dbPTM

MKL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MKL2_HUMAN
UniProt AC	Q9ULH7
Protein Name	MKL/myocardin-like protein 2
Gene Name	MKL2
Organism	Homo sapiens (Human).
Sequence Length	1088
Subcellular Localization	Nucleus.
Protein Description	Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation..
Protein Sequence	MIDSSKKQQQGFPEILTAGDFEPLKEKECLEGSNQKSLKEVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIRSRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNILPVDSSVKEAIIGVGKEDYPHTQGDFSFDEDSSDALSPDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEFLKTPPTADQPPPRPAAPVLPTNTVSSAKPGPALVKQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMDSNYARLLQQQQLFLQLQILSQQKQHYNYQTILPAPFKPLNDKNSNSGNSALNNATPNTPRQNTSTPVRKPGPLPSSLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVNSSGLAAGGIVAVSSSAIVTSNPEVTVALPVTTLHNTVTSSVSTLKAELPPTGTSNATRVENVHSPLPISPSPSEQSSLSTDDTNMADTFTEIMTMMSPSQFLSSSPLRMTNNEDSLSPTSSTLSNLELDAAEKDRKLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVASHAVGQPVSTGGQTLVAKKAVVIKQEVPVGQAEQQSVVSQFYVSSQGQPPPAVVAQPQALLTTQTAQLLLPVSIQGSSVTSVQLPVGSLKLQTSPQAGMQTQPQIATAAQIPTAALASGLAPTVPQTQDTFPQHVLSQPQQVRKVFTNSASSNTVLPYQRHPAPAVQQPFINKASNSVLQSRNAPLPSLQNGPNTPNKPSSPPPPQQFVVQHSLFGSPVAKTKDPPRYEEAIKQTRSTQAPLPEISNAHSQQMDDLFDILIKSGEISLPIKEEPSPISKMRPVTASITTMPVNTVVSRPPPQVQMAPPVSLEPMGSLSASLENQLEAFLDGTLPSANEIPPLQSSSEDREPFSLIEDLQNDLLSHSGMLDHSHSPMETSETQFAAGTPCLSLDLSDSNLDNMEWLDITMPNSSSGLTPLSTTAPSMFSADFLDPQDLPLPWD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22 (in isoform 4)	Phosphorylation	-	55.23	27251275
77 (in isoform 4)	Phosphorylation	-	4.36	27251275
146	Acetylation	GPMELVEKNILPVDS CCHHHHHCCCCCCCC	41.63	26051181
165 (in isoform 4)	Phosphorylation	-	57.77	27251275
186 (in isoform 4)	Phosphorylation	-	45.14	27251275
196 (in isoform 4)	Phosphorylation	-	28.65	27251275
208 (in isoform 4)	Phosphorylation	-	70.43	27251275
222 (in isoform 4)	Phosphorylation	-	9.28	24719451
234 (in isoform 4)	Phosphorylation	-	36.33	27251275
236 (in isoform 4)	Phosphorylation	-	45.51	24719451
259	Acetylation	TNTVSSAKPGPALVK CCCCCCCCCCCCHHH	53.08	26051181
381 (in isoform 4)	Phosphorylation	-	55.34	24719451
388 (in isoform 4)	Phosphorylation	-	33.60	27251275
398	Acetylation	DLKVSELKTELKLRG HCCHHHHHHHHHHCC	35.58	25953088
420 (in isoform 4)	Phosphorylation	-	48.15	24719451
501 (in isoform 4)	Phosphorylation	-	42.53	27251275
506 (in isoform 4)	Phosphorylation	-	43.09	27251275
552 (in isoform 4)	Phosphorylation	-	6.59	24719451
554 (in isoform 4)	Phosphorylation	-	6.47	24719451
619	Acetylation	HSVKSDQKHGSLGSS CCCCCCCCCCCCCCC	55.73	25953088
628	Sumoylation	GSLGSSIKDEASLPD CCCCCCCCCCCCCCC	52.01	25114211
633 (in isoform 4)	Phosphorylation	-	5.52	27251275
643 (in isoform 4)	Phosphorylation	-	3.03	27251275
664	Acetylation	GGQTLVAKKAVVIKQ CCCEEEECEEEEEEE	33.51	25953088
784 (in isoform 4)	Phosphorylation	-	35.34	27251275
802 (in isoform 4)	Phosphorylation	-	2.84	24719451
807 (in isoform 4)	Phosphorylation	-	13.83	27251275
808 (in isoform 4)	Phosphorylation	-	41.97	27251275
819	Acetylation	VQQPFINKASNSVLQ CCCCCCHHHHHHHHH	48.66	26051181
824 (in isoform 4)	Phosphorylation	-	7.06	27251275
857 (in isoform 4)	Phosphorylation	-	18.36	27251275
874 (in isoform 4)	Phosphorylation	-	24.72	24719451
882 (in isoform 4)	Phosphorylation	-	34.90	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MKL2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MKL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MKL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SRF_HUMAN	SRF	physical	14565952
MKL2_HUMAN	MKL2	physical	14565952

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MKL2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; THR-367; THR-370 ANDSER-921, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND MASSSPECTROMETRY.	17081983 [Abstract]