dbPTM

CENPF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CENPF_HUMAN
UniProt AC	P49454
Protein Name	Centromere protein F
Gene Name	CENPF
Organism	Homo sapiens (Human).
Sequence Length	3210
Subcellular Localization	Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus d
Protein Description	Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia..
Protein Sequence	MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGVVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIWENGRGPTPATPESFSKKSKKAVMSGIHPAEDTEGTEFEPEGLPEVVKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKPTAGGSRSQKVKVAQRSPVDSGTILREPTTKSVPVNNLPERSPTDSPREGLRVKRGRLVPSPKAGLESNGSENCKVQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSWALEEWK ------CCCHHHHHH	32.15	26714015
19	Ubiquitination	LPTRALQKIQELEGQ CCHHHHHHHHHHHHH	47.40	21890473
29	Ubiquitination	ELEGQLDKLKKEKQQ HHHHHHHHHHHHHHH	71.45	29967540
50	Ubiquitination	SLEAALQKQKQKVEN HHHHHHHHHHHHHHH	61.38	32015554
63	O-linked_Glycosylation	ENEKTEGTNLKRENQ HHCCCCCCCCHHHHH	31.01	30379171
78	Phosphorylation	RLMEICESLEKTKQK HHHHHHHHHHHHHHH	37.10	21815630
82	Phosphorylation	ICESLEKTKQKISHE HHHHHHHHHHHHHHH	29.36	30622161
87	Phosphorylation	EKTKQKISHELQVKE HHHHHHHHHHHHHCH	20.25	30622161
93	Ubiquitination	ISHELQVKESQVNFQ HHHHHHHCHHHCCCC	38.39	29967540
106	Phosphorylation	FQEGQLNSGKKQIEK CCCCCCCHHHHHHHH	61.66	25159151
108	Acetylation	EGQLNSGKKQIEKLE CCCCCHHHHHHHHHH	41.13	26051181
113	Ubiquitination	SGKKQIEKLEQELKR HHHHHHHHHHHHHHH	59.98	29967540
119	Ubiquitination	EKLEQELKRCKSELE HHHHHHHHHHHHHHH	55.80	32015554
134	Phosphorylation	RSQQAAQSADVSLNP HHHHHHHHCCCCCCC	23.01	22199227
138	Phosphorylation	AAQSADVSLNPCNTP HHHHCCCCCCCCCCC	23.99	25627689
144	Phosphorylation	VSLNPCNTPQKIFTT CCCCCCCCCCCEECC	33.54	30266825
147	Ubiquitination	NPCNTPQKIFTTPLT CCCCCCCCEECCCCC	40.78	29967540
150	Phosphorylation	NTPQKIFTTPLTPSQ CCCCCEECCCCCHHH	30.86	21945579
151	Phosphorylation	TPQKIFTTPLTPSQY CCCCEECCCCCHHHC	12.93	21945579
154	Phosphorylation	KIFTTPLTPSQYYSG CEECCCCCHHHCCCC	23.30	21945579
156	Phosphorylation	FTTPLTPSQYYSGSK ECCCCCHHHCCCCCC	26.11	21945579
158	Phosphorylation	TPLTPSQYYSGSKYE CCCCHHHCCCCCCHH	12.16	21945579
159	Phosphorylation	PLTPSQYYSGSKYED CCCHHHCCCCCCHHH	10.02	21945579
160	Phosphorylation	LTPSQYYSGSKYEDL CCHHHCCCCCCHHHH	31.49	21945579
162	Phosphorylation	PSQYYSGSKYEDLKE HHHCCCCCCHHHHHH	26.56	21945579
163	Ubiquitination	SQYYSGSKYEDLKEK HHCCCCCCHHHHHHH	57.07	32015554
164	Phosphorylation	QYYSGSKYEDLKEKY HCCCCCCHHHHHHHH	19.17	28450419
168	Ubiquitination	GSKYEDLKEKYNKEV CCCHHHHHHHHHHHH	65.56	23503661
186	Ubiquitination	KRLEAEVKALQAKKA HHHHHHHHHHHHHHH	34.58	32015554
192	Ubiquitination	VKALQAKKASQTLPQ HHHHHHHHHHCCCCH	57.18	29967540
194	Phosphorylation	ALQAKKASQTLPQAT HHHHHHHHCCCCHHH	32.36	28555341
196	Phosphorylation	QAKKASQTLPQATMN HHHHHHCCCCHHHCC	37.60	28555341
201	Phosphorylation	SQTLPQATMNHRDIA HCCCCHHHCCHHHHH	17.17	28555341
213	Phosphorylation	DIARHQASSSVFSWQ HHHHHHHCCCCCCCC	19.31	28787133
214	Phosphorylation	IARHQASSSVFSWQQ HHHHHHCCCCCCCCC	33.27	24043423
215	Phosphorylation	ARHQASSSVFSWQQE HHHHHCCCCCCCCCC	25.37	24043423
218	Phosphorylation	QASSSVFSWQQEKTP HHCCCCCCCCCCCCC	23.09	24043423
223	Ubiquitination	VFSWQQEKTPSHLSS CCCCCCCCCCCCCCC	62.49	21963094
224	Phosphorylation	FSWQQEKTPSHLSSN CCCCCCCCCCCCCCC	29.30	25159151
226	Phosphorylation	WQQEKTPSHLSSNSQ CCCCCCCCCCCCCCC	42.14	25627689
229	Phosphorylation	EKTPSHLSSNSQRTP CCCCCCCCCCCCCCC	23.27	25159151
230	Phosphorylation	KTPSHLSSNSQRTPI CCCCCCCCCCCCCCC	47.03	25159151
232	Phosphorylation	PSHLSSNSQRTPIRR CCCCCCCCCCCCCCC	24.00	28985074
235	Phosphorylation	LSSNSQRTPIRRDFS CCCCCCCCCCCCCCC	18.54	18669648
242	Phosphorylation	TPIRRDFSASYFSGE CCCCCCCCCHHCCCC	22.16	25159151
244	Phosphorylation	IRRDFSASYFSGEQE CCCCCCCHHCCCCCE	26.05	28450419
245	Phosphorylation	RRDFSASYFSGEQEV CCCCCCHHCCCCCEE	11.07	29978859
247	Phosphorylation	DFSASYFSGEQEVTP CCCCHHCCCCCEECC	32.94	25159151
253	Phosphorylation	FSGEQEVTPSRSTLQ CCCCCEECCCCCCEE	18.13	25159151
255	Phosphorylation	GEQEVTPSRSTLQIG CCCEECCCCCCEEEC	29.51	28450419
257	Phosphorylation	QEVTPSRSTLQIGKR CEECCCCCCEEECCC	37.49	30576142
258	Phosphorylation	EVTPSRSTLQIGKRD EECCCCCCEEECCCC	22.90	21712546
263	Ubiquitination	RSTLQIGKRDANSSF CCCEEECCCCCCCCC	49.05	32015554
268	Phosphorylation	IGKRDANSSFFDNSS ECCCCCCCCCCCCCC	30.18	23927012
269	Phosphorylation	GKRDANSSFFDNSSS CCCCCCCCCCCCCCC	29.73	23927012
274	Phosphorylation	NSSFFDNSSSPHLLD CCCCCCCCCCHHHHH	33.75	23401153
275	Phosphorylation	SSFFDNSSSPHLLDQ CCCCCCCCCHHHHHH	54.89	22167270
276	Phosphorylation	SFFDNSSSPHLLDQL CCCCCCCCHHHHHHH	19.03	22167270
284	Ubiquitination	PHLLDQLKAQNQELR HHHHHHHHHHCHHHH	42.15	32015554
293	Ubiquitination	QNQELRNKINELELR HCHHHHHHHHHHHHH	40.24	32015554
306	Ubiquitination	LRLQGHEKEMKGQVN HHHHHCHHHHHHHHC	58.39	29967540
314	Ubiquitination	EMKGQVNKFQELQLQ HHHHHHCHHHHHHHH	49.95	21890473
324	Ubiquitination	ELQLQLEKAKVELIE HHHHHHHHHHHHHHH	63.20	29967540
355	Phosphorylation	AQYDQASTKYTALEQ HHHHHHHHHHHHHHH	30.96	21601212
356	Ubiquitination	QYDQASTKYTALEQK HHHHHHHHHHHHHHH	37.80	21890473
363	Ubiquitination	KYTALEQKLKKLTED HHHHHHHHHHHHHHH	53.55	29967540
366	Ubiquitination	ALEQKLKKLTEDLSC HHHHHHHHHHHHHHH	71.70	29967540
372	Phosphorylation	KKLTEDLSCQRQNAE HHHHHHHHHHHHCHH	22.11	22067460
380	Phosphorylation	CQRQNAESARCSLEQ HHHHCHHHHHHHHHH	20.71	21601212
388	Ubiquitination	ARCSLEQKIKEKEKE HHHHHHHHHHHHHHH	46.50	32015554
394	Ubiquitination	QKIKEKEKEFQEELS HHHHHHHHHHHHHHH	74.93	29967540
401	Phosphorylation	KEFQEELSRQQRSFQ HHHHHHHHHHHHHHH	31.18	21601212
406	Phosphorylation	ELSRQQRSFQTLDQE HHHHHHHHHHHHHHH	19.85	21601212
409	Phosphorylation	RQQRSFQTLDQECIQ HHHHHHHHHHHHHHH	30.23	21601212
418	Ubiquitination	DQECIQMKARLTQEL HHHHHHHHHHHHHHH	17.61	32015554
422	Phosphorylation	IQMKARLTQELQQAK HHHHHHHHHHHHHHH	17.91	20068231
429	Ubiquitination	TQELQQAKNMHNVLQ HHHHHHHHHHHHHHH	50.93	29967540
443	Phosphorylation	QAELDKLTSVKQQLE HHHHHHHHHHHHHHH	36.90	27174698
444	Phosphorylation	AELDKLTSVKQQLEN HHHHHHHHHHHHHHH	37.44	27174698
446	Ubiquitination	LDKLTSVKQQLENNL HHHHHHHHHHHHHCH	31.90	29967540
457	Ubiquitination	ENNLEEFKQKLCRAE HHCHHHHHHHHHHHH	50.21	20972266
473	Ubiquitination	AFQASQIKENELRRS HHHHHHHHHHHHHHH	47.02	29967540
480	Phosphorylation	KENELRRSMEEMKKE HHHHHHHHHHHHHHH	24.90	28258704
486	Ubiquitination	RSMEEMKKENNLLKS HHHHHHHHHHCHHHH	65.45	30230243
492	Ubiquitination	KKENNLLKSHSEQKA HHHHCHHHHHHHHHH	49.65	-
493	Phosphorylation	KENNLLKSHSEQKAR HHHCHHHHHHHHHHH	32.01	26074081
495	Phosphorylation	NNLLKSHSEQKAREV HCHHHHHHHHHHHHH	49.14	26074081
498	Ubiquitination	LKSHSEQKAREVCHL HHHHHHHHHHHHHHH	45.41	-
510	Ubiquitination	CHLEAELKNIKQCLN HHHHHHHHHHHHHHH	48.40	32015554
513	Ubiquitination	EAELKNIKQCLNQSQ HHHHHHHHHHHHHCH	44.33	32015554
527	Ubiquitination	QNFAEEMKAKNTSQE HHHHHHHHHCCCCHH	60.53	32015554
529	Ubiquitination	FAEEMKAKNTSQETM HHHHHHHCCCCHHHH	56.06	29967540
543	Acetylation	MLRDLQEKINQQENS HHHHHHHHHHHHHCC	33.71	7962633
543	Ubiquitination	MLRDLQEKINQQENS HHHHHHHHHHHHHCC	33.71	21906983
555	Ubiquitination	ENSLTLEKLKLAVAD HCCCHHHHHHHHHHH	54.77	21890473
557	Ubiquitination	SLTLEKLKLAVADLE CCHHHHHHHHHHHHH	45.53	29967540
565	Acetylation	LAVADLEKQRDCSQD HHHHHHHHHCCCCHH	58.91	26051181
565	Ubiquitination	LAVADLEKQRDCSQD HHHHHHHHHCCCCHH	58.91	29967540
570	Phosphorylation	LEKQRDCSQDLLKKR HHHHCCCCHHHHHHH	30.90	21601212
576	Ubiquitination	CSQDLLKKREHHIEQ CCHHHHHHHHHHHHH	64.09	29967540
587	Ubiquitination	HIEQLNDKLSKTEKE HHHHHHHHHHHHHHH	54.29	29967540
591	Phosphorylation	LNDKLSKTEKESKAL HHHHHHHHHHHHHHH	49.25	28634120
595	Phosphorylation	LSKTEKESKALLSAL HHHHHHHHHHHHHHH	34.01	25599653
596	Ubiquitination	SKTEKESKALLSALE HHHHHHHHHHHHHHH	44.11	32015554
605	Ubiquitination	LLSALELKKKEYEEL HHHHHHHHHHHHHHH	53.04	32015554
613	Ubiquitination	KKEYEELKEEKTLFS HHHHHHHHHHHCHHH	68.08	32015554
616	Ubiquitination	YEELKEEKTLFSCWK HHHHHHHHCHHHHHH	52.17	29967540
623	Acetylation	KTLFSCWKSENEKLL HCHHHHHHHHHHHHH	52.82	26051181
628	Ubiquitination	CWKSENEKLLTQMES HHHHHHHHHHHHHHH	61.45	32015554
637	Ubiquitination	LTQMESEKENLQSKI HHHHHHHHHHHHHHH	62.27	33845483
643	Ubiquitination	EKENLQSKINHLETC HHHHHHHHHHHHHHH	34.27	29967540
652	Ubiquitination	NHLETCLKTQQIKSH HHHHHHHHHHHHHHC	46.57	32015554
653	O-linked_Glycosylation	HLETCLKTQQIKSHE HHHHHHHHHHHHHCH	16.86	30379171
657	Ubiquitination	CLKTQQIKSHEYNER HHHHHHHHHCHHHHH	41.23	29967540
658	O-linked_Glycosylation	LKTQQIKSHEYNERV HHHHHHHHCHHHHHH	24.15	30379171
676	Phosphorylation	EMDRENLSVEIRNLH HCCCCCCCHHHHHHH	29.32	-
689	Ubiquitination	LHNVLDSKSVEVETQ HHHHHCCCCCCHHHH	59.18	21906983
697	Ubiquitination	SVEVETQKLAYMELQ CCCHHHHHHHHHHHH	42.37	21906983
700	Phosphorylation	VETQKLAYMELQQKA HHHHHHHHHHHHHHH	11.10	-
706	Ubiquitination	AYMELQQKAEFSDQK HHHHHHHHHHCCCHH	36.60	21906983
724	Ubiquitination	EIENMCLKTSQLTGQ HHHHHHHHHHHHHCC	41.00	32015554
738	Ubiquitination	QVEDLEHKLQLLSNE CHHHHHHHHHHHHHC	28.66	29967540
743	Phosphorylation	EHKLQLLSNEIMDKD HHHHHHHHHCCCCCH	40.80	20068231
747	Sulfoxidation	QLLSNEIMDKDRCYQ HHHHHCCCCCHHHHH	4.23	21406390
749	Ubiquitination	LSNEIMDKDRCYQDL HHHCCCCCHHHHHHH	29.68	29967540
768	Ubiquitination	ESLRDLLKSKDASLV HHHHHHHHCCCCCCC	63.86	21890473
769	Phosphorylation	SLRDLLKSKDASLVT HHHHHHHCCCCCCCC	35.42	23312004
770	Ubiquitination	LRDLLKSKDASLVTN HHHHHHCCCCCCCCC	56.58	33845483
773	Phosphorylation	LLKSKDASLVTNEDH HHHCCCCCCCCCHHH	33.24	25159151
776	Phosphorylation	SKDASLVTNEDHQRS CCCCCCCCCHHHHHH	37.88	28555341
783	Phosphorylation	TNEDHQRSLLAFDQQ CCHHHHHHHHHHCCC	22.59	20068231
796	Phosphorylation	QQPAMHHSFANIIGE CCCHHCHHHHHHHCC	16.04	20068231
806	Phosphorylation	NIIGEQGSMPSERSE HHHCCCCCCCCCCCC	27.49	27080861
809	Phosphorylation	GEQGSMPSERSECRL CCCCCCCCCCCCHHC	36.68	20068231
812	Phosphorylation	GSMPSERSECRLEAD CCCCCCCCCHHCCCC	36.68	24732914
821	Phosphorylation	CRLEADQSPKNSAIL HHCCCCCCCCCHHHH	38.09	23401153
823	Acetylation	LEADQSPKNSAILQN CCCCCCCCCHHHHHH	69.64	26051181
823	Ubiquitination	LEADQSPKNSAILQN CCCCCCCCCHHHHHH	69.64	23000965
825	Phosphorylation	ADQSPKNSAILQNRV CCCCCCCHHHHHHHH	23.86	24732914
834	Phosphorylation	ILQNRVDSLEFSLES HHHHHHHHHHHHHHH	27.26	30266825
838	Phosphorylation	RVDSLEFSLESQKQM HHHHHHHHHHHHHHH	23.11	30266825
841	Phosphorylation	SLEFSLESQKQMNSD HHHHHHHHHHHHCHH	48.23	22199227
843	Ubiquitination	EFSLESQKQMNSDLQ HHHHHHHHHHCHHHH	61.87	32015554
847	Phosphorylation	ESQKQMNSDLQKQCE HHHHHHCHHHHHHHH	34.06	29978859
869	Ubiquitination	EIEENLMKAEQMHQS HHHHHHHHHHHHHHH	52.52	32015554
876	Phosphorylation	KAEQMHQSFVAETSQ HHHHHHHHHHHHHHH	13.65	30266825
882	O-linked_Glycosylation	QSFVAETSQRISKLQ HHHHHHHHHHHHHHH	14.68	30379171
882	Phosphorylation	QSFVAETSQRISKLQ HHHHHHHHHHHHHHH	14.68	29396449
887	Ubiquitination	ETSQRISKLQEDTSA HHHHHHHHHHHCCHH	52.39	29967540
892	Phosphorylation	ISKLQEDTSAHQNVV HHHHHHCCHHHHHHH	27.36	28555341
904	Phosphorylation	NVVAETLSALENKEK HHHHHHHHHHHCHHH	37.92	28555341
909	Ubiquitination	TLSALENKEKELQLL HHHHHHCHHHHHHHH	61.87	29967540
911	Ubiquitination	SALENKEKELQLLND HHHHCHHHHHHHHHH	66.39	33845483
919	Ubiquitination	ELQLLNDKVETEQAE HHHHHHHHHHHHHHH	40.68	21906983
931	Ubiquitination	QAEIQELKKSNHLLE HHHHHHHHHCCCCHH	54.10	32015554
932	Ubiquitination	AEIQELKKSNHLLED HHHHHHHHCCCCHHH	69.94	33845483
933	Phosphorylation	EIQELKKSNHLLEDS HHHHHHHCCCCHHHH	28.09	25159151
940	Phosphorylation	SNHLLEDSLKELQLL CCCCHHHHHHHHHHH	31.78	25159151
942	Ubiquitination	HLLEDSLKELQLLSE CCHHHHHHHHHHHHH	61.40	32015554
948	Phosphorylation	LKELQLLSETLSLEK HHHHHHHHHHHCCCH	36.81	23403867
950	Phosphorylation	ELQLLSETLSLEKKE HHHHHHHHHCCCHHH	20.47	23403867
955	Ubiquitination	SETLSLEKKEMSSII HHHHCCCHHHHHHHH	60.36	29967540
956	Ubiquitination	ETLSLEKKEMSSIIS HHHCCCHHHHHHHHC	49.64	21890473
959	Phosphorylation	SLEKKEMSSIISLNK CCCHHHHHHHHCCCH	21.34	23403867
960	Phosphorylation	LEKKEMSSIISLNKR CCHHHHHHHHCCCHH	23.72	23403867
963	Phosphorylation	KEMSSIISLNKREIE HHHHHHHCCCHHHHH	24.99	19664994
966	Ubiquitination	SSIISLNKREIEELT HHHHCCCHHHHHHHH	57.62	33845483
973	Phosphorylation	KREIEELTQENGTLK HHHHHHHHHHCCCHH	36.80	-
980	Ubiquitination	TQENGTLKEINASLN HHHCCCHHHHHHHCC	57.28	29967540
985	Phosphorylation	TLKEINASLNQEKMN CHHHHHHHCCHHHHH	24.30	21815630
990	Ubiquitination	NASLNQEKMNLIQKS HHHCCHHHHHHHHHH	24.27	29967540
996	Ubiquitination	EKMNLIQKSESFANY HHHHHHHHHHHHHHH	49.55	32015554
999	Phosphorylation	NLIQKSESFANYIDE HHHHHHHHHHHHHHH	36.43	28674419
1003	Phosphorylation	KSESFANYIDEREKS HHHHHHHHHHHHHHH	13.30	27642862
1009	Ubiquitination	NYIDEREKSISELSD HHHHHHHHHHHHHHH	60.35	29967540
1010	Phosphorylation	YIDEREKSISELSDQ HHHHHHHHHHHHHHH	26.96	22199227
1012	Phosphorylation	DEREKSISELSDQYK HHHHHHHHHHHHHHH	39.31	22199227
1019	Ubiquitination	SELSDQYKQEKLILL HHHHHHHHHHHHHHH	46.47	32015554
1022	Ubiquitination	SDQYKQEKLILLQRC HHHHHHHHHHHHHHH	38.03	21890473
1042	Ubiquitination	AYEDLSQKYKAAQEK HHHHHHHHHHHHHHH	45.39	33845483
1052	Ubiquitination	AAQEKNSKLECLLNE HHHHHHHHHHHHHHH	58.67	29967540
1062	Phosphorylation	CLLNECTSLCENRKN HHHHHHHHHHHHHHH	42.56	28555341
1068	Ubiquitination	TSLCENRKNELEQLK HHHHHHHHHHHHHHH	67.37	29967540
1075	Acetylation	KNELEQLKEAFAKEH HHHHHHHHHHHHHHH	46.84	26051181
1075	Ubiquitination	KNELEQLKEAFAKEH HHHHHHHHHHHHHHH	46.84	29967540
1080	Ubiquitination	QLKEAFAKEHQEFLT HHHHHHHHHHHHHHH	49.64	33845483
1088	Ubiquitination	EHQEFLTKLAFAEER HHHHHHHHHHHHHHH	39.71	33845483
1121	Phosphorylation	MTDNQNNSKSEAGGL CCCCCCCCCHHCCHH	45.14	28985074
1122	Ubiquitination	TDNQNNSKSEAGGLK CCCCCCCCHHCCHHH	55.21	33845483
1129	Ubiquitination	KSEAGGLKQEIMTLK CHHCCHHHHHHHHHH	49.51	32015554
1136	Ubiquitination	KQEIMTLKEEQNKMQ HHHHHHHHHHHHHHH	50.46	21906983
1158	Ubiquitination	QENEQLMKVMKTKHE HHHHHHHHHHHCHHH	48.01	32015554
1163	Acetylation	LMKVMKTKHECQNLE HHHHHHCHHHHHCCC	31.71	26051181
1163	Ubiquitination	LMKVMKTKHECQNLE HHHHHHCHHHHHCCC	31.71	33845483
1177	Phosphorylation	ESEPIRNSVKERESE CCCCCHHHHHHHHHH	25.39	28555341
1183	Phosphorylation	NSVKERESERNQCNF HHHHHHHHHHHCCCC	48.34	28555341
1191	Acetylation	ERNQCNFKPQMDLEV HHHCCCCCCCCCCEE	21.98	26051181
1202	Phosphorylation	DLEVKEISLDSYNAQ CCEEEEEEHHHHHHH	27.50	28348404
1205	Phosphorylation	VKEISLDSYNAQLVQ EEEEEHHHHHHHHHH	26.11	28348404
1223	Ubiquitination	MLRNKELKLQESEKE HHHCCCCCCCHHHHH	49.57	27667366
1229	Ubiquitination	LKLQESEKEKECLQH CCCCHHHHHHHHHHH	81.18	33845483
1231	Ubiquitination	LQESEKEKECLQHEL CCHHHHHHHHHHHHH	65.87	29967540
1247	Phosphorylation	TIRGDLETSNLQDMQ HHHHCHHHCCHHHHH	30.16	25159151
1248	Phosphorylation	IRGDLETSNLQDMQS HHHCHHHCCHHHHHH	26.60	25159151
1255	Phosphorylation	SNLQDMQSQEISGLK CCHHHHHHHCCCCCC	24.12	17525332
1259	Phosphorylation	DMQSQEISGLKDCEI HHHHHCCCCCCCCCC	37.00	25159151
1262	Ubiquitination	SQEISGLKDCEIDAE HHCCCCCCCCCCCHH	64.95	32015554
1274	Phosphorylation	DAEEKYISGPHELST CHHHHCCCCCCCCCC	43.09	21712546
1280	Phosphorylation	ISGPHELSTSQNDNA CCCCCCCCCCCCCCH	24.03	25159151
1281	Phosphorylation	SGPHELSTSQNDNAH CCCCCCCCCCCCCHH	47.13	25159151
1282	Phosphorylation	GPHELSTSQNDNAHL CCCCCCCCCCCCHHH	24.50	17525332
1292	Phosphorylation	DNAHLQCSLQTTMNK CCHHHHHHHHHHHHH	15.56	27080861
1299	Acetylation	SLQTTMNKLNELEKI HHHHHHHHHHHHHHH	41.70	25953088
1299	Ubiquitination	SLQTTMNKLNELEKI HHHHHHHHHHHHHHH	41.70	32015554
1305	Ubiquitination	NKLNELEKICEILQA HHHHHHHHHHHHHHH	66.34	32015554
1314	Ubiquitination	CEILQAEKYELVTEL HHHHHHHHHHHHHHC	47.22	32015554
1315	Phosphorylation	EILQAEKYELVTELN HHHHHHHHHHHHHCC	13.15	29396449
1319	Phosphorylation	AEKYELVTELNDSRS HHHHHHHHHCCCCHH	47.59	20068231
1324	Phosphorylation	LVTELNDSRSECITA HHHHCCCCHHHHHHH	36.31	30266825
1326	Phosphorylation	TELNDSRSECITATR HHCCCCHHHHHHHHH	40.55	18669648
1332	Phosphorylation	RSECITATRKMAEEV HHHHHHHHHHHHHHH	23.36	24719451
1334	Ubiquitination	ECITATRKMAEEVGK HHHHHHHHHHHHHHH	37.80	21890473
1341	Acetylation	KMAEEVGKLLNEVKI HHHHHHHHHHHHHEE	55.78	23749302
1341	Ubiquitination	KMAEEVGKLLNEVKI HHHHHHHHHHHHHEE	55.78	21890473
1353	Phosphorylation	VKILNDDSGLLHGEL HEEECCCCCCCCCEE	33.92	20068231
1380	Phosphorylation	PNEQHPVSLAPLDES CCCCCCCCCCCCCCC	24.22	20068231
1387	Phosphorylation	SLAPLDESNSYEHLT CCCCCCCCCCCCCCC	30.64	20068231
1389	Phosphorylation	APLDESNSYEHLTLS CCCCCCCCCCCCCCC	40.97	20068231
1390	Phosphorylation	PLDESNSYEHLTLSD CCCCCCCCCCCCCCH	16.18	20068231
1394	Phosphorylation	SNSYEHLTLSDKEVQ CCCCCCCCCCHHHHH	26.56	20068231
1396	Phosphorylation	SYEHLTLSDKEVQMH CCCCCCCCHHHHHHH	41.21	20068231
1410	Ubiquitination	HFAELQEKFLSLQSE HHHHHHHHHHHCHHH	38.35	21906983
1413	Phosphorylation	ELQEKFLSLQSEHKI HHHHHHHHCHHHHHH	27.74	28555341
1416	Phosphorylation	EKFLSLQSEHKILHD HHHHHCHHHHHHHHH	47.14	25159151
1419	Ubiquitination	LSLQSEHKILHDQHC HHCHHHHHHHHHHHH	42.80	29967540
1430	Phosphorylation	DQHCQMSSKMSELQT HHHHHHHHHHHHHHH	27.34	22210691
1431	Ubiquitination	QHCQMSSKMSELQTY HHHHHHHHHHHHHHH	38.86	29967540
1433	Phosphorylation	CQMSSKMSELQTYVD HHHHHHHHHHHHHHH	38.60	22210691
1438	Phosphorylation	KMSELQTYVDSLKAE HHHHHHHHHHHHHHH	6.84	28555341
1441	Phosphorylation	ELQTYVDSLKAENLV HHHHHHHHHHHHCCC	23.02	28555341
1443	Ubiquitination	QTYVDSLKAENLVLS HHHHHHHHHHCCCEE	58.57	32015554
1486	Phosphorylation	SCVPDSSSLSSLGDS CCCCCCCCCHHCCCH	35.90	-
1494	Phosphorylation	LSSLGDSSFYRALLE CHHCCCHHHHHHHHH	30.91	19007248
1510	Phosphorylation	TGDMSLLSNLEGAVS HCCCHHHHCCCCCCC	44.66	24275569
1522	Phosphorylation	AVSANQCSVDEVFCS CCCCCCCCCCHHHHH	23.88	22468782
1539	Ubiquitination	QTYVDSLKAENLVLS HHHHHHHHHHCCEEE	58.57	-
1541	Phosphorylation	YVDSLKAENLVLSTN HHHHHHHHCCEEECC	49.89	24719451
1547	Ubiquitination	AENLVLSTNLRNFQG HHCCEEECCHHHCCH	33.83	32015554
1554	Phosphorylation	TNLRNFQGDLVKEMQ CCHHHCCHHHHHHHH	26.53	27251275
1565	Ubiquitination	KEMQLGLEEGLVPSL HHHHHCCCCCCCCCC	48.50	-
1577	Ubiquitination	PSLSSSCVPDSSSLS CCCCCCCCCCCCCCH	6.79	32015554
1579	Ubiquitination	LSSSCVPDSSSLSSL CCCCCCCCCCCCHHC	40.53	32015554
1582	Phosphorylation	SCVPDSSSLSSLGDS CCCCCCCCCHHCCCH	35.90	-
1590	Phosphorylation	LSSLGDSSFYRALLE CHHCCCHHHHHHHHH	30.91	19007248
1600	Ubiquitination	RALLEQTGDMSLLSN HHHHHHHCCCHHHHC	28.46	-
1606	Phosphorylation	TGDMSLLSNLEGVVS HCCCHHHHCCCCCCC	44.66	-
1635	Acetylation	QEENLTRKETPSAPA HHCCCCCCCCCCCCC	61.78	26051181
1637	Phosphorylation	ENLTRKETPSAPAKG CCCCCCCCCCCCCCC	26.11	25159151
1639	Phosphorylation	LTRKETPSAPAKGVE CCCCCCCCCCCCCHH	55.06	20068231
1643	Acetylation	ETPSAPAKGVEELES CCCCCCCCCHHHHHH	63.53	26051181
1650	Phosphorylation	KGVEELESLCEVYRQ CCHHHHHHHHHHHHH	51.44	29396449
1651	Phosphorylation	GVEELESLCEVYRQS CHHHHHHHHHHHHHH	1.79	19664994
1652	Phosphorylation	VEELESLCEVYRQSL HHHHHHHHHHHHHHH	4.65	19651622
1654	Phosphorylation	ELESLCEVYRQSLEK HHHHHHHHHHHHHHH	4.69	19664994
1660	Phosphorylation	EVYRQSLEKLEEKME HHHHHHHHHHHHHHH	61.92	20068231
1668	Phosphorylation	KLEEKMESQGIMKNK HHHHHHHHCCCCCHH	30.15	29083192
1670	Phosphorylation	EEKMESQGIMKNKEI HHHHHHCCCCCHHHH	31.10	-
1673	Acetylation	MESQGIMKNKEIQEL HHHCCCCCHHHHHHH	64.05	87901
1674	Phosphorylation	ESQGIMKNKEIQELE HHCCCCCHHHHHHHH	29.79	27251275
1675	Acetylation	SQGIMKNKEIQELEQ HCCCCCHHHHHHHHH	51.15	26051181
1675	Ubiquitination	SQGIMKNKEIQELEQ HCCCCCHHHHHHHHH	51.15	29967540
1678	Phosphorylation	IMKNKEIQELEQLLS CCCHHHHHHHHHHHH	50.76	20068231
1685	Phosphorylation	QELEQLLSSERQELD HHHHHHHHHHHHHHH	38.45	25627689
1687	Ubiquitination	LEQLLSSERQELDCL HHHHHHHHHHHHHHH	55.82	-
1696	Ubiquitination	QELDCLRKQYLSENE HHHHHHHHHHCCCCH	30.28	29967540
1711	Phosphorylation	QWQQKLTSVTLEMES HHHHHHHHHHHHHHH	24.44	20860994
1722	Phosphorylation	EMESKLAAEKKQTEQ HHHHHHHHHHHHHHH	39.31	20068231
1726	Phosphorylation	KLAAEKKQTEQLSLE HHHHHHHHHHHHHHH	62.43	23186163
1729	Phosphorylation	AEKKQTEQLSLELEV HHHHHHHHHHHHHHH	39.47	24719451
1731	Phosphorylation	KKQTEQLSLELEVAR HHHHHHHHHHHHHHH	21.35	18669648
1747	Phosphorylation	QLQGLDLSSRSLLGI HHCCCCCCCCCCCCC	24.30	19664994
1748	Phosphorylation	LQGLDLSSRSLLGID HCCCCCCCCCCCCCC	32.93	29255136
1750	Phosphorylation	GLDLSSRSLLGIDTE CCCCCCCCCCCCCHH	29.87	19664994
1752	Phosphorylation	DLSSRSLLGIDTEDA CCCCCCCCCCCHHHH	6.27	27251275
1756	Phosphorylation	RSLLGIDTEDAIQGR CCCCCCCHHHHHCCC	33.57	30266825
1766	Phosphorylation	AIQGRNESCDISKEH HHCCCCCCCCCCHHH	22.19	29255136
1770	Phosphorylation	RNESCDISKEHTSET CCCCCCCCHHHCCCC	20.81	29255136
1774	Phosphorylation	CDISKEHTSETTERT CCCCHHHCCCCCCCC	29.38	23663014
1775	Phosphorylation	DISKEHTSETTERTP CCCHHHCCCCCCCCC	34.55	23663014
1777	Phosphorylation	SKEHTSETTERTPKH CHHHCCCCCCCCCCC	33.45	23663014
1777	Ubiquitination	SKEHTSETTERTPKH CHHHCCCCCCCCCCC	33.45	-
1778	Phosphorylation	KEHTSETTERTPKHD HHHCCCCCCCCCCCC	21.30	23663014
1781	Phosphorylation	TSETTERTPKHDVHQ CCCCCCCCCCCCHHH	30.38	23663014
1792	Acetylation	DVHQICDKDAQQDLN CHHHHCCCCHHHHCC	51.02	26051181
1806	Phosphorylation	NLDIEKITETGAVKP CCCHHHHHCCCCCCC	38.26	30278072
1808	Phosphorylation	DIEKITETGAVKPTG CHHHHHCCCCCCCCC	23.07	30278072
1810	Ubiquitination	EKITETGAVKPTGEC HHHHCCCCCCCCCCC	17.36	21890473
1814	Phosphorylation	ETGAVKPTGECSGEQ CCCCCCCCCCCCCCC	39.64	30278072
1818	Phosphorylation	VKPTGECSGEQSPDT CCCCCCCCCCCCCCC	40.85	30278072
1822	Phosphorylation	GECSGEQSPDTNYEP CCCCCCCCCCCCCCC	22.05	23401153
1825	Phosphorylation	SGEQSPDTNYEPPGE CCCCCCCCCCCCCCC	42.98	30278072
1827	Phosphorylation	EQSPDTNYEPPGEDK CCCCCCCCCCCCCCC	31.72	30278072
1830	Ubiquitination	PDTNYEPPGEDKTQG CCCCCCCCCCCCCCC	47.03	-
1835	Phosphorylation	EPPGEDKTQGSSECI CCCCCCCCCCCHHHH	50.95	25627689
1838	Phosphorylation	GEDKTQGSSECISEL CCCCCCCCHHHHHHC	17.10	25627689
1843	Phosphorylation	QGSSECISELSFSGP CCCHHHHHHCCCCCC	44.11	25159151
1845	Ubiquitination	SSECISELSFSGPNA CHHHHHHCCCCCCCE	5.10	-
1846	Phosphorylation	SECISELSFSGPNAL HHHHHHCCCCCCCEE	17.20	25159151
1848	Phosphorylation	CISELSFSGPNALVP HHHHCCCCCCCEEEE	50.38	25159151
1862	Phosphorylation	PMDFLGNQEDIHNLQ ECHHHCCHHHHHHCE	48.19	23186163
1868	Phosphorylation	NQEDIHNLQLRVKET CHHHHHHCEEEEEEC	2.91	23186163
1875	Phosphorylation	LQLRVKETSNENLRL CEEEEEECCCCCCEE	31.00	26471730
1876	Phosphorylation	QLRVKETSNENLRLL EEEEEECCCCCCEEE	43.15	26471730
1888	Ubiquitination	RLLHVIEDRDRKVES EEEEEHHCCHHHHHH	46.81	32015554
1892	Phosphorylation	VIEDRDRKVESLLNE EHHCCHHHHHHHHHH	55.43	24719451
1895	Phosphorylation	DRDRKVESLLNEMKE CCHHHHHHHHHHHHH	40.94	28555341
1906	Ubiquitination	EMKELDSKLHLQEVQ HHHHHHHHHHHHHHH	39.32	21890473
1936	Phosphorylation	GELKKENSDLSEKLE HHHHHHCCCHHHHHH	40.81	26471730
1939	Phosphorylation	KKENSDLSEKLEYFS HHHCCCHHHHHHHHC	37.36	-
1942	Ubiquitination	NSDLSEKLEYFSCDH CCCHHHHHHHHCCCH	5.91	29967540
1944	Phosphorylation	DLSEKLEYFSCDHQE CHHHHHHHHCCCHHH	15.95	-
1946	Phosphorylation	SEKLEYFSCDHQELL HHHHHHHCCCHHHHH	20.10	-
1958	Phosphorylation	ELLQRVETSEGLNSD HHHHHHHHCCCCCCC	29.26	20068231
1959	Phosphorylation	LLQRVETSEGLNSDL HHHHHHHCCCCCCCH	19.03	20068231
1964	Phosphorylation	ETSEGLNSDLEMHAD HHCCCCCCCHHHHCC	48.92	25159151
1968	Sulfoxidation	GLNSDLEMHADKSSR CCCCCHHHHCCCCCH	4.03	21406390
1972	Acetylation	DLEMHADKSSREDIG CHHHHCCCCCHHHHC	51.63	26051181
1973	Phosphorylation	LEMHADKSSREDIGD HHHHCCCCCHHHHCC	34.86	25159151
1973	Ubiquitination	LEMHADKSSREDIGD HHHHCCCCCHHHHCC	34.86	-
1974	Phosphorylation	EMHADKSSREDIGDN HHHCCCCCHHHHCCC	45.49	25159151
1975	Phosphorylation	MHADKSSREDIGDNV HHCCCCCHHHHCCCC	53.34	-
1981	Phosphorylation	SREDIGDNVAKVNDS CHHHHCCCCCCCCHH	30.36	-
1983	Ubiquitination	EDIGDNVAKVNDSWK HHHCCCCCCCCHHHH	19.14	21890473
1987	Ubiquitination	DNVAKVNDSWKERFL CCCCCCCHHHHHHHH	59.88	-
1988	Phosphorylation	NVAKVNDSWKERFLD CCCCCCHHHHHHHHH	34.54	26055452
2001	Phosphorylation	LDVENELSRIRSEKA HHHHHHHHHHHHCCC	21.34	28674419
2009	Phosphorylation	RIRSEKASIEHEALY HHHHCCCCHHHHHHH	39.31	-
2010	Ubiquitination	IRSEKASIEHEALYL HHHCCCCHHHHHHHH	8.17	32015554
2012	Ubiquitination	SEKASIEHEALYLEA HCCCCHHHHHHHHHH	24.78	-
2016	Phosphorylation	SIEHEALYLEADLEV CHHHHHHHHHHCHHH	15.00	27642862
2026	Phosphorylation	ADLEVVQTEKLCLEK HCHHHHHHHHHHEEC	24.39	29759185
2028	Ubiquitination	LEVVQTEKLCLEKDN HHHHHHHHHHEECCC	48.14	-
2036	Ubiquitination	LCLEKDNENKQKVIV HHEECCCCCCCEEEE	75.77	21890473
2042	Ubiquitination	NENKQKVIVCLEEEL CCCCCEEEEEEEHHH	2.03	-
2048	Phosphorylation	VIVCLEEELSVVTSE EEEEEEHHHHHHHHH	36.65	20068231
2051	Ubiquitination	CLEEELSVVTSERNQ EEEHHHHHHHHHHHH	9.46	32015554
2063	Ubiquitination	RNQLRGELDTMSKKT HHHHHHHHHHHHHHH	8.07	-
2068	Acetylation	GELDTMSKKTTALDQ HHHHHHHHHHHHHHH	43.23	25953088
2070	Phosphorylation	LDTMSKKTTALDQLS HHHHHHHHHHHHHHH	22.49	20860994
2070	Ubiquitination	LDTMSKKTTALDQLS HHHHHHHHHHHHHHH	22.49	29967540
2071	Phosphorylation	DTMSKKTTALDQLSE HHHHHHHHHHHHHHH	33.82	20860994
2077	Phosphorylation	TTALDQLSEKMKEKT HHHHHHHHHHHHHHH	29.54	20860994
2079	Ubiquitination	ALDQLSEKMKEKTQE HHHHHHHHHHHHHHH	52.47	21890473
2080	Phosphorylation	LDQLSEKMKEKTQEL HHHHHHHHHHHHHHH	6.26	18491316
2082	Phosphorylation	QLSEKMKEKTQELES HHHHHHHHHHHHHHH	58.81	18491316
2084	Phosphorylation	SEKMKEKTQELESHQ HHHHHHHHHHHHHHH	28.50	28555341
2086	Ubiquitination	KMKEKTQELESHQSE HHHHHHHHHHHHHHH	60.79	-
2108	Phosphorylation	AEAEVKEKTELLQTL HHHHHHHHHHHHHHH	41.40	20068231
2108	Ubiquitination	AEAEVKEKTELLQTL HHHHHHHHHHHHHHH	41.40	-
2123	Ubiquitination	SSDVSELLKDKTHLQ CHHHHHHHHCCHHHH	6.22	29967540
2127	Phosphorylation	SELLKDKTHLQEKLQ HHHHHCCHHHHHHHH	37.64	-
2132	Ubiquitination	DKTHLQEKLQSLEKD CCHHHHHHHHHHHHH	38.57	21890473
2133	Ubiquitination	KTHLQEKLQSLEKDS CHHHHHHHHHHHHHH	4.04	29967540
2140	Phosphorylation	LQSLEKDSQALSLTK HHHHHHHHHHHHHHH	28.55	20068231
2144	Phosphorylation	EKDSQALSLTKCELE HHHHHHHHHHHHHHH	36.69	24719451
2146	Phosphorylation	DSQALSLTKCELENQ HHHHHHHHHHHHHHH	30.21	20068231
2176	Phosphorylation	ESLQARLSESDYEKL HHHHHHCCHHHHHHC	29.51	18491316
2178	Phosphorylation	LQARLSESDYEKLNV HHHHCCHHHHHHCCH	41.96	18491316
2180	Phosphorylation	ARLSESDYEKLNVSK HHCCHHHHHHCCHHH	25.01	-
2181	Ubiquitination	RLSESDYEKLNVSKA HCCHHHHHHCCHHHH	56.93	29967540
2186	Phosphorylation	DYEKLNVSKALEAAL HHHHCCHHHHHHHHH	15.90	-
2189	Phosphorylation	KLNVSKALEAALVEK HCCHHHHHHHHHHHC	5.45	-
2204	Phosphorylation	GEFALRLSSTQEEVH CCEEEECCCCHHHHH	25.55	20068231
2205	Phosphorylation	EFALRLSSTQEEVHQ CEEEECCCCHHHHHH	38.41	24043423
2206	Phosphorylation	FALRLSSTQEEVHQL EEEECCCCHHHHHHH	36.30	24043423
2216	Phosphorylation	EVHQLRRGIEKLRVR HHHHHHHHHHHHHHE	26.44	20068230
2238	Phosphorylation	QLHIAEKLKEREREN HHHHHHHHHHHHHHC	5.39	24719451
2251	Ubiquitination	ENDSLKDKVENLERE HCCHHHHHHHHHHHH	50.27	29967540
2276	Phosphorylation	VILDAENSKAEVETL EEEECCCCHHHHHHH	25.42	25159151
2285	Phosphorylation	AEVETLKTQIEEMAR HHHHHHHHHHHHHHH	37.58	20068230
2303	Phosphorylation	VFELDLVTLRSEKEN CEEEEEEHHHHHHHH	24.61	-
2305	Ubiquitination	ELDLVTLRSEKENLT EEEEEHHHHHHHHHH	33.14	-
2312	Phosphorylation	RSEKENLTKQIQEKQ HHHHHHHHHHHHHHH	32.27	20068230
2323	Phosphorylation	QEKQGQLSELDKLLS HHHHCCHHHHHHHHH	28.38	-
2325	Ubiquitination	KQGQLSELDKLLSSF HHCCHHHHHHHHHHH	6.72	-
2330	Phosphorylation	SELDKLLSSFKSLLE HHHHHHHHHHHHHHH	44.13	29083192
2331	Phosphorylation	ELDKLLSSFKSLLEE HHHHHHHHHHHHHHH	36.34	29083192
2334	Phosphorylation	KLLSSFKSLLEEKEQ HHHHHHHHHHHHHHH	35.86	24719451
2377	Phosphorylation	ALCGDQEIMKATEQS HHHCCHHHHHHHHHH	2.59	20068231
2381	Phosphorylation	DQEIMKATEQSLDPP CHHHHHHHHHHCCCC	29.10	26714015
2384	Phosphorylation	IMKATEQSLDPPIEE HHHHHHHHCCCCHHH	28.62	29214152
2394	Ubiquitination	PPIEEEHQLRNSIEK CCHHHHHHHHHHHHH	45.45	-
2403	Ubiquitination	RNSIEKLRARLEADE HHHHHHHHHHHHHHH	28.82	27667366
2416	Phosphorylation	DEKKQLCVLQQLKES HHHHHHHHHHHHHHC	8.01	24719451
2417	Phosphorylation	EKKQLCVLQQLKESE HHHHHHHHHHHHHCH	2.34	16565220
2425	Ubiquitination	QQLKESEHHADLLKG HHHHHCHHHHHHHHH	30.62	-
2458	Phosphorylation	AALEAENSKGEVETL HHHHHHCCCCCHHHH	33.28	28555341
2467	Ubiquitination	GEVETLKAKIEGMTQ CCHHHHHHHHHHHHH	22.59	-
2473	Phosphorylation	KAKIEGMTQSLRGLE HHHHHHHHHHHCCCE	26.34	20068231
2475	Phosphorylation	KIEGMTQSLRGLELD HHHHHHHHHCCCEEE	15.74	20068231
2482	Ubiquitination	SLRGLELDVVTIRSE HHCCCEEEEEEECCH	24.38	-
2485	Phosphorylation	GLELDVVTIRSEKEN CCEEEEEEECCHHHH	15.55	20068231
2512	Phosphorylation	SELEIINSSFENILQ HHHHHHHHHHHHHHH	26.46	21712546
2513	Phosphorylation	ELEIINSSFENILQE HHHHHHHHHHHHHHH	31.90	26055452
2520	Ubiquitination	SFENILQEKEQEKVQ HHHHHHHHHHHHHHH	55.93	29967540
2528	Ubiquitination	KEQEKVQMKEKSSTA HHHHHHHHHHHHHHH	7.29	33845483
2533	Phosphorylation	VQMKEKSSTAMEMLQ HHHHHHHHHHHHHHH	31.11	28555341
2534	Phosphorylation	QMKEKSSTAMEMLQT HHHHHHHHHHHHHHH	36.79	28555341
2540	Ubiquitination	STAMEMLQTQLKELN HHHHHHHHHHHHHHH	26.37	32015554
2542	Phosphorylation	AMEMLQTQLKELNER HHHHHHHHHHHHHHH	37.26	17525332
2552	Ubiquitination	ELNERVAALHNDQEA HHHHHHHHHHCCHHH	13.39	-
2568	Phosphorylation	KAKEQNLSSQVECLE HHHHCCHHHHHHHHH	26.69	29978859
2569	Phosphorylation	AKEQNLSSQVECLEL HHHCCHHHHHHHHHH	41.22	29978859
2575	Ubiquitination	SSQVECLELEKAQLL HHHHHHHHHHHHHHH	67.55	23503661
2591	Ubiquitination	GLDEAKNNYIVLQSS CHHHHHHCEEEEECH	27.48	-
2601	Ubiquitination	VLQSSVNGLIQEVED EEECHHHCHHHHHHH	23.23	32015554
2606	Phosphorylation	VNGLIQEVEDGKQKL HHCHHHHHHHHHHHH	4.69	20068231
2615	Phosphorylation	DGKQKLEKKDEEISR HHHHHHHHHHHHHHH	75.78	20068231
2617	Ubiquitination	KQKLEKKDEEISRLK HHHHHHHHHHHHHHH	70.59	-
2621	Phosphorylation	EKKDEEISRLKNQIQ HHHHHHHHHHHHHHH	34.54	27794612
2638	Phosphorylation	EQLVSKLSQVEGEHQ HHHHHHHHHHHCHHH	35.60	17525332
2643	Ubiquitination	KLSQVEGEHQLWKEQ HHHHHHCHHHHHHHH	18.24	33845483
2658	Ubiquitination	NLELRNLTVELEQKI CHHHHHHHHHHHHHH	18.58	32015554
2665	Ubiquitination	TVELEQKIQVLQSKN HHHHHHHHHHHHHCC	3.24	32015554
2671	Ubiquitination	KIQVLQSKNASLQDT HHHHHHHCCCCHHHH	43.50	-
2672	Ubiquitination	IQVLQSKNASLQDTL HHHHHHCCCCHHHHH	39.75	23000965
2675	Ubiquitination	LQSKNASLQDTLEVL HHHCCCCHHHHHHHH	5.05	32015554
2676	Ubiquitination	QSKNASLQDTLEVLQ HHCCCCHHHHHHHHH	38.86	23000965
2688	Ubiquitination	VLQSSYKNLENELEL HHHHHHHCHHHHHHH	44.33	29967540
2700	Acetylation	LELTKMDKMSFVEKV HHHHHHHHHHHHHHH	32.71	7664357
2702	Phosphorylation	LTKMDKMSFVEKVNK HHHHHHHHHHHHHHH	31.70	20068231
2709	Ubiquitination	SFVEKVNKMTAKETE HHHHHHHHHHHHHHH	40.38	33845483
2711	Phosphorylation	VEKVNKMTAKETELQ HHHHHHHHHHHHHHH	35.87	20068231
2731	Ubiquitination	MAQKTAELQEELSGE HHHHHHHHHHHHCCC	7.82	23000965
2735	Ubiquitination	TAELQEELSGEKNRL HHHHHHHHCCCHHHH	8.62	23000965
2743	Ubiquitination	SGEKNRLAGELQLLL CCCHHHHHHHHHHHH	13.23	-
2757	Acetylation	LEEIKSSKDQLKELT HHHHHCCHHHHHHHH	57.49	130787
2761	Acetylation	KSSKDQLKELTLENS HCCHHHHHHHHHCCH	45.07	19413330
2761	Ubiquitination	KSSKDQLKELTLENS HCCHHHHHHHHHCCH	45.07	29967540
2764	Phosphorylation	KDQLKELTLENSELK HHHHHHHHHCCHHHH	32.87	19413330
2771	Ubiquitination	TLENSELKKSLDCMH HHCCHHHHHHHHCCC	35.94	29967540
2779	Acetylation	KSLDCMHKDQVEKEG HHHHCCCHHHHCCCC	23.99	19608861
2780	Phosphorylation	SLDCMHKDQVEKEGK HHHCCCHHHHCCCCH	42.98	-
2785	Ubiquitination	HKDQVEKEGKVREEI CHHHHCCCCHHHHHH	51.22	21890473
2795	Phosphorylation	VREEIAEYQLRLHEA HHHHHHHHHHHHHHH	12.11	20049867
2800	Ubiquitination	AEYQLRLHEAEKKHQ HHHHHHHHHHHHHHH	26.28	32015554
2809	Ubiquitination	AEKKHQALLLDTNKQ HHHHHHEEEECCCCE	3.82	-
2825	Ubiquitination	EVEIQTYREKLTSKE EEEHHHHHHHCCCHH	37.65	32015554
2827	Ubiquitination	EIQTYREKLTSKEEC EHHHHHHHCCCHHHH	48.33	21890473
2831	Ubiquitination	YREKLTSKEECLSSQ HHHHCCCHHHHHHCC	52.90	-
2836	Phosphorylation	TSKEECLSSQKLEID CCHHHHHHCCHHHHH	42.24	30576142
2837	Phosphorylation	SKEECLSSQKLEIDL CHHHHHHCCHHHHHH	20.56	30576142
2840	Phosphorylation	ECLSSQKLEIDLLKS HHHHCCHHHHHHHHC	5.60	-
2844	Ubiquitination	SQKLEIDLLKSSKEE CCHHHHHHHHCCHHH	8.78	21890473
2847	Phosphorylation	LEIDLLKSSKEELNN HHHHHHHCCHHHHHH	46.76	26270265
2848	Phosphorylation	EIDLLKSSKEELNNS HHHHHHCCHHHHHHH	42.36	26270265
2859	Phosphorylation	LNNSLKATTQILEEL HHHHHHHHHHHHHHH	20.04	24043423
2860	Phosphorylation	NNSLKATTQILEELK HHHHHHHHHHHHHHH	20.62	24043423
2863	Ubiquitination	LKATTQILEELKKTK HHHHHHHHHHHHHCC	2.77	-
2870	Acetylation	LEELKKTKMDNLKYV HHHHHHCCCCHHHHH	53.81	21339330
2875	Acetylation	KTKMDNLKYVNQLKK HCCCCHHHHHHHHHH	54.10	19608861
2876	Phosphorylation	TKMDNLKYVNQLKKE CCCCHHHHHHHHHHH	14.06	21403953
2881	Acetylation	LKYVNQLKKENERAQ HHHHHHHHHHCHHHH	48.56	21339330
2883	Phosphorylation	YVNQLKKENERAQGK HHHHHHHHCHHHHHH	63.84	24719451
2890	Phosphorylation	ENERAQGKMKLLIKS HCHHHHHHHHHHHHH	22.30	24719451
2893	Phosphorylation	RAQGKMKLLIKSCKQ HHHHHHHHHHHHHHH	5.52	27251275
2897	Phosphorylation	KMKLLIKSCKQLEEE HHHHHHHHHHHHHHH	21.39	17081983
2900	Phosphorylation	LLIKSCKQLEEEKEI HHHHHHHHHHHHHHH	59.44	18669648
2911	Phosphorylation	EKEILQKELSQLQAA HHHHHHHHHHHHHHH	40.47	17081983
2915	Phosphorylation	LQKELSQLQAAQEKQ HHHHHHHHHHHHHHH	3.17	17081983
2922	Phosphorylation	LQAAQEKQKTGTVMD HHHHHHHHCCCCCCC	48.03	19651622
2923	Phosphorylation	QAAQEKQKTGTVMDT HHHHHHHCCCCCCCH	61.05	20068231
2926	Phosphorylation	QEKQKTGTVMDTKVD HHHHCCCCCCCHHHH	20.21	30576142
2927	Ubiquitination	EKQKTGTVMDTKVDE HHHCCCCCCCHHHHH	3.28	-
2930	Phosphorylation	KTGTVMDTKVDELTT CCCCCCCHHHHHHHH	18.18	30576142
2935	Phosphorylation	MDTKVDELTTEIKEL CCHHHHHHHHHHHHH	6.59	27251275
2936	Phosphorylation	DTKVDELTTEIKELK CHHHHHHHHHHHHHH	21.97	23312004
2937	Phosphorylation	TKVDELTTEIKELKE HHHHHHHHHHHHHHH	48.62	23312004
2937	Ubiquitination	TKVDELTTEIKELKE HHHHHHHHHHHHHHH	48.62	23000965
2940	Ubiquitination	DELTTEIKELKETLE HHHHHHHHHHHHHHH	51.25	21890473
2945	Phosphorylation	EIKELKETLEEKTKE HHHHHHHHHHHHHHH	37.57	21601212
2946	Phosphorylation	IKELKETLEEKTKEA HHHHHHHHHHHHHHH	9.32	24719451
2949	Phosphorylation	LKETLEEKTKEADEY HHHHHHHHHHHHHHH	56.36	24719451
2950	Phosphorylation	KETLEEKTKEADEYL HHHHHHHHHHHHHHH	37.08	21601212
2952	Phosphorylation	TLEEKTKEADEYLDK HHHHHHHHHHHHHHH	67.59	24719451
2954	Phosphorylation	EEKTKEADEYLDKYC HHHHHHHHHHHHHHH	46.28	-
2959	Ubiquitination	EADEYLDKYCSLLIS HHHHHHHHHHHHHHC	45.63	29967540
2960	Ubiquitination	ADEYLDKYCSLLISH HHHHHHHHHHHHHCH	6.22	23000965
2962	Phosphorylation	EYLDKYCSLLISHEK HHHHHHHHHHHCHHH	24.11	28555341
2979	Phosphorylation	KAKEMLETQVAHLCS HHHHHHHHHHHHHHH	25.12	24719451
2986	Phosphorylation	TQVAHLCSQQSKQDS HHHHHHHHHCCCCCC	37.30	24719451
2987	Ubiquitination	QVAHLCSQQSKQDSR HHHHHHHHCCCCCCC	51.04	-
2989	Phosphorylation	AHLCSQQSKQDSRGS HHHHHHCCCCCCCCC	25.33	26074081
2993	Phosphorylation	SQQSKQDSRGSPLLG HHCCCCCCCCCCCCC	35.73	23401153
2994	Phosphorylation	QQSKQDSRGSPLLGP HCCCCCCCCCCCCCC	58.88	-
2996	Phosphorylation	SKQDSRGSPLLGPVV CCCCCCCCCCCCCCC	15.97	29255136
2996	Ubiquitination	SKQDSRGSPLLGPVV CCCCCCCCCCCCCCC	15.97	23000965
2997	Phosphorylation	KQDSRGSPLLGPVVP CCCCCCCCCCCCCCC	34.13	-
2998	Phosphorylation	QDSRGSPLLGPVVPG CCCCCCCCCCCCCCC	10.39	19691289
3000	Phosphorylation	SRGSPLLGPVVPGPS CCCCCCCCCCCCCCC	22.19	18669648
3005	Phosphorylation	LLGPVVPGPSPIPSV CCCCCCCCCCCCCCC	24.57	-
3007	Phosphorylation	GPVVPGPSPIPSVTE CCCCCCCCCCCCCCH	41.18	22167270
3011	Phosphorylation	PGPSPIPSVTEKRLS CCCCCCCCCCHHHCC	42.25	30266825
3012	Phosphorylation	GPSPIPSVTEKRLSS CCCCCCCCCHHHCCC	7.22	-
3013	Phosphorylation	PSPIPSVTEKRLSSG CCCCCCCCHHHCCCC	39.88	30266825
3015	Acetylation	PIPSVTEKRLSSGQN CCCCCCHHHCCCCCC	49.64	25953088
3018	Phosphorylation	SVTEKRLSSGQNKAS CCCHHHCCCCCCCCC	36.13	22496350
3019	Phosphorylation	VTEKRLSSGQNKASG CCHHHCCCCCCCCCC	49.33	20068231
3019	Ubiquitination	VTEKRLSSGQNKASG CCHHHCCCCCCCCCC	49.33	23000965
3023	Phosphorylation	RLSSGQNKASGKRQR HCCCCCCCCCCCCCC	35.72	19664994
3025	Phosphorylation	SSGQNKASGKRQRSS CCCCCCCCCCCCCCC	46.59	20068231
3026	Phosphorylation	SGQNKASGKRQRSSG CCCCCCCCCCCCCCC	33.74	20068231
3031	Phosphorylation	ASGKRQRSSGIWENG CCCCCCCCCCCCCCC	25.28	21815630
3032	Phosphorylation	SGKRQRSSGIWENGR CCCCCCCCCCCCCCC	36.16	25159151
3042	Phosphorylation	WENGRGPTPATPESF CCCCCCCCCCCHHHH	28.51	25159151
3043	Phosphorylation	ENGRGPTPATPESFS CCCCCCCCCCHHHHC	36.95	-
3045	Phosphorylation	GRGPTPATPESFSKK CCCCCCCCHHHHCHH	28.88	25159151
3048	Phosphorylation	PTPATPESFSKKSKK CCCCCHHHHCHHHHH	35.70	25159151
3050	Phosphorylation	PATPESFSKKSKKAV CCCHHHHCHHHHHHH	48.75	25159151
3051	Acetylation	ATPESFSKKSKKAVM CCHHHHCHHHHHHHH	60.08	25953088
3053	Phosphorylation	PESFSKKSKKAVMSG HHHHCHHHHHHHHCC	43.03	21601212
3054	Phosphorylation	ESFSKKSKKAVMSGI HHHCHHHHHHHHCCC	54.34	19691289
3058	Phosphorylation	KKSKKAVMSGIHPAE HHHHHHHHCCCCCCC	3.47	-
3059	Phosphorylation	KSKKAVMSGIHPAED HHHHHHHCCCCCCCC	28.17	21130716
3060	Phosphorylation	SKKAVMSGIHPAEDT HHHHHHCCCCCCCCC	12.25	20068231
3067	Phosphorylation	GIHPAEDTEGTEFEP CCCCCCCCCCCCCCC	28.02	21130716
3079	Phosphorylation	FEPEGLPEVVKKGFA CCCCCHHHHHHHCCC	66.05	18669648
3081	Phosphorylation	PEGLPEVVKKGFADI CCCHHHHHHHCCCCC	5.17	19651622
3083	Phosphorylation	GLPEVVKKGFADIPT CHHHHHHHCCCCCCC	47.88	33259812
3090	Phosphorylation	KGFADIPTGKTSPYI HCCCCCCCCCCCCCH	52.20	26055452
3092	Acetylation	FADIPTGKTSPYILR CCCCCCCCCCCCHHH	48.59	25953088
3092	Ubiquitination	FADIPTGKTSPYILR CCCCCCCCCCCCHHH	48.59	-
3093	Phosphorylation	ADIPTGKTSPYILRR CCCCCCCCCCCHHHH	35.96	30266825
3094	Phosphorylation	DIPTGKTSPYILRRT CCCCCCCCCCHHHHC	21.13	23401153
3096	Phosphorylation	PTGKTSPYILRRTTM CCCCCCCCHHHHCCC	16.62	30266825
3098	Phosphorylation	GKTSPYILRRTTMAT CCCCCCHHHHCCCCC	2.21	24719451
3101	Phosphorylation	SPYILRRTTMATRTS CCCHHHHCCCCCCCC	17.94	22199227
3102	Phosphorylation	PYILRRTTMATRTSP CCHHHHCCCCCCCCH	11.73	22199227
3105	Phosphorylation	LRRTTMATRTSPRLA HHHCCCCCCCCHHHH	24.53	22199227
3107	Phosphorylation	RTTMATRTSPRLAAQ HCCCCCCCCHHHHHH	38.43	22199227
3108	Phosphorylation	TTMATRTSPRLAAQK CCCCCCCCHHHHHHH	12.53	22199227
3111	Farnesylation	ATRTSPRLAAQKLAL CCCCCHHHHHHHHCC	5.41	10852915
3111	Methylation	ATRTSPRLAAQKLAL CCCCCHHHHHHHHCC	5.41	-
3115	Acetylation	SPRLAAQKLALSPLS CHHHHHHHHCCCCHH	30.88	25953088
3115	Ubiquitination	SPRLAAQKLALSPLS CHHHHHHHHCCCCHH	30.88	-
3119	Phosphorylation	AAQKLALSPLSLGKE HHHHHCCCCHHHCCC	20.42	19664994
3122	Phosphorylation	KLALSPLSLGKENLA HHCCCCHHHCCCCCH	38.16	30266825
3131	Phosphorylation	GKENLAESSKPTAGG CCCCCHHCCCCCCCC	37.75	24732914
3132	Phosphorylation	KENLAESSKPTAGGS CCCCHHCCCCCCCCC	33.87	24732914
3133	Acetylation	ENLAESSKPTAGGSR CCCHHCCCCCCCCCH	56.52	26051181
3135	Phosphorylation	LAESSKPTAGGSRSQ CHHCCCCCCCCCHHC	41.49	24732914
3139	Phosphorylation	SKPTAGGSRSQKVKV CCCCCCCCHHCCEEE	28.04	24732914
3150	Phosphorylation	KVKVAQRSPVDSGTI CEEEEECCCCCCCCC	19.73	29255136
3154	Phosphorylation	AQRSPVDSGTILREP EECCCCCCCCCCCCC	37.76	23927012
3156	Phosphorylation	RSPVDSGTILREPTT CCCCCCCCCCCCCCC	22.31	23927012
3162	Phosphorylation	GTILREPTTKSVPVN CCCCCCCCCCCCCCC	41.94	23927012
3163	Phosphorylation	TILREPTTKSVPVNN CCCCCCCCCCCCCCC	31.85	23927012
3165	Phosphorylation	LREPTTKSVPVNNLP CCCCCCCCCCCCCCC	29.57	23927012
3175	Phosphorylation	VNNLPERSPTDSPRE CCCCCCCCCCCCCCC	30.41	22167270
3177	Phosphorylation	NLPERSPTDSPREGL CCCCCCCCCCCCCCC	50.81	30266825
3179	Phosphorylation	PERSPTDSPREGLRV CCCCCCCCCCCCCEE	28.47	22167270
3194	Phosphorylation	KRGRLVPSPKAGLES CCCEECCCCCCCCCC	31.39	21815630
3207	Farnesylation	ESNGSENCKVQ---- CCCCCCCCCCC----	3.92	10852915
3207	Methylation	ESNGSENCKVQ---- CCCCCCCCCCC----	3.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CDC20	Q12834	PMID:20053638

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CENPF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
2936	Phosphorylation	2943 (7)	R ⇒ G;*	rs438034	Response to antineoplastic agents	21659360
2940	Ubiquitination	2943 (3)	R ⇒ G;*	rs438034	Response to antineoplastic agents	21659360
2949	Phosphorylation	2943 (6)	R ⇒ G;*	rs438034	Response to antineoplastic agents	21659360
2952	Phosphorylation	2943 (9)	R ⇒ G;*	rs438034	Response to antineoplastic agents	21659360

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPF_HUMAN	CENPF	physical	7642639
NU107_HUMAN	NUP107	physical	17363900
NU133_HUMAN	NUP133	physical	17363900
NQO2_HUMAN	NQO2	physical	22939629
NDEL1_HUMAN	NDEL1	physical	17600710

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616369	Ciliary dyskinesia, primary, 31 (CILD31)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CENPF_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2875, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1750; SER-2996; SER-3007AND SER-3119, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-154; SER-1747; SER-2996;SER-3007 AND SER-3119, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; THR-144; SER-834;SER-1248; SER-1747; SER-1748; SER-1750; SER-2512; SER-2513; SER-2996;SER-3007; SER-3119; SER-3122; SER-3150; SER-3175 AND SER-3179, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3150 AND SER-3175, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-253; SER-1590; SER-3094AND SER-3150, AND MASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1255; SER-1282 ANDSER-2638, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268; SER-274 ANDSER-276, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1315; THR-1319; SER-3119AND SER-3150, AND MASS SPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-821; SER-1324; SER-1747;SER-1750; SER-1988; SER-2513; SER-2996; SER-3007; SER-3094; SER-3119;SER-3175 AND SER-3179, AND MASS SPECTROMETRY.	16565220 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1747; SER-1750 ANDSER-3119, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3150, AND MASSSPECTROMETRY.	17081983 [Abstract]
Prenylation
Reference	PubMed
"Farnesyl transferase inhibitors block the farnesylation of CENP-E andCENP-F and alter the association of CENP-E with the microtubules."; Ashar H.R., James L., Gray K., Carr D., Black S., Armstrong L.,Bishop W.R., Kirschmeier P.; J. Biol. Chem. 275:30451-30457(2000). Cited for: ISOPRENYLATION AT CYS-3207.	10852915 [Abstract]