MI4GD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MI4GD_HUMAN
• UniProt AC: A9UHW6
• Protein Name: MIF4G domain-containing protein
• Gene Name: MIF4GD
• Organism: Homo sapiens (Human).
• Sequence Length: 222
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation..
• Protein Sequence: MGEPSREEYKIQSFDAETQQLLKTALKDPGAVDLEKVANVIVDHSLQDCVFSKEAGRMCYAIIQAESKQAGQSVFRRGLLNRLQQEYQAREQLRARSLQGWVCYVTFICNIFDYLRVNNMPMMALVNPVYDCLFRLAQPDSLSKEEEVDCLVLQLHRVGEQLEKMNGQRMDELFVLIRDGFLLPTGLSSLAQLLLLEIIEFRAAGWKTTPAAHKYYYSEVSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	EPSREEYKIQSFDAE CCCHHHHCCCCCCHH	37.23	-
18	Phosphorylation	IQSFDAETQQLLKTA CCCCCHHHHHHHHHH	24.28	-
23	Ubiquitination	AETQQLLKTALKDPG HHHHHHHHHHHCCCC	40.10	-
27	Ubiquitination	QLLKTALKDPGAVDL HHHHHHHCCCCCCCH	60.45	-
36	Ubiquitination	PGAVDLEKVANVIVD CCCCCHHHHHHHHHC	54.68	-
53	Acetylation	LQDCVFSKEAGRMCY HHHHHCCHHHHHHHH	39.87	23749302
53	Malonylation	LQDCVFSKEAGRMCY HHHHHCCHHHHHHHH	39.87	26320211
53	Ubiquitination	LQDCVFSKEAGRMCY HHHHHCCHHHHHHHH	39.87	-
68	Ubiquitination	AIIQAESKQAGQSVF HHHHHHHHHHCHHHH	35.36	-
214	Ubiquitination	KTTPAAHKYYYSEVS CCCCCHHHHHHCCCC	30.16	-
218	Phosphorylation	AAHKYYYSEVSD--- CHHHHHHCCCCC---	18.52	28102081
221	Phosphorylation	KYYYSEVSD------ HHHHCCCCC------	33.29	27732954
262	Phosphorylation	----------------------------------------------- -----------------------------------------------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MI4GD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MI4GD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MI4GD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VIP1_HUMAN	PPIP5K1	physical	22939629
PDXD1_HUMAN	PDXDC1	physical	22939629
PPARG_HUMAN	PPARG	physical	21988832
CTIF_HUMAN	CTIF	physical	26186194
KLK3_HUMAN	KLK3	physical	26186194
CTIF_HUMAN	CTIF	physical	28514442
KLK3_HUMAN	KLK3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.