GAPR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GAPR1_HUMAN
• UniProt AC: Q9H4G4
• Protein Name: Golgi-associated plant pathogenesis-related protein 1
• Gene Name: GLIPR2
• Organism: Homo sapiens (Human).
• Sequence Length: 154
• Subcellular Localization: Golgi apparatus membrane ; Lipid-anchor . Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.
• Protein Sequence: MGKSASKQFHNEVLKAHNEYRQKHGVPPLKLCKNLNREAQQYSEALASTRILKHSPESSRGQCGENLAWASYDQTGKEVADRWYSEIKNYNFQQPGFTSGTGHFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNVVNEGFFEENVLPPKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGKSASKQF ------CCCCHHHHH	32.40	11865038
2	N-myristoyl glycine	------MGKSASKQF ------CCCCHHHHH	32.40	-
7	Ubiquitination	-MGKSASKQFHNEVL -CCCCHHHHHHHHHH	57.61	-
15	Ubiquitination	QFHNEVLKAHNEYRQ HHHHHHHHHHHHHHH	53.42	2189047
23	Ubiquitination	AHNEYRQKHGVPPLK HHHHHHHHHCCCHHH	33.07	-
30	Ubiquitination	KHGVPPLKLCKNLNR HHCCCHHHHHHHCCH	58.58	-
33	Ubiquitination	VPPLKLCKNLNREAQ CCHHHHHHHCCHHHH	74.94	-
42	Phosphorylation	LNREAQQYSEALAST CCHHHHHHHHHHHHH	9.08	19060867
43	Phosphorylation	NREAQQYSEALASTR CHHHHHHHHHHHHHH	16.44	-
48	Phosphorylation	QYSEALASTRILKHS HHHHHHHHHHHHHCC	21.04	-
49	Phosphorylation	YSEALASTRILKHSP HHHHHHHHHHHHCCC	19.00	-
53	Ubiquitination	LASTRILKHSPESSR HHHHHHHHCCCCCCC	39.40	-
53	Acetylation	LASTRILKHSPESSR HHHHHHHHCCCCCCC	39.40	25953088
55	Phosphorylation	STRILKHSPESSRGQ HHHHHHCCCCCCCCC	28.86	30266825
58	Phosphorylation	ILKHSPESSRGQCGE HHHCCCCCCCCCCCC	28.81	30266825
59	Phosphorylation	LKHSPESSRGQCGEN HHCCCCCCCCCCCCC	38.48	30266825
71	Phosphorylation	GENLAWASYDQTGKE CCCCEEEEECCCCHH	20.67	27251275
77	Ubiquitination	ASYDQTGKEVADRWY EEECCCCHHHHHHHH	53.02	-
88	Ubiquitination	DRWYSEIKNYNFQQP HHHHHHHHHCCCCCC	49.69	-
98	Phosphorylation	NFQQPGFTSGTGHFT CCCCCCCCCCCCEEE	31.96	27251275
99	Phosphorylation	FQQPGFTSGTGHFTA CCCCCCCCCCCEEEE	31.90	27251275
101	Phosphorylation	QPGFTSGTGHFTAMV CCCCCCCCCEEEEEE	27.53	27251275
119	Ubiquitination	TKKMGVGKASASDGS CCCCCCCEEECCCCC	36.44	-
123	Phosphorylation	GVGKASASDGSSFVV CCCEEECCCCCCEEE	39.75	27251275
153	Ubiquitination	EENVLPPKK------ CCCCCCCCC------	70.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GAPR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GAPR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GAPR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAV1_HUMAN	CAV1	physical	11865038
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Identification and characterization of a novel human plantpathogenesis-related protein that localizes to lipid-enrichedmicrodomains in the Golgi complex.";
Eberle H.B., Serrano R.L., Fuellekrug J., Schlosser A., Lehmann W.D.,Lottspeich F., Kaloyanova D., Wieland F.T., Helms J.B.;
J. Cell Sci. 115:827-838(2002).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-49 AND 54-68,SUBCELLULAR LOCATION, MYRISTOYLATION AT GLY-2, AND INTERACTION WITHCAV1.
PubMed: 11865038