753 (in isoform 4)	Phosphorylation	-	28.92	27174698
755	Phosphorylation	ATEPIPASCSGGTHP ECCCCCCCCCCCCCC	11.94	20873877
757	Phosphorylation	EPIPASCSGGTHPVM CCCCCCCCCCCCCCC	37.45	20873877
760	Phosphorylation	PASCSGGTHPVMARL CCCCCCCCCCCCCCC	26.91	20873877
769	Phosphorylation	PVMARLPSPTVARSA CCCCCCCCCCHHHHC	37.48	30266825
771	Phosphorylation	MARLPSPTVARSAVQ CCCCCCCCHHHHCCC	31.00	30266825
800	Acetylation	KDQTNEGKELAEQGE HCCCHHHHHHHHCCC	43.29	26051181
810	Phosphorylation	AEQGEPDSSTLSLAE HHCCCCCHHHHHHHH	35.62	28348404
811	Phosphorylation	EQGEPDSSTLSLAEK HCCCCCHHHHHHHHH	40.52	28348404
812	Phosphorylation	QGEPDSSTLSLAEKL CCCCCHHHHHHHHHH	25.07	28348404
818	Ubiquitination	STLSLAEKLALFNKL HHHHHHHHHHHHHHH	33.19	-
824	Ubiquitination	EKLALFNKLSQPVSK HHHHHHHHHCCCHHH	42.03	-
830	Phosphorylation	NKLSQPVSKAISTRN HHHCCCHHHHHHHCH	24.05	27499020
850	Phosphorylation	QRRMNARYQTQPVTL HHHHHCHHCCCCEEC	17.32	25463755
852	Phosphorylation	RMNARYQTQPVTLGE HHHCHHCCCCEECCC	26.38	19664994
856	Phosphorylation	RYQTQPVTLGEVEQV HHCCCCEECCCEEEE	35.41	30266825
872	Phosphorylation	SGKLIPFSPAVNTSV CCCEEECCCCCCCCH	13.44	22199227
877	Phosphorylation	PFSPAVNTSVSTVAS ECCCCCCCCHHHHHH	24.73	22199227
878	Phosphorylation	FSPAVNTSVSTVAST CCCCCCCCHHHHHHC	14.63	28348404
880	Phosphorylation	PAVNTSVSTVASTVA CCCCCCHHHHHHCCC	19.55	28348404
881	Phosphorylation	AVNTSVSTVASTVAP CCCCCHHHHHHCCCC	20.24	22199227
884	Phosphorylation	TSVSTVASTVAPMYA CCHHHHHHCCCCCCC	21.05	22199227
896	Phosphorylation	MYAGDLRTKPPLDHN CCCCCCCCCCCCCCC	56.02	23312004
905	Phosphorylation	PPLDHNASATDYKFS CCCCCCCCCCCCCCC	36.70	26657352
907	Phosphorylation	LDHNASATDYKFSSS CCCCCCCCCCCCCHH	37.05	28857561
909	Phosphorylation	HNASATDYKFSSSIE CCCCCCCCCCCHHCC	15.02	28857561
912	Phosphorylation	SATDYKFSSSIENSD CCCCCCCCHHCCCCC	21.01	23927012
913	Phosphorylation	ATDYKFSSSIENSDS CCCCCCCHHCCCCCC	38.17	23401153
914	Phosphorylation	TDYKFSSSIENSDSP CCCCCCHHCCCCCCC	32.49	29255136
918	Phosphorylation	FSSSIENSDSPVRSI CCHHCCCCCCCHHHH	27.03	29255136
920	Phosphorylation	SSIENSDSPVRSILK HHCCCCCCCHHHHHH	25.72	19664994
924	Phosphorylation	NSDSPVRSILKSQAW CCCCCHHHHHHHCCC	32.29	30576142
927	Methylation	SPVRSILKSQAWQPL CCHHHHHHHCCCCCC	38.56	115980305
938	Phosphorylation	WQPLVEGSENKGMLR CCCCCCCCCCCCHHH	25.21	20068231
953	Acetylation	EYGETESKRALTGRD HHCHHHCHHHHCCCC	35.14	30592723
957	Phosphorylation	TESKRALTGRDSGME HHCHHHHCCCCCCCH	29.23	27251275
961	Phosphorylation	RALTGRDSGMEKYGS HHHCCCCCCCHHCCC	38.38	29514088
966	Phosphorylation	RDSGMEKYGSFEEAE CCCCCHHCCCHHHHH	12.51	23927012
968	Phosphorylation	SGMEKYGSFEEAEAS CCCHHCCCHHHHHHH	26.79	23927012
975	Phosphorylation	SFEEAEASYPILNRA CHHHHHHHCHHHHCC	23.97	23927012
976	Phosphorylation	FEEAEASYPILNRAR HHHHHHHCHHHHCCC	11.01	23927012
992	Acetylation	GDSHKESKYAVPRRG CCCCCCCCCCCCCCC	38.02	7297757
993	Phosphorylation	DSHKESKYAVPRRGS CCCCCCCCCCCCCCC	23.31	-
1000	Phosphorylation	YAVPRRGSLERANPP CCCCCCCCHHHCCCC	25.83	17081983
1052	Phosphorylation	NVMKRKFSLRAAEFG HHHHHCEEEEHHHHC	21.71	25394399
1078	Phosphorylation	GKTIAQTTAPVSWKP CCEEEEECCCCCCCC	19.51	-
1084	Acetylation	TTAPVSWKPQDSSEQ ECCCCCCCCCCCCCC	25.87	26051181
1088	Phosphorylation	VSWKPQDSSEQPQEK CCCCCCCCCCCHHHH	30.44	28857561
1089	Phosphorylation	SWKPQDSSEQPQEKL CCCCCCCCCCHHHHH	48.84	28857561
1095	Acetylation	SSEQPQEKLCKNPCA CCCCHHHHHCCCCCH	54.67	26051181
1111	Phosphorylation	FAAGEIKTPTGEGLL HHCCCCCCCCCCCCC	31.57	25159151
1113	Phosphorylation	AGEIKTPTGEGLLDS CCCCCCCCCCCCCCC	53.77	22199227
1120	Phosphorylation	TGEGLLDSPSKTMSI CCCCCCCCCCCCCCH	30.92	30266825
1122	Phosphorylation	EGLLDSPSKTMSIKE CCCCCCCCCCCCHHH	44.72	30266825
1124	Phosphorylation	LLDSPSKTMSIKERL CCCCCCCCCCHHHHH	22.08	23312004
1126	Phosphorylation	DSPSKTMSIKERLAL CCCCCCCCHHHHHHH	35.42	28857561
1137	Phosphorylation	RLALLKKSGEEDWRN HHHHHHHHCHHHHHH	50.26	21815630
1158	Phosphorylation	EGGKAPASSLHTQEA CCCCCCHHHHCHHHH	32.16	28857561
1159	Phosphorylation	GGKAPASSLHTQEAG CCCCCHHHHCHHHHH	26.69	26657352
1162	Phosphorylation	APASSLHTQEAGRSL CCHHHHCHHHHHHHH	33.14	28857561
1168	Phosphorylation	HTQEAGRSLIKKRVT CHHHHHHHHHHHHHC	33.26	25159151
1175	Phosphorylation	SLIKKRVTESRESQM HHHHHHHCCCHHHCC	32.07	20363803
1177	Phosphorylation	IKKRVTESRESQMTI HHHHHCCCHHHCCCH	31.79	20363803
1180	Phosphorylation	RVTESRESQMTIEER HHCCCHHHCCCHHHH	24.92	21406692
1183	Phosphorylation	ESRESQMTIEERKQL CCHHHCCCHHHHHHH	20.01	21406692
1188	Ubiquitination	QMTIEERKQLITVRE CCCHHHHHHHHHHHH	53.38	-
1203	Methylation	EAWKTRGRGAANDST HHHHHCCCCCCCCCC	28.43	24129315
1217	Methylation	TQFTVAGRMVKKGLA CCEEECCHHHHCCCC	19.58	115918033
1220	Ubiquitination	TVAGRMVKKGLASPT EECCHHHHCCCCCCC	31.61	-
1221	Ubiquitination	VAGRMVKKGLASPTA ECCHHHHCCCCCCCE	47.98	-
1225	Phosphorylation	MVKKGLASPTAITPV HHHCCCCCCCEECCC	28.03	28355574
1227	Phosphorylation	KKGLASPTAITPVAS HCCCCCCCEECCCCC	28.35	22777824
1230	Phosphorylation	LASPTAITPVASPIC CCCCCEECCCCCCCC	14.83	20068231
1234	Phosphorylation	TAITPVASPICGKTR CEECCCCCCCCCCCC	18.29	24114839
1239	Ubiquitination	VASPICGKTRGTTPV CCCCCCCCCCCCCCC	30.55	-
1240	Phosphorylation	ASPICGKTRGTTPVS CCCCCCCCCCCCCCC	21.44	26437602
1243	Phosphorylation	ICGKTRGTTPVSKPL CCCCCCCCCCCCCCH	25.33	25850435
1244	Phosphorylation	CGKTRGTTPVSKPLE CCCCCCCCCCCCCHH	25.23	26437602
1247	Phosphorylation	TRGTTPVSKPLEDIE CCCCCCCCCCHHHCC	29.74	24719451
1287	Phosphorylation	KVGGMHETVLTVTGK CCCCCCEEEEEEECC	13.21	28111955
1290	Phosphorylation	GMHETVLTVTGKSVK CCCEEEEEEECCCHH	16.22	28111955
1292	Phosphorylation	HETVLTVTGKSVKEV CEEEEEEECCCHHHC	33.39	28111955
1295	Phosphorylation	VLTVTGKSVKEVMKP EEEEECCCHHHCCCC	39.50	28111955
1312	Phosphorylation	DETFAKFYRSVDYNM CHHHHHHHHHCCCCC	10.98	30576142
1314	Phosphorylation	TFAKFYRSVDYNMPR HHHHHHHHCCCCCCC	14.15	23403867
1317	Phosphorylation	KFYRSVDYNMPRSPV HHHHHCCCCCCCCCC	15.94	30576142
1322	Phosphorylation	VDYNMPRSPVEMDED CCCCCCCCCCCCCCC	27.68	28355574
1337	Phosphorylation	FDVIFDPYAPKLTSS CCEECCCCCCCCCHH	37.06	22777824
1343	Phosphorylation	PYAPKLTSSVAEHKR CCCCCCCHHHHHHHH	33.00	28348404
1344	Phosphorylation	YAPKLTSSVAEHKRA CCCCCCHHHHHHHHH	21.80	28348404
1378	Phosphorylation	REDLLQEYTEQRLNV HHHHHHHHHHHHHHH	11.56	-
1379	Phosphorylation	EDLLQEYTEQRLNVA HHHHHHHHHHHHHHH	25.53	23532336
1390	Phosphorylation	LNVAFMESKRMKVEK HHHHHHHHHCCCEEE	17.49	28857561
1399	Phosphorylation	RMKVEKMSSNSNFSE CCCEEECCCCCCCHH	37.12	28857561
1400	Phosphorylation	MKVEKMSSNSNFSEV CCEEECCCCCCCHHH	40.56	26657352
1402	Phosphorylation	VEKMSSNSNFSEVTL EEECCCCCCCHHHHH	41.00	26657352
1405	Phosphorylation	MSSNSNFSEVTLAGL CCCCCCCHHHHHHHH	35.09	30576142
1419	Phosphorylation	LASKENFSNVSLRSV HHCCCCCCCCEEEEC	48.15	25850435
1422	Phosphorylation	KENFSNVSLRSVNLT CCCCCCCEEEECCCC	23.47	29255136
1425	Phosphorylation	FSNVSLRSVNLTEQN CCCCEEEECCCCCCC	22.20	20873877
1429	Phosphorylation	SLRSVNLTEQNSNNS EEEECCCCCCCCCCC	30.26	27251275
1433	Phosphorylation	VNLTEQNSNNSAVPY CCCCCCCCCCCCCCH	36.76	27251275
1436	Phosphorylation	TEQNSNNSAVPYKRL CCCCCCCCCCCHHEE	34.59	27251275
1497	Phosphorylation	VIEKAKASELATLIQ HHHHHHHHHHHHHHH	32.22	24719451
1501	Phosphorylation	AKASELATLIQTKRE HHHHHHHHHHHHHHH	36.70	24719451
1505	Phosphorylation	ELATLIQTKRELGCR HHHHHHHHHHHHCCC	25.69	24719451
1579	Phosphorylation	KLVPDDDYWGKIPKC CCCCCCCCCCCCCCC	24.05	-
1582	Acetylation	PDDDYWGKIPKCSLL CCCCCCCCCCCCCCC	41.51	26051181
1617	Malonylation	EVTLAQRKIAFQLAK EEEHHHHHHHHHHHH	26.72	26320211
1678	Ubiquitination	ETILFKEKFLDWTEL CEEEEEHHHCCHHHH	52.39	-
1688	Phosphorylation	DWTELKRSNEKNPGE CHHHHHHCCCCCHHH	47.99	28509920
1710	Phosphorylation	PRTDVKAYDVTRMVS CCCCCCEEEHHHHCC	12.77	-
1717	Phosphorylation	YDVTRMVSMPQTTAG EEHHHHCCCCCCCCC	18.53	28857561
1790	Phosphorylation	VKWKFMVSTAVGSRQ EEEEEEEEECCCCCC	10.00	-
1791	Phosphorylation	KWKFMVSTAVGSRQK EEEEEEEECCCCCCC	17.60	-
1795	Phosphorylation	MVSTAVGSRQKGEHS EEEECCCCCCCCCCC	25.57	-
1822	Phosphorylation	FWQGRHSTVSEKGTS EECCCCCCCCCCCCE	23.17	30576142
1826	Acetylation	RHSTVSEKGTSALMT CCCCCCCCCCEEEEE	61.04	25953088
1828	Phosphorylation	STVSEKGTSALMTVE CCCCCCCCEEEEEEE	23.15	20068231
1829	Phosphorylation	TVSEKGTSALMTVEL CCCCCCCEEEEEEEE	28.24	20068231
1833	Phosphorylation	KGTSALMTVELDEER CCCEEEEEEEECHHC	16.21	20068231
1904	Phosphorylation	LEVACHCSSLRSRTS EHHHHHCHHCCCCCE	14.56	18212344
1910	Phosphorylation	CSSLRSRTSMVVLNV CHHCCCCCEEEEEEE	23.56	20068231
1911	Phosphorylation	SSLRSRTSMVVLNVN HHCCCCCEEEEEEEC	14.41	20068231
1946	Acetylation	RTAANKIKEQCPLEA HHHHHHHHHHCCCCC	43.26	26051181
2071	O-linked_Glycosylation	IENKITGSARIRWAS ECCEECCCEEEEECC	13.01	30379171
2179	Phosphorylation	DPLKLEIYLTDEDFE CCEEEEEEECCCCCH	8.32	23898821
2181	Phosphorylation	LKLEIYLTDEDFEFA EEEEEEECCCCCHHH	21.99	23898821
2192	Phosphorylation	FEFALDMTRDEYNAL CHHHHHCCHHHHHCC	34.34	23898821
2196	Phosphorylation	LDMTRDEYNALPAWK HHCCHHHHHCCHHHH	15.27	23898821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
238	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SVIL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SVIL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LC7L2_HUMAN	LUC7L2	physical	16169070
ESR1_HUMAN	ESR1	physical	11792840
PPARG_HUMAN	PPARG	physical	11792840
GCR_HUMAN	NR3C1	physical	11792840
ANDR_HUMAN	AR	physical	11792840
K1C18_HUMAN	KRT18	physical	20309963
MI4GD_HUMAN	MIF4GD	physical	20309963
UXT_HUMAN	UXT	physical	20309963
CENPR_HUMAN	ITGB3BP	physical	20309963
BUB1_HUMAN	BUB1	physical	20309963
CENPF_HUMAN	CENPF	physical	20309963
FLNA_HUMAN	FLNA	physical	20309963
HAX1_HUMAN	HAX1	physical	20309963
HS90A_HUMAN	HSP90AA1	physical	20309963
KIFC3_HUMAN	KIFC3	physical	20309963
LMNA_HUMAN	LMNA	physical	20309963
LMNB2_HUMAN	LMNB2	physical	20309963
MPP9_HUMAN	MPHOSPH9	physical	20309963
NDKB_HUMAN	NME2	physical	20309963
ODFP2_HUMAN	ODF2	physical	20309963
PAN3_HUMAN	PAN3	physical	20309963
PCX3_HUMAN	PCNXL3	physical	20309963
HMMR_HUMAN	HMMR	physical	20309963
BACD2_HUMAN	TNFAIP1	physical	20309963
LIMA1_HUMAN	LIMA1	physical	20309963
ATRX_HUMAN	ATRX	physical	20309963
KIF14_HUMAN	KIF14	physical	20309963
MKL2_HUMAN	MKL2	physical	20309963
KMT2A_HUMAN	KMT2A	physical	20309963
SPD2A_HUMAN	SH3PXD2A	physical	20309963
KIF22_HUMAN	KIF22	physical	20309963
STAR9_HUMAN	STARD9	physical	20309963
VINC_HUMAN	VCL	physical	22939629
TRIP6_HUMAN	TRIP6	physical	16880273
DYLT1_HUMAN	DYNLT1	physical	16880273
SPTB2_HUMAN	SPTBN1	physical	12202484
SPTN1_HUMAN	SPTAN1	physical	12202484
MYH2_HUMAN	MYH2	physical	12202484
CLH1_HUMAN	CLTC	physical	12202484
MYO1G_HUMAN	MYO1G	physical	12202484
ACTN4_HUMAN	ACTN4	physical	12202484
ACTN1_HUMAN	ACTN1	physical	12202484
VIME_HUMAN	VIM	physical	12202484
LYN_HUMAN	LYN	physical	12202484
FLOT1_HUMAN	FLOT1	physical	12202484
FLOT2_HUMAN	FLOT2	physical	12202484
ACTB_HUMAN	ACTB	physical	12202484
GNAI1_HUMAN	GNAI1	physical	12202484
GBB1_HUMAN	GNB1	physical	12202484
STOM_HUMAN	STOM	physical	12202484
GPSM3_HUMAN	GPSM3	physical	12202484
ML12A_HUMAN	MYL12A	physical	12202484
GAPR1_HUMAN	GLIPR2	physical	12202484
UBP7_HUMAN	USP7	physical	23382381

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SVIL_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50; SER-221; SER-245;SER-707; SER-920; THR-1111; SER-1120; SER-1225 AND SER-1322, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-920, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 AND SER-270, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-920, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221; SER-245 ANDTHR-1175, AND MASS SPECTROMETRY.	17081983 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-736 AND THR-852, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-852, AND MASSSPECTROMETRY.	15302935 [Abstract]